Dapagliflozin_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dapagliflozin perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dapagliflozin_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KDM2A lysine (K)-specific demethylase 2A 0.12348
FAM13A family with sequence similarity 13, member A 0.103252
GOLGA4 golgin A4 0.0844107
EEF2 eukaryotic translation elongation factor 2 0.0782248
USP34 ubiquitin specific peptidase 34 0.0767342
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0747846
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0728215
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0717648
NAV2 neuron navigator 2 0.0699879
AKAP12 A kinase (PRKA) anchor protein 12 0.0699375
ELL2 elongation factor, RNA polymerase II, 2 0.0663587
NDRG1 N-myc downstream regulated 1 0.0659926
SMAD3 SMAD family member 3 0.0651316
SOD2 superoxide dismutase 2, mitochondrial 0.0648091
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.064474
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0641779
TRIO trio Rho guanine nucleotide exchange factor 0.0629534
ESYT2 extended synaptotagmin-like protein 2 0.0613396
UBA6 ubiquitin-like modifier activating enzyme 6 0.0604577
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0603678
PDIA4 protein disulfide isomerase family A, member 4 0.0583181
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0582672
IGFBP3 insulin-like growth factor binding protein 3 0.0572585
TGM2 transglutaminase 2 0.0568922
NGLY1 N-glycanase 1 0.0567832
MYH9 myosin, heavy chain 9, non-muscle 0.0538293
EGFR epidermal growth factor receptor 0.0534265
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0522091
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0518135
PFKP phosphofructokinase, platelet 0.0499307
ZNF292 zinc finger protein 292 0.0492588
ITCH itchy E3 ubiquitin protein ligase 0.0490098
GRB10 growth factor receptor-bound protein 10 0.0485944
PRELID2 PRELI domain containing 2 0.0484329
TTC3 tetratricopeptide repeat domain 3 0.0480067
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0473948
KMT2C lysine (K)-specific methyltransferase 2C 0.04726
EFNA5 ephrin-A5 0.0459971
RUNX1 runt-related transcription factor 1 0.0449036
OGA O-GlcNAcase 0.0446702
FTH1 ferritin, heavy polypeptide 1 0.0440254
TAS2R14 taste receptor, type 2, member 14 0.0439683
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0437925
SETD5 SET domain containing 5 0.0435189
SDK1 sidekick cell adhesion molecule 1 0.043081
PIAS2 protein inhibitor of activated STAT, 2 0.0422102
CANX calnexin 0.0420439
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0418254
JMJD1C jumonji domain containing 1C 0.041733
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0409534
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0403616
FLNB filamin B, beta 0.0400793
LIMCH1 LIM and calponin homology domains 1 0.0395735
PDE4D phosphodiesterase 4D, cAMP-specific 0.038877
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0384518
PCBP2 poly(rC) binding protein 2 0.0371076
COPA coatomer protein complex, subunit alpha 0.0368346
NBAS neuroblastoma amplified sequence 0.0367726
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0360781
YEATS2 YEATS domain containing 2 0.0360734
MYO1B myosin IB 0.0359756
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0353778
ATP13A3 ATPase type 13A3 0.0352999
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0352628
CA12 carbonic anhydrase XII 0.0351145
HELZ helicase with zinc finger 0.0348316
VEGFA vascular endothelial growth factor A 0.0346787
LMAN1 lectin, mannose-binding, 1 0.0344521
ZNF638 zinc finger protein 638 0.0344283
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0338815
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0333267
MAP2K1 mitogen-activated protein kinase kinase 1 0.0330839
RICTOR RPTOR independent companion of MTOR, complex 2 0.0328149
OTUD7B OTU deubiquitinase 7B 0.0326646
ANO6 anoctamin 6 0.031833
SUCO SUN domain containing ossification factor 0.0317707
DST dystonin 0.0316213
RAB8B RAB8B, member RAS oncogene family 0.031506
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0314561
CD109 CD109 molecule 0.0313664
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0310487
SLTM SAFB-like, transcription modulator 0.031009
DPYSL3 dihydropyrimidinase-like 3 0.0306274
MAML2 mastermind-like 2 (Drosophila) 0.0302988
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0300997
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0299643
H1-0 H1.0 linker histone 0.0299511
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0298886
PDIA3 protein disulfide isomerase family A, member 3 0.0294094
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0292367
MXI1 MAX interactor 1, dimerization protein 0.0291224
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0290708
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.029056
GYS1 glycogen synthase 1 (muscle) 0.0289552
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.0288854
