Dapagliflozin_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dapagliflozin perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dapagliflozin_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.237888
FTH1 ferritin, heavy polypeptide 1 0.179079
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.141415
CANX calnexin 0.0969775
SFTPA2 surfactant protein A2 0.0896575
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0862052
H1-0 H1.0 linker histone 0.0788048
EXT1 exostosin glycosyltransferase 1 0.0758745
SOD2 superoxide dismutase 2, mitochondrial 0.0695804
CXCL8 chemokine (C-X-C motif) ligand 8 0.0660741
MYH9 myosin, heavy chain 9, non-muscle 0.0657803
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0643998
VCL vinculin 0.0608923
FLNA filamin A, alpha 0.0601598
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0594901
COPA coatomer protein complex, subunit alpha 0.0569531
GLIS3 GLIS family zinc finger 3 0.0557686
CALR calreticulin 0.0545211
LOC112694756 uncharaterized LOC112694756 0.0533135
SEC31A SEC31 homolog A (S. cerevisiae) 0.0504353
EEF2 eukaryotic translation elongation factor 2 0.0502207
HDLBP high density lipoprotein binding protein 0.0482528
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0466393
AEBP2 AE binding protein 2 0.0450768
BIRC6 baculoviral IAP repeat containing 6 0.0448584
AKAP12 A kinase (PRKA) anchor protein 12 0.0427238
LCORL ligand dependent nuclear receptor corepressor-like 0.0418421
PDIA4 protein disulfide isomerase family A, member 4 0.0410372
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0407545
TRIO trio Rho guanine nucleotide exchange factor 0.0404405
CD109 CD109 molecule 0.0403001
TAS2R14 taste receptor, type 2, member 14 0.0399574
BZW1 basic leucine zipper and W2 domains 1 0.0397509
PLIN2 perilipin 2 0.0389096
EFNA5 ephrin-A5 0.03872
TBC1D22A TBC1 domain family, member 22A 0.0385443
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0381859
AHNAK AHNAK nucleoprotein 0.0373845
RICTOR RPTOR independent companion of MTOR, complex 2 0.0369943
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0368401
COG5 component of oligomeric golgi complex 5 0.0366154
ANKRD17 ankyrin repeat domain 17 0.0363345
ETNK1 ethanolamine kinase 1 0.0361121
WAC WW domain containing adaptor with coiled-coil 0.0360083
RAI14 retinoic acid induced 14 0.0333995
CALU calumenin 0.033042
MBD5 methyl-CpG binding domain protein 5 0.032855
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0328376
KMT2C lysine (K)-specific methyltransferase 2C 0.0326424
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0324284
HLA-C major histocompatibility complex, class I, C 0.0323028
NCOA7 nuclear receptor coactivator 7 0.0315849
ARHGAP35 Rho GTPase activating protein 35 0.031563
GLUL glutamate-ammonia ligase 0.0307268
PLEC plectin 0.0306308
APP amyloid beta (A4) precursor protein 0.0305767
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0298457
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.029562
HLA-E major histocompatibility complex, class I, E 0.0293707
SUCO SUN domain containing ossification factor 0.0291972
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0290308
ARF1 ADP-ribosylation factor 1 0.0290135
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0287518
TTC3 tetratricopeptide repeat domain 3 0.0284276
MKI67 marker of proliferation Ki-67 0.0282793
FNIP1 folliculin interacting protein 1 0.0282297
MACF1 microtubule-actin crosslinking factor 1 0.028227
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0282224
ZCCHC7 zinc finger, CCHC domain containing 7 0.0281776
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.0279247
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0278287
BHLHE40 basic helix-loop-helix family, member e40 0.0275559
FBXW11 F-box and WD repeat domain containing 11 0.0274691
DHFR dihydrofolate reductase 0.027423
NPAS2 neuronal PAS domain protein 2 0.0273795
RASAL2 RAS protein activator like 2 0.0271063
SYT1 synaptotagmin I 0.0271007
HMGB3 high mobility group box 3 0.0270078
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0269378
DOCK5 dedicator of cytokinesis 5 0.0268848
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0268563
RLIM ring finger protein, LIM domain interacting 0.0268387
ARHGAP5 Rho GTPase activating protein 5 0.0267839
HMGA2 high mobility group AT-hook 2 0.0266347
HIPK2 homeodomain interacting protein kinase 2 0.0265727
UBE2H ubiquitin-conjugating enzyme E2H 0.0265568
LIMCH1 LIM and calponin homology domains 1 0.0260448
CDC73 cell division cycle 73 0.0258582
CEP350 centrosomal protein 350kDa 0.0255646
FNDC3A fibronectin type III domain containing 3A 0.0252787
CTBP2 C-terminal binding protein 2 0.0252591
GLG1 golgi glycoprotein 1 0.0248003
STC2 stanniocalcin 2 0.0247954
DSCAM Down syndrome cell adhesion molecule 0.0245602
