Dapagliflozin_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dapagliflozin perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dapagliflozin_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.172306
EEF2 eukaryotic translation elongation factor 2 0.130279
MMP12 matrix metallopeptidase 12 0.0983667
YAP1 Yes-associated protein 1 0.0961872
PDE4D phosphodiesterase 4D, cAMP-specific 0.0931465
JMJD1C jumonji domain containing 1C 0.0849542
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0842649
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0734459
TENM3 teneurin transmembrane protein 3 0.070431
DST dystonin 0.0695668
MGAT4C MGAT4 family, member C 0.0672964
VMP1 vacuole membrane protein 1 0.0621872
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0599455
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.059779
MED13L mediator complex subunit 13-like 0.0569641
EIF4A2 eukaryotic translation initiation factor 4A2 0.0547312
PDGFC platelet derived growth factor C 0.0546314
GSK3B glycogen synthase kinase 3 beta 0.0538371
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0507956
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0488213
ERRFI1 ERBB receptor feedback inhibitor 1 0.0477359
ARL15 ADP-ribosylation factor-like 15 0.0467041
TSC22D2 TSC22 domain family, member 2 0.046568
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0457583
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0449006
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0448159
USP34 ubiquitin specific peptidase 34 0.0445378
CLTC clathrin, heavy chain (Hc) 0.0442897
PUM2 pumilio RNA-binding family member 2 0.0439413
NEK7 NIMA-related kinase 7 0.043651
DTNA dystrobrevin, alpha 0.0420902
EPHA6 EPH receptor A6 0.0416071
TPM3 tropomyosin 3 0.0415221
XPO1 exportin 1 0.0413494
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0407277
ARHGAP12 Rho GTPase activating protein 12 0.040715
NEBL nebulette 0.0396523
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0395456
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0393184
CCNL1 cyclin L1 0.0385339
TNPO1 transportin 1 0.0382035
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.038057
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0379566
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0378712
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0373587
KMT2E lysine (K)-specific methyltransferase 2E 0.0366714
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0364087
PCM1 pericentriolar material 1 0.0363382
TXNRD1 thioredoxin reductase 1 0.0361318
ADGRG6 adhesion G protein-coupled receptor G6 0.0360975
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0359348
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0358575
SPATS2 spermatogenesis associated, serine-rich 2 0.0358151
PCBP2 poly(rC) binding protein 2 0.0354868
H1-0 H1.0 linker histone 0.0354511
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.035196
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0351951
FER fer (fps/fes related) tyrosine kinase 0.0348574
FXR1 fragile X mental retardation, autosomal homolog 1 0.0348472
RNF13 ring finger protein 13 0.0346248
NECTIN3 nectin cell adhesion molecule 3 0.0345393
MEMO1 mediator of cell motility 1 0.0344659
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0343709
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.034273
PRKCI protein kinase C, iota 0.033713
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0336494
NHSL1 NHS-like 1 0.0332311
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0331514
ADAM17 ADAM metallopeptidase domain 17 0.0330031
BIRC6 baculoviral IAP repeat containing 6 0.0326654
CELF2 CUGBP, Elav-like family member 2 0.0326596
ERBIN erbb2 interacting protein 0.0323647
WNK1 WNK lysine deficient protein kinase 1 0.0322143
ZFAND3 zinc finger, AN1-type domain 3 0.0320424
NBAS neuroblastoma amplified sequence 0.0320153
ATP11B ATPase, class VI, type 11B 0.0319608
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0319121
BRD2 bromodomain containing 2 0.0316955
NCAPD2 non-SMC condensin I complex, subunit D2 0.0316211
MSI2 musashi RNA-binding protein 2 0.0315794
CDK17 cyclin-dependent kinase 17 0.0315367
KLHL24 kelch-like family member 24 0.031509
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0314001
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.03124
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0312158
TRIO trio Rho guanine nucleotide exchange factor 0.0310917
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0310686
NUP58 nucleoporin 58 0.0310496
FBXO11 F-box protein 11 0.0308171
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0307699
UBA6 ubiquitin-like modifier activating enzyme 6 0.0306611
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0303392
TMEM41B transmembrane protein 41B 0.0298331
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0297743
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0297165
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0291571
