| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dapagliflozin_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.564265 |
| COL6A3 | collagen, type VI, alpha 3 | 0.197037 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.129486 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0953473 |
| PLEC | plectin | 0.0874793 |
| ATP13A3 | ATPase type 13A3 | 0.0873747 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0822423 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0801125 |
| HMGA2 | high mobility group AT-hook 2 | 0.0685426 |
| CD44 | CD44 molecule (Indian blood group) | 0.0631943 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0621764 |
| PTK2 | protein tyrosine kinase 2 | 0.0574156 |
| TPM4 | tropomyosin 4 | 0.0565748 |
| LOXL2 | lysyl oxidase-like 2 | 0.0520587 |
| CALR | calreticulin | 0.0514019 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0512201 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0495528 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0487204 |
| CALU | calumenin | 0.0480976 |
| GOLGA4 | golgin A4 | 0.0480665 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.047738 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.046883 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.046791 |
| APP | amyloid beta (A4) precursor protein | 0.0420212 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0415664 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0395479 |
| SPAG9 | sperm associated antigen 9 | 0.0392041 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0386952 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0381556 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.037991 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0371706 |
| MAP1B | microtubule-associated protein 1B | 0.0371503 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0364417 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0355503 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0348129 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0345541 |
| MAP4 | microtubule-associated protein 4 | 0.0343604 |
| RASA2 | RAS p21 protein activator 2 | 0.0325406 |
| POSTN | periostin, osteoblast specific factor | 0.0319662 |
| VEGFA | vascular endothelial growth factor A | 0.0319435 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0317593 |
| ASPH | aspartate beta-hydroxylase | 0.0308058 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0301393 |
| SBF2 | SET binding factor 2 | 0.0299179 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0296388 |
| SMAD3 | SMAD family member 3 | 0.0296237 |
| COL3A1 | collagen, type III, alpha 1 | 0.0294185 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0290514 |
| CANX | calnexin | 0.0289397 |
| MSN | moesin | 0.0286217 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0285906 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0285597 |
| CLIC4 | chloride intracellular channel 4 | 0.0283453 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0277735 |
| H1-0 | H1.0 linker histone | 0.0269786 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0267442 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0266261 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0266045 |
| COG5 | component of oligomeric golgi complex 5 | 0.0264425 |
| SFTPA2 | surfactant protein A2 | 0.0263363 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0262758 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0262069 |
| ZNF148 | zinc finger protein 148 | 0.0258575 |
| LOX | lysyl oxidase | 0.0257833 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0257398 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.025443 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0253715 |
| GLG1 | golgi glycoprotein 1 | 0.0249928 |
| VEGFC | vascular endothelial growth factor C | 0.0248983 |
| STC1 | stanniocalcin 1 | 0.0247182 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0246042 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0243784 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0242787 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0241565 |
| ECE1 | endothelin converting enzyme 1 | 0.0240958 |
| COPA | coatomer protein complex, subunit alpha | 0.0240295 |
| FLNA | filamin A, alpha | 0.0239225 |
| CLTC | clathrin, heavy chain (Hc) | 0.0233354 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0231304 |
| COL1A2 | collagen, type I, alpha 2 | 0.023029 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0228233 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0227972 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0226294 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.02249 |
| OSMR | oncostatin M receptor | 0.0224461 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0224158 |
| TMF1 | TATA element modulatory factor 1 | 0.0222622 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0221662 |
| SMYD3 | SET and MYND domain containing 3 | 0.022163 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0217245 |
| FSTL1 | follistatin-like 1 | 0.0215801 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0215611 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0212767 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0212017 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0211324 |
| FAM20C | family with sequence similarity 20, member C | 0.0211248 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0210634 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.0208316 |
