| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Darinaparsin perturbation in KATO III cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Darinaparsin_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.225458 |
| FGFR2 | fibroblast growth factor receptor 2 | 0.201989 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.201528 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.100712 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0792163 |
| PTMA | prothymosin, alpha | 0.0665406 |
| PGK1 | phosphoglycerate kinase 1 | 0.0648123 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.062784 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0611215 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0594693 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0578133 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0576691 |
| B2M | beta-2-microglobulin | 0.0563462 |
| EHBP1 | EH domain binding protein 1 | 0.0525895 |
| RPS8 | ribosomal protein S8 | 0.0490577 |
| KRT18 | keratin 18, type I | 0.0488609 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0484183 |
| ENO1 | enolase 1, (alpha) | 0.0473273 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.046601 |
| FTL | ferritin, light polypeptide | 0.0465226 |
| TMSB4X | thymosin beta 4, X-linked | 0.0459157 |
| HYOU1 | hypoxia up-regulated 1 | 0.0448297 |
| CALR | calreticulin | 0.0446958 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0439048 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0438848 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0430775 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0426755 |
| HLA-E | major histocompatibility complex, class I, E | 0.0418639 |
| RPS25 | ribosomal protein S25 | 0.0417112 |
| RPL26 | ribosomal protein L26 | 0.0397533 |
| RPL37A | ribosomal protein L37a | 0.0391422 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0389804 |
| CANX | calnexin | 0.0378239 |
| LCN2 | lipocalin 2 | 0.037494 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0372452 |
| ANXA1 | annexin A1 | 0.0362805 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0360858 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0356446 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0333085 |
| RPS27A | ribosomal protein S27a | 0.0331911 |
| AGR2 | anterior gradient 2 | 0.0321152 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0310827 |
| HKDC1 | hexokinase domain containing 1 | 0.0301985 |
| FRMD5 | FERM domain containing 5 | 0.0300406 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0294931 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0289857 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0287749 |
| HLA-A | major histocompatibility complex, class I, A | 0.0285987 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0285376 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.028415 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0280086 |
| RPL19 | ribosomal protein L19 | 0.0270584 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0270276 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0267602 |
| RPS12 | ribosomal protein S12 | 0.0267336 |
| RPS3 | ribosomal protein S3 | 0.0261941 |
| SRPRA | SRP receptor subunit alpha | 0.0256886 |
| FAM13A | family with sequence similarity 13, member A | 0.0252517 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0250757 |
| TPI1 | triosephosphate isomerase 1 | 0.0244452 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0244403 |
| XPOT | exportin, tRNA | 0.0243093 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0241946 |
| RPL7A | ribosomal protein L7a | 0.0241673 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0239193 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0238653 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0236522 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0235329 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | 0.0234885 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0234034 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0232046 |
| RPL35A | ribosomal protein L35a | 0.0230138 |
| TNIK | TRAF2 and NCK interacting kinase | 0.0228149 |
| ATF5 | activating transcription factor 5 | 0.022601 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0222718 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0221436 |
| ZFHX3 | zinc finger homeobox 3 | 0.0220028 |
| TMSB10 | thymosin beta 10 | 0.02182 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0217399 |
| RPL13A | ribosomal protein L13a | 0.0215753 |
| RPS17 | ribosomal protein S17 | 0.0215584 |
| CDK13 | cyclin-dependent kinase 13 | 0.0211253 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.0211149 |
| RPL38 | ribosomal protein L38 | 0.0211135 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0209447 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0205977 |
| RPL34 | ribosomal protein L34 | 0.0205218 |
| EPCAM | epithelial cell adhesion molecule | 0.0204616 |
| CCNY | cyclin Y | 0.0204064 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0203964 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0203644 |
| KLHL29 | kelch-like family member 29 | 0.0202359 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0202355 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0202219 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0198807 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0196855 |
| RPS11 | ribosomal protein S11 | 0.0196265 |
| RPS16 | ribosomal protein S16 | 0.0194919 |
