| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Darinaparsin perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Darinaparsin_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.118389 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.117827 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.110541 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0993815 |
| MT2A | metallothionein 2A | 0.0666893 |
| STC1 | stanniocalcin 1 | 0.0605864 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.054872 |
| INHBA | inhibin, beta A | 0.0512622 |
| IER3 | immediate early response 3 | 0.0462657 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0458648 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.044437 |
| ASPH | aspartate beta-hydroxylase | 0.0443666 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0430281 |
| LDHA | lactate dehydrogenase A | 0.0417864 |
| ENO1 | enolase 1, (alpha) | 0.0415928 |
| VCL | vinculin | 0.039316 |
| CAVIN1 | caveolae associated protein 1 | 0.0388345 |
| CALR | calreticulin | 0.0377054 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0371518 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0363704 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0356284 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0348616 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0345642 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0344573 |
| PLEC | plectin | 0.0344003 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0315395 |
| CANX | calnexin | 0.0311932 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.031158 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0311518 |
| TMSB4X | thymosin beta 4, X-linked | 0.0310064 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0297984 |
| ANGPTL4 | angiopoietin-like 4 | 0.0282052 |
| ACTG1 | actin gamma 1 | 0.0253793 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0247693 |
| HLA-B | major histocompatibility complex, class I, B | 0.0246652 |
| RIGI | RNA sensor RIG-I | 0.0246251 |
| SQSTM1 | sequestosome 1 | 0.0243777 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.024366 |
| RPL26 | ribosomal protein L26 | 0.0236455 |
| RACK1 | receptor for activated C kinase 1 | 0.0227044 |
| KLF6 | Kruppel-like factor 6 | 0.0223689 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0220892 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0217487 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.0212395 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.020936 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0209304 |
| RPL30 | ribosomal protein L30 | 0.0209007 |
| SP100 | SP100 nuclear antigen | 0.0204368 |
| APP | amyloid beta (A4) precursor protein | 0.0203194 |
| RPS8 | ribosomal protein S8 | 0.0201491 |
| PALLD | palladin, cytoskeletal associated protein | 0.0200349 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0199872 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0196464 |
| CNTN5 | contactin 5 | 0.0195793 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0194294 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0193533 |
| B2M | beta-2-microglobulin | 0.0192473 |
| RPS12 | ribosomal protein S12 | 0.0190037 |
| HDAC9 | histone deacetylase 9 | 0.0189023 |
| COL3A1 | collagen, type III, alpha 1 | 0.0184269 |
| RPS3 | ribosomal protein S3 | 0.0183417 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0182659 |
| TBX3 | T-box 3 | 0.0181536 |
| IL6ST | interleukin 6 signal transducer | 0.0178936 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0177967 |
| TMSB10 | thymosin beta 10 | 0.0177266 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0177234 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0176576 |
| LAMC2 | laminin, gamma 2 | 0.0176094 |
| INTS6 | integrator complex subunit 6 | 0.0175903 |
| TPM4 | tropomyosin 4 | 0.0175846 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.0175505 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0174999 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0172197 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0171675 |
| RPL12 | ribosomal protein L12 | 0.0171613 |
| RPL34 | ribosomal protein L34 | 0.0171266 |
| RPL37A | ribosomal protein L37a | 0.0170738 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.0170117 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0169312 |
| HLA-E | major histocompatibility complex, class I, E | 0.0168857 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0167222 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0164949 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0161071 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | 0.015927 |
| IER2 | immediate early response 2 | 0.0157777 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0155461 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0154642 |
| CTSB | cathepsin B | 0.015355 |
| RSU1 | Ras suppressor protein 1 | 0.0153221 |
| RPS24 | ribosomal protein S24 | 0.0151707 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0150632 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0149953 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0148447 |
| RPL13A | ribosomal protein L13a | 0.0148328 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | 0.0147283 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0146085 |
| DUSP6 | dual specificity phosphatase 6 | 0.0145881 |
| AHNAK | AHNAK nucleoprotein | 0.0143952 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0142973 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.228754 |
