| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dapagliflozin_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.311425 |
| TSC22D2 | TSC22 domain family, member 2 | 0.147629 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.137723 |
| PLEC | plectin | 0.118088 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.107879 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.107524 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0979566 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0939604 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.086514 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0862464 |
| PLAU | plasminogen activator, urokinase | 0.0834785 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0832589 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0823928 |
| CD2AP | CD2-associated protein | 0.0791101 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0734133 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0728055 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0696813 |
| F11R | F11 receptor | 0.068748 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0661152 |
| H1-0 | H1.0 linker histone | 0.064521 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0632632 |
| ANXA2 | annexin A2 | 0.0629853 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0624891 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.062235 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0619356 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0618627 |
| CCND1 | cyclin D1 | 0.0618552 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0618014 |
| CALR | calreticulin | 0.061267 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0610799 |
| PGK1 | phosphoglycerate kinase 1 | 0.0600758 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0587899 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0585631 |
| PTK2 | protein tyrosine kinase 2 | 0.0559327 |
| LAMB3 | laminin, beta 3 | 0.0546605 |
| LMO7 | LIM domain 7 | 0.0538277 |
| HLA-A | major histocompatibility complex, class I, A | 0.0533342 |
| MYO6 | myosin VI | 0.0505071 |
| TMSB4X | thymosin beta 4, X-linked | 0.0483546 |
| COPA | coatomer protein complex, subunit alpha | 0.0479344 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.0463449 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0459427 |
| DSPP | dentin sialophosphoprotein | 0.0454153 |
| SFTPA2 | surfactant protein A2 | 0.0452249 |
| RAI14 | retinoic acid induced 14 | 0.0441835 |
| KRT18 | keratin 18, type I | 0.0441321 |
| MAP1B | microtubule-associated protein 1B | 0.0441089 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0438215 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0427635 |
| MSI2 | musashi RNA-binding protein 2 | 0.0426651 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0425785 |
| AHNAK | AHNAK nucleoprotein | 0.0418119 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.041649 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0410336 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0409653 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0405966 |
| TPM4 | tropomyosin 4 | 0.040583 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0404099 |
| ERBIN | erbb2 interacting protein | 0.0403204 |
| RNF145 | ring finger protein 145 | 0.0398134 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0394826 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.038962 |
| FAM13A | family with sequence similarity 13, member A | 0.0384264 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0378619 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0372951 |
| JMJD1C | jumonji domain containing 1C | 0.0370271 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0369314 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.036754 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0364096 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0361869 |
| SLMAP | sarcolemma associated protein | 0.0359973 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0357367 |
| MXD1 | MAX dimerization protein 1 | 0.0355763 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0354873 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0349984 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0349871 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0349527 |
| SPAG9 | sperm associated antigen 9 | 0.034549 |
| FAM168A | family with sequence similarity 168, member A | 0.0345261 |
| FLNB | filamin B, beta | 0.0335477 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.033224 |
| CD109 | CD109 molecule | 0.033123 |
| RASAL2 | RAS protein activator like 2 | 0.0330357 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0326239 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0326225 |
| FLNA | filamin A, alpha | 0.0320985 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0319639 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0319559 |
| GNAS | GNAS complex locus | 0.0318368 |
| HLA-E | major histocompatibility complex, class I, E | 0.0318191 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0317542 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.031621 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0315685 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0315434 |
| BCL2L1 | BCL2-like 1 | 0.0311407 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0309347 |
| DHFR | dihydrofolate reductase | 0.0308675 |
| DST | dystonin | 0.0306072 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0305325 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0302777 |