| MANF | mesencephalic astrocyte-derived neurotrophic factor | 0.0194832 |
| SERINC1 | serine incorporator 1 | 0.0192417 |
| Symbol | Name | Standardized Value |
|---|---|---|
| POTEF | POTE ankyrin domain family, member F | -0.178619 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.110552 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0741777 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0648048 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0595926 |
| ANXA2 | annexin A2 | -0.0557788 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0554049 |
| ITGB4 | integrin, beta 4 | -0.0541992 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0534809 |
| MKI67 | marker of proliferation Ki-67 | -0.0534454 |
| ACTN4 | actinin, alpha 4 | -0.0524862 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0515453 |
| RBM39 | RNA binding motif protein 39 | -0.0489559 |
| MUC17 | mucin 17, cell surface associated | -0.0489439 |
| HMGA1 | high mobility group AT-hook 1 | -0.0481121 |
| ECT2 | epithelial cell transforming 2 | -0.0479778 |
| CLDN4 | claudin 4 | -0.0478752 |
| BCL2L1 | BCL2-like 1 | -0.0456428 |
| TXNRD1 | thioredoxin reductase 1 | -0.0443443 |
| NPSR1 | neuropeptide S receptor 1 | -0.0439885 |
| PRSS3 | protease, serine, 3 | -0.0438881 |
| JUP | junction plakoglobin | -0.0415177 |
| CENPF | centromere protein F, 350/400kDa | -0.0409025 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0405854 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0403641 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0388855 |
| VMP1 | vacuole membrane protein 1 | -0.0384871 |
| PCBP2 | poly(rC) binding protein 2 | -0.0381267 |
| ANXA11 | annexin A11 | -0.0379445 |
| CCNL1 | cyclin L1 | -0.0374465 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0371428 |
| SEPTIN9 | septin 9 | -0.0367205 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.0365365 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0351896 |
| FLNB | filamin B, beta | -0.0349629 |
| WWC1 | WW and C2 domain containing 1 | -0.0341871 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0337897 |
| MYOF | myoferlin | -0.0337014 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0336601 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.03316 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.0331209 |
| TNRC18 | trinucleotide repeat containing 18 | -0.0328236 |
| LYZ | lysozyme | -0.0327754 |
| DIAPH3 | diaphanous-related formin 3 | -0.0314753 |
| MUC1 | mucin 1, cell surface associated | -0.03147 |
| ANLN | anillin, actin binding protein | -0.0314107 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0308039 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0306242 |
| VEGFA | vascular endothelial growth factor A | -0.0305495 |
| CBX3 | chromobox homolog 3 | -0.0305399 |
| EZR | ezrin | -0.0304909 |
| SNX9 | sorting nexin 9 | -0.0302308 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | -0.029574 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0294065 |
| LAMA5 | laminin, alpha 5 | -0.0291976 |
| PTEN | phosphatase and tensin homolog | -0.0284768 |
| FASN | fatty acid synthase | -0.028339 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0279951 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0279552 |
| SH3RF1 | SH3 domain containing ring finger 1 | -0.0275154 |
| COBL | cordon-bleu WH2 repeat protein | -0.0271702 |
| TPX2 | TPX2, microtubule-associated | -0.0268894 |
| KRT19 | keratin 19, type I | -0.0266519 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0262362 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0261232 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0255746 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | -0.025382 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | -0.0253744 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | -0.025246 |
| ARHGAP42 | Rho GTPase activating protein 42 | -0.0252028 |
| TRAK1 | trafficking protein, kinesin binding 1 | -0.0250153 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0249032 |
| TRIM31 | tripartite motif containing 31 | -0.0248616 |
| GPX2 | glutathione peroxidase 2 | -0.0248064 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0246827 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0246089 |
| CLDN7 | claudin 7 | -0.0242254 |
| CAPN8 | calpain 8 | -0.024214 |
| PFN1 | profilin 1 | -0.0237065 |
| LCOR | ligand dependent nuclear receptor corepressor | -0.0236919 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0235751 |
| CHKA | choline kinase alpha | -0.0235721 |
| ETNK1 | ethanolamine kinase 1 | -0.023511 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0234017 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0233581 |
| ARF4 | ADP-ribosylation factor 4 | -0.0233129 |
| PHIP | pleckstrin homology domain interacting protein | -0.0230542 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0230505 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | -0.0229209 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0228101 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0228054 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0225572 |
| ZNF207 | zinc finger protein 207 | -0.0225421 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0224526 |
| ATXN1 | ataxin 1 | -0.0223583 |
| MYO1D | myosin ID | -0.0223352 |
| CLTC | clathrin, heavy chain (Hc) | -0.0221428 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0219377 |
| ATP11A | ATPase, class VI, type 11A | -0.0218778 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0218538 |
