Daptomycin_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Daptomycin perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Daptomycin_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.140701
PDE4D phosphodiesterase 4D, cAMP-specific 0.120984
SRRM2 serine/arginine repetitive matrix 2 0.0805284
SLC38A2 solute carrier family 38, member 2 0.0655704
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0651398
DSCAM Down syndrome cell adhesion molecule 0.0566735
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0563914
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.054952
EZR ezrin 0.0489948
EGFR epidermal growth factor receptor 0.0476239
ZBTB20 zinc finger and BTB domain containing 20 0.046819
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.045475
METTL15 methyltransferase like 15 0.043306
ARL15 ADP-ribosylation factor-like 15 0.0409669
TMSB4X thymosin beta 4, X-linked 0.0405154
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0394763
EFNA5 ephrin-A5 0.0390608
PKM pyruvate kinase, muscle 0.0387853
DSTN destrin (actin depolymerizing factor) 0.0384089
ZNF292 zinc finger protein 292 0.0379892
MBNL1 muscleblind-like splicing regulator 1 0.0375889
PLK2 polo-like kinase 2 0.0372794
PNISR PNN-interacting serine/arginine-rich protein 0.0372541
BRD2 bromodomain containing 2 0.036189
GOLGA4 golgin A4 0.0360718
SPAG9 sperm associated antigen 9 0.0354123
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0350927
AKAP9 A kinase (PRKA) anchor protein 9 0.0348236
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0347546
CANX calnexin 0.0343316
SMYD3 SET and MYND domain containing 3 0.0335254
CALR calreticulin 0.033075
UBC ubiquitin C 0.0312791
TBC1D5 TBC1 domain family, member 5 0.0309805
VMP1 vacuole membrane protein 1 0.0305848
PRELID2 PRELI domain containing 2 0.0302238
YAP1 Yes-associated protein 1 0.0300731
EIF4B eukaryotic translation initiation factor 4B 0.0296982
TRERF1 transcriptional regulating factor 1 0.0296343
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0291455
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0288557
PAPOLA poly(A) polymerase alpha 0.0285949
USO1 USO1 vesicle transport factor 0.028368
SETX senataxin 0.0283343
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.028206
KMT2C lysine (K)-specific methyltransferase 2C 0.0275401
RBBP6 retinoblastoma binding protein 6 0.027149
NBEA neurobeachin 0.0268563
KMT2E lysine (K)-specific methyltransferase 2E 0.0265825
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0262157
SPIDR scaffolding protein involved in DNA repair 0.0261897
EXOC6B exocyst complex component 6B 0.0261823
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0261723
SEC31A SEC31 homolog A (S. cerevisiae) 0.0261034
STAU1 staufen double-stranded RNA binding protein 1 0.0260823
NCOA3 nuclear receptor coactivator 3 0.0256683
PNN pinin, desmosome associated protein 0.0256461
SFPQ splicing factor proline/glutamine-rich 0.0249199
CAPRIN1 cell cycle associated protein 1 0.0246976
TRIP12 thyroid hormone receptor interactor 12 0.0244365
COG6 component of oligomeric golgi complex 6 0.0243272
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0242877
GLI3 GLI family zinc finger 3 0.0240934
EIF5 eukaryotic translation initiation factor 5 0.0240092
RPL21 ribosomal protein L21 0.0239264
DIDO1 death inducer-obliterator 1 0.0236734
DCAF6 DDB1 and CUL4 associated factor 6 0.0236654
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0234932
ANKRD36C ankyrin repeat domain 36C 0.0233619
BRWD1 bromodomain and WD repeat domain containing 1 0.0229146
BPTF bromodomain PHD finger transcription factor 0.0228493
KIF5B kinesin family member 5B 0.0226375
TTC17 tetratricopeptide repeat domain 17 0.0225303
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0224882
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0223871
ARB2A ARB2 cotranscriptional regulator A 0.0222701
TMF1 TATA element modulatory factor 1 0.0220775
HDAC8 histone deacetylase 8 0.0219555
PHF14 PHD finger protein 14 0.0218993
PRRC2C proline-rich coiled-coil 2C 0.0217707
TOP2B topoisomerase (DNA) II beta 180kDa 0.021752
QKI QKI, KH domain containing, RNA binding 0.0217292
GPHN gephyrin 0.0216583
FAM13A family with sequence similarity 13, member A 0.0213985
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0213296
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0211881
CHD9 chromodomain helicase DNA binding protein 9 0.0210398
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0210369
CARD16 caspase recruitment domain family, member 16 0.0208913
RPS3A ribosomal protein S3A 0.0207983
MBD5 methyl-CpG binding domain protein 5 0.0206755
AUH AU RNA binding protein/enoyl-CoA hydratase 0.020439
SGMS1 sphingomyelin synthase 1 0.0204361
CLU clusterin 0.0202744
SP3 Sp3 transcription factor 0.0202574
NAP1L1 nucleosome assembly protein 1-like 1 0.0200738
PIBF1 progesterone immunomodulatory binding factor 1 0.0200599
EIF5B eukaryotic translation initiation factor 5B 0.0199749
