Dapagliflozin_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dapagliflozin perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dapagliflozin_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.263889
APOB apolipoprotein B 0.228769
C3 complement component 3 0.223795
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.143897
ERRFI1 ERBB receptor feedback inhibitor 1 0.133652
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.110351
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.109091
EEF2 eukaryotic translation elongation factor 2 0.103056
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.100109
DSPP dentin sialophosphoprotein 0.0976995
FNDC3B fibronectin type III domain containing 3B 0.0919556
TF transferrin 0.0732623
ELL2 elongation factor, RNA polymerase II, 2 0.0668061
ENO1 enolase 1, (alpha) 0.0587887
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0538782
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0530136
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0526151
A2M alpha-2-macroglobulin 0.0520168
GPC3 glypican 3 0.0501592
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0491805
JMJD1C jumonji domain containing 1C 0.0484569
BCL2L1 BCL2-like 1 0.0465141
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0464349
CFB complement factor B 0.0463911
SOD2 superoxide dismutase 2, mitochondrial 0.0462193
AFDN afadin, adherens junction formation factor 0.0444613
MYH9 myosin, heavy chain 9, non-muscle 0.043796
FBF1 Fas (TNFRSF6) binding factor 1 0.0430498
PEG3 paternally expressed 3 0.0421825
SDC4 syndecan 4 0.0417888
SEPTIN9 septin 9 0.0407142
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0404678
DSCAM Down syndrome cell adhesion molecule 0.0403981
ACSL3 acyl-CoA synthetase long-chain family member 3 0.039761
ARHGAP9 Rho GTPase activating protein 9 0.0392482
NRIP1 nuclear receptor interacting protein 1 0.0390816
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0384727
TRIM26 tripartite motif containing 26 0.0377262
LCOR ligand dependent nuclear receptor corepressor 0.0374789
IGFBP1 insulin-like growth factor binding protein 1 0.0361915
EPAS1 endothelial PAS domain protein 1 0.0357559
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0351405
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0337887
SMAD3 SMAD family member 3 0.0333591
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0333476
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0329739
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0327916
MTUS1 microtubule associated tumor suppressor 1 0.0320548
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0318594
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0312995
DOCK5 dedicator of cytokinesis 5 0.030928
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.030631
SFTPA2 surfactant protein A2 0.0305639
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0302238
LRMDA leucine rich melanocyte differentiation associated 0.029791
MACF1 microtubule-actin crosslinking factor 1 0.0297197
MRTFA myocardin related transcription factor A 0.029613
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0292431
AHSG alpha-2-HS-glycoprotein 0.0292323
MBNL3 muscleblind-like splicing regulator 3 0.0290709
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 0.0290603
PLEC plectin 0.0289194
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0287835
ICAM1 intercellular adhesion molecule 1 0.0286869
SOS1 son of sevenless homolog 1 (Drosophila) 0.0286588
WAC WW domain containing adaptor with coiled-coil 0.0279713
VCL vinculin 0.0274524
CPE carboxypeptidase E 0.027396
EIF4B eukaryotic translation initiation factor 4B 0.0273202
FAT1 FAT atypical cadherin 1 0.0271881
LYZ lysozyme 0.0271393
ITGAV integrin, alpha V 0.0268139
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0264913
AFF4 AF4/FMR2 family, member 4 0.0261809
YAP1 Yes-associated protein 1 0.0259911
CTNND1 catenin (cadherin-associated protein), delta 1 0.0258049
IGF1R insulin-like growth factor 1 receptor 0.0252071
ABTB3 ankyrin repeat and BTB domain containing 3 0.025031
TRIO trio Rho guanine nucleotide exchange factor 0.0248974
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0247401
CD2AP CD2-associated protein 0.0245704
ADAM9 ADAM metallopeptidase domain 9 0.0243421
MED13L mediator complex subunit 13-like 0.0240714
FOXO1 forkhead box O1 0.0240662
NKD1 naked cuticle homolog 1 (Drosophila) 0.0240395
PHF3 PHD finger protein 3 0.0239977
TOP1 topoisomerase (DNA) I 0.0237856
MBNL2 muscleblind-like splicing regulator 2 0.0234561
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0233782
AKAP13 A kinase (PRKA) anchor protein 13 0.0233395
KDM6A lysine (K)-specific demethylase 6A 0.0231828
SESTD1 SEC14 and spectrin domains 1 0.0231425
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0229437
CSDE1 cold shock domain containing E1, RNA-binding 0.0224591
SERINC1 serine incorporator 1 0.0221561
PCBP2 poly(rC) binding protein 2 0.0221167
