Dapagliflozin_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dapagliflozin perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dapagliflozin_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0755325
PLAT plasminogen activator, tissue 0.0644273
AKAP12 A kinase (PRKA) anchor protein 12 0.0606898
ITPRID2 ITPR interacting domain containing 2 0.0579042
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0495806
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0450161
EEF2 eukaryotic translation elongation factor 2 0.044934
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0440613
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0426656
SOS1 son of sevenless homolog 1 (Drosophila) 0.0410711
EFNA5 ephrin-A5 0.0381519
FMN1 formin 1 0.0373926
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.034665
MKI67 marker of proliferation Ki-67 0.0342856
MYH9 myosin, heavy chain 9, non-muscle 0.0342589
SETD5 SET domain containing 5 0.0341517
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0337389
AFF4 AF4/FMR2 family, member 4 0.0330856
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0329196
CLTC clathrin, heavy chain (Hc) 0.0327924
TRIO trio Rho guanine nucleotide exchange factor 0.0315466
CEMIP cell migration inducing protein, hyaluronan binding 0.0311006
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0310315
AMOTL1 angiomotin like 1 0.0294653
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0289009
MAP1B microtubule-associated protein 1B 0.0270892
GPC5 glypican 5 0.0268691
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0267355
WDR45B WD repeat domain 45B 0.02651
FNDC3B fibronectin type III domain containing 3B 0.0261771
SHB Src homology 2 domain containing adaptor protein B 0.0257049
ZNF148 zinc finger protein 148 0.0252152
AFF3 AF4/FMR2 family, member 3 0.0251591
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0246428
MBNL2 muscleblind-like splicing regulator 2 0.0245342
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0244032
DST dystonin 0.0241474
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.023788
DPH6 diphthamine biosynthesis 6 0.0237773
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0237175
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0232478
CEP170 centrosomal protein 170kDa 0.0231124
PHIP pleckstrin homology domain interacting protein 0.0229822
CENPF centromere protein F, 350/400kDa 0.0228486
USP8 ubiquitin specific peptidase 8 0.0226471
TBC1D22A TBC1 domain family, member 22A 0.0224036
UNC5C unc-5 homolog C (C. elegans) 0.0222976
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0221055
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0213632
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0213472
COG5 component of oligomeric golgi complex 5 0.0212986
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit 0.0212611
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0210728
TPR translocated promoter region, nuclear basket protein 0.0209548
EIF4A2 eukaryotic translation initiation factor 4A2 0.0208039
OGA O-GlcNAcase 0.0206071
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0205903
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0205873
EPAS1 endothelial PAS domain protein 1 0.0203167
SERINC1 serine incorporator 1 0.0199158
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0199107
TENT4A terminal nucleotidyltransferase 4A 0.0197485
ARID5B AT rich interactive domain 5B (MRF1-like) 0.019509
ZBTB20 zinc finger and BTB domain containing 20 0.0194388
NPAS3 neuronal PAS domain protein 3 0.0193621
ZDHHC17 zinc finger, DHHC-type containing 17 0.019022
CCNY cyclin Y 0.01893
RFC3 replication factor C (activator 1) 3, 38kDa 0.0188882
GRB2 growth factor receptor-bound protein 2 0.018861
MYO9A myosin IXA 0.0188021
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 0.0186783
ZFC3H1 zinc finger, C3H1-type containing 0.0186702
RHOA ras homolog family member A 0.0185802
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0185012
NUMA1 nuclear mitotic apparatus protein 1 0.0184734
USP34 ubiquitin specific peptidase 34 0.0184178
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0183039
SETBP1 SET binding protein 1 0.0182384
CCDC93 coiled-coil domain containing 93 0.0182339
YEATS2 YEATS domain containing 2 0.0181127
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 0.0180457
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0178508
UBA6 ubiquitin-like modifier activating enzyme 6 0.0178186
MRTFA myocardin related transcription factor A 0.0177784
PTPRE protein tyrosine phosphatase, receptor type, E 0.017762
ETNK1 ethanolamine kinase 1 0.017649
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0174886
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0174745
RUNX1 runt-related transcription factor 1 0.0174528
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 0.017443
COL4A5 collagen, type IV, alpha 5 0.0174018
VGF VGF nerve growth factor inducible 0.0174012
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0172571
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.0171414
