Daptomycin_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Daptomycin perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Daptomycin_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.0760718
CDH13 cadherin 13 0.0535402
AKAP12 A kinase (PRKA) anchor protein 12 0.0472152
CADM1 cell adhesion molecule 1 0.0438793
ZSWIM6 zinc finger, SWIM-type containing 6 0.0421471
ELL2 elongation factor, RNA polymerase II, 2 0.0396184
MYH9 myosin, heavy chain 9, non-muscle 0.039588
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0391937
IGFBP3 insulin-like growth factor binding protein 3 0.0375571
MACF1 microtubule-actin crosslinking factor 1 0.0374329
TRIO trio Rho guanine nucleotide exchange factor 0.0358449
PARD3 par-3 family cell polarity regulator 0.0351631
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.032918
ZFAND3 zinc finger, AN1-type domain 3 0.0312306
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.029812
BIRC6 baculoviral IAP repeat containing 6 0.0295588
PTGES2 prostaglandin E synthase 2 0.0283001
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0278056
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0272666
VEGFC vascular endothelial growth factor C 0.026461
SBF2 SET binding factor 2 0.0263617
TFG TRK-fused gene 0.0263248
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0260232
COG6 component of oligomeric golgi complex 6 0.0258208
PRRC2C proline-rich coiled-coil 2C 0.0258136
NDRG1 N-myc downstream regulated 1 0.0256646
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.025645
TPM3 tropomyosin 3 0.0256048
RSRC2 arginine/serine-rich coiled-coil 2 0.0254991
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.024965
USP47 ubiquitin specific peptidase 47 0.0246669
CD109 CD109 molecule 0.0245778
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0238724
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0238074
WDFY2 WD repeat and FYVE domain containing 2 0.0233886
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0232558
CCDC14 coiled-coil domain containing 14 0.0232196
COG5 component of oligomeric golgi complex 5 0.0231551
USP37 ubiquitin specific peptidase 37 0.0231164
EEF2 eukaryotic translation elongation factor 2 0.0228432
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0227468
ESYT2 extended synaptotagmin-like protein 2 0.0223536
SMC3 structural maintenance of chromosomes 3 0.0223203
APLP2 amyloid beta (A4) precursor-like protein 2 0.0218115
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.021592
GPC6 glypican 6 0.0212913
WDR43 WD repeat domain 43 0.0211728
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0211614
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0211613
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0211477
MRPS6 mitochondrial ribosomal protein S6 0.0210116
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) 0.0209897
CTBP2 C-terminal binding protein 2 0.0207747
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.020475
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0201691
ARRDC3 arrestin domain containing 3 0.0200958
TBC1D22A TBC1 domain family, member 22A 0.0199746
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0197605
ANKRD17 ankyrin repeat domain 17 0.0196528
ERBIN erbb2 interacting protein 0.0195149
FAM219A family with sequence similarity 219, member A 0.0195077
KYNU kynureninase 0.0193423
MSN moesin 0.0193409
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0193274
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0192999
ADM adrenomedullin 0.0192241
CLASP2 cytoplasmic linker associated protein 2 0.0191058
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0190632
ALCAM activated leukocyte cell adhesion molecule 0.018947
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0186647
TOP1 topoisomerase (DNA) I 0.0186396
DENND5A DENN/MADD domain containing 5A 0.0184959
ACBD3 acyl-CoA binding domain containing 3 0.018469
HIPK2 homeodomain interacting protein kinase 2 0.0184065
COPA coatomer protein complex, subunit alpha 0.0181356
EXOC4 exocyst complex component 4 0.0180693
ZNF451 zinc finger protein 451 0.018061
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0179649
CCNL1 cyclin L1 0.0178412
CCNT2 cyclin T2 0.0177904
BASP1 brain abundant, membrane attached signal protein 1 0.0177899
TPR translocated promoter region, nuclear basket protein 0.0177591
PHF14 PHD finger protein 14 0.0177088
TMEM132D transmembrane protein 132D 0.0176519
MYOF myoferlin 0.0176398
MYLK myosin light chain kinase 0.0176271
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0175809
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0175033
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0173539
EXT1 exostosin glycosyltransferase 1 0.0173092
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.016906
EIF5 eukaryotic translation initiation factor 5 0.0168717
ITSN1 intersectin 1 (SH3 domain protein) 0.0168604
NSD3 nuclear receptor binding SET domain protein 3 0.0167921
NCAPG2 non-SMC condensin II complex, subunit G2 0.0166959
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 0.0166447
