Dapagliflozin_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dapagliflozin perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dapagliflozin_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.181333
GRAMD1B GRAM domain containing 1B 0.138946
RAD51B RAD51 paralog B 0.09432
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0702793
PDE4D phosphodiesterase 4D, cAMP-specific 0.0702571
TXNRD1 thioredoxin reductase 1 0.066654
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0660807
ERRFI1 ERBB receptor feedback inhibitor 1 0.0615017
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0600561
EXOC4 exocyst complex component 4 0.0558482
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0558334
THSD4 thrombospondin, type I, domain containing 4 0.0556845
EEF2 eukaryotic translation elongation factor 2 0.0537694
MACF1 microtubule-actin crosslinking factor 1 0.0518248
PTK2 protein tyrosine kinase 2 0.0516361
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0491593
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0489707
TRIO trio Rho guanine nucleotide exchange factor 0.0487581
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0454722
ZCCHC7 zinc finger, CCHC domain containing 7 0.0449604
DOCK5 dedicator of cytokinesis 5 0.0444387
ANO6 anoctamin 6 0.0441656
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0429692
EML4 echinoderm microtubule associated protein like 4 0.0425924
ZFAND3 zinc finger, AN1-type domain 3 0.0423476
KDM2A lysine (K)-specific demethylase 2A 0.041865
NF1 neurofibromin 1 0.0417686
MYH9 myosin, heavy chain 9, non-muscle 0.0411512
MCL1 myeloid cell leukemia 1 0.0401734
YAP1 Yes-associated protein 1 0.0390302
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0372814
FMNL2 formin-like 2 0.0369061
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0363226
MARCHF4 membrane associated ring-CH-type finger 4 0.0362888
TBC1D5 TBC1 domain family, member 5 0.0356169
IGF1R insulin-like growth factor 1 receptor 0.0352007
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0348032
RIMS2 regulating synaptic membrane exocytosis 2 0.0347039
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0342411
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0341229
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.03391
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0339007
CDK17 cyclin-dependent kinase 17 0.033765
AFF3 AF4/FMR2 family, member 3 0.0335057
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.03325
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0331813
TPM3 tropomyosin 3 0.0325732
DENND5B DENN/MADD domain containing 5B 0.0323036
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0321838
YBX3 Y box binding protein 3 0.0316968
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0314842
FAF1 Fas (TNFRSF6) associated factor 1 0.0314748
CLTC clathrin, heavy chain (Hc) 0.0313976
ATP11A ATPase, class VI, type 11A 0.0313635
PDE10A phosphodiesterase 10A 0.0308596
EXT1 exostosin glycosyltransferase 1 0.030781
RRM2 ribonucleotide reductase M2 0.0302508
RICTOR RPTOR independent companion of MTOR, complex 2 0.0302316
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0301996
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.030152
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0296602
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0296526
WNK1 WNK lysine deficient protein kinase 1 0.0294497
TAS2R14 taste receptor, type 2, member 14 0.0294367
SMAD3 SMAD family member 3 0.0291705
PLEC plectin 0.0291327
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0291009
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0283747
BIRC6 baculoviral IAP repeat containing 6 0.028153
BCAS3 breast carcinoma amplified sequence 3 0.0278245
TRIP12 thyroid hormone receptor interactor 12 0.027631
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0275245
ZNF638 zinc finger protein 638 0.0274866
RABGAP1L RAB GTPase activating protein 1-like 0.0274012
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.027368
WDPCP WD repeat containing planar cell polarity effector 0.027148
ZSWIM6 zinc finger, SWIM-type containing 6 0.0267056
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0264789
SPIDR scaffolding protein involved in DNA repair 0.0261778
VMP1 vacuole membrane protein 1 0.0259369
ELL2 elongation factor, RNA polymerase II, 2 0.0256614
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0250946
MED13L mediator complex subunit 13-like 0.0249099
JMJD1C jumonji domain containing 1C 0.0248718
PRKCE protein kinase C, epsilon 0.0245972
DST dystonin 0.0245371
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0239886
MMP12 matrix metallopeptidase 12 0.0239539
WDR70 WD repeat domain 70 0.0238975
EXOC6B exocyst complex component 6B 0.0236165
ACTN1 actinin, alpha 1 0.0235147
XPO1 exportin 1 0.0235075
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0234822
