Darinaparsin_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Darinaparsin perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Darinaparsin_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.1997
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.174205
NAP1L1 nucleosome assembly protein 1-like 1 0.115683
PTMA prothymosin, alpha 0.0935149
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0897879
VIM vimentin 0.0896351
TPI1 triosephosphate isomerase 1 0.0889826
PDE4D phosphodiesterase 4D, cAMP-specific 0.0839748
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.082871
ASPH aspartate beta-hydroxylase 0.0743392
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0671859
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0641733
MYL12B myosin, light chain 12B, regulatory 0.062396
MACF1 microtubule-actin crosslinking factor 1 0.059903
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0598424
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0582318
IPO7 importin 7 0.0558598
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0557456
MMP12 matrix metallopeptidase 12 0.0542864
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0537472
TMEM41B transmembrane protein 41B 0.0537136
ERRFI1 ERBB receptor feedback inhibitor 1 0.0532701
NLGN1 neuroligin 1 0.0522737
TPT1 tumor protein, translationally-controlled 1 0.0513749
CALR calreticulin 0.0511668
RRM2 ribonucleotide reductase M2 0.0501168
ACTG1 actin gamma 1 0.0493996
TMSB10 thymosin beta 10 0.0492352
AKAP12 A kinase (PRKA) anchor protein 12 0.0483569
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0479509
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0476725
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0475994
IFIH1 interferon induced with helicase C domain 1 0.0475427
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.046165
MTAP methylthioadenosine phosphorylase 0.0441559
ENO1 enolase 1, (alpha) 0.044001
HMGA2 high mobility group AT-hook 2 0.0438409
AHNAK AHNAK nucleoprotein 0.0435703
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0435492
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0416102
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.041517
TBC1D5 TBC1 domain family, member 5 0.0413766
NHSL1 NHS-like 1 0.0409976
LMO7 LIM domain 7 0.0395558
ANXA1 annexin A1 0.0380998
GCG glucagon 0.0368712
WWOX WW domain containing oxidoreductase 0.0367747
EHBP1 EH domain binding protein 1 0.0362364
CANX calnexin 0.0358624
HSPA8 heat shock 70kDa protein 8 0.0357231
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0357061
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0356584
SPATS2 spermatogenesis associated, serine-rich 2 0.034429
SET SET nuclear proto-oncogene 0.0342916
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0342621
PGK1 phosphoglycerate kinase 1 0.0339378
RPS8 ribosomal protein S8 0.0332271
KDM3A lysine (K)-specific demethylase 3A 0.0328583
TAS2R14 taste receptor, type 2, member 14 0.0324252
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0323835
TPM3 tropomyosin 3 0.0320761
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0320042
MYH9 myosin, heavy chain 9, non-muscle 0.0318574
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.031395
TRIO trio Rho guanine nucleotide exchange factor 0.031316
RPS27A ribosomal protein S27a 0.0312831
LDHA lactate dehydrogenase A 0.0303372
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0295349
FGFR1 fibroblast growth factor receptor 1 0.0291823
CTNND1 catenin (cadherin-associated protein), delta 1 0.0291049
RPS3 ribosomal protein S3 0.0287486
YAP1 Yes-associated protein 1 0.0286911
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0285418
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0281514
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.028045
DSPP dentin sialophosphoprotein 0.0279723
NEBL nebulette 0.027865
EIF4A2 eukaryotic translation initiation factor 4A2 0.0273815
ZNF217 zinc finger protein 217 0.0273577
EIF4A1 eukaryotic translation initiation factor 4A1 0.027235
CHD4 chromodomain helicase DNA binding protein 4 0.0271853
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0268407
PDE4B phosphodiesterase 4B, cAMP-specific 0.0268139
TPM4 tropomyosin 4 0.0267203
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0265043
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0263973
SKP1 S-phase kinase-associated protein 1 0.0261915
LRMDA leucine rich melanocyte differentiation associated 0.0259042
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0250986
VCL vinculin 0.024385
KLF6 Kruppel-like factor 6 0.0241374
EZR ezrin 0.0240463
XPO1 exportin 1 0.0239149
PRDX1 peroxiredoxin 1 0.0238738
PCDH7 protocadherin 7 0.023778
CPNE1 copine I 0.0237717
SLC38A1 solute carrier family 38, member 1 0.0236213
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0236008
XPOT exportin, tRNA 0.0235497
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0235437

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.110954
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0678391
