Dapagliflozin_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dapagliflozin perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dapagliflozin_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.125321
EEF2 eukaryotic translation elongation factor 2 0.122938
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.116122
BCAR3 breast cancer anti-estrogen resistance 3 0.111496
PSD3 pleckstrin and Sec7 domain containing 3 0.104336
DST dystonin 0.100821
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0992346
APP amyloid beta (A4) precursor protein 0.0983302
FMNL2 formin-like 2 0.0971232
EZR ezrin 0.0868191
MACF1 microtubule-actin crosslinking factor 1 0.085714
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0831762
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0775932
CANX calnexin 0.0759125
DLG1 discs, large homolog 1 (Drosophila) 0.0751214
TXNRD1 thioredoxin reductase 1 0.074091
RUNX1 runt-related transcription factor 1 0.0734302
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0677549
TRIO trio Rho guanine nucleotide exchange factor 0.0633541
CAPRIN2 caprin family member 2 0.0626092
AHNAK AHNAK nucleoprotein 0.0618555
ADGRG6 adhesion G protein-coupled receptor G6 0.0599125
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0589572
EHBP1 EH domain binding protein 1 0.0579751
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0554715
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0541125
ENO1 enolase 1, (alpha) 0.0528431
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0523106
RAI1 retinoic acid induced 1 0.0513484
CD44 CD44 molecule (Indian blood group) 0.0513167
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0496301
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0489195
TTC3 tetratricopeptide repeat domain 3 0.0486496
MBNL2 muscleblind-like splicing regulator 2 0.0486252
PLK2 polo-like kinase 2 0.047988
DPYD dihydropyrimidine dehydrogenase 0.0476935
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0473304
SPATS2L spermatogenesis associated, serine-rich 2-like 0.047154
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0466334
TSC22D1 TSC22 domain family, member 1 0.0461577
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.046054
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0451491
WWTR1 WW domain containing transcription regulator 1 0.0450052
MYOF myoferlin 0.0449158
NCOR1 nuclear receptor corepressor 1 0.0448533
OGA O-GlcNAcase 0.0445289
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0439784
TMSB4X thymosin beta 4, X-linked 0.0439565
USP34 ubiquitin specific peptidase 34 0.0437675
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0429594
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.042738
NPAS2 neuronal PAS domain protein 2 0.0422978
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.0421467
FAF1 Fas (TNFRSF6) associated factor 1 0.0421249
PGK1 phosphoglycerate kinase 1 0.0412498
KTN1 kinectin 1 (kinesin receptor) 0.0408545
KMT2E lysine (K)-specific methyltransferase 2E 0.0397071
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0393267
ANKRD17 ankyrin repeat domain 17 0.0390888
HDLBP high density lipoprotein binding protein 0.0390468
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0388557
EREG epiregulin 0.0388142
KMT2C lysine (K)-specific methyltransferase 2C 0.0386532
MAP4 microtubule-associated protein 4 0.0386202
PTPRF protein tyrosine phosphatase, receptor type, F 0.038508
EMP1 epithelial membrane protein 1 0.0382234
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0378813
ANTXR2 anthrax toxin receptor 2 0.0370651
ZEB1 zinc finger E-box binding homeobox 1 0.0368913
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0367466
TMEM41B transmembrane protein 41B 0.0366401
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0364304
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.036368
ERBIN erbb2 interacting protein 0.0363523
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.035546
RAB27B RAB27B, member RAS oncogene family 0.0353516
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0350068
ATXN2 ataxin 2 0.0349397
ADAM10 ADAM metallopeptidase domain 10 0.0347959
YEATS2 YEATS domain containing 2 0.0344516
FNIP1 folliculin interacting protein 1 0.0344391
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.034076
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0339068
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0337207
KDM3A lysine (K)-specific demethylase 3A 0.0335249
CDK6 cyclin-dependent kinase 6 0.0334356
PTK2 protein tyrosine kinase 2 0.0332771
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0330869
MARCHF6 membrane associated ring-CH-type finger 6 0.0330677
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.032929
FXR1 fragile X mental retardation, autosomal homolog 1 0.0328164
XPO1 exportin 1 0.0326738
AFF4 AF4/FMR2 family, member 4 0.0326381
SRPK2 SRSF protein kinase 2 0.0324912
