Dapagliflozin_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dapagliflozin perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dapagliflozin_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.189264
FAT1 FAT atypical cadherin 1 0.0968152
PDIA4 protein disulfide isomerase family A, member 4 0.0931875
GOLGA4 golgin A4 0.0878915
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0869074
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0863972
ITGA6 integrin, alpha 6 0.0853551
KRT18 keratin 18, type I 0.0775454
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0770823
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0768173
DSPP dentin sialophosphoprotein 0.0737335
ZFAND3 zinc finger, AN1-type domain 3 0.0722998
NDRG1 N-myc downstream regulated 1 0.0698611
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0686457
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.064714
VEGFA vascular endothelial growth factor A 0.0639847
FLNB filamin B, beta 0.0625521
MACF1 microtubule-actin crosslinking factor 1 0.0614309
EREG epiregulin 0.0610222
SETD5 SET domain containing 5 0.0595266
RNF145 ring finger protein 145 0.0589214
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0588334
FAM13A family with sequence similarity 13, member A 0.0584101
MBNL2 muscleblind-like splicing regulator 2 0.0570469
CALR calreticulin 0.0570176
PLEC plectin 0.056769
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0566013
MED13L mediator complex subunit 13-like 0.0558387
FTH1 ferritin, heavy polypeptide 1 0.0544481
MYH9 myosin, heavy chain 9, non-muscle 0.0533598
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0507015
CCNY cyclin Y 0.0491282
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0489188
PIGR polymeric immunoglobulin receptor 0.0488718
ATXN1 ataxin 1 0.048845
MYO5B myosin VB 0.0487941
AHNAK AHNAK nucleoprotein 0.0483739
ANKRD11 ankyrin repeat domain 11 0.0480506
TPD52 tumor protein D52 0.0470408
COPA coatomer protein complex, subunit alpha 0.0467925
PTEN phosphatase and tensin homolog 0.0466587
TNS4 tensin 4 0.0455707
KMT2C lysine (K)-specific methyltransferase 2C 0.0455187
UBA6 ubiquitin-like modifier activating enzyme 6 0.0454407
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0451283
DSCAM Down syndrome cell adhesion molecule 0.0439537
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0434369
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0432964
CEMIP cell migration inducing protein, hyaluronan binding 0.0424003
WAC WW domain containing adaptor with coiled-coil 0.0423552
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0422862
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0421986
BIRC6 baculoviral IAP repeat containing 6 0.042123
KRT8 keratin 8, type II 0.0417403
HDLBP high density lipoprotein binding protein 0.0408202
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.040516
TXNIP thioredoxin interacting protein 0.040062
ANKRD17 ankyrin repeat domain 17 0.0397803
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0397226
MLEC malectin 0.0391013
CANX calnexin 0.0387026
APP amyloid beta (A4) precursor protein 0.0386545
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0379296
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0376631
BTBD9 BTB (POZ) domain containing 9 0.0374311
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.037402
MCTP2 multiple C2 domains, transmembrane 2 0.0373899
CD2AP CD2-associated protein 0.0370404
EIF4A2 eukaryotic translation initiation factor 4A2 0.0367376
NBAS neuroblastoma amplified sequence 0.0366684
MAML3 mastermind-like 3 (Drosophila) 0.036658
TBC1D22A TBC1 domain family, member 22A 0.0365093
KDM6A lysine (K)-specific demethylase 6A 0.0364882
UBE2H ubiquitin-conjugating enzyme E2H 0.0363803
USP3 ubiquitin specific peptidase 3 0.0363444
BCL2L1 BCL2-like 1 0.036046
PTK2 protein tyrosine kinase 2 0.0360341
JMJD1C jumonji domain containing 1C 0.0359576
FNDC3B fibronectin type III domain containing 3B 0.0358797
OGA O-GlcNAcase 0.035819
ZNF292 zinc finger protein 292 0.0358146
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.034733
ITPRID2 ITPR interacting domain containing 2 0.0345083
LPP LIM domain containing preferred translocation partner in lipoma 0.0342623
NCOR1 nuclear receptor corepressor 1 0.0337335
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0332742
TMF1 TATA element modulatory factor 1 0.0332567
P4HB prolyl 4-hydroxylase, beta polypeptide 0.033206
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.0327933
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0326668
GPHN gephyrin 0.0324775
NCOR2 nuclear receptor corepressor 2 0.0324625
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0323114
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0321267
PUM2 pumilio RNA-binding family member 2 0.0319181
