Daptomycin_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Daptomycin perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Daptomycin_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0550526
AHR aryl hydrocarbon receptor 0.051084
SRRM2 serine/arginine repetitive matrix 2 0.037883
ATM ATM serine/threonine kinase 0.0329396
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0323001
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0303309
HYOU1 hypoxia up-regulated 1 0.0280364
MKI67 marker of proliferation Ki-67 0.0275202
CALR calreticulin 0.0262388
NPSR1 neuropeptide S receptor 1 0.0248471
MECOM MDS1 and EVI1 complex locus 0.0240835
DSPP dentin sialophosphoprotein 0.0236295
ATF7IP2 activating transcription factor 7 interacting protein 2 0.0233269
TRIM31 tripartite motif containing 31 0.0228824
SHROOM3 shroom family member 3 0.022762
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0211966
SMC4 structural maintenance of chromosomes 4 0.0203629
PRSS3 protease, serine, 3 0.0200111
CD46 CD46 molecule, complement regulatory protein 0.0198256
MUC13 mucin 13, cell surface associated 0.0188508
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0179344
TNRC6B trinucleotide repeat containing 6B 0.0172577
CENPF centromere protein F, 350/400kDa 0.016911
TNRC18 trinucleotide repeat containing 18 0.0166454
SKAP2 src kinase associated phosphoprotein 2 0.0163677
PHF3 PHD finger protein 3 0.016015
POF1B premature ovarian failure, 1B 0.0155286
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0155023
CADPS2 Ca++-dependent secretion activator 2 0.0151191
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 0.0150952
BPTF bromodomain PHD finger transcription factor 0.0149995
ZNF146 zinc finger protein 146 0.0149301
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0149201
TRIP12 thyroid hormone receptor interactor 12 0.01463
PHIP pleckstrin homology domain interacting protein 0.0145929
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0143811
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0142546
PLS1 plastin 1 0.0141294
CEP57 centrosomal protein 57kDa 0.0140967
PDIA3 protein disulfide isomerase family A, member 3 0.0138328
USO1 USO1 vesicle transport factor 0.0138246
KDM4C lysine (K)-specific demethylase 4C 0.0135918
EHF ets homologous factor 0.0134575
ARHGAP11A Rho GTPase activating protein 11A 0.0134193
CKAP2 cytoskeleton associated protein 2 0.0132652
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.0132535
KIF4A kinesin family member 4A 0.0131348
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0130572
TTC3 tetratricopeptide repeat domain 3 0.0129988
AKAP9 A kinase (PRKA) anchor protein 9 0.0129984
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0129661
NFE2L1 nuclear factor, erythroid 2-like 1 0.0126676
COG6 component of oligomeric golgi complex 6 0.0126628
CENPE centromere protein E, 312kDa 0.0126569
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.0125933
KLF3 Kruppel-like factor 3 (basic) 0.0125283
FRY furry homolog (Drosophila) 0.0124892
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0124652
ZNF451 zinc finger protein 451 0.0123567
AKAP11 A kinase (PRKA) anchor protein 11 0.0123278
TENM1 teneurin transmembrane protein 1 0.012321
TPP2 tripeptidyl peptidase II 0.0122285
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0122145
SGO2 shugoshin 2 0.0121857
LARP1B La ribonucleoprotein domain family, member 1B 0.0121405
FAM120A family with sequence similarity 120A 0.0120869
PLSCR1 phospholipid scramblase 1 0.0119355
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0118819
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0117905
EIF5 eukaryotic translation initiation factor 5 0.0116713
EPSTI1 epithelial stromal interaction 1 (breast) 0.0115737
TNRC6C trinucleotide repeat containing 6C 0.0114891
UBN2 ubinuclein 2 0.0114863
RPN1 ribophorin I 0.0113965
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0113592
IRF1 interferon regulatory factor 1 0.0113457
EXOC4 exocyst complex component 4 0.0112829
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.0112546
SETX senataxin 0.0111807
PAPOLA poly(A) polymerase alpha 0.0110983
RBBP6 retinoblastoma binding protein 6 0.0109784
SMC1A structural maintenance of chromosomes 1A 0.0109752
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 0.0109344
ADD3 adducin 3 (gamma) 0.0109016
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0108593
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0108022
TTC17 tetratricopeptide repeat domain 17 0.0106573
ADAM10 ADAM metallopeptidase domain 10 0.0106226
CEMIP2 cell migration inducing hyaluronidase 2 0.0105589
PDS5B PDS5 cohesin associated factor B 0.0105076
SET SET nuclear proto-oncogene 0.0104756
GAN gigaxonin 0.0104365
GALK2 galactokinase 2 0.0104306
