| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Darinaparsin perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Darinaparsin_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.129849 |
| UBC | ubiquitin C | 0.0859686 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0859279 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0814911 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0796006 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0662875 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0607974 |
| MT2A | metallothionein 2A | 0.0570173 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0525421 |
| TMSB10 | thymosin beta 10 | 0.0522146 |
| FLNA | filamin A, alpha | 0.0517052 |
| TPM3 | tropomyosin 3 | 0.0515599 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0502655 |
| PTMA | prothymosin, alpha | 0.0495995 |
| ASPH | aspartate beta-hydroxylase | 0.0495505 |
| ENO1 | enolase 1, (alpha) | 0.0492196 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0482102 |
| CALR | calreticulin | 0.0472986 |
| SQSTM1 | sequestosome 1 | 0.0465827 |
| COL3A1 | collagen, type III, alpha 1 | 0.0459402 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0456252 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0449719 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0445607 |
| POTEF | POTE ankyrin domain family, member F | 0.04416 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0436582 |
| APP | amyloid beta (A4) precursor protein | 0.0421203 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0413376 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0409542 |
| PKM | pyruvate kinase, muscle | 0.0406974 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0406643 |
| TMSB4X | thymosin beta 4, X-linked | 0.040203 |
| MSN | moesin | 0.0401474 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0395879 |
| LDHA | lactate dehydrogenase A | 0.0388874 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0382915 |
| VIM | vimentin | 0.0379134 |
| AHNAK | AHNAK nucleoprotein | 0.0373423 |
| LMNA | lamin A/C | 0.0372314 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0369752 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0365231 |
| SET | SET nuclear proto-oncogene | 0.0361997 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0361692 |
| CENPF | centromere protein F, 350/400kDa | 0.0360134 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0351931 |
| NAV2 | neuron navigator 2 | 0.0351413 |
| SMAD3 | SMAD family member 3 | 0.0346026 |
| CDH13 | cadherin 13 | 0.0345889 |
| PLEC | plectin | 0.0343498 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0343049 |
| VCL | vinculin | 0.033934 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0339076 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0338671 |
| SP100 | SP100 nuclear antigen | 0.0331583 |
| RIGI | RNA sensor RIG-I | 0.0328098 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0326468 |
| B2M | beta-2-microglobulin | 0.0312205 |
| FSTL1 | follistatin-like 1 | 0.0311457 |
| CD44 | CD44 molecule (Indian blood group) | 0.030716 |
| RPS27A | ribosomal protein S27a | 0.0303404 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.030281 |
| RRM2 | ribonucleotide reductase M2 | 0.0300807 |
| PLAT | plasminogen activator, tissue | 0.0296514 |
| HDAC9 | histone deacetylase 9 | 0.0292616 |
| SON | SON DNA binding protein | 0.0286486 |
| INTS6 | integrator complex subunit 6 | 0.0285738 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0285469 |
| MCL1 | myeloid cell leukemia 1 | 0.0283963 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0279822 |
| RNF213 | ring finger protein 213 | 0.0279735 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0279578 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0279315 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0273261 |
| DSPP | dentin sialophosphoprotein | 0.0272624 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0270555 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.027053 |
| ANKRD11 | ankyrin repeat domain 11 | 0.027046 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0266846 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0264574 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0264558 |
| PRSS23 | protease, serine, 23 | 0.0260267 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0259306 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.025143 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.024699 |
| TPM4 | tropomyosin 4 | 0.0240081 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0237749 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0236122 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0234871 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0229581 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0228989 |
| ACTG1 | actin gamma 1 | 0.0228556 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0227227 |
| RPL23 | ribosomal protein L23 | 0.0225981 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0221588 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0218167 |
| COL5A2 | collagen, type V, alpha 2 | 0.0216028 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0215015 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0213766 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0212781 |
| FAT1 | FAT atypical cadherin 1 | 0.0211571 |
| ACTN1 | actinin, alpha 1 | 0.0211417 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.296894 |