LPP LIM domain containing preferred translocation partner in lipoma 0.0234403
SSH2 slingshot protein phosphatase 2 0.0232583
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0232066
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0231142
EGFR epidermal growth factor receptor 0.0230597
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0229429
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0229305

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.199123
TMSB10 thymosin beta 10 -0.0755549
VIM vimentin -0.0737642
PTMA prothymosin, alpha -0.0613459
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0587109
RPL35A ribosomal protein L35a -0.0535956
RPS8 ribosomal protein S8 -0.0531247
RPL26 ribosomal protein L26 -0.0437417
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0417184
RPL37 ribosomal protein L37 -0.04133
RPL37A ribosomal protein L37a -0.0410293
RPL23 ribosomal protein L23 -0.0400437
RPS21 ribosomal protein S21 -0.0400017
RPS27 ribosomal protein S27 -0.039788
RPLP1 ribosomal protein, large, P1 -0.0396928
RPL12 ribosomal protein L12 -0.0393707
RPS19 ribosomal protein S19 -0.0385298
TPT1 tumor protein, translationally-controlled 1 -0.0361179
RPS12 ribosomal protein S12 -0.0335454
RPLP2 ribosomal protein, large, P2 -0.0321979
RPS29 ribosomal protein S29 -0.0312614
RPL34 ribosomal protein L34 -0.0299131
RPL19 ribosomal protein L19 -0.0287405
RPL36 ribosomal protein L36 -0.0269946
FTL ferritin, light polypeptide -0.0265365
ACTG1 actin gamma 1 -0.0264406
RPS3 ribosomal protein S3 -0.0261526
RPL9 ribosomal protein L9 -0.0258114
NAP1L1 nucleosome assembly protein 1-like 1 -0.0254242
HLA-B major histocompatibility complex, class I, B -0.0253367
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0249293
TPI1 triosephosphate isomerase 1 -0.0246254
EIF1 eukaryotic translation initiation factor 1 -0.0243116
S100A10 S100 calcium binding protein A10 -0.0242754
RPS15 ribosomal protein S15 -0.0237843
RPL11 ribosomal protein L11 -0.0231183
RPS24 ribosomal protein S24 -0.0230799
RPL32 ribosomal protein L32 -0.0228107
RPL5 ribosomal protein L5 -0.0227286
RPL38 ribosomal protein L38 -0.0226463
RPL31 ribosomal protein L31 -0.0222671
ATP5F1E ATP synthase F1 subunit epsilon -0.0220362
RPLP0 ribosomal protein, large, P0 -0.0213026
NACA nascent polypeptide-associated complex alpha subunit -0.0212675
RACK1 receptor for activated C kinase 1 -0.0212465
RPS6 ribosomal protein S6 -0.0212327
RPL36A ribosomal protein L36a -0.0212169
RPS25 ribosomal protein S25 -0.0206206
RPS27A ribosomal protein S27a -0.020406
VDAC1 voltage-dependent anion channel 1 -0.0199267
RPL28 ribosomal protein L28 -0.0197821
RPS17 ribosomal protein S17 -0.0194625
RPL13A ribosomal protein L13a -0.0193051
LOC102724023 ES1 protein homolog, mitochondrial -0.019286
RPS20 ribosomal protein S20 -0.0190133
MYL12B myosin, light chain 12B, regulatory -0.0182933
RPS13 ribosomal protein S13 -0.0182788
RPS10 ribosomal protein S10 -0.0179003
RPL27 ribosomal protein L27 -0.0177121
GNAS GNAS complex locus -0.0173928
RPL30 ribosomal protein L30 -0.0172734
TFPI2 tissue factor pathway inhibitor 2 -0.0169534
RPL8 ribosomal protein L8 -0.0166075
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0162221
ATP5F1B ATP synthase F1 subunit beta -0.0160447
S100A6 S100 calcium binding protein A6 -0.0156252
S100A11 S100 calcium binding protein A11 -0.0155947
RPS14 ribosomal protein S14 -0.0155942
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0147928
RPS16 ribosomal protein S16 -0.0147359
RPL35 ribosomal protein L35 -0.0144679
GSTP1 glutathione S-transferase pi 1 -0.0141813
IFI6 interferon, alpha-inducible protein 6 -0.0140942
WSB1 WD repeat and SOCS box containing 1 -0.0136846
RPS23 ribosomal protein S23 -0.0135067
HMGA1 high mobility group AT-hook 1 -0.013246
SEC61G Sec61 gamma subunit -0.0131293
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0130335
EIF5B eukaryotic translation initiation factor 5B -0.0123783
PABPN1 poly(A) binding protein, nuclear 1 -0.0122721
SEPTIN7 septin 7 -0.0122694
ATF4 activating transcription factor 4 -0.0122416
RBM39 RNA binding motif protein 39 -0.0120017
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0117907
RPL27A ribosomal protein L27a -0.011744
RPL10A ribosomal protein L10a -0.0117051
PFN1 profilin 1 -0.0112283
RPL7A ribosomal protein L7a -0.0112022
RPL18 ribosomal protein L18 -0.0108689
RPS2 ribosomal protein S2 -0.010734
RPS11 ribosomal protein S11 -0.0107184
YBX1 Y box binding protein 1 -0.0104251
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0103808
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.0101337
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 -0.0101248
MT2A metallothionein 2A -0.0099328
RBM25 RNA binding motif protein 25 -0.00983733
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.00981461
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.00981204
ROMO1 reactive oxygen species modulator 1 -0.00979999