| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dapagliflozin_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0800475 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0654656 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0639564 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0637494 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.063104 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0610434 |
| ZNF609 | zinc finger protein 609 | 0.0594847 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0574121 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0559011 |
| ERBIN | erbb2 interacting protein | 0.0554835 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0539125 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.0519185 |
| ZNF292 | zinc finger protein 292 | 0.0503754 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0481568 |
| TXNRD1 | thioredoxin reductase 1 | 0.0475626 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0471486 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0469362 |
| RAB6A | RAB6A, member RAS oncogene family | 0.045684 |
| TXNIP | thioredoxin interacting protein | 0.0455555 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0453893 |
| MATR3 | matrin 3 | 0.0450988 |
| GOLGA2 | golgin A2 | 0.0449343 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0423638 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0411696 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0401264 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.03984 |
| COG6 | component of oligomeric golgi complex 6 | 0.0398274 |
| RAB10 | RAB10, member RAS oncogene family | 0.0396962 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0388882 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0386437 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0379033 |
| CCDC91 | coiled-coil domain containing 91 | 0.0378575 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0373701 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0372569 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0372555 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0372247 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0368978 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0367477 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0366513 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0364813 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0364158 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0361422 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0360281 |
| SNX14 | sorting nexin 14 | 0.0352618 |
| RNF145 | ring finger protein 145 | 0.0350524 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0346536 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0343821 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0339696 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0337979 |
| ANXA5 | annexin A5 | 0.0332979 |
| AGO2 | argonaute RISC catalytic component 2 | 0.032867 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0328178 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0326124 |
| ZDHHC20 | zinc finger, DHHC-type containing 20 | 0.032375 |
| PRRC1 | proline-rich coiled-coil 1 | 0.0322974 |
| CALR | calreticulin | 0.0320741 |
| DERA | deoxyribose-phosphate aldolase (putative) | 0.0320022 |
| RANBP9 | RAN binding protein 9 | 0.0318589 |
| CDC27 | cell division cycle 27 | 0.0317573 |
| PHACTR4 | phosphatase and actin regulator 4 | 0.0315416 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0314285 |
| EXOC5 | exocyst complex component 5 | 0.0313334 |
| MED13 | mediator complex subunit 13 | 0.0312053 |
| NUP58 | nucleoporin 58 | 0.0310765 |
| PPP4R2 | protein phosphatase 4, regulatory subunit 2 | 0.0308664 |
| ATXN2L | ataxin 2-like | 0.0308059 |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | 0.0302495 |
| DYNC1LI2 | dynein, cytoplasmic 1, light intermediate chain 2 | 0.0300998 |
| MSN | moesin | 0.0299529 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0296264 |
| CCNL1 | cyclin L1 | 0.0295659 |
| ZNF207 | zinc finger protein 207 | 0.029512 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.02945 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0294418 |
| FAT1 | FAT atypical cadherin 1 | 0.0293576 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0292495 |
| SRPK2 | SRSF protein kinase 2 | 0.0288295 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0288112 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0285841 |
| FAM168A | family with sequence similarity 168, member A | 0.0284909 |
| PPP2R1B | protein phosphatase 2, regulatory subunit A, beta | 0.0284496 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0283598 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0283331 |
| USP3 | ubiquitin specific peptidase 3 | 0.0280488 |
| CASC3 | cancer susceptibility candidate 3 | 0.0279947 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.027863 |
| TAOK1 | TAO kinase 1 | 0.0275479 |
| SQSTM1 | sequestosome 1 | 0.0275046 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0274279 |
| ANGPTL4 | angiopoietin-like 4 | 0.0273992 |
| SLMAP | sarcolemma associated protein | 0.0272108 |
| TP53BP1 | tumor protein p53 binding protein 1 | 0.0270255 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0267453 |
| RAB1A | RAB1A, member RAS oncogene family | 0.026648 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0266459 |
| GAPVD1 | GTPase activating protein and VPS9 domains 1 | 0.0265923 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.026471 |