SPAG9 sperm associated antigen 9 0.0165274
RANBP2 RAN binding protein 2 0.0163623
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0163272
TEX10 testis expressed 10 0.0162946

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.179443
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.177434
MT2A metallothionein 2A -0.156736
HLA-B major histocompatibility complex, class I, B -0.153487
TMSB10 thymosin beta 10 -0.134778
TGFBI transforming growth factor, beta-induced, 68kDa -0.10144
VIM vimentin -0.0957121
FTL ferritin, light polypeptide -0.0789237
FN1 fibronectin 1 -0.0742877
MT1X metallothionein 1X -0.0735563
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0658361
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0642419
B2M beta-2-microglobulin -0.0609668
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0565555
F3 coagulation factor III (thromboplastin, tissue factor) -0.0565391
CALD1 caldesmon 1 -0.0549671
EIF1 eukaryotic translation initiation factor 1 -0.0549215
HLA-C major histocompatibility complex, class I, C -0.0521457
COL1A2 collagen, type I, alpha 2 -0.0504063
SDC4 syndecan 4 -0.0487419
LOXL2 lysyl oxidase-like 2 -0.0468963
PRSS23 protease, serine, 23 -0.0459734
COL1A1 collagen, type I, alpha 1 -0.0459289
MEF2A myocyte enhancer factor 2A -0.043136
GCC2 GRIP and coiled-coil domain containing 2 -0.0431166
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0424308
RPL34 ribosomal protein L34 -0.0422702
GLIS3 GLIS family zinc finger 3 -0.0418961
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0408884
TFPI2 tissue factor pathway inhibitor 2 -0.0396053
NAMPT nicotinamide phosphoribosyltransferase -0.03919
LOC112694756 uncharaterized LOC112694756 -0.0389993
TPT1 tumor protein, translationally-controlled 1 -0.0384078
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0381718
H3-3B H3.3 histone B -0.0380887
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0374617
RTN4 reticulon 4 -0.0373178
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0373058
S100A6 S100 calcium binding protein A6 -0.0371107
ENO1 enolase 1, (alpha) -0.0368527
ZMYND8 zinc finger, MYND-type containing 8 -0.0365085
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0364995
S100A10 S100 calcium binding protein A10 -0.0361849
LDHA lactate dehydrogenase A -0.0351925
PRELID2 PRELI domain containing 2 -0.0348849
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0345365
FTH1 ferritin, heavy polypeptide 1 -0.0344605
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0343131
CALU calumenin -0.0342292
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0337897
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0321568
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0320198
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0309485
ANXA2 annexin A2 -0.0308829
TENT5A terminal nucleotidyltransferase 5A -0.0308245
COL6A2 collagen, type VI, alpha 2 -0.0302495
WSB1 WD repeat and SOCS box containing 1 -0.0296638
RRBP1 ribosome binding protein 1 -0.0293625
CAV1 caveolin 1, caveolae protein, 22kDa -0.0290664
PGK1 phosphoglycerate kinase 1 -0.0285583
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0282352
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0280618
PTPRF protein tyrosine phosphatase, receptor type, F -0.0278839
WTAP Wilms tumor 1 associated protein -0.0277613
ECE1 endothelin converting enzyme 1 -0.026404
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0263086
HIP1 huntingtin interacting protein 1 -0.0262018
RPL27A ribosomal protein L27a -0.0261321
RPS24 ribosomal protein S24 -0.0259961
RPL28 ribosomal protein L28 -0.0258255
ANKRD12 ankyrin repeat domain 12 -0.0258205
S100A9 S100 calcium binding protein A9 -0.025642
RPS14 ribosomal protein S14 -0.0255917
FAM20C family with sequence similarity 20, member C -0.0248434
NOP58 NOP58 ribonucleoprotein -0.0247348
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0245914
RARS1 arginyl-tRNA synthetase 1 -0.0242946
ANXA5 annexin A5 -0.0241452
RPLP2 ribosomal protein, large, P2 -0.0239816
RPL11 ribosomal protein L11 -0.023624
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0235207
GNAS GNAS complex locus -0.0233427
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.023236
CSNK1A1 casein kinase 1, alpha 1 -0.0232272
AHNAK AHNAK nucleoprotein -0.02287
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0228391
RPL35A ribosomal protein L35a -0.022828
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0226908
RPL26 ribosomal protein L26 -0.0223819
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0221113
WASF2 WAS protein family, member 2 -0.0220466
SFTPA2 surfactant protein A2 -0.0219531
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0218645
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0215971
MAP4 microtubule-associated protein 4 -0.0215703
EGR1 early growth response 1 -0.0215598
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0211497
RPL36 ribosomal protein L36 -0.0208736
KDM5B lysine (K)-specific demethylase 5B -0.0207154
FNDC3B fibronectin type III domain containing 3B -0.0205077