Dapagliflozin_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dapagliflozin perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dapagliflozin_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.0883013
IGFBP3 insulin-like growth factor binding protein 3 0.0811697
ELL2 elongation factor, RNA polymerase II, 2 0.0668692
EFNA5 ephrin-A5 0.0666585
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.057445
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0541169
LIMCH1 LIM and calponin homology domains 1 0.051416
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0512538
BZW1 basic leucine zipper and W2 domains 1 0.0456269
FAM13A family with sequence similarity 13, member A 0.0442246
NDRG1 N-myc downstream regulated 1 0.0429739
ESYT2 extended synaptotagmin-like protein 2 0.0421786
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0396872
ERRFI1 ERBB receptor feedback inhibitor 1 0.0395256
SPAG9 sperm associated antigen 9 0.0393868
LAMA1 laminin, alpha 1 0.0382686
KMT2E lysine (K)-specific methyltransferase 2E 0.0367602
PYGL phosphorylase, glycogen, liver 0.036093
TRIO trio Rho guanine nucleotide exchange factor 0.0347442
RNF145 ring finger protein 145 0.0332318
EEF2 eukaryotic translation elongation factor 2 0.0327422
NEK7 NIMA-related kinase 7 0.0319874
KMT2C lysine (K)-specific methyltransferase 2C 0.0313239
ITPRID2 ITPR interacting domain containing 2 0.0311954
PDE4D phosphodiesterase 4D, cAMP-specific 0.0309691
DGKD diacylglycerol kinase, delta 130kDa 0.0303283
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0298067
TPD52 tumor protein D52 0.0292165
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0283586
TGFBI transforming growth factor, beta-induced, 68kDa 0.0281386
MSN moesin 0.0276453
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0275032
UBA6 ubiquitin-like modifier activating enzyme 6 0.027396
PDGFA platelet-derived growth factor alpha polypeptide 0.0267302
FLNB filamin B, beta 0.0264755
FTH1 ferritin, heavy polypeptide 1 0.0264647
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0259694
TSC22D2 TSC22 domain family, member 2 0.025752
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0256333
NCKAP1 NCK-associated protein 1 0.0254366
ZNF292 zinc finger protein 292 0.0253908
KDM6A lysine (K)-specific demethylase 6A 0.0247267
AVL9 AVL9 homolog (S. cerevisiase) 0.0246909
MAML3 mastermind-like 3 (Drosophila) 0.0246133
NUP58 nucleoporin 58 0.0244985
NGLY1 N-glycanase 1 0.0244523
RLIM ring finger protein, LIM domain interacting 0.024133
GOLGA4 golgin A4 0.0240773
CXCL8 chemokine (C-X-C motif) ligand 8 0.0239563
MARCHF1 membrane associated ring-CH-type finger 1 0.0238728
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0237914
SFTPA2 surfactant protein A2 0.0237886
MXI1 MAX interactor 1, dimerization protein 0.023464
PGK1 phosphoglycerate kinase 1 0.0232685
FNDC3A fibronectin type III domain containing 3A 0.0231163
OGA O-GlcNAcase 0.0223475
JMJD1C jumonji domain containing 1C 0.0220669
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0217128
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0215431
BIRC6 baculoviral IAP repeat containing 6 0.0207451
PLCB4 phospholipase C, beta 4 0.0202048
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0200887
BRWD3 bromodomain and WD repeat domain containing 3 0.0200663
DHFR dihydrofolate reductase 0.0197945
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0197614
HELZ helicase with zinc finger 0.0196206
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.019348
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0193176
ZBTB38 zinc finger and BTB domain containing 38 0.0192788
USP3 ubiquitin specific peptidase 3 0.0191155
LPGAT1 lysophosphatidylglycerol acyltransferase 1 0.018466
EPHA4 EPH receptor A4 0.0184044
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0183126
RGS2 regulator of G-protein signaling 2 0.018251
PTK2 protein tyrosine kinase 2 0.0181751
CTBP2 C-terminal binding protein 2 0.0180775
SUCO SUN domain containing ossification factor 0.0176139
RAB6A RAB6A, member RAS oncogene family 0.0173747
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0172516
GPRIN3 GPRIN family member 3 0.0172083
ADAM9 ADAM metallopeptidase domain 9 0.017176
PHF21A PHD finger protein 21A 0.0171315
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0170857
PM20D1 peptidase M20 domain containing 1 0.0170717
DDIT4 DNA-damage-inducible transcript 4 0.0170408
USP37 ubiquitin specific peptidase 37 0.0169301
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0167286
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0167049
COG5 component of oligomeric golgi complex 5 0.0165681
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0164378
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0160828
PBX1 pre-B-cell leukemia homeobox 1 0.01602
BMERB1 bMERB domain containing 1 0.0159408
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.015894
