Daptomycin_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Daptomycin perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Daptomycin_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.23035
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.119595
RPS6 ribosomal protein S6 0.104646
FAM13A family with sequence similarity 13, member A 0.0934281
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0827318
SRRM2 serine/arginine repetitive matrix 2 0.0739607
DSPP dentin sialophosphoprotein 0.0705094
EREG epiregulin 0.069675
CENPF centromere protein F, 350/400kDa 0.0696241
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0684582
TPM4 tropomyosin 4 0.065444
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0627122
ANXA2 annexin A2 0.0616204
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0606641
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0598956
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0595986
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0562452
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.05501
TMSB4X thymosin beta 4, X-linked 0.0512926
GCC2 GRIP and coiled-coil domain containing 2 0.0502228
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0501038
ACTG1 actin gamma 1 0.0498761
TXNIP thioredoxin interacting protein 0.0473553
ZNF292 zinc finger protein 292 0.0472524
CENPE centromere protein E, 312kDa 0.0469032
KTN1 kinectin 1 (kinesin receptor) 0.0392281
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0382011
S100A6 S100 calcium binding protein A6 0.037774
ERRFI1 ERBB receptor feedback inhibitor 1 0.0374991
DSG2 desmoglein 2 0.0371508
MKI67 marker of proliferation Ki-67 0.0368833
KRT18 keratin 18, type I 0.0366482
H1-0 H1.0 linker histone 0.0366238
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0350559
PTPRR protein tyrosine phosphatase, receptor type, R 0.0350056
EIF5B eukaryotic translation initiation factor 5B 0.0348613
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0348228
MXI1 MAX interactor 1, dimerization protein 0.0341435
SMC4 structural maintenance of chromosomes 4 0.0332341
KMT2E lysine (K)-specific methyltransferase 2E 0.0330311
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0327867
S100A10 S100 calcium binding protein A10 0.0327601
PCM1 pericentriolar material 1 0.0325009
KDM2A lysine (K)-specific demethylase 2A 0.0324641
KIF5B kinesin family member 5B 0.032385
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0322637
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0320192
OGA O-GlcNAcase 0.031704
AKAP12 A kinase (PRKA) anchor protein 12 0.0314885
SLTM SAFB-like, transcription modulator 0.0312218
JMJD1C jumonji domain containing 1C 0.0311018
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0303447
RPS12 ribosomal protein S12 0.0299799
TPX2 TPX2, microtubule-associated 0.0297926
PERP PERP, TP53 apoptosis effector 0.029586
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0295266
PRRC2C proline-rich coiled-coil 2C 0.0288192
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0281254
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.0280674
RPL5 ribosomal protein L5 0.0280559
EHF ets homologous factor 0.0277372
RREB1 ras responsive element binding protein 1 0.0274631
CEP55 centrosomal protein 55kDa 0.0270187
KPNB1 karyopherin (importin) beta 1 0.0269005
H2AZ1 H2A.Z variant histone 1 0.026756
LIMA1 LIM domain and actin binding 1 0.0266978
LMNA lamin A/C 0.0265622
SET SET nuclear proto-oncogene 0.0265451
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0264512
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0264477
MUC13 mucin 13, cell surface associated 0.0264255
CBX3 chromobox homolog 3 0.0264247
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0263736
CAPRIN1 cell cycle associated protein 1 0.0263255
CTTN cortactin 0.0263062
GOLGA4 golgin A4 0.0262073
CKAP2 cytoskeleton associated protein 2 0.0261468
SLK STE20-like kinase 0.025255
DST dystonin 0.0252427
HP1BP3 heterochromatin protein 1, binding protein 3 0.0248973
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.0248397
ARHGAP21 Rho GTPase activating protein 21 0.0246718
NAMPT nicotinamide phosphoribosyltransferase 0.0246349
RLF rearranged L-myc fusion 0.0245583
WASF2 WAS protein family, member 2 0.024472
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.024363
BZW1 basic leucine zipper and W2 domains 1 0.0242587
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0241145
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0239645
RPL11 ribosomal protein L11 0.0232843
CDCP1 CUB domain containing protein 1 0.0232526
KIF13A kinesin family member 13A 0.0232394
CANX calnexin 0.0232351
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0232317
FNBP1L formin binding protein 1-like 0.0231392
DSTN destrin (actin depolymerizing factor) 0.0229062
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.022723
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0227105
EIF5 eukaryotic translation initiation factor 5 0.0227001
CKAP5 cytoskeleton associated protein 5 0.0224641

decreased expression

