| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Darinaparsin perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Darinaparsin_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.347314 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.10279 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0979013 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.079244 |
| MT2A | metallothionein 2A | 0.0790988 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0727821 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0621104 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0525396 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0491158 |
| KYNU | kynureninase | 0.0430487 |
| DTNA | dystrobrevin, alpha | 0.0424391 |
| PLIN2 | perilipin 2 | 0.0417458 |
| ATXN1 | ataxin 1 | 0.0351744 |
| RPLP0 | ribosomal protein, large, P0 | 0.0286179 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0285902 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0277762 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0275652 |
| FTL | ferritin, light polypeptide | 0.0275265 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0263829 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0261319 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0255763 |
| INTS6 | integrator complex subunit 6 | 0.0251352 |
| SVIL | supervillin | 0.0247094 |
| GPC6 | glypican 6 | 0.0245555 |
| MYO1B | myosin IB | 0.024329 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0233436 |
| ASPH | aspartate beta-hydroxylase | 0.0232208 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0226085 |
| DSPP | dentin sialophosphoprotein | 0.0223718 |
| KIAA1217 | KIAA1217 | 0.0221035 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0220659 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0214938 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0207444 |
| KIF21A | kinesin family member 21A | 0.0207244 |
| DUSP16 | dual specificity phosphatase 16 | 0.0202941 |
| RDX | radixin | 0.020125 |
| BBX | bobby sox homolog (Drosophila) | 0.0184295 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0179914 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.0174019 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0165442 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0165057 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0164955 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.01648 |
| DST | dystonin | 0.0161127 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0156953 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0156423 |
| TENM1 | teneurin transmembrane protein 1 | 0.0154065 |
| CCDC88A | coiled-coil domain containing 88A | 0.0150236 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0149092 |
| FRMD5 | FERM domain containing 5 | 0.0148025 |
| ANXA5 | annexin A5 | 0.0143328 |
| MT1X | metallothionein 1X | 0.0143101 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0141151 |
| SNX13 | sorting nexin 13 | 0.0140074 |
| RPS2 | ribosomal protein S2 | 0.0139935 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0136487 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0135863 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0135358 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0134096 |
| RAD51B | RAD51 paralog B | 0.0132024 |
| GPATCH2L | G patch domain containing 2-like | 0.0131313 |
| VCAN | versican | 0.0131164 |
| FHIT | fragile histidine triad | 0.0129926 |
| SEC62 | SEC62 homolog (S. cerevisiae) | 0.0129047 |
| KLF10 | Kruppel-like factor 10 | 0.0128984 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0128842 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0128391 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0127208 |
| TBC1D23 | TBC1 domain family, member 23 | 0.0127151 |
| RPS5 | ribosomal protein S5 | 0.0126173 |
| ERLIN1 | ER lipid raft associated 1 | 0.0125625 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | 0.0124611 |
| PALLD | palladin, cytoskeletal associated protein | 0.0124003 |
| GPR39 | G protein-coupled receptor 39 | 0.012276 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0122301 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0122193 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0121034 |
| UGT2B7 | UDP glucuronosyltransferase 2 family, polypeptide B7 | 0.0120722 |
| MT1E | metallothionein 1E | 0.0119795 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0119782 |
| CAPRIN2 | caprin family member 2 | 0.0119405 |
| YAP1 | Yes-associated protein 1 | 0.0118224 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0118187 |
| FOSL2 | FOS-like antigen 2 | 0.0118176 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | 0.0117721 |
| INSIG2 | insulin induced gene 2 | 0.0117559 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0117438 |
| FERMT2 | fermitin family member 2 | 0.0117405 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.01174 |
| FAM13A | family with sequence similarity 13, member A | 0.0117205 |
| FAM117B | family with sequence similarity 117, member B | 0.0116803 |
| VIM | vimentin | 0.0116622 |
| RPL27 | ribosomal protein L27 | 0.0114499 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0114031 |
| SERTAD2 | SERTA domain containing 2 | 0.0113909 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0113798 |
| STK38L | serine/threonine kinase 38 like | 0.0113651 |
| WWOX | WW domain containing oxidoreductase | 0.011342 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0113223 |