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.0287702
VEGFC vascular endothelial growth factor C 0.0287277
RIOK3 RIO kinase 3 0.0286828
FBXL13 F-box and leucine-rich repeat protein 13 0.0286794
LRRC49 leucine rich repeat containing 49 0.028668

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.185633
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.155672
VIM vimentin -0.154408
FTL ferritin, light polypeptide -0.0908837
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0873542
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0763845
TPT1 tumor protein, translationally-controlled 1 -0.069454
RPLP1 ribosomal protein, large, P1 -0.0693964
GLCCI1 glucocorticoid induced 1 -0.0689955
TFPI2 tissue factor pathway inhibitor 2 -0.0647826
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0633613
EXT1 exostosin glycosyltransferase 1 -0.0628844
RPL35A ribosomal protein L35a -0.06226
HMGA2 high mobility group AT-hook 2 -0.058892
NTN4 netrin 4 -0.0576479
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0565202
CD44 CD44 molecule (Indian blood group) -0.0543951
S100A6 S100 calcium binding protein A6 -0.0525763
RPS19 ribosomal protein S19 -0.0495673
EIF1 eukaryotic translation initiation factor 1 -0.0493469
RPL34 ribosomal protein L34 -0.0490582
RPS21 ribosomal protein S21 -0.0489675
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0488393
PTMA prothymosin, alpha -0.047429
MT2A metallothionein 2A -0.0436334
RPS24 ribosomal protein S24 -0.0432053
RPL23 ribosomal protein L23 -0.0419948
C15ORF48 chromosome 15 open reading frame 48 -0.0417131
VRK2 vaccinia related kinase 2 -0.0402435
SLC38A1 solute carrier family 38, member 1 -0.0392413
NRG1 neuregulin 1 -0.0379362
EREG epiregulin -0.0372555
IER3 immediate early response 3 -0.036836
B2M beta-2-microglobulin -0.0363014
S100A10 S100 calcium binding protein A10 -0.0352957
TM4SF1 transmembrane 4 L six family member 1 -0.0352677
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0351548
LOC102724023 ES1 protein homolog, mitochondrial -0.0346701
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0346665
RPLP2 ribosomal protein, large, P2 -0.0345479
SAMD9 sterile alpha motif domain containing 9 -0.0334978
RPS29 ribosomal protein S29 -0.0330051
ACTG1 actin gamma 1 -0.0329462
RPL36 ribosomal protein L36 -0.0327466
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0321836
TNNC1 troponin C type 1 (slow) -0.031817
EGR1 early growth response 1 -0.0314649
NAP1L1 nucleosome assembly protein 1-like 1 -0.0312601
RPS8 ribosomal protein S8 -0.0307369
IFI6 interferon, alpha-inducible protein 6 -0.0302592
RBM39 RNA binding motif protein 39 -0.0297011
SP100 SP100 nuclear antigen -0.0295736
CLMP CXADR-like membrane protein -0.0295321
WSB1 WD repeat and SOCS box containing 1 -0.0294251
HLA-B major histocompatibility complex, class I, B -0.0293775
RPLP0 ribosomal protein, large, P0 -0.0291179
GLIS3 GLIS family zinc finger 3 -0.0279819
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0270291
RPL37A ribosomal protein L37a -0.0267853
PID1 phosphotyrosine interaction domain containing 1 -0.0266012
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0265002
TMSB4X thymosin beta 4, X-linked -0.0264833
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0263465
RPL31 ribosomal protein L31 -0.026197
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0261381
DDIT3 DNA-damage-inducible transcript 3 -0.0259213
AADAC arylacetamide deacetylase -0.0256061
RPL19 ribosomal protein L19 -0.025606
RAB7A RAB7A, member RAS oncogene family -0.0255036
DPYD dihydropyrimidine dehydrogenase -0.0253014
RPL9 ribosomal protein L9 -0.0249141
OSMR oncostatin M receptor -0.0247896
STC1 stanniocalcin 1 -0.0247444
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.02471
RPL37 ribosomal protein L37 -0.0246459
RPL5 ribosomal protein L5 -0.0246455
RPL32 ribosomal protein L32 -0.0246298
BTG1 B-cell translocation gene 1, anti-proliferative -0.024095
RPL30 ribosomal protein L30 -0.0239959
RPS25 ribosomal protein S25 -0.0239653
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0237957
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0230237
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0228915
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -0.0224389
LOX lysyl oxidase -0.0220993
RPL27A ribosomal protein L27a -0.0220768
SOX4 SRY (sex determining region Y)-box 4 -0.0216546
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0214951
FAM20C family with sequence similarity 20, member C -0.0213503
MSRB3 methionine sulfoxide reductase B3 -0.0212812
RPL38 ribosomal protein L38 -0.021213
RPL28 ribosomal protein L28 -0.0209796
RPL12 ribosomal protein L12 -0.0208886
BASP1 brain abundant, membrane attached signal protein 1 -0.0208839
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.020826
RPL26 ribosomal protein L26 -0.0207719
HEG1 heart development protein with EGF-like domains 1 -0.0203818
THBD thrombomodulin -0.0202776
PRSS23 protease, serine, 23 -0.0198629
RPS16 ribosomal protein S16 -0.0198434