Daptomycin_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Daptomycin perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Daptomycin_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.244123
MKI67 marker of proliferation Ki-67 0.0620722
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0614214
THSD4 thrombospondin, type I, domain containing 4 0.0544282
SRRM2 serine/arginine repetitive matrix 2 0.0525049
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0522922
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0516235
TPM3 tropomyosin 3 0.0490958
ERRFI1 ERBB receptor feedback inhibitor 1 0.0444026
ADAR adenosine deaminase, RNA-specific 0.0440147
UBC ubiquitin C 0.0425813
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0420972
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0420852
EEF2 eukaryotic translation elongation factor 2 0.0417424
AFF3 AF4/FMR2 family, member 3 0.0400705
STAU1 staufen double-stranded RNA binding protein 1 0.037633
TRIO trio Rho guanine nucleotide exchange factor 0.0369484
VCL vinculin 0.0366319
SYNE2 spectrin repeat containing, nuclear envelope 2 0.036302
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.036153
AHNAK AHNAK nucleoprotein 0.0357547
CANX calnexin 0.0342212
PUM2 pumilio RNA-binding family member 2 0.0339742
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0335867
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.033215
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0329616
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0328156
STK4 serine/threonine kinase 4 0.0319046
BIRC2 baculoviral IAP repeat containing 2 0.0317232
NF1 neurofibromin 1 0.0312243
PDE4D phosphodiesterase 4D, cAMP-specific 0.0311933
DSPP dentin sialophosphoprotein 0.0310834
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0307928
CTTN cortactin 0.0307521
RAB10 RAB10, member RAS oncogene family 0.0305963
CAPRIN1 cell cycle associated protein 1 0.0304041
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0302928
MACF1 microtubule-actin crosslinking factor 1 0.0298157
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0282629
TM4SF1 transmembrane 4 L six family member 1 0.0281816
CAVIN1 caveolae associated protein 1 0.0281754
ANO6 anoctamin 6 0.028119
NUP153 nucleoporin 153kDa 0.0278111
TRIP12 thyroid hormone receptor interactor 12 0.0275621
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0272654
TNPO3 transportin 3 0.026962
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0268401
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0267443
HSPA8 heat shock 70kDa protein 8 0.026595
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0264467
ZNF217 zinc finger protein 217 0.0263258
PDIA4 protein disulfide isomerase family A, member 4 0.0259329
SINHCAF SIN3-HDAC complex associated factor 0.0254744
KDM3A lysine (K)-specific demethylase 3A 0.0253577
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0249264
SFPQ splicing factor proline/glutamine-rich 0.0249112
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0245545
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0240637
IFI6 interferon, alpha-inducible protein 6 0.0240484
HMGA2 high mobility group AT-hook 2 0.0240124
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0237145
SETX senataxin 0.0234647
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0232758
MAPK8 mitogen-activated protein kinase 8 0.0232571
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.023209
KCMF1 potassium channel modulatory factor 1 0.0229472
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0228066
PATJ PATJ crumbs cell polarity complex component 0.0227816
EIF4B eukaryotic translation initiation factor 4B 0.0227626
NCAPH non-SMC condensin I complex, subunit H 0.0226869
ZFAND3 zinc finger, AN1-type domain 3 0.0226689
DOCK5 dedicator of cytokinesis 5 0.0226623
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0226559
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0226449
C1ORF159 chromosome 1 open reading frame 159 0.0225425
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.022522
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0224909
PRPF8 pre-mRNA processing factor 8 0.0224778
ICAM1 intercellular adhesion molecule 1 0.022436
FAF1 Fas (TNFRSF6) associated factor 1 0.0224218
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0223915
AGO3 argonaute RISC catalytic component 3 0.0223811
ACTN1 actinin, alpha 1 0.0223459
RNF213 ring finger protein 213 0.0222361
BZW1 basic leucine zipper and W2 domains 1 0.0221415
TOP2B topoisomerase (DNA) II beta 180kDa 0.0221306
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0216722
NCAPG2 non-SMC condensin II complex, subunit G2 0.0215521
IL6ST interleukin 6 signal transducer 0.0215112
IQGAP1 IQ motif containing GTPase activating protein 1 0.0213802
TLN1 talin 1 0.0213304
OSMR oncostatin M receptor 0.0211874
RBBP6 retinoblastoma binding protein 6 0.0210158
