Daptomycin_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Daptomycin perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Daptomycin_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.115823
LOX lysyl oxidase 0.101151
FBN1 fibrillin 1 0.0875208
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0725474
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0667847
THBS2 thrombospondin 2 0.0619804
UBC ubiquitin C 0.0590284
COL1A2 collagen, type I, alpha 2 0.054615
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0525953
DPYSL3 dihydropyrimidinase-like 3 0.0516526
STC1 stanniocalcin 1 0.0498012
SRRM2 serine/arginine repetitive matrix 2 0.0480247
AUTS2 autism susceptibility candidate 2 0.047982
PSD3 pleckstrin and Sec7 domain containing 3 0.0452477
SOD2 superoxide dismutase 2, mitochondrial 0.0438977
CD44 CD44 molecule (Indian blood group) 0.0425896
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.042546
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0418529
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0416657
PRELID2 PRELI domain containing 2 0.0407761
ARL15 ADP-ribosylation factor-like 15 0.0402777
C1D C1D nuclear receptor corepressor 0.0401885
FLNA filamin A, alpha 0.0393098
ELL2 elongation factor, RNA polymerase II, 2 0.0376802
FNDC3B fibronectin type III domain containing 3B 0.0374638
ZBTB20 zinc finger and BTB domain containing 20 0.0349611
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0349154
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0328896
DST dystonin 0.0320354
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0308722
GPC6 glypican 6 0.0304386
VCL vinculin 0.0303658
ATP13A3 ATPase type 13A3 0.0302775
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0285478
CLU clusterin 0.0275057
MYH9 myosin, heavy chain 9, non-muscle 0.0259072
CYLD cylindromatosis (turban tumor syndrome) 0.0257835
AKAP12 A kinase (PRKA) anchor protein 12 0.025493
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0248364
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0246459
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0239468
TDRD7 tudor domain containing 7 0.0232064
EEF2 eukaryotic translation elongation factor 2 0.0231507
PARP14 poly (ADP-ribose) polymerase family, member 14 0.023094
COL5A2 collagen, type V, alpha 2 0.0225967
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0224946
FTH1 ferritin, heavy polypeptide 1 0.0224343
OPTN optineurin 0.022359
SBF2 SET binding factor 2 0.0222489
IQGAP1 IQ motif containing GTPase activating protein 1 0.0222273
ZEB2 zinc finger E-box binding homeobox 2 0.0222073
ATXN1 ataxin 1 0.0218746
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0213929
OGA O-GlcNAcase 0.0212946
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0211589
ADAR adenosine deaminase, RNA-specific 0.0209585
NAP1L1 nucleosome assembly protein 1-like 1 0.0209353
GOLGA4 golgin A4 0.0209214
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0208258
FMNL2 formin-like 2 0.0201635
EHBP1 EH domain binding protein 1 0.0200516
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0197428
LIFR leukemia inhibitory factor receptor alpha 0.0197159
COG5 component of oligomeric golgi complex 5 0.0190891
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0190621
CTSB cathepsin B 0.0189801
MBNL2 muscleblind-like splicing regulator 2 0.0187838
ERRFI1 ERBB receptor feedback inhibitor 1 0.0183912
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0178394
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0176605
FBXL7 F-box and leucine-rich repeat protein 7 0.0176501
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.017581
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0175347
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0174806
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0174185
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0173231
RICTOR RPTOR independent companion of MTOR, complex 2 0.0171935
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0171652
ARHGAP5 Rho GTPase activating protein 5 0.0170938
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0170918
ARRDC3 arrestin domain containing 3 0.0169891
ARHGAP21 Rho GTPase activating protein 21 0.0169676
IGF2R insulin-like growth factor 2 receptor 0.0168272
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0167464
PRKD3 protein kinase D3 0.0166451
ANKRD36C ankyrin repeat domain 36C 0.0166379
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 0.016586
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.016519
VMP1 vacuole membrane protein 1 0.016493
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0162337
NAMPT nicotinamide phosphoribosyltransferase 0.0161905
ANTXR1 anthrax toxin receptor 1 0.0160965
ANKRD36 ankyrin repeat domain 36 0.015842
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0157701
TRIM22 tripartite motif containing 22 0.0157014
RAB8B RAB8B, member RAS oncogene family 0.0155315
SLC22A23 solute carrier family 22, member 23 0.0155097
TM4SF1 transmembrane 4 L six family member 1 0.01525
