Daptomycin_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Daptomycin perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Daptomycin_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
THSD4 thrombospondin, type I, domain containing 4 0.0645799
SRRM2 serine/arginine repetitive matrix 2 0.0564845
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0556057
GRAMD1B GRAM domain containing 1B 0.0527484
SLTM SAFB-like, transcription modulator 0.052621
MKI67 marker of proliferation Ki-67 0.034447
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0340016
MYH9 myosin, heavy chain 9, non-muscle 0.0299508
FAM13A family with sequence similarity 13, member A 0.02605
SMAD3 SMAD family member 3 0.0251216
HSPA8 heat shock 70kDa protein 8 0.0251141
TBC1D22A TBC1 domain family, member 22A 0.0246028
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0227576
PLEC plectin 0.0226779
DOCK5 dedicator of cytokinesis 5 0.0225093
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0221736
CSNK1A1 casein kinase 1, alpha 1 0.0220632
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.021479
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0213058
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0204136
ATP11A ATPase, class VI, type 11A 0.0192306
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0189452
TPM3 tropomyosin 3 0.0186796
BCAR3 breast cancer anti-estrogen resistance 3 0.0185953
TRIP12 thyroid hormone receptor interactor 12 0.018197
OSMR oncostatin M receptor 0.0180913
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0180408
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0176332
CES1 carboxylesterase 1 0.0175936
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0175336
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0174427
EFNA5 ephrin-A5 0.0171103
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0167117
CCNL1 cyclin L1 0.0164868
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0159158
RPL3 ribosomal protein L3 0.0157327
LGALS12 lectin, galactoside-binding, soluble, 12 0.0157184
ANKRD11 ankyrin repeat domain 11 0.0157129
ZNF292 zinc finger protein 292 0.0155932
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0147623
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0146918
EEF2 eukaryotic translation elongation factor 2 0.0145416
CEMIP cell migration inducing protein, hyaluronan binding 0.0145211
STK24 serine/threonine kinase 24 0.0142416
KLC1 kinesin light chain 1 0.0142297
IGFBP3 insulin-like growth factor binding protein 3 0.0140582
RAB27B RAB27B, member RAS oncogene family 0.0139704
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0139431
FLNA filamin A, alpha 0.0138457
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0134137
DOCK1 dedicator of cytokinesis 1 0.0131475
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0131447
NCKAP1 NCK-associated protein 1 0.013106
SFPQ splicing factor proline/glutamine-rich 0.0130923
PRELID2 PRELI domain containing 2 0.0130899
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.012821
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0123554
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0121901
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0120402
MGST1 microsomal glutathione S-transferase 1 0.0118635
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0115156
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0115029
TBC1D5 TBC1 domain family, member 5 0.0114801
PAPOLA poly(A) polymerase alpha 0.011368
BCL9L B-cell CLL/lymphoma 9-like 0.0113455
RAD51B RAD51 paralog B 0.0112272
TRAPPC9 trafficking protein particle complex 9 0.0111935
FAT1 FAT atypical cadherin 1 0.0111577
CEP192 centrosomal protein 192kDa 0.0110782
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0108936
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0106713
GIGYF2 GRB10 interacting GYF protein 2 0.0105974
GPHN gephyrin 0.0105894
EIF4B eukaryotic translation initiation factor 4B 0.0105096
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0103715
USO1 USO1 vesicle transport factor 0.0103151
DOCK4 dedicator of cytokinesis 4 0.0102485
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0101931
CTNND1 catenin (cadherin-associated protein), delta 1 0.0101089
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0100928
TNIP1 TNFAIP3 interacting protein 1 0.010025
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0100245
SAMD4A sterile alpha motif domain containing 4A 0.0100117
ELL2 elongation factor, RNA polymerase II, 2 0.00998151
PTK2 protein tyrosine kinase 2 0.00979819
ZC3H12B zinc finger CCCH-type containing 12B 0.00974328
DST dystonin 0.00973137
CENPF centromere protein F, 350/400kDa 0.00961026
BPTF bromodomain PHD finger transcription factor 0.00960008
EGLN1 egl-9 family hypoxia-inducible factor 1 0.00957834
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.009563
SUMF1 sulfatase modifying factor 1 0.00954194
EIF5 eukaryotic translation initiation factor 5 0.00953812
MSN moesin 0.00944035