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0289029
LRP6 low density lipoprotein receptor-related protein 6 0.0288085
FNDC3B fibronectin type III domain containing 3B 0.0284871
PICALM phosphatidylinositol binding clathrin assembly protein 0.0279303

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.147918
TMSB10 thymosin beta 10 -0.143316
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.095423
AREG amphiregulin -0.094899
PTMA prothymosin, alpha -0.0905347
TPT1 tumor protein, translationally-controlled 1 -0.0867063
MYL12B myosin, light chain 12B, regulatory -0.081994
RPLP1 ribosomal protein, large, P1 -0.0692734
RPL35A ribosomal protein L35a -0.0668973
ACTG1 actin gamma 1 -0.0613757
RPL23 ribosomal protein L23 -0.0610368
FTL ferritin, light polypeptide -0.0581995
RPL12 ribosomal protein L12 -0.0566498
NAP1L1 nucleosome assembly protein 1-like 1 -0.055718
RPS24 ribosomal protein S24 -0.0542901
RPS6 ribosomal protein S6 -0.0503877
RPL26 ribosomal protein L26 -0.0502192
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0493693
LOC102724023 ES1 protein homolog, mitochondrial -0.0478328
RPL34 ribosomal protein L34 -0.0467879
RPS19 ribosomal protein S19 -0.0466839
RPS8 ribosomal protein S8 -0.0464528
RPS3 ribosomal protein S3 -0.0443982
RPS27A ribosomal protein S27a -0.0443889
RPL37 ribosomal protein L37 -0.0430018
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0408835
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0396389
RPL9 ribosomal protein L9 -0.0390224
RPS13 ribosomal protein S13 -0.0388534
RPL38 ribosomal protein L38 -0.0383975
RPL31 ribosomal protein L31 -0.0364281
EIF1 eukaryotic translation initiation factor 1 -0.0359898
IFIH1 interferon induced with helicase C domain 1 -0.0344294
RPS27 ribosomal protein S27 -0.0343655
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0341942
RPL19 ribosomal protein L19 -0.0340085
RPS16 ribosomal protein S16 -0.0339069
GCG glucagon -0.0333946
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.033323
RPS14 ribosomal protein S14 -0.0323874
RPLP2 ribosomal protein, large, P2 -0.0323467
RACK1 receptor for activated C kinase 1 -0.0319355
RPLP0 ribosomal protein, large, P0 -0.0317607
ATP5F1E ATP synthase F1 subunit epsilon -0.0317183
RPL27 ribosomal protein L27 -0.0314478
RPS21 ribosomal protein S21 -0.0309928
RPL11 ribosomal protein L11 -0.0304679
HMGB1 high mobility group box 1 -0.0303954
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.029548
RPS29 ribosomal protein S29 -0.0293945
RPL36 ribosomal protein L36 -0.0290924
TM4SF1 transmembrane 4 L six family member 1 -0.0287201
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0284558
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0274114
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0273074
SLC38A1 solute carrier family 38, member 1 -0.0269898
NACA nascent polypeptide-associated complex alpha subunit -0.0269475
CNRIP1 cannabinoid receptor interacting protein 1 -0.0269152
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0265739
RPL7 ribosomal protein L7 -0.0265404
RPL36A ribosomal protein L36a -0.0263703
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.026138
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0254093
NLGN1 neuroligin 1 -0.0253108
EIF5B eukaryotic translation initiation factor 5B -0.025191
CCND1 cyclin D1 -0.0250064
S100A10 S100 calcium binding protein A10 -0.0249513
RPL27A ribosomal protein L27a -0.0245457
RPL5 ribosomal protein L5 -0.0243011
TBCA tubulin folding cofactor A -0.024087
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0239704
RPS25 ribosomal protein S25 -0.023857
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0238164
RPL37A ribosomal protein L37a -0.0237832
RPL7A ribosomal protein L7a -0.0228036
RPS20 ribosomal protein S20 -0.0225841
VDAC1 voltage-dependent anion channel 1 -0.0225642
RPL32 ribosomal protein L32 -0.0224255
HSPB1 heat shock 27kDa protein 1 -0.0218322
BIRC3 baculoviral IAP repeat containing 3 -0.0215282
EGR1 early growth response 1 -0.0203266
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0201931
RPL8 ribosomal protein L8 -0.0199392
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0196108
HMGA2 high mobility group AT-hook 2 -0.019538
RPS23 ribosomal protein S23 -0.0191962
RAD21 RAD21 homolog (S. pombe) -0.0191903
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0191535
PRDX1 peroxiredoxin 1 -0.0186749
RPL28 ribosomal protein L28 -0.0186221
BRCA1 breast cancer 1, early onset -0.0185525
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.0185095
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0183594
KPNB1 karyopherin (importin) beta 1 -0.0181022
NPR2 natriuretic peptide receptor 2 -0.0179724
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0178005
S100A11 S100 calcium binding protein A11 -0.0177342
RPL30 ribosomal protein L30 -0.0177103
LRRC23 leucine rich repeat containing 23 -0.0176869
HLA-B major histocompatibility complex, class I, B -0.0176396