TMSB4X thymosin beta 4, X-linked 0.0241392
FAM20C family with sequence similarity 20, member C 0.0239267
ERRFI1 ERBB receptor feedback inhibitor 1 0.0238559
STAU1 staufen double-stranded RNA binding protein 1 0.0235467
RIC1 RAB6A GEF complex partner 1 0.023546
MARCHF6 membrane associated ring-CH-type finger 6 0.0235444

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.205449
MT2A metallothionein 2A -0.178909
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0921808
FTL ferritin, light polypeptide -0.0839765
TMSB10 thymosin beta 10 -0.078802
IFI27 interferon, alpha-inducible protein 27 -0.0696445
B2M beta-2-microglobulin -0.0674148
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.066174
RPL9 ribosomal protein L9 -0.0603192
RPS6 ribosomal protein S6 -0.0588164
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0534593
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0510925
RPS19 ribosomal protein S19 -0.045767
RPL26 ribosomal protein L26 -0.0438269
RPS2 ribosomal protein S2 -0.0436312
RPS12 ribosomal protein S12 -0.0434928
RPL35A ribosomal protein L35a -0.0412674
RPL37A ribosomal protein L37a -0.0402151
RPL38 ribosomal protein L38 -0.0395208
S100A6 S100 calcium binding protein A6 -0.0365338
TPT1 tumor protein, translationally-controlled 1 -0.0357081
RBM39 RNA binding motif protein 39 -0.0356096
SOX4 SRY (sex determining region Y)-box 4 -0.0349442
RPS29 ribosomal protein S29 -0.034606
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0339055
RPS27 ribosomal protein S27 -0.0331639
LOC102724023 ES1 protein homolog, mitochondrial -0.0330493
TMEM156 transmembrane protein 156 -0.0326172
RACK1 receptor for activated C kinase 1 -0.0319287
RPLP1 ribosomal protein, large, P1 -0.0317817
RPS8 ribosomal protein S8 -0.0317314
RPS21 ribosomal protein S21 -0.0309793
PTMA prothymosin, alpha -0.0309062
RPL31 ribosomal protein L31 -0.0305605
RPL23 ribosomal protein L23 -0.0303121
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0291825
RPLP2 ribosomal protein, large, P2 -0.0288025
RPS25 ribosomal protein S25 -0.0284889
RPL37 ribosomal protein L37 -0.0283664
RPS24 ribosomal protein S24 -0.0281462
ASPH aspartate beta-hydroxylase -0.0281247
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0279303
S100A10 S100 calcium binding protein A10 -0.0270976
RPL36 ribosomal protein L36 -0.0270488
RPS3 ribosomal protein S3 -0.0268286
RPL30 ribosomal protein L30 -0.0267356
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0265467
FNBP1 formin binding protein 1 -0.0257952
EIF1 eukaryotic translation initiation factor 1 -0.0256024
S100A9 S100 calcium binding protein A9 -0.0255888
WSB1 WD repeat and SOCS box containing 1 -0.0254219
NAP1L1 nucleosome assembly protein 1-like 1 -0.025329
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0251833
ETV1 ets variant 1 -0.025018
ZMYND8 zinc finger, MYND-type containing 8 -0.0245031
ATP5F1E ATP synthase F1 subunit epsilon -0.0241034
EREG epiregulin -0.0239245
TFPI2 tissue factor pathway inhibitor 2 -0.0236187
IFI6 interferon, alpha-inducible protein 6 -0.0233681
CD163L1 CD163 molecule-like 1 -0.0233126
RPS16 ribosomal protein S16 -0.0232642
RPS23 ribosomal protein S23 -0.0231932
RPS20 ribosomal protein S20 -0.0231254
RBM25 RNA binding motif protein 25 -0.0230168
SVIL supervillin -0.0229844
RPL28 ribosomal protein L28 -0.0229296
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.022384
RPL11 ribosomal protein L11 -0.0222958
LY6E lymphocyte antigen 6 complex, locus E -0.0221813
RPL7 ribosomal protein L7 -0.0217486
RPL12 ribosomal protein L12 -0.0213915
AREG amphiregulin -0.0213424
RPL34 ribosomal protein L34 -0.0213337
EIF5B eukaryotic translation initiation factor 5B -0.0211265
MTDH metadherin -0.0210138
RPL8 ribosomal protein L8 -0.0209238
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0207861
CSNK1A1 casein kinase 1, alpha 1 -0.0204419
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.020315
KLHL5 kelch-like family member 5 -0.0202628
LRMDA leucine rich melanocyte differentiation associated -0.0200834
KTN1 kinectin 1 (kinesin receptor) -0.0200566
S100A11 S100 calcium binding protein A11 -0.0198262
HMGA1 high mobility group AT-hook 1 -0.0196437
ACTG1 actin gamma 1 -0.0196261
SLC38A1 solute carrier family 38, member 1 -0.0196088
LMNA lamin A/C -0.0194677
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -0.0191562
MT1X metallothionein 1X -0.0191525
VIM vimentin -0.0188355
NDUFA4 NDUFA4, mitochondrial complex associated -0.0187527
RPL5 ribosomal protein L5 -0.0186196
RPS5 ribosomal protein S5 -0.0185596
RPS27A ribosomal protein S27a -0.0185055
RPL18 ribosomal protein L18 -0.0183872
PLAUR plasminogen activator, urokinase receptor -0.0183598
CCSER1 coiled-coil serine-rich protein 1 -0.0183524
PCBP2 poly(rC) binding protein 2 -0.018338
RPL36A ribosomal protein L36a -0.0182145
SERF2 small EDRK-rich factor 2 -0.018128