| SNX14 | sorting nexin 14 | 0.0111542 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.314237 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.150603 |
| FN1 | fibronectin 1 | -0.120716 |
| APOB | apolipoprotein B | -0.117168 |
| C3 | complement component 3 | -0.114178 |
| GPC3 | glypican 3 | -0.0922862 |
| RPS27A | ribosomal protein S27a | -0.0822004 |
| UBC | ubiquitin C | -0.0816797 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.077712 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0753114 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.07171 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.067559 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0626425 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0578915 |
| TRIM26 | tripartite motif containing 26 | -0.0563557 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0535695 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0532767 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0528407 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0512492 |
| ENO1 | enolase 1, (alpha) | -0.0511015 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0499428 |
| TMEM123 | transmembrane protein 123 | -0.049449 |
| RBM39 | RNA binding motif protein 39 | -0.0484998 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0478151 |
| JMJD1C | jumonji domain containing 1C | -0.0467334 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0460155 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0458001 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0446795 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0445898 |
| CFB | complement factor B | -0.0438559 |
| A2M | alpha-2-macroglobulin | -0.0422833 |
| RPS12 | ribosomal protein S12 | -0.041718 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0412615 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0411505 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0410508 |
| VMP1 | vacuole membrane protein 1 | -0.0407845 |
| RPL37A | ribosomal protein L37a | -0.0399498 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0392723 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.038956 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0382817 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0382137 |
| TF | transferrin | -0.0381462 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0380162 |
| PCBP2 | poly(rC) binding protein 2 | -0.037785 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | -0.0376821 |
| ITGA1 | integrin, alpha 1 | -0.0375701 |
| PEG10 | paternally expressed 10 | -0.036555 |
| KIF5B | kinesin family member 5B | -0.03643 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0362332 |
| RPL23 | ribosomal protein L23 | -0.0354243 |
| RPS3 | ribosomal protein S3 | -0.0351892 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0346644 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0330428 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0329451 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0327027 |
| RUNX1 | runt-related transcription factor 1 | -0.0326193 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0326092 |
| SESTD1 | SEC14 and spectrin domains 1 | -0.0325862 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0317917 |
| DSCAM | Down syndrome cell adhesion molecule | -0.031778 |
| APOE | apolipoprotein E | -0.0314155 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0313064 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0311037 |
| RPS24 | ribosomal protein S24 | -0.031018 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.0305654 |
| LDHA | lactate dehydrogenase A | -0.0304652 |
| DENND4A | DENN/MADD domain containing 4A | -0.0302153 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0300886 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0300401 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0300205 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0297993 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0296859 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0296711 |
| SELENOP | selenoprotein P | -0.0296652 |
| FLNB | filamin B, beta | -0.0290139 |
| MCL1 | myeloid cell leukemia 1 | -0.028989 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0286265 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0284902 |
| SMAD3 | SMAD family member 3 | -0.0284489 |
| ABI1 | abl-interactor 1 | -0.0277213 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0273427 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0272002 |
| PERP | PERP, TP53 apoptosis effector | -0.0268799 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.0267292 |
| LYZ | lysozyme | -0.0266187 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0265921 |
| RPL11 | ribosomal protein L11 | -0.0264962 |
| ARHGAP9 | Rho GTPase activating protein 9 | -0.0264351 |
| JUN | jun proto-oncogene | -0.0263932 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0263559 |
| EHBP1 | EH domain binding protein 1 | -0.0262404 |
| SET | SET nuclear proto-oncogene | -0.0261629 |
| MYO6 | myosin VI | -0.0255643 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0253651 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.025233 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0252208 |
| RPS17 | ribosomal protein S17 | -0.0251352 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0245214 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.024509 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0243875 |