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0094122
CTTN cortactin 0.00933606
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0093017
CDCP1 CUB domain containing protein 1 0.00916306
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.00912983
LPCAT2 lysophosphatidylcholine acyltransferase 2 0.00903448

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.228949
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.224799
TMSB10 thymosin beta 10 -0.12088
EGFR epidermal growth factor receptor -0.0963157
FTL ferritin, light polypeptide -0.0716697
MT2A metallothionein 2A -0.0692044
LDHA lactate dehydrogenase A -0.0654604
TPT1 tumor protein, translationally-controlled 1 -0.0585125
FTH1 ferritin, heavy polypeptide 1 -0.0564038
RPLP1 ribosomal protein, large, P1 -0.0560167
RPL35A ribosomal protein L35a -0.0523963
LOC112694756 uncharaterized LOC112694756 -0.0521892
CAV1 caveolin 1, caveolae protein, 22kDa -0.0512005
EGR1 early growth response 1 -0.0504996
ASPH aspartate beta-hydroxylase -0.0484993
ANXA2 annexin A2 -0.0435317
EIF1 eukaryotic translation initiation factor 1 -0.0427305
PGK1 phosphoglycerate kinase 1 -0.0402611
LAMB3 laminin, beta 3 -0.0391124
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0388679
ACTG1 actin gamma 1 -0.0388139
PKM pyruvate kinase, muscle -0.0382777
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0370011
SEC61G Sec61 gamma subunit -0.0360615
RPS3 ribosomal protein S3 -0.0358458
PTMA prothymosin, alpha -0.0351052
RPS8 ribosomal protein S8 -0.0339206
BTG1 B-cell translocation gene 1, anti-proliferative -0.0335459
S100A10 S100 calcium binding protein A10 -0.0335203
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0332148
B2M beta-2-microglobulin -0.033014
RPLP0 ribosomal protein, large, P0 -0.0322729
RPS24 ribosomal protein S24 -0.0322511
RAB7A RAB7A, member RAS oncogene family -0.0320291
NDRG1 N-myc downstream regulated 1 -0.0319772
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0313104
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0306948
CST3 cystatin C -0.0298071
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0296762
RPL34 ribosomal protein L34 -0.0288738
HMGA1 high mobility group AT-hook 1 -0.0287795
AKR1C1 aldo-keto reductase family 1, member C1 -0.0287533
TOP1 topoisomerase (DNA) I -0.0281337
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0279377
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0278813
H1-0 H1.0 linker histone -0.0276752
WASF2 WAS protein family, member 2 -0.027455
RPS23 ribosomal protein S23 -0.0272261
S100P S100 calcium binding protein P -0.0269101
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0268043
ABLIM1 actin binding LIM protein 1 -0.0266194
PDLIM5 PDZ and LIM domain 5 -0.0265586
PERP PERP, TP53 apoptosis effector -0.026258
DSCAM Down syndrome cell adhesion molecule -0.0262262
RPL31 ribosomal protein L31 -0.0261695
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0257162
TMEM165 transmembrane protein 165 -0.0256543
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0255849
HDLBP high density lipoprotein binding protein -0.0253995
RTN4 reticulon 4 -0.0251602
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0248283
MORF4L2 mortality factor 4 like 2 -0.0239789
RPL7 ribosomal protein L7 -0.023946
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0239074
RPS25 ribosomal protein S25 -0.0232613
NAMPT nicotinamide phosphoribosyltransferase -0.0231238
LMO7 LIM domain 7 -0.0230877
SPDYA speedy/RINGO cell cycle regulator family member A -0.0222593
PRRC2C proline-rich coiled-coil 2C -0.0221351
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0220879
DTNA dystrobrevin, alpha -0.0220684
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0218806
S100A11 S100 calcium binding protein A11 -0.0211497
TES testin LIM domain protein -0.0209637
CCNI cyclin I -0.0209105
RPS21 ribosomal protein S21 -0.0208098
GM2A GM2 ganglioside activator -0.0207273
RAB1A RAB1A, member RAS oncogene family -0.020597
PTPRM protein tyrosine phosphatase, receptor type, M -0.0202995
RPL11 ribosomal protein L11 -0.0200045
RPL37A ribosomal protein L37a -0.0200015
PNRC1 proline-rich nuclear receptor coactivator 1 -0.019799
MT1X metallothionein 1X -0.0197291
SLC38A1 solute carrier family 38, member 1 -0.0197283
AGO2 argonaute RISC catalytic component 2 -0.0196585
NSUN6 NOP2/Sun domain family, member 6 -0.0195593
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0194762
AHNAK AHNAK nucleoprotein -0.0193741
RPS19 ribosomal protein S19 -0.0191802
FBXO11 F-box protein 11 -0.0191495
RPL8 ribosomal protein L8 -0.01893
RPS29 ribosomal protein S29 -0.0188885
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0186145
EXT1 exostosin glycosyltransferase 1 -0.0183912
CSTB cystatin B (stefin B) -0.0183474
JMJD1C jumonji domain containing 1C -0.0183205
ANKRD37 ankyrin repeat domain 37 -0.0178809
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0177891
BIRC3 baculoviral IAP repeat containing 3 -0.0173612
IER3 immediate early response 3 -0.0173272