| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dapagliflozin_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.159731 |
| SLTM | SAFB-like, transcription modulator | 0.13334 |
| PTMA | prothymosin, alpha | 0.121424 |
| RNF213 | ring finger protein 213 | 0.106655 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.103423 |
| LAMA4 | laminin, alpha 4 | 0.100441 |
| ASPH | aspartate beta-hydroxylase | 0.100135 |
| MCL1 | myeloid cell leukemia 1 | 0.0894385 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0888645 |
| SMYD3 | SET and MYND domain containing 3 | 0.0887981 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0875541 |
| EZR | ezrin | 0.0854302 |
| MYO1E | myosin IE | 0.0795529 |
| EGFR | epidermal growth factor receptor | 0.0790035 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0789137 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0778532 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0756716 |
| PKM | pyruvate kinase, muscle | 0.072523 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0717474 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0712136 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0706549 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0663787 |
| CES1 | carboxylesterase 1 | 0.065864 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0646762 |
| PLEC | plectin | 0.0643004 |
| EFNA5 | ephrin-A5 | 0.0630556 |
| TES | testin LIM domain protein | 0.0606376 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0605896 |
| TMSB4X | thymosin beta 4, X-linked | 0.0575735 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0573296 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0569644 |
| RAD51B | RAD51 paralog B | 0.0567282 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0563492 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0549913 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0549898 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0541834 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0536136 |
| FAM117B | family with sequence similarity 117, member B | 0.0534906 |
| VMP1 | vacuole membrane protein 1 | 0.0531158 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0527715 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0522786 |
| EPCAM | epithelial cell adhesion molecule | 0.0512512 |
| APP | amyloid beta (A4) precursor protein | 0.0511327 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.0509143 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0481794 |
| TPM1 | tropomyosin 1 (alpha) | 0.0476783 |
| RIGI | RNA sensor RIG-I | 0.0471745 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0467267 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0467203 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0459071 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0455054 |
| VCL | vinculin | 0.0451108 |
| TENM3 | teneurin transmembrane protein 3 | 0.0444783 |
| EVI5 | ecotropic viral integration site 5 | 0.0441994 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.044101 |
| JMJD1C | jumonji domain containing 1C | 0.0438637 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0430954 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0430505 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.042883 |
| CANX | calnexin | 0.0428778 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0419057 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0419022 |
| MTMR3 | myotubularin related protein 3 | 0.0415621 |
| COG5 | component of oligomeric golgi complex 5 | 0.0410997 |
| ANXA2 | annexin A2 | 0.0407836 |
| IPO7 | importin 7 | 0.040723 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0404875 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | 0.0399891 |
| CMIP | c-Maf inducing protein | 0.0394746 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0393372 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.0390348 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0388544 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | 0.0388061 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0383436 |
| MSI2 | musashi RNA-binding protein 2 | 0.0381924 |
| EHBP1 | EH domain binding protein 1 | 0.0377927 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0377809 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0373612 |
| RASA2 | RAS p21 protein activator 2 | 0.0367671 |
| MEF2A | myocyte enhancer factor 2A | 0.0364408 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0361566 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0361518 |
| ZNF148 | zinc finger protein 148 | 0.036116 |
| FER | fer (fps/fes related) tyrosine kinase | 0.036071 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0358686 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0358564 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.0357699 |
| ZNF207 | zinc finger protein 207 | 0.035036 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0347685 |
| SEC24A | SEC24 family member A | 0.0345534 |
| TLK1 | tousled-like kinase 1 | 0.0344973 |
| BRD2 | bromodomain containing 2 | 0.0342302 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0339911 |
| QKI | QKI, KH domain containing, RNA binding | 0.033871 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0337447 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0337372 |
| ANXA1 | annexin A1 | 0.0337021 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0324941 |
| PRKCA | protein kinase C, alpha | 0.0320631 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0319448 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.200636 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.141525 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.135042 |
| LMO7 | LIM domain 7 | -0.123143 |
| RPL35A | ribosomal protein L35a | -0.0892056 |
| VIM | vimentin | -0.0868047 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0797321 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0735902 |
| NDRG1 | N-myc downstream regulated 1 | -0.0734691 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0732417 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0724561 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0706126 |
| KRT17 | keratin 17, type I | -0.0681582 |
| FMNL2 | formin-like 2 | -0.0662185 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0642355 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.062958 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0616728 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0614433 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0602161 |
| ABHD17C | abhydrolase domain containing 17C | -0.0598881 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0571646 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0563233 |
| MMP1 | matrix metallopeptidase 1 | -0.054172 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0537248 |
| ATOSA | atos homolog A | -0.0531316 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0521137 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0513181 |
| IER3 | immediate early response 3 | -0.0495192 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.0493715 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0483522 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0482098 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0467245 |
| TXNRD1 | thioredoxin reductase 1 | -0.0465557 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0465535 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0450887 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | -0.0450055 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0448816 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0445532 |
| UBC | ubiquitin C | -0.043269 |
| TMEM165 | transmembrane protein 165 | -0.0425184 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0420265 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0411599 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0405564 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0397359 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.039013 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0387187 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0387002 |
| SFTPA2 | surfactant protein A2 | -0.0382712 |
| CD44 | CD44 molecule (Indian blood group) | -0.0380171 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0379243 |
| NHSL1 | NHS-like 1 | -0.0377032 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0374986 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0372724 |
| RAB10 | RAB10, member RAS oncogene family | -0.0369968 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0369233 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.036912 |
| EPS15 | epidermal growth factor receptor pathway substrate 15 | -0.0367369 |
| SP100 | SP100 nuclear antigen | -0.0366365 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0364314 |
| CDK19 | cyclin-dependent kinase 19 | -0.0363779 |
| CHD4 | chromodomain helicase DNA binding protein 4 | -0.0360572 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0356804 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | -0.0352933 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0352904 |
| RACK1 | receptor for activated C kinase 1 | -0.0351177 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.034928 |
| FAM13A | family with sequence similarity 13, member A | -0.0348094 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0346497 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0340583 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0338503 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0336609 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0333809 |
| HLA-B | major histocompatibility complex, class I, B | -0.0331576 |
| RPL26 | ribosomal protein L26 | -0.0330628 |
| INHBA | inhibin, beta A | -0.0320221 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0319718 |
| CSNK1E | casein kinase 1, epsilon | -0.0316266 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.031502 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0312837 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0312465 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.03119 |
| RPS21 | ribosomal protein S21 | -0.0308283 |
| PCNX1 | pecanex 1 | -0.0308067 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0301473 |
| STAG2 | stromal antigen 2 | -0.0301462 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0301061 |
| ARFGEF3 | ARFGEF family member 3 | -0.0300858 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.030056 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0298584 |
| ADM | adrenomedullin | -0.0296876 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0293814 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0293286 |
| RPL8 | ribosomal protein L8 | -0.0290504 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0288084 |
| HDLBP | high density lipoprotein binding protein | -0.0285513 |
| PDSS2 | prenyl (decaprenyl) diphosphate synthase, subunit 2 | -0.0284852 |
| YTHDC1 | YTH domain containing 1 | -0.0282089 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | -0.0281772 |
| CLTC | clathrin, heavy chain (Hc) | -0.0281658 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0280959 |
