Daptomycin_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Daptomycin perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Daptomycin_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.182083
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.113644
AKAP12 A kinase (PRKA) anchor protein 12 0.100502
ELL2 elongation factor, RNA polymerase II, 2 0.0789122
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.067476
EEF2 eukaryotic translation elongation factor 2 0.0593122
KDM2A lysine (K)-specific demethylase 2A 0.0562353
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0544801
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0541296
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0474348
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.047322
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0468946
GOLGA4 golgin A4 0.0458635
BASP1 brain abundant, membrane attached signal protein 1 0.0452019
NPC1 Niemann-Pick disease, type C1 0.04508
FAM13A family with sequence similarity 13, member A 0.0433235
OSMR oncostatin M receptor 0.0430182
CXCL5 chemokine (C-X-C motif) ligand 5 0.0426769
TXNRD1 thioredoxin reductase 1 0.0411571
RAB8B RAB8B, member RAS oncogene family 0.0394601
MKI67 marker of proliferation Ki-67 0.0384816
SPAG9 sperm associated antigen 9 0.0364579
ATP13A3 ATPase type 13A3 0.0360616
SMAD3 SMAD family member 3 0.036057
CENPF centromere protein F, 350/400kDa 0.0350016
ZNF292 zinc finger protein 292 0.034798
FLNB filamin B, beta 0.0346966
CD44 CD44 molecule (Indian blood group) 0.0343896
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0341624
KDM3A lysine (K)-specific demethylase 3A 0.0340664
MYH9 myosin, heavy chain 9, non-muscle 0.033103
SRRM2 serine/arginine repetitive matrix 2 0.0325859
CALR calreticulin 0.0321768
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0316963
ANXA1 annexin A1 0.0314925
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0312702
CANX calnexin 0.0303936
AKAP9 A kinase (PRKA) anchor protein 9 0.0302476
SAMD4A sterile alpha motif domain containing 4A 0.0297629
KIF5B kinesin family member 5B 0.029703
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0295366
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0292092
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0290723
RAB27B RAB27B, member RAS oncogene family 0.0288306
CTNND1 catenin (cadherin-associated protein), delta 1 0.0287594
XPO1 exportin 1 0.0283377
CSDE1 cold shock domain containing E1, RNA-binding 0.0283283
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0281764
RB1CC1 RB1-inducible coiled-coil 1 0.0281502
TPM3 tropomyosin 3 0.0275726
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0275508
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0275076
ADD3 adducin 3 (gamma) 0.0270958
NAV2 neuron navigator 2 0.0269736
AHR aryl hydrocarbon receptor 0.026901
PDIA4 protein disulfide isomerase family A, member 4 0.026893
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.0267912
UBC ubiquitin C 0.0265811
TNIP1 TNFAIP3 interacting protein 1 0.026554
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0263294
MAP1B microtubule-associated protein 1B 0.0262142
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0261324
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0261007
SOD2 superoxide dismutase 2, mitochondrial 0.0260798
SMC4 structural maintenance of chromosomes 4 0.0253455
OGA O-GlcNAcase 0.0251859
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0246355
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0246099
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0245717
TM4SF1 transmembrane 4 L six family member 1 0.0245057
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.0243114
SBF2 SET binding factor 2 0.0242802
CDCP1 CUB domain containing protein 1 0.024249
BACE2 beta-site APP-cleaving enzyme 2 0.024005
SLTM SAFB-like, transcription modulator 0.0239641
RUNX1 runt-related transcription factor 1 0.0238766
SRP54 signal recognition particle 54kDa 0.0236701
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0236595
MXI1 MAX interactor 1, dimerization protein 0.0231301
KLF6 Kruppel-like factor 6 0.0230801
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0228436
CENPE centromere protein E, 312kDa 0.0227054
UBA6 ubiquitin-like modifier activating enzyme 6 0.0224947
POM121 POM121 transmembrane nucleoporin 0.0222297
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0221176
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0220659
NCKAP1 NCK-associated protein 1 0.0216158
FRMD5 FERM domain containing 5 0.0215945
UGCG UDP-glucose ceramide glucosyltransferase 0.021549
RICTOR RPTOR independent companion of MTOR, complex 2 0.0214516
SPRED1 sprouty-related, EVH1 domain containing 1 0.0213747
BIRC2 baculoviral IAP repeat containing 2 0.0213077
SS18 synovial sarcoma translocation, chromosome 18 0.0211514
RLF rearranged L-myc fusion 0.0210274
TPR translocated promoter region, nuclear basket protein 0.0205081
YEATS2 YEATS domain containing 2 0.0204979
