Daptomycin_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Daptomycin perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

180 genes differentially expressed following the Daptomycin_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A 0.197743
STC1 stanniocalcin 1 0.172084
EGFR epidermal growth factor receptor 0.170929
VGF VGF nerve growth factor inducible 0.148735
THSD4 thrombospondin, type I, domain containing 4 0.136156
NDRG1 N-myc downstream regulated 1 0.126067
LAMA4 laminin, alpha 4 0.113867
PGK1 phosphoglycerate kinase 1 0.0990647
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0978874
RUNX1 runt-related transcription factor 1 0.0960762
FAM13A family with sequence similarity 13, member A 0.0851884
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.084207
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0827921
AKAP12 A kinase (PRKA) anchor protein 12 0.0798787
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0794573
NKD1 naked cuticle homolog 1 (Drosophila) 0.0782639
SLTM SAFB-like, transcription modulator 0.0744861
ANKRD12 ankyrin repeat domain 12 0.0743775
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0665886
MED13 mediator complex subunit 13 0.0661617
TMEM123 transmembrane protein 123 0.0640343
ASPH aspartate beta-hydroxylase 0.0636873
RORA RAR-related orphan receptor A 0.060384
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0602061
ERRFI1 ERBB receptor feedback inhibitor 1 0.0600356
PARD3 par-3 family cell polarity regulator 0.0596685
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0551175
SAMD4A sterile alpha motif domain containing 4A 0.0531842
POTEF POTE ankyrin domain family, member F 0.052135
ANKRD11 ankyrin repeat domain 11 0.0519689
RAD51B RAD51 paralog B 0.049779
RBM39 RNA binding motif protein 39 0.0480113
KTN1 kinectin 1 (kinesin receptor) 0.0464024
GOLGA4 golgin A4 0.0460597
GRB10 growth factor receptor-bound protein 10 0.0458895
WSB1 WD repeat and SOCS box containing 1 0.0423019
ANKRD17 ankyrin repeat domain 17 0.0389446
NCOA3 nuclear receptor coactivator 3 0.0356319
CEMIP cell migration inducing protein, hyaluronan binding 0.0323425
DST dystonin 0.0319575
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0272562
ZFAND3 zinc finger, AN1-type domain 3 0.0239198
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0227784
PEG10 paternally expressed 10 0.0222478
KMT2E lysine (K)-specific methyltransferase 2E 0.0217717
PDE4D phosphodiesterase 4D, cAMP-specific 0.0213329
SPAG9 sperm associated antigen 9 0.0205854
TRIO trio Rho guanine nucleotide exchange factor 0.0192144
MAML2 mastermind-like 2 (Drosophila) 0.0185688
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0184346
ZNF292 zinc finger protein 292 0.0175093
PCBP2 poly(rC) binding protein 2 0.0174383
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0157364
NALF1 NALCN channel auxiliary factor 1 0.0143397
NCOR1 nuclear receptor corepressor 1 0.0141826
ATXN1 ataxin 1 0.0139702
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0123091
EFNA5 ephrin-A5 0.012003
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0120002
EEF2 eukaryotic translation elongation factor 2 0.0106115
DSCAM Down syndrome cell adhesion molecule 0.0105156
CDK6 cyclin-dependent kinase 6 0.0102592
MYO1E myosin IE 0.00991699
SETD5 SET domain containing 5 0.00975205
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.00974455
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.00817323
GPATCH2L G patch domain containing 2-like 0.00812787
TPM4 tropomyosin 4 0.00686913
RNF213 ring finger protein 213 0.00632454
MCL1 myeloid cell leukemia 1 0.00602414
RPS6 ribosomal protein S6 0.00596336
DTNA dystrobrevin, alpha 0.00567922
HMGA2 high mobility group AT-hook 2 0.00552592
SP100 SP100 nuclear antigen 0.00456572
ZSWIM6 zinc finger, SWIM-type containing 6 0.00302107
EIF1 eukaryotic translation initiation factor 1 0.00208626
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.00203128
PACS1 phosphofurin acidic cluster sorting protein 1 0.00173691
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 8.52293E-4
ARID4B AT rich interactive domain 4B (RBP1-like) 8.88687E-5

decreased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 -0.116511
JMJD1C jumonji domain containing 1C -0.111252
FNDC3B fibronectin type III domain containing 3B -0.107035
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0988377
GMDS GDP-mannose 4,6-dehydratase -0.0957155
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0950488