| TXNRD1 | thioredoxin reductase 1 | 0.020807 |
| FMNL2 | formin-like 2 | 0.0208008 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.129318 |
| COL1A1 | collagen, type I, alpha 1 | -0.07868 |
| MT2A | metallothionein 2A | -0.0738582 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0707685 |
| IER3 | immediate early response 3 | -0.0688602 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0602209 |
| TMSB10 | thymosin beta 10 | -0.054668 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0544942 |
| CADM1 | cell adhesion molecule 1 | -0.0543225 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0511314 |
| SQSTM1 | sequestosome 1 | -0.0465283 |
| FTL | ferritin, light polypeptide | -0.0401152 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0379071 |
| RPL35A | ribosomal protein L35a | -0.0363036 |
| RPS8 | ribosomal protein S8 | -0.0359487 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0320261 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0319299 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0313002 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0295295 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0293451 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0286078 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0278899 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0270832 |
| CDH13 | cadherin 13 | -0.0269504 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0258676 |
| ACTG1 | actin gamma 1 | -0.02571 |
| HLA-B | major histocompatibility complex, class I, B | -0.0254443 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0247227 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.024537 |
| RPS19 | ribosomal protein S19 | -0.0243523 |
| VIM | vimentin | -0.0234004 |
| RPS6 | ribosomal protein S6 | -0.0231699 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0230309 |
| RPL28 | ribosomal protein L28 | -0.0224337 |
| RPL23 | ribosomal protein L23 | -0.0215565 |
| RPLP1 | ribosomal protein, large, P1 | -0.0213619 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0211868 |
| RPLP2 | ribosomal protein, large, P2 | -0.0205614 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0204016 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0202392 |
| HMGA1 | high mobility group AT-hook 1 | -0.0200937 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0200148 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0197782 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0197326 |
| RPL26 | ribosomal protein L26 | -0.0194703 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0194693 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0190209 |
| FBXO32 | F-box protein 32 | -0.0189852 |
| B2M | beta-2-microglobulin | -0.0189838 |
| S100A10 | S100 calcium binding protein A10 | -0.0189165 |
| GOLGB1 | golgin B1 | -0.0187963 |
| GPC6 | glypican 6 | -0.0186931 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.018667 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0185403 |
| PFN1 | profilin 1 | -0.018459 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0184517 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0183198 |
| DGKI | diacylglycerol kinase, iota | -0.0182618 |
| RPS14 | ribosomal protein S14 | -0.0181889 |
| RPS20 | ribosomal protein S20 | -0.0181857 |
| MT1X | metallothionein 1X | -0.0179151 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0178492 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.0174479 |
| RPL5 | ribosomal protein L5 | -0.017357 |
| TMEM178B | transmembrane protein 178B | -0.0171995 |
| RPL36 | ribosomal protein L36 | -0.0171941 |
| LDHA | lactate dehydrogenase A | -0.0169769 |
| RPL30 | ribosomal protein L30 | -0.0168788 |
| PRSS23 | protease, serine, 23 | -0.0165846 |
| RPL9 | ribosomal protein L9 | -0.0165744 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0165344 |
| UBC | ubiquitin C | -0.0163907 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0163246 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0161935 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0160881 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0159401 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0157162 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0154823 |
| GNAS | GNAS complex locus | -0.0154733 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0151132 |
| RPL8 | ribosomal protein L8 | -0.0150438 |
| EGFR | epidermal growth factor receptor | -0.015038 |
| RBM39 | RNA binding motif protein 39 | -0.0148727 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0146638 |
| LMNA | lamin A/C | -0.0144378 |
| EPHB1 | EPH receptor B1 | -0.0144294 |
| COL5A1 | collagen, type V, alpha 1 | -0.0144043 |
| RPL34 | ribosomal protein L34 | -0.0142197 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0141791 |
| S100A9 | S100 calcium binding protein A9 | -0.0141045 |
| IL6ST | interleukin 6 signal transducer | -0.0140659 |
| RPL18 | ribosomal protein L18 | -0.0139971 |
| NCKAP5 | NCK-associated protein 5 | -0.0139276 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.0138308 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0137788 |
| PCBP2 | poly(rC) binding protein 2 | -0.0136799 |
| RPS27A | ribosomal protein S27a | -0.0135405 |
| DEK | DEK proto-oncogene | -0.0133907 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0132626 |
| KCTD16 | potassium channel tetramerization domain containing 16 | -0.0132601 |