RPS6 ribosomal protein S6 0.0199592
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0199524

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.141711
BMP10 bone morphogenetic protein 10 -0.116144
RPL35A ribosomal protein L35a -0.100617
RPLP1 ribosomal protein, large, P1 -0.0869712
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0868608
DIAPH3 diaphanous-related formin 3 -0.0730555
DLG1 discs, large homolog 1 (Drosophila) -0.0690799
SOX6 SRY (sex determining region Y)-box 6 -0.0689514
LDHA lactate dehydrogenase A -0.0629699
PGK1 phosphoglycerate kinase 1 -0.0572798
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.056612
VCL vinculin -0.0553
ARL4C ADP-ribosylation factor-like 4C -0.0545971
HSPB1 heat shock 27kDa protein 1 -0.0526794
ZEB1 zinc finger E-box binding homeobox 1 -0.0525584
TUBB tubulin, beta class I -0.0514381
GARS1 glycyl-tRNA synthetase 1 -0.0498514
CAMTA1 calmodulin binding transcription activator 1 -0.0496558
TPT1 tumor protein, translationally-controlled 1 -0.0486083
RPS13 ribosomal protein S13 -0.0477455
RPS19 ribosomal protein S19 -0.0477329
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0476025
LOC112694756 uncharaterized LOC112694756 -0.046731
RPS8 ribosomal protein S8 -0.0435003
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0434714
RPL34 ribosomal protein L34 -0.0433642
HJURP Holliday junction recognition protein -0.0430958
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0427603
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0422516
RACK1 receptor for activated C kinase 1 -0.0420037
ANK2 ankyrin 2, neuronal -0.0414019
FOXP1 forkhead box P1 -0.0412934
HMGA1 high mobility group AT-hook 1 -0.0409602
RHOA ras homolog family member A -0.0403553
RPL23 ribosomal protein L23 -0.0395641
EML4 echinoderm microtubule associated protein like 4 -0.0395055
RPS21 ribosomal protein S21 -0.0385058
TUBB4B tubulin, beta 4B class IVb -0.0384305
PDE4B phosphodiesterase 4B, cAMP-specific -0.0383088
RPL36 ribosomal protein L36 -0.0381609
B2M beta-2-microglobulin -0.0380811
AHNAK AHNAK nucleoprotein -0.0373269
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0372932
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.037159
S100A4 S100 calcium binding protein A4 -0.0368006
SAMD4A sterile alpha motif domain containing 4A -0.0366005
LPP LIM domain containing preferred translocation partner in lipoma -0.0359625
MYOF myoferlin -0.0355909
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.035195
RPL26 ribosomal protein L26 -0.0350879
RUSC2 RUN and SH3 domain containing 2 -0.0339494
RPS23 ribosomal protein S23 -0.0334178
TUBA1B tubulin, alpha 1b -0.033094
NFIA nuclear factor I/A -0.0320696
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 -0.0315474
TXNIP thioredoxin interacting protein -0.0312095
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0300442
SSBP2 single-stranded DNA binding protein 2 -0.02999
RPLP0 ribosomal protein, large, P0 -0.0299439
RPL7 ribosomal protein L7 -0.0295911
ANKRD11 ankyrin repeat domain 11 -0.0294745
CREB5 cAMP responsive element binding protein 5 -0.0292189
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0285708
NPAS2 neuronal PAS domain protein 2 -0.0283667
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0278464
NT5C2 5'-nucleotidase, cytosolic II -0.0278086
IARS1 isoleucyl-tRNA synthetase 1 -0.0275261
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0275033
CD47 CD47 molecule -0.0274666
NUP58 nucleoporin 58 -0.027173
USP3 ubiquitin specific peptidase 3 -0.0268063
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0268019
PYGB phosphorylase, glycogen; brain -0.0267649
RPS24 ribosomal protein S24 -0.0265642
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0264226
TMEM41B transmembrane protein 41B -0.0263968
ANLN anillin, actin binding protein -0.0262808
ENOSF1 enolase superfamily member 1 -0.0256494
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0255142
GLS2 glutaminase 2 (liver, mitochondrial) -0.0254684
RPL9 ribosomal protein L9 -0.0253019
MYL12B myosin, light chain 12B, regulatory -0.02484
SESN2 sestrin 2 -0.024812
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0246987
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0246601
ZMYND8 zinc finger, MYND-type containing 8 -0.0241552
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0238977
HMGB2 high mobility group box 2 -0.0238798
FAM91A1 family with sequence similarity 91, member A1 -0.0238556
SMC4 structural maintenance of chromosomes 4 -0.023813
TCEA1 transcription elongation factor A (SII), 1 -0.0236985
RFC3 replication factor C (activator 1) 3, 38kDa -0.0231232
HEG1 heart development protein with EGF-like domains 1 -0.0226193
RHEB Ras homolog enriched in brain -0.0225662
CCNY cyclin Y -0.0224287
ADAM9 ADAM metallopeptidase domain 9 -0.0223505
HOOK2 hook microtubule-tethering protein 2 -0.0223182
SDK1 sidekick cell adhesion molecule 1 -0.0222476
YARS1 tyrosyl-tRNA synthetase 1 -0.022015
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) -0.0219358