SETD5 SET domain containing 5 0.0158334
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.0157752
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0157468
CHD1 chromodomain helicase DNA binding protein 1 0.0157085
BHLHE40 basic helix-loop-helix family, member e40 0.015689
KDM2A lysine (K)-specific demethylase 2A 0.0155882

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.142531
TMSB10 thymosin beta 10 -0.140236
UBC ubiquitin C -0.113673
RPS27A ribosomal protein S27a -0.113084
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.102025
COL5A2 collagen, type V, alpha 2 -0.101806
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0997898
PTMA prothymosin, alpha -0.0920688
RPL23 ribosomal protein L23 -0.0861718
RPLP1 ribosomal protein, large, P1 -0.0816296
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0745043
TPT1 tumor protein, translationally-controlled 1 -0.0741144
NAMPT nicotinamide phosphoribosyltransferase -0.073398
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0703329
RPL26 ribosomal protein L26 -0.0655861
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.06429
ASPH aspartate beta-hydroxylase -0.0641088
RPS8 ribosomal protein S8 -0.0637461
SH3KBP1 SH3-domain kinase binding protein 1 -0.0598457
RPS24 ribosomal protein S24 -0.059121
PCBP3 poly(rC) binding protein 3 -0.0591115
RPS12 ribosomal protein S12 -0.0571429
RPL37A ribosomal protein L37a -0.0567529
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0558807
RPS6 ribosomal protein S6 -0.0557655
ENO1 enolase 1, (alpha) -0.0549334
RPL9 ribosomal protein L9 -0.0549026
RPL12 ribosomal protein L12 -0.0542306
RPL31 ribosomal protein L31 -0.0537493
NAP1L1 nucleosome assembly protein 1-like 1 -0.052976
PCBP2 poly(rC) binding protein 2 -0.0514268
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.045439
ACTG1 actin gamma 1 -0.0441115
RPLP2 ribosomal protein, large, P2 -0.0440162
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0416091
INHBA inhibin, beta A -0.0413151
CDH13 cadherin 13 -0.0411604
PDLIM5 PDZ and LIM domain 5 -0.0410213
SLC38A2 solute carrier family 38, member 2 -0.040614
RPS19 ribosomal protein S19 -0.0404543
RPL35A ribosomal protein L35a -0.0401381
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.039346
LDHA lactate dehydrogenase A -0.0388284
RPL19 ribosomal protein L19 -0.0387817
TM4SF1 transmembrane 4 L six family member 1 -0.0387257
EXT1 exostosin glycosyltransferase 1 -0.0383655
RACK1 receptor for activated C kinase 1 -0.0377877
RPL34 ribosomal protein L34 -0.0374612
RPL36A ribosomal protein L36a -0.0373906
RPS27 ribosomal protein S27 -0.0368527
RPS3 ribosomal protein S3 -0.0368201
PDE10A phosphodiesterase 10A -0.0363467
RPL5 ribosomal protein L5 -0.0355452
SQSTM1 sequestosome 1 -0.035229
SOX4 SRY (sex determining region Y)-box 4 -0.0344612
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0344432
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0335131
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0331724
MYOF myoferlin -0.0329856
COL4A5 collagen, type IV, alpha 5 -0.0328747
AHNAK AHNAK nucleoprotein -0.0327227
RPL38 ribosomal protein L38 -0.0326894
RPL37 ribosomal protein L37 -0.0326874
RPL7A ribosomal protein L7a -0.0324686
RPS23 ribosomal protein S23 -0.0322338
FTL ferritin, light polypeptide -0.032225
NALF1 NALCN channel auxiliary factor 1 -0.0320188
S100A10 S100 calcium binding protein A10 -0.0318552
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0311569
S100A6 S100 calcium binding protein A6 -0.0299782
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0297604
TXNRD1 thioredoxin reductase 1 -0.0295094
NRCAM neuronal cell adhesion molecule -0.0292104
RPS29 ribosomal protein S29 -0.0290093
RPS21 ribosomal protein S21 -0.0289872
RPS17 ribosomal protein S17 -0.028888
RPS25 ribosomal protein S25 -0.0283231
BASP1 brain abundant, membrane attached signal protein 1 -0.0282149
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0273989
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0270964
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0269336
RPS14 ribosomal protein S14 -0.0262943
NACA nascent polypeptide-associated complex alpha subunit -0.0258268
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0256634
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0255621
RPS13 ribosomal protein S13 -0.0253807
NTN4 netrin 4 -0.0253375
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0251013
PRDX1 peroxiredoxin 1 -0.0250456
B2M beta-2-microglobulin -0.025011
KYNU kynureninase -0.0248168
SAMD4A sterile alpha motif domain containing 4A -0.0247455
FNDC3B fibronectin type III domain containing 3B -0.0247344
RPL4 ribosomal protein L4 -0.0246831
PKM pyruvate kinase, muscle -0.0243691
RPL36 ribosomal protein L36 -0.0243203
RPS4X ribosomal protein S4, X-linked -0.0242017
CD44 CD44 molecule (Indian blood group) -0.0238469
EEF1G eukaryotic translation elongation factor 1 gamma -0.0235532
SRGN serglycin -0.0234838