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0209742
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0209575
GON4L gon-4-like (C. elegans) 0.0207742
MOB1A MOB kinase activator 1A 0.0207543
TPM4 tropomyosin 4 0.020703
NUSAP1 nucleolar and spindle associated protein 1 0.0205627
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0204844

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.176789
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.124588
TFPI2 tissue factor pathway inhibitor 2 -0.118787
RPLP1 ribosomal protein, large, P1 -0.102536
EGR1 early growth response 1 -0.0987569
RPL35A ribosomal protein L35a -0.0875205
KTN1 kinectin 1 (kinesin receptor) -0.0856586
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0841459
MT2A metallothionein 2A -0.0827162
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.079825
VIM vimentin -0.0782708
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0666767
TPI1 triosephosphate isomerase 1 -0.0653916
RPS21 ribosomal protein S21 -0.0636702
YBX1 Y box binding protein 1 -0.0623542
TPM2 tropomyosin 2 (beta) -0.0619275
RPS19 ribosomal protein S19 -0.0614275
POTEF POTE ankyrin domain family, member F -0.0603216
RPS27 ribosomal protein S27 -0.0599162
RPL23 ribosomal protein L23 -0.0595127
RPS29 ribosomal protein S29 -0.0590404
PTMA prothymosin, alpha -0.057431
RPL12 ribosomal protein L12 -0.056183
PCBP2 poly(rC) binding protein 2 -0.0545448
RPL9 ribosomal protein L9 -0.0541304
RPL31 ribosomal protein L31 -0.0534294
FTL ferritin, light polypeptide -0.0515945
RPS15 ribosomal protein S15 -0.051298
LDHB lactate dehydrogenase B -0.0507663
RPS4X ribosomal protein S4, X-linked -0.0492197
RPS8 ribosomal protein S8 -0.049016
RPL26 ribosomal protein L26 -0.0489932
EIF5B eukaryotic translation initiation factor 5B -0.0486078
HMGA1 high mobility group AT-hook 1 -0.0478977
PFN1 profilin 1 -0.0478557
RPL36 ribosomal protein L36 -0.0468371
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0463512
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0454061
RPL8 ribosomal protein L8 -0.0451814
RPL37A ribosomal protein L37a -0.0449714
RPS10 ribosomal protein S10 -0.0449447
ATP5F1E ATP synthase F1 subunit epsilon -0.0441032
RPS3 ribosomal protein S3 -0.0439635
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0436409
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0434382
TUBA1B tubulin, alpha 1b -0.0420519
SEPTIN7 septin 7 -0.041476
WSB1 WD repeat and SOCS box containing 1 -0.040837
YBX3 Y box binding protein 3 -0.0407297
MYL12B myosin, light chain 12B, regulatory -0.0401899
RPL19 ribosomal protein L19 -0.0398378
RPL32 ribosomal protein L32 -0.0393301
RPL37 ribosomal protein L37 -0.0392274
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0391543
NACA nascent polypeptide-associated complex alpha subunit -0.0383081
PKM pyruvate kinase, muscle -0.0377189
RPL34 ribosomal protein L34 -0.0373312
RPLP0 ribosomal protein, large, P0 -0.0373011
RPL28 ribosomal protein L28 -0.0366947
RTN4 reticulon 4 -0.0365744
RAN RAN, member RAS oncogene family -0.0365262
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0363785
RPL27 ribosomal protein L27 -0.036295
RPL7 ribosomal protein L7 -0.0361105
RPL5 ribosomal protein L5 -0.0355641
RPS14 ribosomal protein S14 -0.0351739
ACTG1 actin gamma 1 -0.0348627
RPS20 ribosomal protein S20 -0.0339558
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0337879
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0336384
ATP5F1B ATP synthase F1 subunit beta -0.0334419
S100A11 S100 calcium binding protein A11 -0.0332221
SEC61G Sec61 gamma subunit -0.0320803
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0319066
RPS23 ribosomal protein S23 -0.0317849
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.0315977
RPS6 ribosomal protein S6 -0.0315571
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0314689
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0313197
RPL18 ribosomal protein L18 -0.0308543
RPS17 ribosomal protein S17 -0.0307702
TUBB4B tubulin, beta 4B class IVb -0.0304257
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0303197
GSTP1 glutathione S-transferase pi 1 -0.0295445
RPLP2 ribosomal protein, large, P2 -0.0295331
NAP1L1 nucleosome assembly protein 1-like 1 -0.029004
ATXN1 ataxin 1 -0.0287659
PRRC2C proline-rich coiled-coil 2C -0.0285631
VDAC1 voltage-dependent anion channel 1 -0.0284788
PABPN1 poly(A) binding protein, nuclear 1 -0.0278459
RPL27A ribosomal protein L27a -0.0277917
RPL11 ribosomal protein L11 -0.0277481
CALD1 caldesmon 1 -0.0272756
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0272093
SRSF11 serine/arginine-rich splicing factor 11 -0.0271626
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0265544
LOC112694756 uncharaterized LOC112694756 -0.0265153
RBM25 RNA binding motif protein 25 -0.0261182
RPL35 ribosomal protein L35 -0.0257898
UBXN4 UBX domain protein 4 -0.0255831