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0151577
ITSN2 intersectin 2 0.0150893

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.342073
TMSB10 thymosin beta 10 -0.199662
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.166932
PODXL podocalyxin-like -0.138371
CDH13 cadherin 13 -0.129073
S100A10 S100 calcium binding protein A10 -0.0881596
LMNA lamin A/C -0.0814435
COL5A1 collagen, type V, alpha 1 -0.0767751
S100A6 S100 calcium binding protein A6 -0.0763133
MT2A metallothionein 2A -0.0756314
PLAT plasminogen activator, tissue -0.0747032
ABI3BP ABI family, member 3 (NESH) binding protein -0.0703268
CSTB cystatin B (stefin B) -0.0663413
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0660565
SLC39A11 solute carrier family 39, member 11 -0.065517
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0638744
FN1 fibronectin 1 -0.0630164
B2M beta-2-microglobulin -0.0622233
PRSS23 protease, serine, 23 -0.0621185
HLA-B major histocompatibility complex, class I, B -0.0602508
TAGLN2 transgelin 2 -0.058888
POTEF POTE ankyrin domain family, member F -0.0548306
SLC38A1 solute carrier family 38, member 1 -0.053787
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.051936
NAV1 neuron navigator 1 -0.0514778
LDHA lactate dehydrogenase A -0.0503695
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0492061
TPM4 tropomyosin 4 -0.0487355
NDRG1 N-myc downstream regulated 1 -0.0477118
EGFR epidermal growth factor receptor -0.0469516
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0465961
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0459648
S100A11 S100 calcium binding protein A11 -0.0430725
TUBB4B tubulin, beta 4B class IVb -0.041072
PBX3 pre-B-cell leukemia homeobox 3 -0.0398122
CCND1 cyclin D1 -0.0387233
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0386746
SEPTIN7 septin 7 -0.0377186
RPL35A ribosomal protein L35a -0.0373844
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0365028
FLT1 fms-related tyrosine kinase 1 -0.0364846
S100A4 S100 calcium binding protein A4 -0.0362043
DCLK2 doublecortin-like kinase 2 -0.0361923
AHNAK AHNAK nucleoprotein -0.0360626
CD59 CD59 molecule, complement regulatory protein -0.0359799
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0356428
MAP1B microtubule-associated protein 1B -0.0356111
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0352914
DGKG diacylglycerol kinase, gamma 90kDa -0.0342925
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0340351
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0339013
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0331961
LRRC17 leucine rich repeat containing 17 -0.0324295
EFNA5 ephrin-A5 -0.031955
SORBS2 sorbin and SH3 domain containing 2 -0.0318611
SPDL1 spindle apparatus coiled-coil protein 1 -0.0317358
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0314937
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0313966
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0312893
ANXA2 annexin A2 -0.0311922
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.030325
SUCNR1 succinate receptor 1 -0.0301382
PKM pyruvate kinase, muscle -0.0290278
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.028758
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0286409
TRIO trio Rho guanine nucleotide exchange factor -0.0284889
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0281062
IGFBP3 insulin-like growth factor binding protein 3 -0.0280704
PGK1 phosphoglycerate kinase 1 -0.0278894
PTMA prothymosin, alpha -0.0277489
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.027532
MYL12B myosin, light chain 12B, regulatory -0.0273957
RTN4 reticulon 4 -0.027134
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0268208
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.026767
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.0265257
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0264029
MACF1 microtubule-actin crosslinking factor 1 -0.0262772
ASPH aspartate beta-hydroxylase -0.0262024
CKAP4 cytoskeleton-associated protein 4 -0.0261925
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0261528
KPNB1 karyopherin (importin) beta 1 -0.0259599
GADD45A growth arrest and DNA-damage-inducible, alpha -0.0255722
GARS1 glycyl-tRNA synthetase 1 -0.0254799
IL7R interleukin 7 receptor -0.0253891
ULK1 unc-51 like autophagy activating kinase 1 -0.0253027
FRMD4A FERM domain containing 4A -0.025235
ANKRD11 ankyrin repeat domain 11 -0.0250468
ZMYND8 zinc finger, MYND-type containing 8 -0.0249775
MYADM myeloid-associated differentiation marker -0.0249033
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0248915
SH3KBP1 SH3-domain kinase binding protein 1 -0.0244878
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -0.0244551
DLG1 discs, large homolog 1 (Drosophila) -0.0242185
MT1X metallothionein 1X -0.0241836
PFN1 profilin 1 -0.0241793
KRT81 keratin 81, type II -0.0241111
RPS24 ribosomal protein S24 -0.023811
CAVIN1 caveolae associated protein 1 -0.0237565
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0236924