| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dapagliflozin_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.101837 |
| H1-0 | H1.0 linker histone | 0.0820216 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0797635 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0751276 |
| CES1 | carboxylesterase 1 | 0.0732452 |
| NDRG1 | N-myc downstream regulated 1 | 0.0729289 |
| PLEC | plectin | 0.0723788 |
| JMJD1C | jumonji domain containing 1C | 0.0708676 |
| USP34 | ubiquitin specific peptidase 34 | 0.0698217 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0689075 |
| TSC22D2 | TSC22 domain family, member 2 | 0.067003 |
| HYOU1 | hypoxia up-regulated 1 | 0.0668062 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0644877 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0639755 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0610474 |
| FAM13A | family with sequence similarity 13, member A | 0.0609719 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0606538 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0605099 |
| TOP1 | topoisomerase (DNA) I | 0.0599298 |
| CPE | carboxypeptidase E | 0.0585492 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0547361 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0544622 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0538122 |
| SLTM | SAFB-like, transcription modulator | 0.0529834 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.052671 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0523218 |
| TMEM165 | transmembrane protein 165 | 0.0515383 |
| MCL1 | myeloid cell leukemia 1 | 0.0508431 |
| OGA | O-GlcNAcase | 0.0484474 |
| GRAMD1B | GRAM domain containing 1B | 0.048127 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0479982 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0479542 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0470243 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0460941 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0454269 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0453087 |
| FAM193A | family with sequence similarity 193, member A | 0.0447068 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0443662 |
| NGLY1 | N-glycanase 1 | 0.0441709 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0429802 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0426052 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0413622 |
| HDLBP | high density lipoprotein binding protein | 0.041327 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0409674 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0395681 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0392251 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0384387 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.0383739 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0379385 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0374791 |
| EGFR | epidermal growth factor receptor | 0.0374689 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0373602 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0373234 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0372576 |
| INTS6 | integrator complex subunit 6 | 0.0369141 |
| ZNF638 | zinc finger protein 638 | 0.0368609 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0368486 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.036571 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.036203 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0352769 |
| PKM | pyruvate kinase, muscle | 0.0350655 |
| LRP12 | low density lipoprotein receptor-related protein 12 | 0.034979 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.034952 |
| PTK2 | protein tyrosine kinase 2 | 0.0348732 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0347517 |
| SRP54 | signal recognition particle 54kDa | 0.0346949 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0346527 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0341278 |
| TPD52 | tumor protein D52 | 0.0339782 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0339662 |
| COPA | coatomer protein complex, subunit alpha | 0.033878 |
| CANX | calnexin | 0.0337497 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.0336003 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0335784 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0334704 |
| DHFR | dihydrofolate reductase | 0.033302 |
| BRD2 | bromodomain containing 2 | 0.0331881 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0331799 |
| PAPOLA | poly(A) polymerase alpha | 0.0331136 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0328292 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0327495 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0320932 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0320496 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0319966 |
| NCKAP1 | NCK-associated protein 1 | 0.0318997 |
| COG5 | component of oligomeric golgi complex 5 | 0.0316262 |
| ANO6 | anoctamin 6 | 0.0316109 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0314646 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.031377 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0313609 |
| NBAS | neuroblastoma amplified sequence | 0.0312663 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0309454 |
| MKI67 | marker of proliferation Ki-67 | 0.03063 |
| ATP11A | ATPase, class VI, type 11A | 0.0306003 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0304131 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0301868 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0300149 |
