Darinaparsin_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Darinaparsin perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Darinaparsin_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.201756
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.117306
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.110766
INTS6 integrator complex subunit 6 0.0967737
SQSTM1 sequestosome 1 0.0689504
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0687587
SMAD3 SMAD family member 3 0.0637986
EFNB2 ephrin-B2 0.0550726
PLSCR2 phospholipid scramblase 2 0.0542743
ZSWIM6 zinc finger, SWIM-type containing 6 0.0456401
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0443211
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0425399
MYO1E myosin IE 0.0419656
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0411328
GCLC glutamate-cysteine ligase, catalytic subunit 0.0389755
TOX3 TOX high mobility group box family member 3 0.0379755
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0378112
KYNU kynureninase 0.036555
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0365194
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0358939
DST dystonin 0.0343038
DSPP dentin sialophosphoprotein 0.0312919
CATSPERB catsper channel auxiliary subunit beta 0.0304762
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0301664
FNIP2 folliculin interacting protein 2 0.0298048
POF1B premature ovarian failure, 1B 0.0286132
KLF5 Kruppel-like factor 5 (intestinal) 0.0284816
ERRFI1 ERBB receptor feedback inhibitor 1 0.0284735
LAMB3 laminin, beta 3 0.0281652
SHB Src homology 2 domain containing adaptor protein B 0.0275749
ANXA2 annexin A2 0.0271015
AHNAK AHNAK nucleoprotein 0.0270224
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.0265924
SP100 SP100 nuclear antigen 0.0252277
APOL1 apolipoprotein L, 1 0.0249897
VCL vinculin 0.0240906
CXCL8 chemokine (C-X-C motif) ligand 8 0.0235434
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0234682
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0234632
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 0.0232365
TLE4 transducin-like enhancer of split 4 0.0231731
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0231108
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.022902
SDC4 syndecan 4 0.0228694
UTRN utrophin 0.0227505
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0226079
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0225678
MYH9 myosin, heavy chain 9, non-muscle 0.0219566
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0217311
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0217023
H1-0 H1.0 linker histone 0.0216062
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0210853
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0209355
NCOA7 nuclear receptor coactivator 7 0.0209046
MUC20 mucin 20, cell surface associated 0.0206645
HKDC1 hexokinase domain containing 1 0.0204562
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0197105
PRELID2 PRELI domain containing 2 0.0196379
CAPN8 calpain 8 0.0193118
DUSP10 dual specificity phosphatase 10 0.0191622
EREG epiregulin 0.0190182
NABP1 nucleic acid binding protein 1 0.0189902
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.01856
LPP LIM domain containing preferred translocation partner in lipoma 0.0182286
MEIS2 Meis homeobox 2 0.0180652
EZR ezrin 0.0178683
AREG amphiregulin 0.0175796
RDH10 retinol dehydrogenase 10 (all-trans) 0.0174705
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0172648
DPP4 dipeptidyl-peptidase 4 0.0168895
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0168388
DOCK1 dedicator of cytokinesis 1 0.0167165
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0165659
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.0163631
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0160493
ASPH aspartate beta-hydroxylase 0.0156836
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0156063
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0154911
TRIM2 tripartite motif containing 2 0.0154554
PDLIM5 PDZ and LIM domain 5 0.0153008
APLP2 amyloid beta (A4) precursor-like protein 2 0.0152804
RNF213 ring finger protein 213 0.015259
PDZD8 PDZ domain containing 8 0.0151091
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.0149299
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0148942
STX3 syntaxin 3 0.0148729
KRT23 keratin 23, type I 0.0148295
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 0.0147485
CEMIP cell migration inducing protein, hyaluronan binding 0.0147371
HOMER1 homer scaffolding protein 1 0.0145802
CCDC146 coiled-coil domain containing 146 0.014512
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae) 0.0144698
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0143339
NPSR1 neuropeptide S receptor 1 0.0141551
LURAP1L leucine rich adaptor protein 1-like 0.0141476
CFLAR CASP8 and FADD-like apoptosis regulator 0.0140261
ZNF518A zinc finger protein 518A 0.0139558
ANKRD10 ankyrin repeat domain 10 0.0139236
