Dapagliflozin_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dapagliflozin perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dapagliflozin_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.163699
TSC22D2 TSC22 domain family, member 2 0.111263
HDAC9 histone deacetylase 9 0.0944557
ZNF292 zinc finger protein 292 0.0778936
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0692334
PEG10 paternally expressed 10 0.0668742
DST dystonin 0.0637484
CDC73 cell division cycle 73 0.0622644
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0603466
TRPS1 trichorhinophalangeal syndrome I 0.0592353
PDGFC platelet derived growth factor C 0.0584571
KMT2E lysine (K)-specific methyltransferase 2E 0.0540726
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0521226
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0517042
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0512145
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.050783
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0497363
FNDC3B fibronectin type III domain containing 3B 0.0483991
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0474855
ADAM9 ADAM metallopeptidase domain 9 0.0469789
EEF2 eukaryotic translation elongation factor 2 0.0468384
MTF2 metal response element binding transcription factor 2 0.0459942
ZFAND3 zinc finger, AN1-type domain 3 0.0458623
WDR43 WD repeat domain 43 0.0453782
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0447356
RYBP RING1 and YY1 binding protein 0.0421616
ZEB2 zinc finger E-box binding homeobox 2 0.0421135
THBS1 thrombospondin 1 0.0398352
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0389912
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0389713
PUM1 pumilio RNA-binding family member 1 0.0387806
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0384438
QKI QKI, KH domain containing, RNA binding 0.0381502
PGAP1 post-GPI attachment to proteins 1 0.0378361
MATR3 matrin 3 0.0376373
ENAH enabled homolog (Drosophila) 0.0359835
RBM33 RNA binding motif protein 33 0.0358043
MARCHF6 membrane associated ring-CH-type finger 6 0.0356965
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0355859
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0353781
RAD21 RAD21 homolog (S. pombe) 0.0353674
ZNF608 zinc finger protein 608 0.035059
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0346091
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0345024
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0343059
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0341855
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0340126
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0339375
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0338915
CXADR coxsackie virus and adenovirus receptor 0.0337118
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0334873
NCKAP1 NCK-associated protein 1 0.0331389
PDS5B PDS5 cohesin associated factor B 0.0331384
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0329904
MEMO1 mediator of cell motility 1 0.0326612
APP amyloid beta (A4) precursor protein 0.032492
TPM3 tropomyosin 3 0.0323949
POTEF POTE ankyrin domain family, member F 0.0323581
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0322995
CENPF centromere protein F, 350/400kDa 0.0321224
RASAL2 RAS protein activator like 2 0.032001
KIF1B kinesin family member 1B 0.0317335
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0307602
RTN4 reticulon 4 0.0306947
STRN3 striatin, calmodulin binding protein 3 0.0306111
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0302516
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0300998
NCOR1 nuclear receptor corepressor 1 0.0300239
CSDE1 cold shock domain containing E1, RNA-binding 0.0299393
SFPQ splicing factor proline/glutamine-rich 0.0299332
IPO7 importin 7 0.0297673
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0293791
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0292074
SIK3 SIK family kinase 3 0.02903
TPX2 TPX2, microtubule-associated 0.0288105
RLF rearranged L-myc fusion 0.0284322
FAM171B family with sequence similarity 171, member B 0.0283203
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0281947
ANXA1 annexin A1 0.0281756
CLTC clathrin, heavy chain (Hc) 0.0281103
NOP58 NOP58 ribonucleoprotein 0.0279363
STAG2 stromal antigen 2 0.0276528
SETD5 SET domain containing 5 0.0276067
MRPS30 mitochondrial ribosomal protein S30 0.027593
TMSB4X thymosin beta 4, X-linked 0.0273465
LYPLA1 lysophospholipase I 0.0271739
PCBP2 poly(rC) binding protein 2 0.0270839
UTRN utrophin 0.0270268
RHEB Ras homolog enriched in brain 0.0266558
SHROOM3 shroom family member 3 0.026572
ANLN anillin, actin binding protein 0.0265715
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0264313
TRA2A transformer 2 alpha homolog (Drosophila) 0.0261577
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0260606
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0259615
