| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/444031 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Darifenacin relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TSPAN3 | tetraspanin 3 | 0.87 |
| PPP2R2D | protein phosphatase 2, regulatory subunit B, delta | 0.77 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.74 |
| WTIP | Wilms tumor 1 interacting protein | 0.61 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.61 |
| CALU | calumenin | 0.55 |
| RYBP | RING1 and YY1 binding protein | 0.55 |
| BDNF | brain-derived neurotrophic factor | 0.54 |
| HSPA2 | heat shock 70kDa protein 2 | 0.52 |
| MOSPD3 | motile sperm domain containing 3 | 0.49 |
| NEK2 | NIMA-related kinase 2 | 0.48 |
| ACTBL2 | actin, beta-like 2 | 0.45 |
| ELOB | elongin B | 0.45 |
| RNF169 | ring finger protein 169 | 0.45 |
| LRPAP1 | low density lipoprotein receptor-related protein associated protein 1 | 0.44 |
| SP100 | SP100 nuclear antigen | 0.44 |
| SLC49A4 | solute carrier family 49 member 4 | 0.43 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 0.43 |
| UNC119B | unc-119 homolog B (C. elegans) | 0.42 |
| RPL26 | ribosomal protein L26 | 0.41 |
| MAP2K2 | mitogen-activated protein kinase kinase 2 | 0.41 |
| PTMA | prothymosin, alpha | 0.4 |
| TMEM222 | transmembrane protein 222 | 0.4 |
| MSX1 | msh homeobox 1 | 0.4 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.39 |
| SS18 | synovial sarcoma translocation, chromosome 18 | 0.39 |
| SDR16C5 | short chain dehydrogenase/reductase family 16C, member 5 | 0.39 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | 0.39 |
| DST | dystonin | 0.38 |
| NDRG2 | NDRG family member 2 | 0.38 |
| SOX13 | SRY (sex determining region Y)-box 13 | 0.38 |
| TPM1 | tropomyosin 1 (alpha) | 0.38 |
| DNAH1 | dynein, axonemal, heavy chain 1 | 0.38 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.37 |
| HIPK3 | homeodomain interacting protein kinase 3 | 0.36 |
| CASZ1 | castor zinc finger 1 | 0.36 |
| CD63 | CD63 molecule | 0.36 |
| CD82 | CD82 molecule | 0.36 |
| SMIM12 | small integral membrane protein 12 | 0.36 |
| SLC25A39 | solute carrier family 25, member 39 | 0.35 |
| APOB | apolipoprotein B | 0.35 |
| PCDH1 | protocadherin 1 | 0.35 |
| ACP1 | acid phosphatase 1, soluble | 0.35 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.35 |
| TLE5 | TLE family member 5, transcriptional modulator | 0.35 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | 0.34 |
| CDCA4 | cell division cycle associated 4 | 0.34 |
| RFXANK | regulatory factor X-associated ankyrin-containing protein | 0.34 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 0.33 |
| HMGN4 | high mobility group nucleosomal binding domain 4 | 0.33 |
| MISP3 | MISP family member 3 | 0.33 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.33 |
| ERG28 | ergosterol biosynthesis 28 homolog | 0.33 |
| MYL12B | myosin, light chain 12B, regulatory | 0.33 |
| NDUFA10 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa | 0.32 |
| PPM1H | protein phosphatase, Mg2+/Mn2+ dependent, 1H | 0.32 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.32 |
| GPRC5C | G protein-coupled receptor, class C, group 5, member C | 0.32 |
| ARHGEF35 | Rho guanine nucleotide exchange factor (GEF) 35 | 0.32 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 0.32 |
| RAB6B | RAB6B, member RAS oncogene family | 0.32 |
| COTL1 | coactosin-like F-actin binding protein 1 | 0.32 |
| NOTCH3 | notch 3 | 0.32 |
| MPZL2 | myelin protein zero-like 2 | 0.32 |
| PTPN18 | protein tyrosine phosphatase, non-receptor type 18 (brain-derived) | 0.31 |