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0136556
SLC38A2 solute carrier family 38, member 2 0.0136455

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.136706
EPSTI1 epithelial stromal interaction 1 (breast) -0.113761
LYZ lysozyme -0.107312
TPT1 tumor protein, translationally-controlled 1 -0.106565
PTMA prothymosin, alpha -0.0921637
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0913352
LCN2 lipocalin 2 -0.0697244
RPS6 ribosomal protein S6 -0.066635
HLA-B major histocompatibility complex, class I, B -0.0663241
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.06378
RPL35A ribosomal protein L35a -0.0604419
FTL ferritin, light polypeptide -0.0600331
RPL23 ribosomal protein L23 -0.0579403
ZMYND8 zinc finger, MYND-type containing 8 -0.0568017
TMSB10 thymosin beta 10 -0.0533665
RABGAP1L RAB GTPase activating protein 1-like -0.0531857
C6ORF132 chromosome 6 open reading frame 132 -0.052282
TXNIP thioredoxin interacting protein -0.0507985
IFI27 interferon, alpha-inducible protein 27 -0.0483874
EGR1 early growth response 1 -0.0475932
POTEF POTE ankyrin domain family, member F -0.0460204
SPATA13 spermatogenesis associated 13 -0.0436885
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0434707
BCLAF1 BCL2-associated transcription factor 1 -0.0432178
NDRG1 N-myc downstream regulated 1 -0.042378
IFI6 interferon, alpha-inducible protein 6 -0.0411411
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0389278
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0367431
MX1 MX dynamin-like GTPase 1 -0.0365398
EIF1 eukaryotic translation initiation factor 1 -0.0363856
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0356883
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0352292
HLA-A major histocompatibility complex, class I, A -0.0349391
RPL34 ribosomal protein L34 -0.0344842
RPL19 ribosomal protein L19 -0.0336947
RPLP1 ribosomal protein, large, P1 -0.0330696
RPS19 ribosomal protein S19 -0.0329061
RPS8 ribosomal protein S8 -0.0326893
UFM1 ubiquitin-fold modifier 1 -0.0325701
MT2A metallothionein 2A -0.0321185
RPS27 ribosomal protein S27 -0.0321182
COG6 component of oligomeric golgi complex 6 -0.031894
CCNL1 cyclin L1 -0.0318758
HM13 histocompatibility (minor) 13 -0.0318353
MPHOSPH8 M-phase phosphoprotein 8 -0.0318311
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0314031
OARD1 O-acyl-ADP-ribose deacylase 1 -0.0306919
PMP22 peripheral myelin protein 22 -0.0306493
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0303737
RPL31 ribosomal protein L31 -0.0300781
SRRM2 serine/arginine repetitive matrix 2 -0.0296239
EPHB2 EPH receptor B2 -0.0291514
AHI1 Abelson helper integration site 1 -0.0288211
SLC38A1 solute carrier family 38, member 1 -0.0287733
PTEN phosphatase and tensin homolog -0.0281001
RPL26 ribosomal protein L26 -0.0279034
RAB6A RAB6A, member RAS oncogene family -0.0276315
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0275363
ZBTB20 zinc finger and BTB domain containing 20 -0.0274775
S100A6 S100 calcium binding protein A6 -0.0273181
AKAP9 A kinase (PRKA) anchor protein 9 -0.0272387
SCARB1 scavenger receptor class B, member 1 -0.0271036
BTBD9 BTB (POZ) domain containing 9 -0.0270512
FTH1 ferritin, heavy polypeptide 1 -0.0269261
VEGFA vascular endothelial growth factor A -0.0267085
TNS4 tensin 4 -0.0265199
NF1 neurofibromin 1 -0.0261922
S100A9 S100 calcium binding protein A9 -0.0261816
RPL9 ribosomal protein L9 -0.0260919
MAP7 microtubule-associated protein 7 -0.026075
PRRC2C proline-rich coiled-coil 2C -0.0260505
IFITM3 interferon induced transmembrane protein 3 -0.0259456
RPS24 ribosomal protein S24 -0.0258761
ACBD3 acyl-CoA binding domain containing 3 -0.0257549
RPL11 ribosomal protein L11 -0.0257315
ANKRD11 ankyrin repeat domain 11 -0.0254124
RPS12 ribosomal protein S12 -0.0252855
TMC5 transmembrane channel-like 5 -0.0252255
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0250664
TAOK3 TAO kinase 3 -0.0249947
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0248119
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0246418
RBM26 RNA binding motif protein 26 -0.0245154
IGFBP3 insulin-like growth factor binding protein 3 -0.0245102
RPS29 ribosomal protein S29 -0.0245035
RHOBTB3 Rho-related BTB domain containing 3 -0.0243728
MON2 MON2 homolog (S. cerevisiae) -0.0243386
RPS3 ribosomal protein S3 -0.0242449
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0241005
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0240858
ZNF207 zinc finger protein 207 -0.024038
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0240256
ZNF609 zinc finger protein 609 -0.0236121
ISG15 ISG15 ubiquitin-like modifier -0.0235256
ATF4 activating transcription factor 4 -0.0234171
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0232679
CD46 CD46 molecule, complement regulatory protein -0.0231193
TMEM165 transmembrane protein 165 -0.0226576
MED13L mediator complex subunit 13-like -0.0226546
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0226507