NAV2 neuron navigator 2 -0.0887689
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.086233
SNX9 sorting nexin 9 -0.0854984
PTMA prothymosin, alpha -0.0808183
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0769449
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0746197
ITGA6 integrin, alpha 6 -0.0740563
RPS8 ribosomal protein S8 -0.0716012
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0701088
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0653466
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0643594
RPL19 ribosomal protein L19 -0.0638447
RPL12 ribosomal protein L12 -0.0626082
ANXA2 annexin A2 -0.0616122
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0615472
ZBTB20 zinc finger and BTB domain containing 20 -0.059658
RPL23 ribosomal protein L23 -0.0591523
NF1 neurofibromin 1 -0.0575666
BBX bobby sox homolog (Drosophila) -0.0550485
NCKAP1 NCK-associated protein 1 -0.0536445
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0532093
EXT1 exostosin glycosyltransferase 1 -0.0505935
STAG2 stromal antigen 2 -0.0503684
TPT1 tumor protein, translationally-controlled 1 -0.0484173
SLC38A1 solute carrier family 38, member 1 -0.0482042
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0475196
MACF1 microtubule-actin crosslinking factor 1 -0.0473392
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0472368
UBE2K ubiquitin-conjugating enzyme E2K -0.046895
IGFBP3 insulin-like growth factor binding protein 3 -0.0452901
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0444072
LMO7 LIM domain 7 -0.0442869
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0425556
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0412656
LAMB3 laminin, beta 3 -0.0409302
CARD16 caspase recruitment domain family, member 16 -0.0398617
FNDC3A fibronectin type III domain containing 3A -0.0393621
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0387213
MT2A metallothionein 2A -0.0386694
RPL26 ribosomal protein L26 -0.03735
CANX calnexin -0.0368095
CADM2 cell adhesion molecule 2 -0.0358009
ENO1 enolase 1, (alpha) -0.035652
RPLP2 ribosomal protein, large, P2 -0.0353949
SLC35F3 solute carrier family 35, member F3 -0.0351701
SMYD3 SET and MYND domain containing 3 -0.0336567
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0335355
MYO1B myosin IB -0.0332081
VIM vimentin -0.0323094
ARHGAP32 Rho GTPase activating protein 32 -0.0310736
ATP11A ATPase, class VI, type 11A -0.0304625
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.030313
MYO10 myosin X -0.0297852
FN1 fibronectin 1 -0.0291129
ARHGAP29 Rho GTPase activating protein 29 -0.0286093
ZNF608 zinc finger protein 608 -0.0282488
AFF4 AF4/FMR2 family, member 4 -0.0281936
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0280273
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0279044
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0268692
ARRDC3 arrestin domain containing 3 -0.0267811
UBE2Z ubiquitin-conjugating enzyme E2Z -0.0258901
RPLP1 ribosomal protein, large, P1 -0.0255068
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0244857
EGR1 early growth response 1 -0.0244646
FLNB filamin B, beta -0.0244539
PUM2 pumilio RNA-binding family member 2 -0.0241707
FTH1 ferritin, heavy polypeptide 1 -0.024151
TMSB10 thymosin beta 10 -0.0237318
RPL37 ribosomal protein L37 -0.0207635
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0207463
MYO5B myosin VB -0.0207332
MYOF myoferlin -0.0201354
LPP LIM domain containing preferred translocation partner in lipoma -0.0198926
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0196802
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0188796
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.018332
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0179501
SPATA13 spermatogenesis associated 13 -0.0178191
NPC1 Niemann-Pick disease, type C1 -0.017622
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0166282
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0162588
FNIP1 folliculin interacting protein 1 -0.0153826
VCL vinculin -0.0150832
GOLGB1 golgin B1 -0.0147672
WASF2 WAS protein family, member 2 -0.0145769
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0135705
FMNL2 formin-like 2 -0.0135166
EZR ezrin -0.0131822
BIRC6 baculoviral IAP repeat containing 6 -0.0127396
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.012054
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0118018
VMP1 vacuole membrane protein 1 -0.0117446
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0109859