| NDRG1 | N-myc downstream regulated 1 | -0.189896 |
| CADM1 | cell adhesion molecule 1 | -0.142383 |
| VEGFA | vascular endothelial growth factor A | -0.0994581 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0986941 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0792219 |
| PDE10A | phosphodiesterase 10A | -0.0770039 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0731024 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0730137 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0623832 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.053007 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0508849 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0494899 |
| PTK2 | protein tyrosine kinase 2 | -0.0492083 |
| GOLGA4 | golgin A4 | -0.0481152 |
| QKI | QKI, KH domain containing, RNA binding | -0.0466597 |
| COL6A3 | collagen, type VI, alpha 3 | -0.045863 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.045561 |
| ATP13A3 | ATPase type 13A3 | -0.0430528 |
| COL5A1 | collagen, type V, alpha 1 | -0.0422807 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0416927 |
| ZNF292 | zinc finger protein 292 | -0.0406725 |
| TRAM1 | translocation associated membrane protein 1 | -0.0393228 |
| RUNX1 | runt-related transcription factor 1 | -0.0383937 |
| RBM39 | RNA binding motif protein 39 | -0.0377515 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0370513 |
| CD109 | CD109 molecule | -0.0369084 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0366929 |
| TMEM165 | transmembrane protein 165 | -0.0364808 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.035864 |
| USP3 | ubiquitin specific peptidase 3 | -0.0352373 |
| COPA | coatomer protein complex, subunit alpha | -0.0328578 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0326026 |
| KIF13A | kinesin family member 13A | -0.0325321 |
| TFG | TRK-fused gene | -0.0323915 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0317046 |
| NOTCH2 | notch 2 | -0.0314824 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0313872 |
| CDH13 | cadherin 13 | -0.0310536 |
| MATR3 | matrin 3 | -0.0308046 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0303323 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0292842 |
| SBF2 | SET binding factor 2 | -0.0292382 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.02863 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0283077 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0282843 |
| RLF | rearranged L-myc fusion | -0.0281107 |
| CCNL1 | cyclin L1 | -0.027767 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0276996 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0273521 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0273124 |
| TBC1D23 | TBC1 domain family, member 23 | -0.0270297 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.027026 |
| HELZ | helicase with zinc finger | -0.026865 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0265842 |
| CD44 | CD44 molecule (Indian blood group) | -0.0265714 |
| EGFR | epidermal growth factor receptor | -0.0264033 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0263736 |
| CABIN1 | calcineurin binding protein 1 | -0.0263432 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0261564 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0261562 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0259904 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0258918 |
| PDE8A | phosphodiesterase 8A | -0.0258561 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0257856 |
| RNF145 | ring finger protein 145 | -0.0253479 |
| NBAS | neuroblastoma amplified sequence | -0.0252018 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0251632 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0251228 |
| TENT4A | terminal nucleotidyltransferase 4A | -0.0249075 |
| PTEN | phosphatase and tensin homolog | -0.0247359 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0247033 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0245919 |
| SETD5 | SET domain containing 5 | -0.0244858 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0244408 |
| ATP11B | ATPase, class VI, type 11B | -0.0243625 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | -0.0242985 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0240966 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0237929 |
| PCBP2 | poly(rC) binding protein 2 | -0.0235616 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0234906 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0233411 |
| VEGFC | vascular endothelial growth factor C | -0.0231193 |
| COL6A1 | collagen, type VI, alpha 1 | -0.023105 |
| PARD3 | par-3 family cell polarity regulator | -0.0230513 |
| ZNF207 | zinc finger protein 207 | -0.0230398 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0230126 |
| ACTN4 | actinin, alpha 4 | -0.0226513 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0226046 |
| MYO9B | myosin IXB | -0.0223753 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0222637 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0222589 |
| SRPK2 | SRSF protein kinase 2 | -0.0221992 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0221982 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0221365 |
| ARF4 | ADP-ribosylation factor 4 | -0.0220852 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | -0.0219279 |
| PRR16 | proline rich 16 | -0.0218618 |
| SPAG9 | sperm associated antigen 9 | -0.0217283 |
| LAMA5 | laminin, alpha 5 | -0.021586 |