| RITA1 | RBPJ interacting and tubulin associated 1 | 0.31 |
| GPATCH3 | G patch domain containing 3 | 0.31 |
| DISP2 | dispatched homolog 2 (Drosophila) | 0.31 |
| KCTD21 | potassium channel tetramerization domain containing 21 | 0.3 |
| GEM | GTP binding protein overexpressed in skeletal muscle | 0.3 |
| ABLIM2 | actin binding LIM protein family, member 2 | 0.3 |
| NHP2 | NHP2 ribonucleoprotein | 0.3 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.3 |
| PIP | prolactin-induced protein | 0.29 |
| CRIP2 | cysteine-rich protein 2 | 0.29 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | 0.29 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.29 |
| BMP8A | bone morphogenetic protein 8a | 0.29 |
| IGSF8 | immunoglobulin superfamily, member 8 | 0.29 |
| BBS4 | Bardet-Biedl syndrome 4 | 0.29 |
| ANTXR2 | anthrax toxin receptor 2 | 0.29 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.29 |
| TRIM21 | tripartite motif containing 21 | 0.29 |
| ITGA7 | integrin, alpha 7 | 0.29 |
| AKTIP | AKT interacting protein | 0.28 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.28 |
| EIF1AX | eukaryotic translation initiation factor 1A, X-linked | 0.28 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | 0.28 |
| HSD17B8 | hydroxysteroid (17-beta) dehydrogenase 8 | 0.28 |
| ACTG1 | actin gamma 1 | 0.28 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | 0.28 |
| HSPA12B | heat shock 70kD protein 12B | 0.28 |
| VWA5A | von Willebrand factor A domain containing 5A | 0.28 |
| LOXL2 | lysyl oxidase-like 2 | 0.27 |
| EIF4E2 | eukaryotic translation initiation factor 4E family member 2 | 0.27 |
| DHRS1 | dehydrogenase/reductase (SDR family) member 1 | 0.27 |
| CCDC9B | coiled-coil domain containing 9B | 0.27 |
| AIF1L | allograft inflammatory factor 1-like | 0.27 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | 0.27 |
| CEP85L | centrosomal protein 85kDa-like | 0.27 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ANKRD24 | ankyrin repeat domain 24 | -2.03 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -1.67 |
| FGB | fibrinogen beta chain | -0.88 |
| ARL6IP6 | ADP-ribosylation factor-like 6 interacting protein 6 | -0.84 |
| MGLL | monoglyceride lipase | -0.74 |
| FSD1L | fibronectin type III and SPRY domain containing 1-like | -0.69 |
| PIGL | phosphatidylinositol glycan anchor biosynthesis, class L | -0.67 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.65 |
| COL7A1 | collagen, type VII, alpha 1 | -0.64 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.63 |
| SOX12 | SRY (sex determining region Y)-box 12 | -0.6 |
| SESN2 | sestrin 2 | -0.57 |
| NEB | nebulin | -0.54 |
| ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | -0.53 |
| ZFAND2A | zinc finger, AN1-type domain 2A | -0.53 |
| ZNF408 | zinc finger protein 408 | -0.52 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.52 |
| TMEM97 | transmembrane protein 97 | -0.51 |
| CCAR2 | cell cycle and apoptosis regulator 2 | -0.51 |
| UPP1 | uridine phosphorylase 1 | -0.5 |
| B4GALT2 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 | -0.5 |
| ZG16B | zymogen granule protein 16B | -0.5 |
| LAMA1 | laminin, alpha 1 | -0.48 |
| TMEM175 | transmembrane protein 175 | -0.47 |
| TRIB3 | tribbles pseudokinase 3 | -0.45 |
| NF1 | neurofibromin 1 | -0.44 |
| TPM4 | tropomyosin 4 | -0.44 |
| THAP9 | THAP domain containing 9 | -0.44 |
| OTC | ornithine carbamoyltransferase | -0.43 |
| ZNF561 | zinc finger protein 561 | -0.42 |
| SPIN4 | spindlin family, member 4 | -0.42 |
| TMEM64 | transmembrane protein 64 | -0.42 |
| YIF1A | Yip1 interacting factor homolog A (S. cerevisiae) | -0.42 |