ADGRG6 adhesion G protein-coupled receptor G6 0.0169215
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0168759
USP53 ubiquitin specific peptidase 53 0.0168239
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0167865
STAG2 stromal antigen 2 0.0167431
NEK7 NIMA-related kinase 7 0.0167343

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.177852
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.122859
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.110283
RPS6 ribosomal protein S6 -0.10643
RPL23 ribosomal protein L23 -0.100508
LSAMP limbic system-associated membrane protein -0.0920724
PTMA prothymosin, alpha -0.0818619
VIM vimentin -0.0732665
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.071691
RPLP1 ribosomal protein, large, P1 -0.0646063
RPL35A ribosomal protein L35a -0.0548283
RPL19 ribosomal protein L19 -0.0512539
TPT1 tumor protein, translationally-controlled 1 -0.0483788
B2M beta-2-microglobulin -0.0482561
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0438914
TMSB10 thymosin beta 10 -0.0433022
ACTG1 actin gamma 1 -0.0423024
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0417186
RPS19 ribosomal protein S19 -0.0406621
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0405558
TLE4 transducin-like enhancer of split 4 -0.0397554
RPL34 ribosomal protein L34 -0.0397508
RPL26 ribosomal protein L26 -0.0394514
RHOBTB3 Rho-related BTB domain containing 3 -0.0392514
RPLP0 ribosomal protein, large, P0 -0.0382838
RPS25 ribosomal protein S25 -0.0380283
RPS29 ribosomal protein S29 -0.038008
RPS24 ribosomal protein S24 -0.0370529
FNBP1 formin binding protein 1 -0.0347866
RPL38 ribosomal protein L38 -0.0342946
PTPRD protein tyrosine phosphatase, receptor type, D -0.0340011
EXT1 exostosin glycosyltransferase 1 -0.0338221
RPS16 ribosomal protein S16 -0.0334447
RPS14 ribosomal protein S14 -0.0323145
FTH1 ferritin, heavy polypeptide 1 -0.0322517
RPS12 ribosomal protein S12 -0.0320829
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0308322
FTL ferritin, light polypeptide -0.0298631
NAP1L1 nucleosome assembly protein 1-like 1 -0.0298029
GNAS GNAS complex locus -0.0296124
RPS8 ribosomal protein S8 -0.0291365
ZNF292 zinc finger protein 292 -0.0289089
RPS23 ribosomal protein S23 -0.0279663
RPL31 ribosomal protein L31 -0.027697
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0275573
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0270972
SYT1 synaptotagmin I -0.0270775
RACK1 receptor for activated C kinase 1 -0.0268107
ENAH enabled homolog (Drosophila) -0.0267724
RPL12 ribosomal protein L12 -0.0267221
BCAS3 breast carcinoma amplified sequence 3 -0.0265898
HILPDA hypoxia inducible lipid droplet-associated -0.0265834
RPS27 ribosomal protein S27 -0.0261735
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0256318
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0255924
RBM39 RNA binding motif protein 39 -0.0254155
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0247865
S100A9 S100 calcium binding protein A9 -0.0247512
POTEF POTE ankyrin domain family, member F -0.0245584
MX2 MX dynamin-like GTPase 2 -0.0242015
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0241619
RPL9 ribosomal protein L9 -0.0237872
CRH corticotropin releasing hormone -0.0237573
FOXN3 forkhead box N3 -0.0236783
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0236216
RPS17 ribosomal protein S17 -0.0236109
GATA3 GATA binding protein 3 -0.0234181
RPL32 ribosomal protein L32 -0.0234151
LRP1B low density lipoprotein receptor-related protein 1B -0.0232926
SOX4 SRY (sex determining region Y)-box 4 -0.0230772
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0230271
RPL7A ribosomal protein L7a -0.0227224
RPL37A ribosomal protein L37a -0.0226524
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0222144
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0217522
COL1A1 collagen, type I, alpha 1 -0.0216339
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0208864
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0207892
YBX1 Y box binding protein 1 -0.0207206
PNISR PNN-interacting serine/arginine-rich protein -0.0204665
RPL36 ribosomal protein L36 -0.0203492
MEIS2 Meis homeobox 2 -0.02026
RSF1 remodeling and spacing factor 1 -0.0201141
RPL35 ribosomal protein L35 -0.0200982
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0200567
RPL27 ribosomal protein L27 -0.0200367
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0199816
MARCKS myristoylated alanine-rich protein kinase C substrate -0.019859
CNTN4 contactin 4 -0.0197863
EIF5B eukaryotic translation initiation factor 5B -0.0197701
RAB7A RAB7A, member RAS oncogene family -0.019636
RPS3 ribosomal protein S3 -0.0196206
RPS2 ribosomal protein S2 -0.0194449
TRA2A transformer 2 alpha homolog (Drosophila) -0.0191548
LIMA1 LIM domain and actin binding 1 -0.0189386
CEMIP2 cell migration inducing hyaluronidase 2 -0.0188575
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0188547
FHIT fragile histidine triad -0.0188328
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0187534
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0186954