CCN2 cellular communication network factor 2 -0.0647352
SLC38A2 solute carrier family 38, member 2 -0.0546659
AREG amphiregulin -0.0527422
CCNL1 cyclin L1 -0.0464033
PCBP2 poly(rC) binding protein 2 -0.0462652
POTEF POTE ankyrin domain family, member F -0.0436946
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0427981
PFN1 profilin 1 -0.0422315
ATP5F1B ATP synthase F1 subunit beta -0.0421304
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0416604
BIRC3 baculoviral IAP repeat containing 3 -0.0406038
YBX1 Y box binding protein 1 -0.0387074
EGR1 early growth response 1 -0.0380987
TSC22D2 TSC22 domain family, member 2 -0.0338669
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0314788
ZBTB20 zinc finger and BTB domain containing 20 -0.0295656
PCM1 pericentriolar material 1 -0.029496
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0280512
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0275665
TXNRD1 thioredoxin reductase 1 -0.0268084
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.026675
FTH1 ferritin, heavy polypeptide 1 -0.0250507
AKAP9 A kinase (PRKA) anchor protein 9 -0.0248132
MEMO1 mediator of cell motility 1 -0.0234899
EEF1G eukaryotic translation elongation factor 1 gamma -0.0229807
ADAM17 ADAM metallopeptidase domain 17 -0.0228752
NCEH1 neutral cholesterol ester hydrolase 1 -0.022705
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0226832
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0221427
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0220413
ARL5B ADP-ribosylation factor-like 5B -0.0220367
RAB7A RAB7A, member RAS oncogene family -0.0217929
ECT2 epithelial cell transforming 2 -0.0213098
COPA coatomer protein complex, subunit alpha -0.0211735
CENPF centromere protein F, 350/400kDa -0.0208339
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0206637
RB1CC1 RB1-inducible coiled-coil 1 -0.0206116
PTMS parathymosin -0.0204321
WASF2 WAS protein family, member 2 -0.0199993
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.0194083
WNK1 WNK lysine deficient protein kinase 1 -0.019216
LRRC58 leucine rich repeat containing 58 -0.0188391
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0188194
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0187894
HLA-A major histocompatibility complex, class I, A -0.0186731
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0185773
ZNF207 zinc finger protein 207 -0.0184296
ATN1 atrophin 1 -0.0184218
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.018383
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0183323
RPL28 ribosomal protein L28 -0.0183208
CELF2 CUGBP, Elav-like family member 2 -0.0181759
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0181314
RPS6 ribosomal protein S6 -0.0175051
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0173785
LRP6 low density lipoprotein receptor-related protein 6 -0.0172996
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 -0.0172809
FOXM1 forkhead box M1 -0.0171452
PHC3 polyhomeotic homolog 3 (Drosophila) -0.0171064
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) -0.0168655
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.016738
PTEN phosphatase and tensin homolog -0.0165959
ETNK1 ethanolamine kinase 1 -0.016582
HMGA1 high mobility group AT-hook 1 -0.0161352
ADAM9 ADAM metallopeptidase domain 9 -0.0160001
EDN1 endothelin 1 -0.0159373
MON2 MON2 homolog (S. cerevisiae) -0.0158468
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.015734
ANKRD17 ankyrin repeat domain 17 -0.0157174
DDB2 damage-specific DNA binding protein 2, 48kDa -0.0155997
KLHL24 kelch-like family member 24 -0.0155161
TGM2 transglutaminase 2 -0.0153885
GARS1 glycyl-tRNA synthetase 1 -0.0152742
QKI QKI, KH domain containing, RNA binding -0.0152567
PUM2 pumilio RNA-binding family member 2 -0.0150873
RAP1B RAP1B, member of RAS oncogene family -0.0149678
KMT2D lysine (K)-specific methyltransferase 2D -0.0148126
RBMS2 RNA binding motif, single stranded interacting protein 2 -0.0147848
MEF2D myocyte enhancer factor 2D -0.0147783
RC3H1 ring finger and CCCH-type domains 1 -0.014664
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -0.0144365
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0144174
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) -0.0142734
AFTPH aftiphilin -0.0142356
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa -0.0140451
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0139547
NEGR1 neuronal growth regulator 1 -0.013858
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0137867
SCLT1 sodium channel and clathrin linker 1 -0.0137373
ATF7 activating transcription factor 7 -0.0137082
FER fer (fps/fes related) tyrosine kinase -0.0137005
STRN3 striatin, calmodulin binding protein 3 -0.0136837
SMC4 structural maintenance of chromosomes 4 -0.0135861
NABP1 nucleic acid binding protein 1 -0.0134722
RAB22A RAB22A, member RAS oncogene family -0.0134671
UBA1 ubiquitin-like modifier activating enzyme 1 -0.0132528
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0132504
ELP4 elongator acetyltransferase complex subunit 4 -0.013108