SDCCAG8 serologically defined colon cancer antigen 8 0.0323547
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0322839
H1-0 H1.0 linker histone 0.0322221
HOOK2 hook microtubule-tethering protein 2 0.0320562
NCEH1 neutral cholesterol ester hydrolase 1 0.031983
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0316597

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.147924
MT2A metallothionein 2A -0.140364
VIM vimentin -0.0963954
TMSB10 thymosin beta 10 -0.0771359
PTMA prothymosin, alpha -0.0635041
RPL35A ribosomal protein L35a -0.0434355
RPL12 ribosomal protein L12 -0.0419124
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0391431
RPS6 ribosomal protein S6 -0.0387288
RPS19 ribosomal protein S19 -0.0374866
RAB7A RAB7A, member RAS oncogene family -0.0361742
HLA-B major histocompatibility complex, class I, B -0.0345057
RPS8 ribosomal protein S8 -0.0338432
RPLP2 ribosomal protein, large, P2 -0.0332997
TPT1 tumor protein, translationally-controlled 1 -0.0329839
FTL ferritin, light polypeptide -0.0289143
RPL23 ribosomal protein L23 -0.027596
RPLP1 ribosomal protein, large, P1 -0.0265595
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.0263531
RPL9 ribosomal protein L9 -0.0262177
RPS23 ribosomal protein S23 -0.0261913
RPL26 ribosomal protein L26 -0.0242285
MT1E metallothionein 1E -0.0219479
RPL28 ribosomal protein L28 -0.0211413
IFITM1 interferon induced transmembrane protein 1 -0.0210963
FTH1 ferritin, heavy polypeptide 1 -0.0203923
EGR1 early growth response 1 -0.0202395
MT1X metallothionein 1X -0.0198434
NEK10 NIMA-related kinase 10 -0.0197196
B2M beta-2-microglobulin -0.0191783
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0189728
RPL38 ribosomal protein L38 -0.0188785
RPL36 ribosomal protein L36 -0.018354
S100A9 S100 calcium binding protein A9 -0.0183323
SMC4 structural maintenance of chromosomes 4 -0.0175093
PFN1 profilin 1 -0.0174471
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0174382
IFI6 interferon, alpha-inducible protein 6 -0.0173545
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0173057
HLA-A major histocompatibility complex, class I, A -0.0172712
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0172097
RPL34 ribosomal protein L34 -0.0168712
HMGA1 high mobility group AT-hook 1 -0.0165438
RPL36A ribosomal protein L36a -0.0162603
RPS27 ribosomal protein S27 -0.0162408
S100A10 S100 calcium binding protein A10 -0.0156352
POTEF POTE ankyrin domain family, member F -0.0147805
FOSL1 FOS-like antigen 1 -0.0146294
UBC ubiquitin C -0.0145359
RPS14 ribosomal protein S14 -0.0143735
HILPDA hypoxia inducible lipid droplet-associated -0.0142813
RPS29 ribosomal protein S29 -0.0142144
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0140974
RPL8 ribosomal protein L8 -0.0138452
INTS6 integrator complex subunit 6 -0.0138198
RPLP0 ribosomal protein, large, P0 -0.0138135
RPS24 ribosomal protein S24 -0.0136384
RPS13 ribosomal protein S13 -0.0134341
RPL7 ribosomal protein L7 -0.0134214
RPS12 ribosomal protein S12 -0.0134032
ACTG1 actin gamma 1 -0.0133964
SESN2 sestrin 2 -0.0131785
RPL18 ribosomal protein L18 -0.0130349
CRY1 cryptochrome circadian clock 1 -0.0130282
AMPD3 adenosine monophosphate deaminase 3 -0.01293
RPL31 ribosomal protein L31 -0.012766
COTL1 coactosin-like F-actin binding protein 1 -0.0127557
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0126068
HMGB1 high mobility group box 1 -0.0123986
PCBP2 poly(rC) binding protein 2 -0.0122713
RPS28 ribosomal protein S28 -0.0122487
RPL11 ribosomal protein L11 -0.0122324
RPL21 ribosomal protein L21 -0.0122247
RPL37A ribosomal protein L37a -0.0120895
NAP1L1 nucleosome assembly protein 1-like 1 -0.0120432
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0118659
RPL37 ribosomal protein L37 -0.0117376
RPL5 ribosomal protein L5 -0.0117199
PLSCR1 phospholipid scramblase 1 -0.0116741
RPS15 ribosomal protein S15 -0.0116133
RPL27A ribosomal protein L27a -0.0115767
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0111332
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.011038
RBM25 RNA binding motif protein 25 -0.0109777
BTG1 B-cell translocation gene 1, anti-proliferative -0.0109641
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0108857
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0107526
EEF1G eukaryotic translation elongation factor 1 gamma -0.0107194
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -0.010649
RPL7A ribosomal protein L7a -0.0106375
ECE1 endothelin converting enzyme 1 -0.01058
LOC102724023 ES1 protein homolog, mitochondrial -0.0104972
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0103325
IFRD1 interferon-related developmental regulator 1 -0.0102206
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0102109
UBE2C ubiquitin-conjugating enzyme E2C -0.0101901
NABP1 nucleic acid binding protein 1 -0.0101458
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0100106
GOLT1A golgi transport 1A -0.0100044
HELLS helicase, lymphoid-specific -0.00992807