| Symbol | Name | Standardized Value |
|---|---|---|
| UBC | ubiquitin C | -0.164846 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.134734 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.10075 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0911813 |
| POTEF | POTE ankyrin domain family, member F | -0.0690428 |
| RPL23 | ribosomal protein L23 | -0.0674177 |
| RPS27A | ribosomal protein S27a | -0.0546322 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0530253 |
| RPL9 | ribosomal protein L9 | -0.0523405 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0521607 |
| PCBP2 | poly(rC) binding protein 2 | -0.0506477 |
| TMSB10 | thymosin beta 10 | -0.0486368 |
| RACK1 | receptor for activated C kinase 1 | -0.047955 |
| MT2A | metallothionein 2A | -0.0465432 |
| RPLP2 | ribosomal protein, large, P2 | -0.0430209 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0406835 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0396186 |
| RPL34 | ribosomal protein L34 | -0.0360804 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0351059 |
| RPL7 | ribosomal protein L7 | -0.0337867 |
| RPS2 | ribosomal protein S2 | -0.0332232 |
| RPS8 | ribosomal protein S8 | -0.0331646 |
| RPL26 | ribosomal protein L26 | -0.0327326 |
| RPS3 | ribosomal protein S3 | -0.0326845 |
| RPS12 | ribosomal protein S12 | -0.0326356 |
| RPL32 | ribosomal protein L32 | -0.0315564 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | -0.0306747 |
| RPS23 | ribosomal protein S23 | -0.0305346 |
| RPL19 | ribosomal protein L19 | -0.0295362 |
| RPL30 | ribosomal protein L30 | -0.0294634 |
| RPL8 | ribosomal protein L8 | -0.0289765 |
| TXNRD1 | thioredoxin reductase 1 | -0.0287118 |
| NDRG1 | N-myc downstream regulated 1 | -0.0286248 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0274572 |
| LDHA | lactate dehydrogenase A | -0.0274399 |
| RPLP1 | ribosomal protein, large, P1 | -0.0270127 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0263804 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0259706 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | -0.0258853 |
| GPX4 | glutathione peroxidase 4 | -0.0257819 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.02491 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0248694 |
| S100A6 | S100 calcium binding protein A6 | -0.0246006 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0241961 |
| RPS19 | ribosomal protein S19 | -0.0239695 |
| RPS17 | ribosomal protein S17 | -0.0235124 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0231413 |
| RPS13 | ribosomal protein S13 | -0.0227365 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | -0.0224463 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0221815 |
| RPL37 | ribosomal protein L37 | -0.0217776 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0213107 |
| RPL5 | ribosomal protein L5 | -0.0207042 |
| RPS6 | ribosomal protein S6 | -0.0205918 |
| RPS15 | ribosomal protein S15 | -0.0203303 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0203088 |
| RPS27 | ribosomal protein S27 | -0.0199287 |
| RPL15 | ribosomal protein L15 | -0.0198765 |
| S100A10 | S100 calcium binding protein A10 | -0.0197819 |
| HMGB2 | high mobility group box 2 | -0.0192289 |
| SKP1 | S-phase kinase-associated protein 1 | -0.0187052 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0185959 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0184013 |
| FHIT | fragile histidine triad | -0.0182987 |
| RPS21 | ribosomal protein S21 | -0.018224 |
| RPL3 | ribosomal protein L3 | -0.0180102 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0175677 |
| RPL38 | ribosomal protein L38 | -0.0171795 |
| EPCAM | epithelial cell adhesion molecule | -0.0171284 |
| PARP12 | poly (ADP-ribose) polymerase family, member 12 | -0.0170926 |
| RPS25 | ribosomal protein S25 | -0.0170181 |
| RPL37A | ribosomal protein L37a | -0.016854 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -0.0166442 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | -0.0165294 |
| RPL27 | ribosomal protein L27 | -0.0163452 |
| RPS5 | ribosomal protein S5 | -0.0162848 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | -0.0161867 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0161662 |
| MKI67 | marker of proliferation Ki-67 | -0.0161217 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0159652 |
| SRSF5 | serine/arginine-rich splicing factor 5 | -0.0158886 |
| RPS29 | ribosomal protein S29 | -0.0152879 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0149415 |
| RPL36 | ribosomal protein L36 | -0.0148051 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0147676 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0147465 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0145813 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0144458 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0144237 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.0141381 |
| PAIP1 | poly(A) binding protein interacting protein 1 | -0.0140622 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0138853 |
| FBXO33 | F-box protein 33 | -0.0138599 |
| RPS11 | ribosomal protein S11 | -0.0138014 |
| RPL28 | ribosomal protein L28 | -0.0137232 |
| HMGA1 | high mobility group AT-hook 1 | -0.0136497 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0135153 |
| RPL12 | ribosomal protein L12 | -0.013424 |
| TENT2 | terminal nucleotidyltransferase 2 | -0.0133288 |
| NPC2 | Niemann-Pick disease, type C2 | -0.0133014 |