SYAP1 synapse associated protein 1 0.0203845
USP3 ubiquitin specific peptidase 3 0.0202475
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0202304
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 0.0201186

decreased expression

Symbol Name Standardized Value
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.182833
SDK1 sidekick cell adhesion molecule 1 -0.178232
PDE4D phosphodiesterase 4D, cAMP-specific -0.163683
CDH13 cadherin 13 -0.120295
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.119199
FN1 fibronectin 1 -0.117839
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.112886
FAM20C family with sequence similarity 20, member C -0.108832
TMSB10 thymosin beta 10 -0.0999622
HMGA2 high mobility group AT-hook 2 -0.0954352
VIM vimentin -0.0815836
NRG1 neuregulin 1 -0.0815772
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0804779
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0802816
PSD3 pleckstrin and Sec7 domain containing 3 -0.0756018
GRB10 growth factor receptor-bound protein 10 -0.0730509
DPYD dihydropyrimidine dehydrogenase -0.0703001
RPL35A ribosomal protein L35a -0.0699969
MTSS1 metastasis suppressor 1 -0.0689813
GLCCI1 glucocorticoid induced 1 -0.0667384
MAML3 mastermind-like 3 (Drosophila) -0.0629762
ZSWIM6 zinc finger, SWIM-type containing 6 -0.060542
GPC6 glypican 6 -0.0594569
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0573354
AADAC arylacetamide deacetylase -0.05679
INTS6 integrator complex subunit 6 -0.0543753
TAS2R14 taste receptor, type 2, member 14 -0.0532678
EXT1 exostosin glycosyltransferase 1 -0.0531672
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0529541
FTL ferritin, light polypeptide -0.0528969
MEF2A myocyte enhancer factor 2A -0.050215
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.048716
NLK nemo-like kinase -0.046335
SEPTIN9 septin 9 -0.0457023
MSRB3 methionine sulfoxide reductase B3 -0.0445595
CUX1 cut-like homeobox 1 -0.044076
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0439287
EFNA5 ephrin-A5 -0.0435188
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0432254
CDK14 cyclin-dependent kinase 14 -0.0421874
OXR1 oxidation resistance 1 -0.0420236
STC1 stanniocalcin 1 -0.0417287
SYT1 synaptotagmin I -0.0408823
RAI14 retinoic acid induced 14 -0.0405993
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0401185
LRMDA leucine rich melanocyte differentiation associated -0.0398378
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0397875
RPLP1 ribosomal protein, large, P1 -0.0388016
RPL31 ribosomal protein L31 -0.0387302
TGFB1 transforming growth factor, beta 1 -0.0384369
FBN1 fibrillin 1 -0.0383088
CLMP CXADR-like membrane protein -0.0382247
VCL vinculin -0.0381797
EFCAB13 EF-hand calcium binding domain 13 -0.0377328
COL7A1 collagen, type VII, alpha 1 -0.0376577
DDIT3 DNA-damage-inducible transcript 3 -0.0367991
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0365797
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0362326
GLIS3 GLIS family zinc finger 3 -0.0360001
RPS29 ribosomal protein S29 -0.0356341
NDRG1 N-myc downstream regulated 1 -0.0353234
TPT1 tumor protein, translationally-controlled 1 -0.0352184
TMEM165 transmembrane protein 165 -0.0352151
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0349623
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0347495
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0346809
HDAC4 histone deacetylase 4 -0.0343919
NPAS2 neuronal PAS domain protein 2 -0.0340866
ATG7 autophagy related 7 -0.0336639
RPL37A ribosomal protein L37a -0.033344
EGR1 early growth response 1 -0.0331925
SOS1 son of sevenless homolog 1 (Drosophila) -0.033084
ZNF804A zinc finger protein 804A -0.0330736
RPS19 ribosomal protein S19 -0.0330172
NTN4 netrin 4 -0.0329831
FBXO11 F-box protein 11 -0.0329302
ENO2 enolase 2 (gamma, neuronal) -0.0328118
DIAPH2 diaphanous-related formin 2 -0.0326058
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0324811
PRKCA protein kinase C, alpha -0.0321195
NUMB numb homolog (Drosophila) -0.0320054
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0318347
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0317365
HMGA1 high mobility group AT-hook 1 -0.0312783
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -0.0311614
GREB1L growth regulation by estrogen in breast cancer-like -0.0300993
NAV1 neuron navigator 1 -0.0299417
RPS8 ribosomal protein S8 -0.0297214
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0293456
TFPI2 tissue factor pathway inhibitor 2 -0.0291146
DLG1 discs, large homolog 1 (Drosophila) -0.0288545
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0287588
ATXN1 ataxin 1 -0.0285363
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0281619
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0280032
RAB7A RAB7A, member RAS oncogene family -0.0277892
RPS25 ribosomal protein S25 -0.0275452
BTG1 B-cell translocation gene 1, anti-proliferative -0.0275082
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0274311
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0273481