Dapagliflozin_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dapagliflozin perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

131 genes differentially expressed following the Dapagliflozin_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 0.149327
TRIO trio Rho guanine nucleotide exchange factor 0.128764
IGFBP3 insulin-like growth factor binding protein 3 0.120279
EGFR epidermal growth factor receptor 0.110257
STC1 stanniocalcin 1 0.106404
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.101355
SDK1 sidekick cell adhesion molecule 1 0.0998348
SBF2 SET binding factor 2 0.099371
RICTOR RPTOR independent companion of MTOR, complex 2 0.0927037
USP34 ubiquitin specific peptidase 34 0.0896511
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0894361
ELL2 elongation factor, RNA polymerase II, 2 0.0861795
GOLGA4 golgin A4 0.0841956
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0831554
KMT2C lysine (K)-specific methyltransferase 2C 0.0789771
EZR ezrin 0.0748255
NCOA3 nuclear receptor coactivator 3 0.0741551
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0732396
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0721997
STK24 serine/threonine kinase 24 0.0717419
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0687227
NDRG1 N-myc downstream regulated 1 0.0684563
ZMYND8 zinc finger, MYND-type containing 8 0.0673761
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0672325
RPL12 ribosomal protein L12 0.0656835
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0637392
SPAG9 sperm associated antigen 9 0.0611397
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0583751
GARS1 glycyl-tRNA synthetase 1 0.054769
TPT1 tumor protein, translationally-controlled 1 0.053626
KMT2E lysine (K)-specific methyltransferase 2E 0.0517129
FTL ferritin, light polypeptide 0.0517116
YBX3 Y box binding protein 3 0.0480143
PRRC2C proline-rich coiled-coil 2C 0.0466933
TPM4 tropomyosin 4 0.0455962
FTH1 ferritin, heavy polypeptide 1 0.0441593
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0389742
ARID4B AT rich interactive domain 4B (RBP1-like) 0.03562
DSCAM Down syndrome cell adhesion molecule 0.0354755
PTPRK protein tyrosine phosphatase, receptor type, K 0.0346147
VIM vimentin 0.0340913
PDE4D phosphodiesterase 4D, cAMP-specific 0.0295429
ALCAM activated leukocyte cell adhesion molecule 0.029506
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0270961
ZFAND3 zinc finger, AN1-type domain 3 0.0268461
ANKRD12 ankyrin repeat domain 12 0.026151
CTNND1 catenin (cadherin-associated protein), delta 1 0.0260864
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0249829
NIPBL Nipped-B homolog (Drosophila) 0.0240157
RAB7A RAB7A, member RAS oncogene family 0.0222815
RPS8 ribosomal protein S8 0.0219021
PTK2 protein tyrosine kinase 2 0.0205302
ANKRD17 ankyrin repeat domain 17 0.0200208
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0193502
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0178005
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0176321
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0170309
MYO10 myosin X 0.0160729
MYO1E myosin IE 0.0146816
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0139215
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0128376
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0122569
WSB1 WD repeat and SOCS box containing 1 0.0111163
VMP1 vacuole membrane protein 1 0.00984023
NAMPT nicotinamide phosphoribosyltransferase 0.00767918
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.00760584
SEC31A SEC31 homolog A (S. cerevisiae) 0.00638848
CEMIP cell migration inducing protein, hyaluronan binding 0.00593321
FNDC3B fibronectin type III domain containing 3B 0.00567963
DENND1A DENN/MADD domain containing 1A 0.00567786
KTN1 kinectin 1 (kinesin receptor) 0.00504001
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.00478844
SLTM SAFB-like, transcription modulator 0.00373744
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.00227692
GRB10 growth factor receptor-bound protein 10 6.9104E-4

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.250256
PTMA prothymosin, alpha -0.199402
UBC ubiquitin C -0.179572
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.113971
NRG3 neuregulin 3 -0.113367
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.105815
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0962397
ZBTB20 zinc finger and BTB domain containing 20 -0.0897045
ANXA2 annexin A2 -0.0870991
MYH9 myosin, heavy chain 9, non-muscle -0.0859254
NUP58 nucleoporin 58 -0.0811801
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0739936
RLF rearranged L-myc fusion -0.0713216
ADAM10 ADAM metallopeptidase domain 10 -0.066909
RTN4 reticulon 4 -0.0614853
ACTN4 actinin, alpha 4 -0.0608447
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0581965
RPS27A ribosomal protein S27a -0.0577782
RPS6 ribosomal protein S6 -0.0573747
LDHA lactate dehydrogenase A -0.0559936
DST dystonin -0.0559269
SMYD3 SET and MYND domain containing 3 -0.0557357
RPL23 ribosomal protein L23 -0.055659
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0551371
LPP LIM domain containing preferred translocation partner in lipoma -0.0543493
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0540463
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0524812
PARD3 par-3 family cell polarity regulator -0.0518201
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0514515
TMSB10 thymosin beta 10 -0.0510859
MT2A metallothionein 2A -0.0488476
SRPK2 SRSF protein kinase 2 -0.043277
PGK1 phosphoglycerate kinase 1 -0.0426135
GPC6 glypican 6 -0.0411539
FN1 fibronectin 1 -0.0410274
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0395795
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0381881
SETD5 SET domain containing 5 -0.0341276
CD44 CD44 molecule (Indian blood group) -0.0319047
RPL31 ribosomal protein L31 -0.0313561
CCNI cyclin I -0.0310628
EEF2 eukaryotic translation elongation factor 2 -0.0266749
WAC WW domain containing adaptor with coiled-coil -0.0241633
PKM pyruvate kinase, muscle -0.0239419
HMGA2 high mobility group AT-hook 2 -0.022059
RPLP1 ribosomal protein, large, P1 -0.0218469
RPS3 ribosomal protein S3 -0.0194442
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0190968
ENO1 enolase 1, (alpha) -0.016756
PRKCA protein kinase C, alpha -0.011904
AKAP12 A kinase (PRKA) anchor protein 12 -0.0109623
MYO6 myosin VI -0.010592
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.00743474
CXCL8 chemokine (C-X-C motif) ligand 8 -0.00529554
ASPH aspartate beta-hydroxylase -0.00478503
ZNF292 zinc finger protein 292 -0.00106602