Daptomycin_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Daptomycin perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Daptomycin_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0952422
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0664463
DPH6 diphthamine biosynthesis 6 0.0635718
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0598686
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0521729
CENPF centromere protein F, 350/400kDa 0.051006
MEIS2 Meis homeobox 2 0.0508166
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.050139
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0483749
FMN1 formin 1 0.0440469
ANTXR1 anthrax toxin receptor 1 0.0439693
EEF2 eukaryotic translation elongation factor 2 0.0426586
MKI67 marker of proliferation Ki-67 0.0419233
PDE4D phosphodiesterase 4D, cAMP-specific 0.0415446
ITPRID2 ITPR interacting domain containing 2 0.040183
AHR aryl hydrocarbon receptor 0.0397721
LIMCH1 LIM and calponin homology domains 1 0.0389894
SRRM2 serine/arginine repetitive matrix 2 0.0382056
RNF213 ring finger protein 213 0.0330553
ANGPT1 angiopoietin 1 0.0327196
CANX calnexin 0.0317721
CCNG2 cyclin G2 0.0298347
SOS1 son of sevenless homolog 1 (Drosophila) 0.0296965
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0295721
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0295078
TENT5A terminal nucleotidyltransferase 5A 0.0292261
DST dystonin 0.0287153
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0283198
EIF4B eukaryotic translation initiation factor 4B 0.0266715
MBTD1 mbt domain containing 1 0.0265895
MBD5 methyl-CpG binding domain protein 5 0.0264497
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0264085
TOR1AIP2 torsin A interacting protein 2 0.0261724
NRG1 neuregulin 1 0.0258307
MAP1B microtubule-associated protein 1B 0.0256908
BPTF bromodomain PHD finger transcription factor 0.0255004
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0252124
CHD9 chromodomain helicase DNA binding protein 9 0.0244507
PTPRE protein tyrosine phosphatase, receptor type, E 0.0243421
PCM1 pericentriolar material 1 0.0242638
TRIB2 tribbles pseudokinase 2 0.0240611
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0238859
AEBP2 AE binding protein 2 0.0232846
KLHL13 kelch-like family member 13 0.0231324
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0230725
KCNIP4 Kv channel interacting protein 4 0.0230579
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0229754
SCLT1 sodium channel and clathrin linker 1 0.0228301
NCAM2 neural cell adhesion molecule 2 0.0226325
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0224004
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0220643
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0216021
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0213891
PTPRD protein tyrosine phosphatase, receptor type, D 0.0213739
TTC3 tetratricopeptide repeat domain 3 0.0213474
SP100 SP100 nuclear antigen 0.0208742
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.020169
HSPA8 heat shock 70kDa protein 8 0.0201497
SLC38A2 solute carrier family 38, member 2 0.0200729
MACROD2 MACRO domain containing 2 0.0199158
UNC5C unc-5 homolog C (C. elegans) 0.0198487
PCDH7 protocadherin 7 0.0197944
CDK19 cyclin-dependent kinase 19 0.019732
MBNL2 muscleblind-like splicing regulator 2 0.0196795
NREP neuronal regeneration related protein 0.0196478
ADGRB3 adhesion G protein-coupled receptor B3 0.0194564
NFE2L1 nuclear factor, erythroid 2-like 1 0.0194432
ZFC3H1 zinc finger, C3H1-type containing 0.0193567
GIGYF2 GRB10 interacting GYF protein 2 0.0193562
PBX1 pre-B-cell leukemia homeobox 1 0.0193197
ADAR adenosine deaminase, RNA-specific 0.0191889
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.0190259
TENM1 teneurin transmembrane protein 1 0.0190102
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0188911
PLSCR1 phospholipid scramblase 1 0.0187346
THBS1 thrombospondin 1 0.0185087
FBXO32 F-box protein 32 0.0182677
AUTS2 autism susceptibility candidate 2 0.0181913
RGS5 regulator of G-protein signaling 5 0.018095
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0180695
RFC3 replication factor C (activator 1) 3, 38kDa 0.0180011
BCAS3 breast carcinoma amplified sequence 3 0.0179369
TBC1D5 TBC1 domain family, member 5 0.0178241
SLFN5 schlafen family member 5 0.0175061
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0174943
MYH10 myosin, heavy chain 10, non-muscle 0.0174577
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0172058
CENPE centromere protein E, 312kDa 0.0171719
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0169414
SET SET nuclear proto-oncogene 0.0168926
DUSP10 dual specificity phosphatase 10 0.0168089
TMEM14B transmembrane protein 14B 0.0167552
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 0.0166558
TMF1 TATA element modulatory factor 1 0.0165219
ZNF652 zinc finger protein 652 0.0164957