| NBEAL1 | neurobeachin-like 1 | 0.0298911 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0297072 |
| NPTN | neuroplastin | 0.0295732 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.185344 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.184736 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.127881 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.100679 |
| PTMA | prothymosin, alpha | -0.0943376 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.091313 |
| MT2A | metallothionein 2A | -0.0885357 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0792611 |
| FTL | ferritin, light polypeptide | -0.0783307 |
| S100A10 | S100 calcium binding protein A10 | -0.0701417 |
| RPL35A | ribosomal protein L35a | -0.0675971 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0658677 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0635091 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.061291 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0611478 |
| RPLP1 | ribosomal protein, large, P1 | -0.0549275 |
| RPS24 | ribosomal protein S24 | -0.0544877 |
| RNF213 | ring finger protein 213 | -0.0516818 |
| ACTG1 | actin gamma 1 | -0.0513434 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0459268 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0454564 |
| LDHA | lactate dehydrogenase A | -0.0445551 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0441963 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0440385 |
| RPL12 | ribosomal protein L12 | -0.0420106 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0411794 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0383612 |
| B2M | beta-2-microglobulin | -0.0383017 |
| IER3 | immediate early response 3 | -0.0376363 |
| RPLP0 | ribosomal protein, large, P0 | -0.0344962 |
| RPL34 | ribosomal protein L34 | -0.0344473 |
| CSTB | cystatin B (stefin B) | -0.0342258 |
| EGR1 | early growth response 1 | -0.0328474 |
| RPS8 | ribosomal protein S8 | -0.0327965 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0326247 |
| RPS25 | ribosomal protein S25 | -0.0325424 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0325076 |
| SEC61G | Sec61 gamma subunit | -0.0317862 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0315963 |
| EFNA5 | ephrin-A5 | -0.0309198 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0297929 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | -0.0295657 |
| CST3 | cystatin C | -0.029417 |
| RPL23 | ribosomal protein L23 | -0.0288845 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0287443 |
| MT1X | metallothionein 1X | -0.0287361 |
| CCND1 | cyclin D1 | -0.0283495 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0282284 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0279612 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.027553 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0275474 |
| AREG | amphiregulin | -0.0274985 |
| ANXA2 | annexin A2 | -0.0274811 |
| RPL37A | ribosomal protein L37a | -0.0272384 |
| RPS6 | ribosomal protein S6 | -0.0272133 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0271794 |
| RPL9 | ribosomal protein L9 | -0.0270716 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0270328 |
| S100P | S100 calcium binding protein P | -0.0268837 |
| RPS21 | ribosomal protein S21 | -0.0265596 |
| HMGA1 | high mobility group AT-hook 1 | -0.0261389 |
| LAMC2 | laminin, gamma 2 | -0.0257092 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.025512 |
| S100A9 | S100 calcium binding protein A9 | -0.0248467 |
| RPL30 | ribosomal protein L30 | -0.0247368 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0246043 |
| RPL36A | ribosomal protein L36a | -0.0246033 |
| S100A6 | S100 calcium binding protein A6 | -0.0244785 |
| RPS27A | ribosomal protein S27a | -0.0243567 |
| RPL31 | ribosomal protein L31 | -0.0243432 |
| RPS14 | ribosomal protein S14 | -0.0239137 |
| RPS23 | ribosomal protein S23 | -0.0238809 |
| RPL19 | ribosomal protein L19 | -0.0236335 |
| RPS19 | ribosomal protein S19 | -0.0236053 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0235656 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0234974 |
| RPLP2 | ribosomal protein, large, P2 | -0.0234701 |
| KRT19 | keratin 19, type I | -0.023246 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0230145 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0229959 |
| KRT7 | keratin 7, type II | -0.022646 |
| PERP | PERP, TP53 apoptosis effector | -0.0225303 |
| S100A11 | S100 calcium binding protein A11 | -0.0217013 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0216663 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.021483 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.020933 |
| HLA-B | major histocompatibility complex, class I, B | -0.0203343 |
| RPS17 | ribosomal protein S17 | -0.0198208 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0195658 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0193787 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0190476 |
| UBC | ubiquitin C | -0.018856 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0188455 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0185684 |
| SPTSSA | serine palmitoyltransferase, small subunit A | -0.0185666 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0184205 |
| RPS29 | ribosomal protein S29 | -0.0183876 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0181928 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0180603 |
| RPL8 | ribosomal protein L8 | -0.0179529 |