| ORC3 | origin recognition complex, subunit 3 | -0.42 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.42 |
| TMEM67 | transmembrane protein 67 | -0.41 |
| SLC25A21 | solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 | -0.41 |
| FBXO31 | F-box protein 31 | -0.41 |
| NALCN | sodium leak channel, non selective | -0.41 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | -0.41 |
| GGACT | gamma-glutamylamine cyclotransferase | -0.4 |
| TOMM7 | translocase of outer mitochondrial membrane 7 homolog (yeast) | -0.4 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.4 |
| TOR2A | torsin family 2, member A | -0.39 |
| MEGF8 | multiple EGF-like-domains 8 | -0.39 |
| C19ORF44 | chromosome 19 open reading frame 44 | -0.38 |
| TBC1D32 | TBC1 domain family, member 32 | -0.37 |
| CCDC85B | coiled-coil domain containing 85B | -0.37 |
| KLHDC10 | kelch domain containing 10 | -0.37 |
| GSTA1 | glutathione S-transferase alpha 1 | -0.37 |
| ANKRD12 | ankyrin repeat domain 12 | -0.37 |
| ZNF706 | zinc finger protein 706 | -0.36 |
| GTPBP2 | GTP binding protein 2 | -0.36 |
| TSPAN14 | tetraspanin 14 | -0.36 |
| NIPA2 | non imprinted in Prader-Willi/Angelman syndrome 2 | -0.36 |
| SERF2 | small EDRK-rich factor 2 | -0.35 |
| GLRX2 | glutaredoxin 2 | -0.35 |
| CBR1 | carbonyl reductase 1 | -0.35 |
| FBXO44 | F-box protein 44 | -0.34 |
| PLEKHG4 | pleckstrin homology domain containing, family G (with RhoGef domain) member 4 | -0.34 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.34 |
| BOK | BCL2-related ovarian killer | -0.34 |
| SLC45A1 | solute carrier family 45, member 1 | -0.34 |
| MTFMT | mitochondrial methionyl-tRNA formyltransferase | -0.34 |
| BLOC1S3 | biogenesis of lysosomal organelles complex-1, subunit 3 | -0.34 |
| RNASE4 | ribonuclease, RNase A family, 4 | -0.33 |
| CHST3 | carbohydrate (chondroitin 6) sulfotransferase 3 | -0.33 |
| TRIM68 | tripartite motif containing 68 | -0.33 |
| SEPTIN7 | septin 7 | -0.33 |
| NUDT6 | nudix (nucleoside diphosphate linked moiety X)-type motif 6 | -0.33 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.33 |
| ZNF584 | zinc finger protein 584 | -0.33 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -0.33 |
| PDRG1 | p53 and DNA-damage regulated 1 | -0.33 |
| R3HDM4 | R3H domain containing 4 | -0.33 |
| RFT1 | RFT1 homolog (S. cerevisiae) | -0.33 |
| THBS2 | thrombospondin 2 | -0.32 |
| ADIPOR1 | adiponectin receptor 1 | -0.32 |
| CLN8 | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) | -0.32 |
| POP5 | processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) | -0.32 |
| MCOLN3 | mucolipin 3 | -0.32 |
| NKAPD1 | NKAP domain containing 1 | -0.32 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | -0.32 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | -0.32 |
| ZNF57 | zinc finger protein 57 | -0.32 |
| PLAUR | plasminogen activator, urokinase receptor | -0.32 |
| VCPKMT | valosin containing protein lysine (K) methyltransferase | -0.32 |
| FSTL1 | follistatin-like 1 | -0.31 |
| INHBA | inhibin, beta A | -0.31 |
| MCOLN1 | mucolipin 1 | -0.31 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.31 |
| FRS2 | fibroblast growth factor receptor substrate 2 | -0.31 |
| PPIE | peptidylprolyl isomerase E (cyclophilin E) | -0.31 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.31 |
| ZDHHC21 | zinc finger, DHHC-type containing 21 | -0.31 |
| LENG9 | leukocyte receptor cluster (LRC) member 9 | -0.31 |
| SPHK2 | sphingosine kinase 2 | -0.31 |
| NAAA | N-acylethanolamine acid amidase | -0.31 |
| ITPKB | inositol-trisphosphate 3-kinase B | -0.31 |