SH3RF1 SH3 domain containing ring finger 1 0.0164218
RPS3A ribosomal protein S3A 0.0163841
ZNF292 zinc finger protein 292 0.0163541
DCP2 decapping mRNA 2 0.0162548
MMP2 matrix metallopeptidase 2 0.0160201

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.240396
AKAP12 A kinase (PRKA) anchor protein 12 -0.149938
EXT1 exostosin glycosyltransferase 1 -0.105046
DTNA dystrobrevin, alpha -0.101984
PTMA prothymosin, alpha -0.0857255
RPL35A ribosomal protein L35a -0.082696
STC1 stanniocalcin 1 -0.0815042
RPLP1 ribosomal protein, large, P1 -0.0745324
NALF1 NALCN channel auxiliary factor 1 -0.0736139
ACTG1 actin gamma 1 -0.07308
VIM vimentin -0.0661252
NDRG1 N-myc downstream regulated 1 -0.0658118
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0607943
PALM2AKAP2 PALM2 and AKAP2 fusion -0.057431
COL1A1 collagen, type I, alpha 1 -0.0527173
RPS24 ribosomal protein S24 -0.0526554
WDR45B WD repeat domain 45B -0.0499858
RPS6 ribosomal protein S6 -0.0494339
RPL23 ribosomal protein L23 -0.0458196
VCL vinculin -0.0453097
IER3 immediate early response 3 -0.0452474
RPL34 ribosomal protein L34 -0.0452461
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0444848
ELL2 elongation factor, RNA polymerase II, 2 -0.0443964
HELZ helicase with zinc finger -0.0437396
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0434482
CXCL8 chemokine (C-X-C motif) ligand 8 -0.042747
TPT1 tumor protein, translationally-controlled 1 -0.042441
TMSB10 thymosin beta 10 -0.0419189
RPL19 ribosomal protein L19 -0.0414112
CDH13 cadherin 13 -0.0404768
GPC5 glypican 5 -0.0399513
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0395016
MED13 mediator complex subunit 13 -0.0384287
FNDC3B fibronectin type III domain containing 3B -0.0378625
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0360896
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0358164
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0352573
NUP58 nucleoporin 58 -0.0347151
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.033818
CRH corticotropin releasing hormone -0.0328398
LSAMP limbic system-associated membrane protein -0.0327646
MCL1 myeloid cell leukemia 1 -0.0326091
CREB5 cAMP responsive element binding protein 5 -0.0322382
IGF2 insulin-like growth factor 2 -0.0316787
RPS8 ribosomal protein S8 -0.0314422
RPS19 ribosomal protein S19 -0.0313797
DLG1 discs, large homolog 1 (Drosophila) -0.0310436
AKAP13 A kinase (PRKA) anchor protein 13 -0.0308015
B2M beta-2-microglobulin -0.0306127
RAB7A RAB7A, member RAS oncogene family -0.0303613
TOP1 topoisomerase (DNA) I -0.0297194
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0290392
PTK2 protein tyrosine kinase 2 -0.0288485
RPLP0 ribosomal protein, large, P0 -0.0285458
KLF6 Kruppel-like factor 6 -0.0284947
RAP1B RAP1B, member of RAS oncogene family -0.0283817
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0283703
EGR1 early growth response 1 -0.0283692
NPEPPS aminopeptidase puromycin sensitive -0.0282392
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0280543
RPL26 ribosomal protein L26 -0.0277799
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0274639
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0274573
RPL27 ribosomal protein L27 -0.0274311
S100A6 S100 calcium binding protein A6 -0.0274062
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0273643
RPS3 ribosomal protein S3 -0.0272139
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0271928
PKM pyruvate kinase, muscle -0.0271715
EIF1 eukaryotic translation initiation factor 1 -0.0268689
COL3A1 collagen, type III, alpha 1 -0.0267639
CEMIP cell migration inducing protein, hyaluronan binding -0.0267321
WSB1 WD repeat and SOCS box containing 1 -0.0254044
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0253959
AFF3 AF4/FMR2 family, member 3 -0.0252661
H3-3B H3.3 histone B -0.0251091
KMT2C lysine (K)-specific methyltransferase 2C -0.0250641
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0250525
S100A9 S100 calcium binding protein A9 -0.0250342
USP53 ubiquitin specific peptidase 53 -0.0248024
GARS1 glycyl-tRNA synthetase 1 -0.0247979
HMGA2 high mobility group AT-hook 2 -0.0247778
LPIN1 lipin 1 -0.0245135
MYO9B myosin IXB -0.0242615
RPL31 ribosomal protein L31 -0.0242155
GNAS GNAS complex locus -0.0241977
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0240861
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.02385
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0237239
HMGA1 high mobility group AT-hook 1 -0.0236701
LOC102724023 ES1 protein homolog, mitochondrial -0.023647
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0233174
FBXO11 F-box protein 11 -0.0232312
SEPTIN9 septin 9 -0.0229948
HMGB1 high mobility group box 1 -0.0226337
RACK1 receptor for activated C kinase 1 -0.0226043
RPS21 ribosomal protein S21 -0.0225251
POTEF POTE ankyrin domain family, member F -0.0221908
RPS11 ribosomal protein S11 -0.0221685