| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dapagliflozin_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.177228 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.128613 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.101088 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0990008 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0964761 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0875208 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0851833 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0827922 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0822702 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0801089 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.074352 |
| TPM3 | tropomyosin 3 | 0.0679875 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0664481 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0658458 |
| FMNL2 | formin-like 2 | 0.0652298 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0639135 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0638143 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0618747 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0618706 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0613456 |
| COPA | coatomer protein complex, subunit alpha | 0.0612719 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0583322 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0572911 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.05687 |
| CMIP | c-Maf inducing protein | 0.055305 |
| PTK2 | protein tyrosine kinase 2 | 0.0539102 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0537947 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0530974 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0513129 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0506328 |
| APP | amyloid beta (A4) precursor protein | 0.0498558 |
| FLNA | filamin A, alpha | 0.0489117 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0473622 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.047194 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0471153 |
| MSN | moesin | 0.046296 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0459608 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0458498 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0452402 |
| SFTPA2 | surfactant protein A2 | 0.0444968 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0442767 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0440088 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0429846 |
| MCL1 | myeloid cell leukemia 1 | 0.0423538 |
| PLEC | plectin | 0.0419961 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.041375 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0411278 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0407819 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0406681 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0395779 |
| GLG1 | golgi glycoprotein 1 | 0.039303 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0386911 |
| ASPH | aspartate beta-hydroxylase | 0.0380982 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0379963 |
| PM20D1 | peptidase M20 domain containing 1 | 0.037885 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.037872 |
| CALR | calreticulin | 0.0376856 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.037597 |
| ATXN1 | ataxin 1 | 0.0375461 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0363558 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0361604 |
| POTEF | POTE ankyrin domain family, member F | 0.0361113 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0358404 |
| SVIL | supervillin | 0.0355939 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0354878 |
| FAM107B | family with sequence similarity 107, member B | 0.0352325 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0348503 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0347912 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0344019 |
| ACTN1 | actinin, alpha 1 | 0.0343175 |
| PYGL | phosphorylase, glycogen, liver | 0.0338185 |
| EGFR | epidermal growth factor receptor | 0.033811 |
| CALU | calumenin | 0.0336485 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0335476 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0334792 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0332044 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0329761 |
| CCNL1 | cyclin L1 | 0.0327765 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.032715 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.032138 |
| FLNB | filamin B, beta | 0.0320961 |
| MRTFA | myocardin related transcription factor A | 0.0314504 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0309569 |
| BRD2 | bromodomain containing 2 | 0.030902 |
| PARD3 | par-3 family cell polarity regulator | 0.0303998 |
| MYO1E | myosin IE | 0.0303583 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.029997 |
| HYOU1 | hypoxia up-regulated 1 | 0.0295694 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0295191 |
| JMJD1C | jumonji domain containing 1C | 0.0293171 |
| SMAD3 | SMAD family member 3 | 0.0292953 |
| UTRN | utrophin | 0.0292474 |
| DST | dystonin | 0.0291141 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0290632 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0290544 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0288396 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0286416 |
| NUMB | numb homolog (Drosophila) | 0.0286371 |