TBC1D12 TBC1 domain family, member 12 0.0259129
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0257361
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.025157
RAD23B RAD23 homolog B (S. cerevisiae) 0.0249987
JMJD1C jumonji domain containing 1C 0.0249921

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.173964
TMSB10 thymosin beta 10 -0.170774
VIM vimentin -0.129706
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.114193
RPS16 ribosomal protein S16 -0.109991
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0947029
TPT1 tumor protein, translationally-controlled 1 -0.0917812
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0914683
RPS8 ribosomal protein S8 -0.0894231
RPL35A ribosomal protein L35a -0.082739
B2M beta-2-microglobulin -0.0766732
RPLP1 ribosomal protein, large, P1 -0.071158
ISG15 ISG15 ubiquitin-like modifier -0.0674612
WSB1 WD repeat and SOCS box containing 1 -0.066969
RPL37 ribosomal protein L37 -0.0645578
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0617726
RPS19 ribosomal protein S19 -0.0608007
RPL31 ribosomal protein L31 -0.0588672
RPL37A ribosomal protein L37a -0.0572091
RPS6 ribosomal protein S6 -0.0555663
EIF1 eukaryotic translation initiation factor 1 -0.0513229
RPS27A ribosomal protein S27a -0.0507562
RPS12 ribosomal protein S12 -0.0501133
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0488051
CNRIP1 cannabinoid receptor interacting protein 1 -0.0452049
PCDH9 protocadherin 9 -0.0447233
RPL9 ribosomal protein L9 -0.0444991
RPL11 ribosomal protein L11 -0.0421576
ACTG1 actin gamma 1 -0.0418154
RPS21 ribosomal protein S21 -0.0416976
CADM2 cell adhesion molecule 2 -0.0415348
RPLP2 ribosomal protein, large, P2 -0.04144
S100A10 S100 calcium binding protein A10 -0.0412999
FNDC3A fibronectin type III domain containing 3A -0.0411521
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0405712
PARD3B par-3 family cell polarity regulator beta -0.0405571
RPL19 ribosomal protein L19 -0.0403381
RPS13 ribosomal protein S13 -0.0395955
MT2A metallothionein 2A -0.0390266
RPL38 ribosomal protein L38 -0.0389517
FTL ferritin, light polypeptide -0.0387869
MDK midkine (neurite growth-promoting factor 2) -0.0385982
RPS24 ribosomal protein S24 -0.0385572
CAVIN1 caveolae associated protein 1 -0.0385565
RPL12 ribosomal protein L12 -0.0383483
RPL34 ribosomal protein L34 -0.0382931
COL3A1 collagen, type III, alpha 1 -0.0379582
NEBL nebulette -0.0364735
RPL23 ribosomal protein L23 -0.0360331
COL1A2 collagen, type I, alpha 2 -0.0352095
CEP350 centrosomal protein 350kDa -0.0351308
PCLO piccolo presynaptic cytomatrix protein -0.034768
TBCA tubulin folding cofactor A -0.0343751
RPL28 ribosomal protein L28 -0.0339196
ANKRD12 ankyrin repeat domain 12 -0.033881
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0330099
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.032943
RPS29 ribosomal protein S29 -0.0327851
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0324359
RIGI RNA sensor RIG-I -0.0316898
RPS3 ribosomal protein S3 -0.031568
RPL26 ribosomal protein L26 -0.0315047
RPS25 ribosomal protein S25 -0.031357
RAD51B RAD51 paralog B -0.0311725
MYL12B myosin, light chain 12B, regulatory -0.0308677
RPL7A ribosomal protein L7a -0.0307207
AKAP12 A kinase (PRKA) anchor protein 12 -0.0300231
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0296056
RPL27 ribosomal protein L27 -0.0295789
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0294665
LRRC4C leucine rich repeat containing 4C -0.0293279
ATF4 activating transcription factor 4 -0.0292721
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0291976
RPS17 ribosomal protein S17 -0.0287873
GPC3 glypican 3 -0.0284679
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0279687
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0278161
FAM177A1 family with sequence similarity 177, member A1 -0.0277973
SQSTM1 sequestosome 1 -0.0275625
APOE apolipoprotein E -0.0273253
RPL36A ribosomal protein L36a -0.0271186
HSPB1 heat shock 27kDa protein 1 -0.0270593
RACK1 receptor for activated C kinase 1 -0.0266129
RPS27 ribosomal protein S27 -0.0264603
RPS23 ribosomal protein S23 -0.026241
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0261329
COL5A2 collagen, type V, alpha 2 -0.0260352
ENO1 enolase 1, (alpha) -0.025812
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0256009
RPS10 ribosomal protein S10 -0.0255538
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0254391
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0248785
TTC28 tetratricopeptide repeat domain 28 -0.0244897
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0244877
PKM pyruvate kinase, muscle -0.0242944
IFIH1 interferon induced with helicase C domain 1 -0.0241747
PGK1 phosphoglycerate kinase 1 -0.0238118
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.023745
RPLP0 ribosomal protein, large, P0 -0.0233
SERF2 small EDRK-rich factor 2 -0.0232345