KDM7A lysine (K)-specific demethylase 7A 0.0220642
TLK1 tousled-like kinase 1 0.0219436
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.021826
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0216864

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.168948
AKAP12 A kinase (PRKA) anchor protein 12 -0.134652
MT2A metallothionein 2A -0.051047
ASPH aspartate beta-hydroxylase -0.0461337
TMSB10 thymosin beta 10 -0.0459792
RPL23 ribosomal protein L23 -0.0427524
MAML2 mastermind-like 2 (Drosophila) -0.0404316
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0396973
RPLP1 ribosomal protein, large, P1 -0.0345236
APOA2 apolipoprotein A-II -0.0335348
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0332638
TPT1 tumor protein, translationally-controlled 1 -0.032234
RPS19 ribosomal protein S19 -0.0300818
HMGA1 high mobility group AT-hook 1 -0.030077
GMDS GDP-mannose 4,6-dehydratase -0.0278879
RPS8 ribosomal protein S8 -0.0273663
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0258195
RPS12 ribosomal protein S12 -0.0255539
TIMP1 TIMP metallopeptidase inhibitor 1 -0.024767
RPL35A ribosomal protein L35a -0.0232644
STK17A serine/threonine kinase 17a -0.0232426
RPS6 ribosomal protein S6 -0.022903
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0227961
ISG15 ISG15 ubiquitin-like modifier -0.0220989
DTNA dystrobrevin, alpha -0.0217772
RPL11 ribosomal protein L11 -0.0215735
RPS3 ribosomal protein S3 -0.0211136
RPL34 ribosomal protein L34 -0.0210629
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.020835
NPAS2 neuronal PAS domain protein 2 -0.0204001
GK glycerol kinase -0.0203312
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0202063
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0199839
RNF213 ring finger protein 213 -0.0195601
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 -0.0194632
RPL37A ribosomal protein L37a -0.0194229
RPS14 ribosomal protein S14 -0.0189625
RPL26 ribosomal protein L26 -0.0186994
RPS21 ribosomal protein S21 -0.0183045
RPL5 ribosomal protein L5 -0.0182862
RPL27 ribosomal protein L27 -0.0180466
PLXDC2 plexin domain containing 2 -0.0177678
RPL9 ribosomal protein L9 -0.0177311
ZBTB20 zinc finger and BTB domain containing 20 -0.0175155
FRMD5 FERM domain containing 5 -0.0171445
RPS29 ribosomal protein S29 -0.0169508
INTS6 integrator complex subunit 6 -0.0168381
NAP1L1 nucleosome assembly protein 1-like 1 -0.0166777
HDAC4 histone deacetylase 4 -0.0166106
RPS13 ribosomal protein S13 -0.0165565
PLIN2 perilipin 2 -0.0164311
RPL35 ribosomal protein L35 -0.0162092
PDGFB platelet-derived growth factor beta polypeptide -0.015838
RPLP2 ribosomal protein, large, P2 -0.0156771
RPL12 ribosomal protein L12 -0.0155255
RAD51B RAD51 paralog B -0.0151639
ESYT2 extended synaptotagmin-like protein 2 -0.0150811
RPL32 ribosomal protein L32 -0.0149621
RPL38 ribosomal protein L38 -0.014821
RPS24 ribosomal protein S24 -0.014778
GNAS GNAS complex locus -0.0146809
WSB1 WD repeat and SOCS box containing 1 -0.0146461
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0145475
RPL36 ribosomal protein L36 -0.0144921
RIGI RNA sensor RIG-I -0.0144475
RPL31 ribosomal protein L31 -0.0142394
NPR2 natriuretic peptide receptor 2 -0.0142117
NDRG1 N-myc downstream regulated 1 -0.01407
FTL ferritin, light polypeptide -0.0139046
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0136392
ATP10A ATPase, class V, type 10A -0.0134116
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0133804
RPL28 ribosomal protein L28 -0.0131358
IFI6 interferon, alpha-inducible protein 6 -0.0131206
PLSCR1 phospholipid scramblase 1 -0.0123994
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.012188
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0121492
ATP5F1E ATP synthase F1 subunit epsilon -0.0121458
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0121448
RPS20 ribosomal protein S20 -0.0120721
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0118368
PNRC1 proline-rich nuclear receptor coactivator 1 -0.011828
RPS23 ribosomal protein S23 -0.0117197
RPS25 ribosomal protein S25 -0.0117182
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0116108
LRRC23 leucine rich repeat containing 23 -0.0116061
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0115189
EIF5B eukaryotic translation initiation factor 5B -0.0113834
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0112297
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0112126
IFITM1 interferon induced transmembrane protein 1 -0.0110973
IFIH1 interferon induced with helicase C domain 1 -0.0110713
SLC38A1 solute carrier family 38, member 1 -0.011015
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.0107588
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 -0.0107363
SOX4 SRY (sex determining region Y)-box 4 -0.0106421
SEC24A SEC24 family member A -0.0105677
BMERB1 bMERB domain containing 1 -0.0104968
SOX5 SRY (sex determining region Y)-box 5 -0.0102704
MX2 MX dynamin-like GTPase 2 -0.0102623