Dapagliflozin_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dapagliflozin perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dapagliflozin_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0948997
PDE4B phosphodiesterase 4B, cAMP-specific 0.0911322
EEF2 eukaryotic translation elongation factor 2 0.0865145
CPED1 cadherin-like and PC-esterase domain containing 1 0.0755185
SSBP2 single-stranded DNA binding protein 2 0.0644756
KMT2E lysine (K)-specific methyltransferase 2E 0.0560892
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0534981
TMSB4X thymosin beta 4, X-linked 0.0480053
MINDY2 MINDY lysine 48 deubiquitinase 2 0.044096
ZEB1 zinc finger E-box binding homeobox 1 0.0423595
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0421767
QKI QKI, KH domain containing, RNA binding 0.0412427
NCOR1 nuclear receptor corepressor 1 0.0380342
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0370385
NFIA nuclear factor I/A 0.0352565
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0351916
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0351513
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0351451
LPP LIM domain containing preferred translocation partner in lipoma 0.033862
PDGFC platelet derived growth factor C 0.0337328
FOXP1 forkhead box P1 0.0336473
ECT2 epithelial cell transforming 2 0.0336412
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0324065
COPA coatomer protein complex, subunit alpha 0.0308775
GNPDA1 glucosamine-6-phosphate deaminase 1 0.030297
HELZ helicase with zinc finger 0.0302168
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0301058
TJP1 tight junction protein 1 0.0297615
EIF4A2 eukaryotic translation initiation factor 4A2 0.0297438
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0285656
CAMKMT calmodulin-lysine N-methyltransferase 0.0284431
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.027485
SETD5 SET domain containing 5 0.0269418
MSI2 musashi RNA-binding protein 2 0.0269317
LOC112694756 uncharaterized LOC112694756 0.0269028
FBLN2 fibulin 2 0.0257146
ELOVL5 ELOVL fatty acid elongase 5 0.0256463
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.025388
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0253831
FKBP10 FK506 binding protein 10, 65 kDa 0.0253434
CALR calreticulin 0.0253279
RNF145 ring finger protein 145 0.0249333
ZNF292 zinc finger protein 292 0.0246717
NBEA neurobeachin 0.0244664
DHFR dihydrofolate reductase 0.024351
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0242614
CDC73 cell division cycle 73 0.0239216
SENP6 SUMO1/sentrin specific peptidase 6 0.0239074
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.023656
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.0235548
EPS8 epidermal growth factor receptor pathway substrate 8 0.0233312
HDLBP high density lipoprotein binding protein 0.0231039
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0230628
GPHN gephyrin 0.0226754
GOLGA4 golgin A4 0.0226233
WAC WW domain containing adaptor with coiled-coil 0.0224843
TTC3 tetratricopeptide repeat domain 3 0.0222622
KMT2C lysine (K)-specific methyltransferase 2C 0.0221898
SOX6 SRY (sex determining region Y)-box 6 0.0219406
NCKAP1 NCK-associated protein 1 0.021912
EFNA5 ephrin-A5 0.021715
TRERF1 transcriptional regulating factor 1 0.0214342
EVI5 ecotropic viral integration site 5 0.0209671
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.020598
KDM3A lysine (K)-specific demethylase 3A 0.0205527
NF1 neurofibromin 1 0.0203069
FNDC3B fibronectin type III domain containing 3B 0.0202469
RAD23B RAD23 homolog B (S. cerevisiae) 0.0201948
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0201874
RBM39 RNA binding motif protein 39 0.0201788
RNMT RNA (guanine-7-) methyltransferase 0.019873
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0198604
PUM2 pumilio RNA-binding family member 2 0.0197976
ATOSA atos homolog A 0.0197495
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0197317
TNRC6B trinucleotide repeat containing 6B 0.0197196
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0196716
KDM2A lysine (K)-specific demethylase 2A 0.0194216
LCORL ligand dependent nuclear receptor corepressor-like 0.0193352
UBA6 ubiquitin-like modifier activating enzyme 6 0.0189291
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0189022
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.018891
OGA O-GlcNAcase 0.0188661
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0187618
KDM6A lysine (K)-specific demethylase 6A 0.0187593
ANKRD11 ankyrin repeat domain 11 0.0187056
SFTPA2 surfactant protein A2 0.0186736
MLEC malectin 0.0186581
NAMPT nicotinamide phosphoribosyltransferase 0.0185714
RLF rearranged L-myc fusion 0.0185018
TRA2A transformer 2 alpha homolog (Drosophila) 0.0184494