SUCO SUN domain containing ossification factor 0.0317833
KDM2A lysine (K)-specific demethylase 2A 0.0317365
CSDE1 cold shock domain containing E1, RNA-binding 0.0317257
SBF2 SET binding factor 2 0.0316179
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0315961

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.130075
PTMA prothymosin, alpha -0.10525
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0786063
TPT1 tumor protein, translationally-controlled 1 -0.0704364
RPS6 ribosomal protein S6 -0.0673741
RPLP1 ribosomal protein, large, P1 -0.0652344
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0588951
NPSR1 neuropeptide S receptor 1 -0.0542266
RPL35A ribosomal protein L35a -0.0539871
RPS8 ribosomal protein S8 -0.050305
ONECUT3 one cut homeobox 3 -0.0494607
RPL23 ribosomal protein L23 -0.0473801
RPL26 ribosomal protein L26 -0.0468574
RPL34 ribosomal protein L34 -0.0465048
RPLP2 ribosomal protein, large, P2 -0.0420977
RPL12 ribosomal protein L12 -0.0408619
RPS24 ribosomal protein S24 -0.039787
ACTG1 actin gamma 1 -0.038357
LOC102724023 ES1 protein homolog, mitochondrial -0.0379534
S100A6 S100 calcium binding protein A6 -0.0377675
RPL9 ribosomal protein L9 -0.0350061
POF1B premature ovarian failure, 1B -0.0349469
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0340457
VCL vinculin -0.0332971
RPL36 ribosomal protein L36 -0.0315519
S100A10 S100 calcium binding protein A10 -0.0315229
RACK1 receptor for activated C kinase 1 -0.0304172
EPCAM epithelial cell adhesion molecule -0.029844
KLF6 Kruppel-like factor 6 -0.0298331
HMGB1 high mobility group box 1 -0.029064
RPL5 ribosomal protein L5 -0.0286326
RPS21 ribosomal protein S21 -0.0285736
RPL38 ribosomal protein L38 -0.0282999
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0281989
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0280423
RPLP0 ribosomal protein, large, P0 -0.0275076
ACTN4 actinin, alpha 4 -0.0270501
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0261316
RAD21 RAD21 homolog (S. pombe) -0.0256732
RPL30 ribosomal protein L30 -0.0249269
RPS19 ribosomal protein S19 -0.0246662
FTL ferritin, light polypeptide -0.0245545
AGR2 anterior gradient 2 -0.0240777
EIF1 eukaryotic translation initiation factor 1 -0.0239225
RPS29 ribosomal protein S29 -0.0237861
RPS27 ribosomal protein S27 -0.0235459
LDHA lactate dehydrogenase A -0.022745
RPL28 ribosomal protein L28 -0.0226223
RPS2 ribosomal protein S2 -0.0221164
RPS12 ribosomal protein S12 -0.0220043
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0216848
RPL35 ribosomal protein L35 -0.0212477
BTG1 B-cell translocation gene 1, anti-proliferative -0.0211373
KLF5 Kruppel-like factor 5 (intestinal) -0.0210807
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0209328
RPL37 ribosomal protein L37 -0.0207069
RPS20 ribosomal protein S20 -0.0206309
RPL32 ribosomal protein L32 -0.019942
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0197162
FHL2 four and a half LIM domains 2 -0.0195853
IER3 immediate early response 3 -0.0194285
RPL7 ribosomal protein L7 -0.0194041
ANXA1 annexin A1 -0.019166
RPS3 ribosomal protein S3 -0.0190999
EGR1 early growth response 1 -0.0188423
TUBB4B tubulin, beta 4B class IVb -0.0187559
NAP1L1 nucleosome assembly protein 1-like 1 -0.0187519
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0185006
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0182564
LGALS3 lectin, galactoside-binding, soluble, 3 -0.018158
HMGA1 high mobility group AT-hook 1 -0.0180354
RPL27A ribosomal protein L27a -0.0178382
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0176751
RPS14 ribosomal protein S14 -0.0176139
RPL13A ribosomal protein L13a -0.0175254
RPL27 ribosomal protein L27 -0.0174832
MYL12B myosin, light chain 12B, regulatory -0.0172239
RPS25 ribosomal protein S25 -0.0170989
ATP5F1B ATP synthase F1 subunit beta -0.0169632
RPS27A ribosomal protein S27a -0.0169201
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.016879
CD44 CD44 molecule (Indian blood group) -0.0168333
NACA nascent polypeptide-associated complex alpha subunit -0.0167579
MARCHF3 membrane associated ring-CH-type finger 3 -0.0167444
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0167006
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0166949
RBM25 RNA binding motif protein 25 -0.0165762
LMNA lamin A/C -0.0165117
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0163546
RPL19 ribosomal protein L19 -0.0163475
ABLIM1 actin binding LIM protein 1 -0.0160814
LRRK1 leucine-rich repeat kinase 1 -0.0160024
NPR2 natriuretic peptide receptor 2 -0.0159621
RPS13 ribosomal protein S13 -0.0159346
GNAS GNAS complex locus -0.0159195
PFN1 profilin 1 -0.0155327
TRIB1 tribbles pseudokinase 1 -0.0155188
SOX4 SRY (sex determining region Y)-box 4 -0.0153755
ADIPOR2 adiponectin receptor 2 -0.0153165
SLC38A2 solute carrier family 38, member 2 -0.0152355