| LOX | lysyl oxidase | -0.15201 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0859059 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0723616 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0660464 |
| PODXL | podocalyxin-like | -0.0600817 |
| THBS2 | thrombospondin 2 | -0.0569048 |
| NDRG1 | N-myc downstream regulated 1 | -0.0555706 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0537484 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0497455 |
| LOXL2 | lysyl oxidase-like 2 | -0.0467656 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0459651 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0434191 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0400506 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0395634 |
| MAP4 | microtubule-associated protein 4 | -0.0353847 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0346207 |
| FBN1 | fibrillin 1 | -0.0341981 |
| AUTS2 | autism susceptibility candidate 2 | -0.0340539 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0339355 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0320615 |
| FN1 | fibronectin 1 | -0.0316044 |
| COL1A2 | collagen, type I, alpha 2 | -0.0302642 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0290187 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.028847 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.028398 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0274485 |
| MYADM | myeloid-associated differentiation marker | -0.0273156 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0262677 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0252173 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0232844 |
| GOLGA4 | golgin A4 | -0.0232386 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.021014 |
| PRRX1 | paired related homeobox 1 | -0.0209349 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | -0.0207086 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0204865 |
| TAPBP | TAP binding protein (tapasin) | -0.0201772 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0196428 |
| VEGFC | vascular endothelial growth factor C | -0.0190949 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0190236 |
| CD109 | CD109 molecule | -0.0186606 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0179573 |
| EXOC6B | exocyst complex component 6B | -0.01787 |
| KIFAP3 | kinesin-associated protein 3 | -0.0178528 |
| VEGFA | vascular endothelial growth factor A | -0.0173627 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0172774 |
| LAMA5 | laminin, alpha 5 | -0.0172428 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0171715 |
| INSIG1 | insulin induced gene 1 | -0.0167322 |
| FRMD5 | FERM domain containing 5 | -0.0167175 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0166902 |
| EHBP1 | EH domain binding protein 1 | -0.0165288 |
| SUCNR1 | succinate receptor 1 | -0.0161776 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0151471 |
| SBF2 | SET binding factor 2 | -0.0150711 |
| YEATS2 | YEATS domain containing 2 | -0.014693 |
| C1D | C1D nuclear receptor corepressor | -0.0146802 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0146363 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0143742 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0143274 |
| MEIS2 | Meis homeobox 2 | -0.0140681 |
| ZBTB7C | zinc finger and BTB domain containing 7C | -0.0140318 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0139953 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0138115 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0137465 |
| NF1 | neurofibromin 1 | -0.0136987 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0136121 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0134019 |
| NGLY1 | N-glycanase 1 | -0.0131346 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.013125 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0130578 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0129117 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0128369 |
| ATP11B | ATPase, class VI, type 11B | -0.0127708 |
| BSG | basigin (Ok blood group) | -0.0123796 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.0123478 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0123075 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0121688 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.012131 |
| FNIP1 | folliculin interacting protein 1 | -0.0120498 |
| TMEM165 | transmembrane protein 165 | -0.0119684 |
| HIP1 | huntingtin interacting protein 1 | -0.0119308 |
| LMAN1 | lectin, mannose-binding, 1 | -0.011922 |
| PRKD1 | protein kinase D1 | -0.0118138 |
| RFX7 | regulatory factor X, 7 | -0.0117862 |
| POM121C | POM121 transmembrane nucleoporin C | -0.0117496 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | -0.0117106 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0116696 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0116436 |
| RCOR3 | REST corepressor 3 | -0.0116173 |
| LRRC49 | leucine rich repeat containing 49 | -0.0115366 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0114765 |
| MEF2D | myocyte enhancer factor 2D | -0.0111856 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0111666 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0111158 |
| HGSNAT | heparan-alpha-glucosaminide N-acetyltransferase | -0.0110843 |
| FNBP4 | formin binding protein 4 | -0.0110344 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0109642 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0107171 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0106447 |