Symbol Name Standardized Value
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.203778
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.169494
GMDS GDP-mannose 4,6-dehydratase -0.154763
MYO1E myosin IE -0.128187
NALF1 NALCN channel auxiliary factor 1 -0.119211
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.117741
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.10515
CEMIP cell migration inducing protein, hyaluronan binding -0.101859
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0976076
LOC112694756 uncharaterized LOC112694756 -0.0823191
GPHN gephyrin -0.0792401
ANTXR2 anthrax toxin receptor 2 -0.072387
ACTN4 actinin, alpha 4 -0.0684987
LDHA lactate dehydrogenase A -0.0658871
ONECUT3 one cut homeobox 3 -0.0632016
VCL vinculin -0.0631659
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0614599
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0575757
TMSB10 thymosin beta 10 -0.0557816
FNDC3B fibronectin type III domain containing 3B -0.0549407
TRIM2 tripartite motif containing 2 -0.052491
TUBB4B tubulin, beta 4B class IVb -0.0515143
FAT1 FAT atypical cadherin 1 -0.0506624
PDLIM5 PDZ and LIM domain 5 -0.0481944
GREB1L growth regulation by estrogen in breast cancer-like -0.0480795
PKM pyruvate kinase, muscle -0.0465905
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0463193
PTPRK protein tyrosine phosphatase, receptor type, K -0.0460365
CADPS Ca++-dependent secretion activator -0.0444788
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0440849
LOC102724023 ES1 protein homolog, mitochondrial -0.0438041
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0414293
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0412803
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0403836
SMYD3 SET and MYND domain containing 3 -0.0403351
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -0.0398399
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0398069
TNS4 tensin 4 -0.0387914
PARD3B par-3 family cell polarity regulator beta -0.0386839
RPLP1 ribosomal protein, large, P1 -0.0384932
NEBL nebulette -0.0377673
RACK1 receptor for activated C kinase 1 -0.0373099
BTBD9 BTB (POZ) domain containing 9 -0.0369095
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0368566
EXT1 exostosin glycosyltransferase 1 -0.0367281
FOXO1 forkhead box O1 -0.0366363
TUBA1B tubulin, alpha 1b -0.0356438
FHIT fragile histidine triad -0.0356372
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0356358
IARS1 isoleucyl-tRNA synthetase 1 -0.0354561
ASPH aspartate beta-hydroxylase -0.035416
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0351186
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0350135
MT2A metallothionein 2A -0.0349939
TTC3 tetratricopeptide repeat domain 3 -0.0347515
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0340903
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0338015
SEPTIN9 septin 9 -0.0334553
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0334521
MBNL1 muscleblind-like splicing regulator 1 -0.0327139
PARD3 par-3 family cell polarity regulator -0.0327137
TUBB tubulin, beta class I -0.032479
SOX9 SRY (sex determining region Y)-box 9 -0.0320206
ABR active BCR-related -0.0320197
CCSER1 coiled-coil serine-rich protein 1 -0.0319636
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0316191
MYO5B myosin VB -0.0311637
LMO7 LIM domain 7 -0.0306459
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0303255
HMGA1 high mobility group AT-hook 1 -0.0301313
NCEH1 neutral cholesterol ester hydrolase 1 -0.0296451
HDLBP high density lipoprotein binding protein -0.0295247
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0291662
RAD51B RAD51 paralog B -0.0291622
EGR1 early growth response 1 -0.0284292
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0282119
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0278793
GRB10 growth factor receptor-bound protein 10 -0.0278648
PDE4D phosphodiesterase 4D, cAMP-specific -0.0278119
PTPRG protein tyrosine phosphatase, receptor type, G -0.0277638
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0272885
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0270727
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0268381
ABLIM1 actin binding LIM protein 1 -0.0266896
UBE2H ubiquitin-conjugating enzyme E2H -0.0265726
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0265404
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0265232
PKP2 plakophilin 2 -0.0265008
TGFBR3 transforming growth factor, beta receptor III -0.0260614
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0260436
ATXN1 ataxin 1 -0.0254599
UBC ubiquitin C -0.025317
MECOM MDS1 and EVI1 complex locus -0.0253032
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0252725
VMP1 vacuole membrane protein 1 -0.0252695
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0251699
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0251476
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.025069
CEMIP2 cell migration inducing hyaluronidase 2 -0.0250563
NPAS2 neuronal PAS domain protein 2 -0.0249734