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.010403
CANX calnexin 0.0103267
ITCH itchy E3 ubiquitin protein ligase 0.0102846
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0102382
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.010208
HSPA8 heat shock 70kDa protein 8 0.0100516
NUCB2 nucleobindin 2 0.0100499

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.153273
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.123527
TPT1 tumor protein, translationally-controlled 1 -0.11889
EMP1 epithelial membrane protein 1 -0.109912
RPL35A ribosomal protein L35a -0.0994708
FTL ferritin, light polypeptide -0.0881134
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0865364
S100A6 S100 calcium binding protein A6 -0.0706596
RPL23 ribosomal protein L23 -0.0704109
RPLP1 ribosomal protein, large, P1 -0.0697599
EZR ezrin -0.0688768
PTMA prothymosin, alpha -0.0686949
AHNAK AHNAK nucleoprotein -0.0604786
ANXA2 annexin A2 -0.0573409
ACTN4 actinin, alpha 4 -0.056893
RPS19 ribosomal protein S19 -0.0560148
NDRG1 N-myc downstream regulated 1 -0.0544077
KRT18 keratin 18, type I -0.0544045
S100A10 S100 calcium binding protein A10 -0.0542395
KRT19 keratin 19, type I -0.0541089
LCN2 lipocalin 2 -0.0537712
LOC112694756 uncharaterized LOC112694756 -0.0528284
RPS25 ribosomal protein S25 -0.0520267
MAML2 mastermind-like 2 (Drosophila) -0.0517569
S100P S100 calcium binding protein P -0.050272
AGR2 anterior gradient 2 -0.0487242
PGK1 phosphoglycerate kinase 1 -0.0487173
RPS8 ribosomal protein S8 -0.04693
ATF5 activating transcription factor 5 -0.0467734
HMGA1 high mobility group AT-hook 1 -0.0464097
RPS6 ribosomal protein S6 -0.0462358
FTH1 ferritin, heavy polypeptide 1 -0.0462275
B2M beta-2-microglobulin -0.0461173
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0460507
RPL34 ribosomal protein L34 -0.045458
RPL19 ribosomal protein L19 -0.0451213
ITGA6 integrin, alpha 6 -0.0448924
LAMB3 laminin, beta 3 -0.043006
SNX9 sorting nexin 9 -0.0428236
S100A11 S100 calcium binding protein A11 -0.0427241
RPL26 ribosomal protein L26 -0.0426365
RPS21 ribosomal protein S21 -0.0417239
GARS1 glycyl-tRNA synthetase 1 -0.0416351
S100A9 S100 calcium binding protein A9 -0.0412404
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0402439
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.039806
ACTG1 actin gamma 1 -0.0390455
KRT8 keratin 8, type II -0.0386373
EIF1 eukaryotic translation initiation factor 1 -0.0382059
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0380593
ANKRD10 ankyrin repeat domain 10 -0.0379937
ATXN1 ataxin 1 -0.0378828
TM4SF1 transmembrane 4 L six family member 1 -0.0375733
RPL12 ribosomal protein L12 -0.036991
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0369399
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0367084
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0359373
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0359189
RPS24 ribosomal protein S24 -0.0355743
FLNB filamin B, beta -0.035458
TES testin LIM domain protein -0.0347892
POTEF POTE ankyrin domain family, member F -0.0342623
SEPTIN9 septin 9 -0.0340303
ANXA1 annexin A1 -0.0337721
TUBA1B tubulin, alpha 1b -0.0337023
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0334529
C6ORF132 chromosome 6 open reading frame 132 -0.0332615
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0330918
RPS3 ribosomal protein S3 -0.0326929
TUBB4B tubulin, beta 4B class IVb -0.0323319
KRT7 keratin 7, type II -0.0319133
UBE2H ubiquitin-conjugating enzyme E2H -0.0313981
HMGB1 high mobility group box 1 -0.0310527
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0309261
TUBB tubulin, beta class I -0.0303252
DSG2 desmoglein 2 -0.0302544
GNAS GNAS complex locus -0.0299453
HLA-A major histocompatibility complex, class I, A -0.0299351
ANO1 anoctamin 1, calcium activated chloride channel -0.0299026
WDR45B WD repeat domain 45B -0.0296975
LMO7 LIM domain 7 -0.0294027
IFI27 interferon, alpha-inducible protein 27 -0.0293932
CMIP c-Maf inducing protein -0.029318
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0293177
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0292083
RPL18 ribosomal protein L18 -0.0288054
GSTP1 glutathione S-transferase pi 1 -0.0287389
AKAP13 A kinase (PRKA) anchor protein 13 -0.0284715
IARS1 isoleucyl-tRNA synthetase 1 -0.0281612
AGR3 anterior gradient 3 -0.0280981
RPL35 ribosomal protein L35 -0.0280861
LDHA lactate dehydrogenase A -0.0279823
ESYT2 extended synaptotagmin-like protein 2 -0.0277204
LMNA lamin A/C -0.027361
JMJD1C jumonji domain containing 1C -0.0273056
AREG amphiregulin -0.0272232
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0266713
FGFR2 fibroblast growth factor receptor 2 -0.0265873
RPS27 ribosomal protein S27 -0.0264135
TMC5 transmembrane channel-like 5 -0.0262267