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0184325
YAP1 Yes-associated protein 1 0.0183497
FXR1 fragile X mental retardation, autosomal homolog 1 0.0181641
GOLGA2 golgin A2 0.0180879
NUP58 nucleoporin 58 0.0179522
NOP58 NOP58 ribonucleoprotein 0.0179052
ANXA1 annexin A1 0.0178951
PLXNA1 plexin A1 0.0178934
ITCH itchy E3 ubiquitin protein ligase 0.0178669

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.292527
PTMA prothymosin, alpha -0.22117
PKM pyruvate kinase, muscle -0.131263
UBC ubiquitin C -0.109508
AHNAK AHNAK nucleoprotein -0.0872765
RPS8 ribosomal protein S8 -0.0866169
TPT1 tumor protein, translationally-controlled 1 -0.0828001
RPS27A ribosomal protein S27a -0.0819344
RPL23 ribosomal protein L23 -0.0738569
RPL35A ribosomal protein L35a -0.0724692
PDE4D phosphodiesterase 4D, cAMP-specific -0.0705675
RPS6 ribosomal protein S6 -0.0668196
S100A6 S100 calcium binding protein A6 -0.0639147
ARL4C ADP-ribosylation factor-like 4C -0.0636207
RPL9 ribosomal protein L9 -0.0617381
ENO1 enolase 1, (alpha) -0.0615344
ACTG1 actin gamma 1 -0.0593453
RPLP1 ribosomal protein, large, P1 -0.0591091
TXNRD1 thioredoxin reductase 1 -0.0585613
RPL26 ribosomal protein L26 -0.0585156
RPL37A ribosomal protein L37a -0.053475
RPLP2 ribosomal protein, large, P2 -0.0534267
RPS13 ribosomal protein S13 -0.0527528
RPL31 ribosomal protein L31 -0.052745
RPL34 ribosomal protein L34 -0.0518262
RPS23 ribosomal protein S23 -0.0486914
RPS3 ribosomal protein S3 -0.048231
RPS19 ribosomal protein S19 -0.0478118
RPS12 ribosomal protein S12 -0.0450611
PCBP2 poly(rC) binding protein 2 -0.0440065
S100A4 S100 calcium binding protein A4 -0.0435667
POTEF POTE ankyrin domain family, member F -0.0431915
RPL12 ribosomal protein L12 -0.0422105
LDHA lactate dehydrogenase A -0.0419715
RTN4 reticulon 4 -0.0416329
TMSB10 thymosin beta 10 -0.0403008
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0396567
RPS25 ribosomal protein S25 -0.0395466
EIF1 eukaryotic translation initiation factor 1 -0.0395437
IFI16 interferon, gamma-inducible protein 16 -0.0391952
FLNB filamin B, beta -0.0387282
RPS21 ribosomal protein S21 -0.0372098
S100A10 S100 calcium binding protein A10 -0.0365426
MYL12B myosin, light chain 12B, regulatory -0.0363514
RPL19 ribosomal protein L19 -0.0348101
S100A9 S100 calcium binding protein A9 -0.03467
RPL5 ribosomal protein L5 -0.0345109
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0344544
CCND1 cyclin D1 -0.0340418
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0335545
HSPB1 heat shock 27kDa protein 1 -0.032084
RPL36 ribosomal protein L36 -0.0320791
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0317109
RACK1 receptor for activated C kinase 1 -0.0313529
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0302198
RPL30 ribosomal protein L30 -0.0291522
RPS24 ribosomal protein S24 -0.0275681
RPL8 ribosomal protein L8 -0.0273904
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.027347
RPS27 ribosomal protein S27 -0.0273089
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0271228
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0270474
RPL28 ribosomal protein L28 -0.0268778
B2M beta-2-microglobulin -0.0268067
RPL18 ribosomal protein L18 -0.0266365
RPL36A ribosomal protein L36a -0.0265716
MT2A metallothionein 2A -0.0262706
BMP10 bone morphogenetic protein 10 -0.0258836
RPS15 ribosomal protein S15 -0.0254652
EEF1G eukaryotic translation elongation factor 1 gamma -0.0252693
RPS11 ribosomal protein S11 -0.0251409
SLC38A2 solute carrier family 38, member 2 -0.0247537
RPL32 ribosomal protein L32 -0.0247002
RHOA ras homolog family member A -0.0246373
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0245326
PFN1 profilin 1 -0.0242202
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0241766
RPS29 ribosomal protein S29 -0.0240637
RPL11 ribosomal protein L11 -0.0234448
RPL7A ribosomal protein L7a -0.0232717
PRDX2 peroxiredoxin 2 -0.0227882
NAP1L1 nucleosome assembly protein 1-like 1 -0.0224349
RPL27A ribosomal protein L27a -0.0224152
PTMS parathymosin -0.0223469
RPS14 ribosomal protein S14 -0.0221088
RPS17 ribosomal protein S17 -0.0220043
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0219293
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0217419
RPL15 ribosomal protein L15 -0.0214112
LDHB lactate dehydrogenase B -0.0211469
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0210484
KLF3 Kruppel-like factor 3 (basic) -0.0209512
RPS5 ribosomal protein S5 -0.0208467
IGF2 insulin-like growth factor 2 -0.0207349
RPS16 ribosomal protein S16 -0.0205475
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0203074
RPS10 ribosomal protein S10 -0.0202648
S100A11 S100 calcium binding protein A11 -0.0201139
ATF4 activating transcription factor 4 -0.0200213
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0200046