| NCKAP1 | NCK-associated protein 1 | 0.0285909 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0285619 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.137814 |
| MT2A | metallothionein 2A | -0.126226 |
| TMSB10 | thymosin beta 10 | -0.114105 |
| FTL | ferritin, light polypeptide | -0.0898612 |
| TXNRD1 | thioredoxin reductase 1 | -0.0897468 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0790674 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0701001 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0612105 |
| RPL23 | ribosomal protein L23 | -0.0585558 |
| VIM | vimentin | -0.0513488 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0492014 |
| RPLP1 | ribosomal protein, large, P1 | -0.0438529 |
| RPS21 | ribosomal protein S21 | -0.0401438 |
| IGF2 | insulin-like growth factor 2 | -0.040093 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0392818 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0389227 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0386662 |
| PTMA | prothymosin, alpha | -0.037572 |
| ACTG1 | actin gamma 1 | -0.0358305 |
| NRG1 | neuregulin 1 | -0.0332763 |
| BICC1 | BicC family RNA binding protein 1 | -0.0329357 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0315596 |
| CAVIN1 | caveolae associated protein 1 | -0.028531 |
| RPL35A | ribosomal protein L35a | -0.0278655 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0274869 |
| RPL30 | ribosomal protein L30 | -0.0269561 |
| RPS19 | ribosomal protein S19 | -0.0269535 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0262281 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0260172 |
| IER3 | immediate early response 3 | -0.0256345 |
| RPL36 | ribosomal protein L36 | -0.0247598 |
| ZNF804A | zinc finger protein 804A | -0.0233301 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0230583 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0227886 |
| RPS29 | ribosomal protein S29 | -0.022738 |
| TUBB | tubulin, beta class I | -0.0213474 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0210374 |
| RPLP0 | ribosomal protein, large, P0 | -0.020985 |
| HDAC9 | histone deacetylase 9 | -0.0203308 |
| RPL19 | ribosomal protein L19 | -0.0200513 |
| RACK1 | receptor for activated C kinase 1 | -0.0199218 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0198145 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0198132 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0196974 |
| HMGB1 | high mobility group box 1 | -0.0196355 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0195355 |
| RPS12 | ribosomal protein S12 | -0.0192441 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0191603 |
| AK1 | adenylate kinase 1 | -0.0189385 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0189221 |
| HMGA1 | high mobility group AT-hook 1 | -0.0185788 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0183113 |
| NCOA7 | nuclear receptor coactivator 7 | -0.018099 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0179014 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0178756 |
| RPS8 | ribosomal protein S8 | -0.017536 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0173686 |
| RPL38 | ribosomal protein L38 | -0.0172236 |
| RPS20 | ribosomal protein S20 | -0.017042 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | -0.0169431 |
| GNAS | GNAS complex locus | -0.0167996 |
| RPL4 | ribosomal protein L4 | -0.016393 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0161337 |
| RPLP2 | ribosomal protein, large, P2 | -0.0160706 |
| RPL26 | ribosomal protein L26 | -0.0155263 |
| ECT2 | epithelial cell transforming 2 | -0.015308 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | -0.0153066 |
| S100A11 | S100 calcium binding protein A11 | -0.0150146 |
| TFRC | transferrin receptor | -0.01471 |
| UBB | ubiquitin B | -0.0146754 |
| NPR2 | natriuretic peptide receptor 2 | -0.0146113 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.0145905 |
| LDHA | lactate dehydrogenase A | -0.0145568 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | -0.0143972 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0143827 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.014347 |
| RPL12 | ribosomal protein L12 | -0.0141554 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0140603 |
| WWOX | WW domain containing oxidoreductase | -0.0135292 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0134766 |
| RPL37 | ribosomal protein L37 | -0.0132435 |
| RPL9 | ribosomal protein L9 | -0.0131852 |
| CENPE | centromere protein E, 312kDa | -0.0130098 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0128535 |
| RPL32 | ribosomal protein L32 | -0.0128369 |
| RPS24 | ribosomal protein S24 | -0.0128033 |
| EIF3J | eukaryotic translation initiation factor 3, subunit J | -0.0127782 |
| GNL3 | guanine nucleotide binding protein-like 3 (nucleolar) | -0.0127605 |
| WDR35 | WD repeat domain 35 | -0.0126728 |
| CENPF | centromere protein F, 350/400kDa | -0.0125988 |
| RPL37A | ribosomal protein L37a | -0.0125925 |
| KHSRP | KH-type splicing regulatory protein | -0.0125578 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0125263 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0124461 |
| TMEM87A | transmembrane protein 87A | -0.0123361 |
| EGR1 | early growth response 1 | -0.0122015 |
| ZC3H15 | zinc finger CCCH-type containing 15 | -0.0120824 |
| RBM39 | RNA binding motif protein 39 | -0.0120341 |
| SSB | Sjogren syndrome antigen B (autoantigen La) | -0.0120014 |
| KLF6 | Kruppel-like factor 6 | -0.0119292 |