| SERINC1 | serine incorporator 1 | 0.0263212 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.025999 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0259644 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.095589 |
| OSMR | oncostatin M receptor | -0.0940052 |
| SMYD3 | SET and MYND domain containing 3 | -0.0773817 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0674425 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.062744 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0600478 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.057139 |
| ACTG1 | actin gamma 1 | -0.0557397 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0554482 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0526942 |
| VIM | vimentin | -0.0525573 |
| YBX3 | Y box binding protein 3 | -0.0503562 |
| VCL | vinculin | -0.0496492 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0491583 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0485697 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0482333 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0430458 |
| NCOA1 | nuclear receptor coactivator 1 | -0.0427531 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0425687 |
| HMGA2 | high mobility group AT-hook 2 | -0.0414216 |
| LDHA | lactate dehydrogenase A | -0.0406 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0403622 |
| RPL35A | ribosomal protein L35a | -0.0397025 |
| RPS6 | ribosomal protein S6 | -0.0395371 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0392272 |
| RPS25 | ribosomal protein S25 | -0.0387828 |
| SKP1 | S-phase kinase-associated protein 1 | -0.0386994 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0385505 |
| FNIP1 | folliculin interacting protein 1 | -0.0384039 |
| RPLP2 | ribosomal protein, large, P2 | -0.0382093 |
| GNAS | GNAS complex locus | -0.0380674 |
| RPL23 | ribosomal protein L23 | -0.0373167 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0371456 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0366886 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0363475 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.035906 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0353586 |
| TTC19 | tetratricopeptide repeat domain 19 | -0.0346173 |
| SLC36A4 | solute carrier family 36 (proton/amino acid symporter), member 4 | -0.034153 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0341327 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0339181 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0336703 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | -0.0335423 |
| CD44 | CD44 molecule (Indian blood group) | -0.0331936 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0331689 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0322754 |
| HDLBP | high density lipoprotein binding protein | -0.0319584 |
| TPM4 | tropomyosin 4 | -0.0319505 |
| SEPTIN10 | septin 10 | -0.0317663 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0313488 |
| NALCN | sodium leak channel, non selective | -0.0307128 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0306675 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0305231 |
| DIS3 | DIS3 exosome endoribonuclease and 3'-5' exoribonuclease | -0.0303202 |
| GPATCH2L | G patch domain containing 2-like | -0.0301325 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0299611 |
| TMSB10 | thymosin beta 10 | -0.029804 |
| FUS | FUS RNA binding protein | -0.0293754 |
| RPL32 | ribosomal protein L32 | -0.0293474 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0293094 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0292767 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | -0.0292344 |
| RPS13 | ribosomal protein S13 | -0.0287676 |
| PHF14 | PHD finger protein 14 | -0.0281374 |
| LMO7 | LIM domain 7 | -0.0276987 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0276374 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.0275535 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0274487 |
| RPS29 | ribosomal protein S29 | -0.0274351 |
| RPL10A | ribosomal protein L10a | -0.02742 |
| EXOC6B | exocyst complex component 6B | -0.0274065 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0273647 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.027215 |
| RPL35 | ribosomal protein L35 | -0.0271721 |
| MIPOL1 | mirror-image polydactyly 1 | -0.0271527 |
| SP3 | Sp3 transcription factor | -0.027064 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0269526 |
| SDC4 | syndecan 4 | -0.0269234 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | -0.026754 |
| RPL11 | ribosomal protein L11 | -0.026595 |
| EXOC4 | exocyst complex component 4 | -0.0260826 |
| ATP9B | ATPase, class II, type 9B | -0.0260713 |
| RB1 | retinoblastoma 1 | -0.0260183 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0257568 |
| NKTR | natural killer cell triggering receptor | -0.0257465 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0252996 |
| RPL26 | ribosomal protein L26 | -0.0252301 |
| KMT5B | lysine methyltransferase 5B | -0.0250433 |
| RPS27A | ribosomal protein S27a | -0.0249976 |
| AP3D1 | adaptor-related protein complex 3, delta 1 subunit | -0.0249312 |
| LASP1 | LIM and SH3 protein 1 | -0.0248412 |
| COX19 | COX19 cytochrome c oxidase assembly factor | -0.0241789 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0240982 |
| RPL9 | ribosomal protein L9 | -0.0238711 |
| RPS17 | ribosomal protein S17 | -0.0238097 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0238008 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0237401 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0237225 |
| RPLP1 | ribosomal protein, large, P1 | -0.023627 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0236101 |
