| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Darinaparsin perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Darinaparsin_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LAMC2 | laminin, gamma 2 | 0.129032 |
| SLTM | SAFB-like, transcription modulator | 0.122201 |
| LAMA4 | laminin, alpha 4 | 0.100299 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0964103 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.08947 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0727378 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0650586 |
| TOP1 | topoisomerase (DNA) I | 0.0631523 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0616781 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0600799 |
| VCL | vinculin | 0.0592067 |
| LMO7 | LIM domain 7 | 0.0581869 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0557769 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0524633 |
| NABP1 | nucleic acid binding protein 1 | 0.0524108 |
| AREG | amphiregulin | 0.0522726 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0476471 |
| OSMR | oncostatin M receptor | 0.0445479 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0433559 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0408151 |
| GRAMD1B | GRAM domain containing 1B | 0.0398818 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0385301 |
| AGO2 | argonaute RISC catalytic component 2 | 0.038254 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0377489 |
| STC1 | stanniocalcin 1 | 0.0357247 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0356788 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0352523 |
| BMP6 | bone morphogenetic protein 6 | 0.0351415 |
| LAMB3 | laminin, beta 3 | 0.0349122 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0347222 |
| KIAA1217 | KIAA1217 | 0.034264 |
| PM20D1 | peptidase M20 domain containing 1 | 0.033603 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0333912 |
| PLEC | plectin | 0.0333881 |
| RTN4 | reticulon 4 | 0.033349 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0333309 |
| MCL1 | myeloid cell leukemia 1 | 0.0331175 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0329554 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0326681 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0316666 |
| UBR1 | ubiquitin protein ligase E3 component n-recognin 1 | 0.0302609 |
| SYAP1 | synapse associated protein 1 | 0.0294219 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.0293616 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0289578 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0287077 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0286936 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0282114 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0281657 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0278577 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0273408 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0272573 |
| PLAUR | plasminogen activator, urokinase receptor | 0.027169 |
| RBBP6 | retinoblastoma binding protein 6 | 0.0268251 |
| MYO1E | myosin IE | 0.0265775 |
| DCUN1D3 | DCN1, defective in cullin neddylation 1, domain containing 3 | 0.0264307 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0263713 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.026294 |
| EXOC6B | exocyst complex component 6B | 0.0261741 |
| SP100 | SP100 nuclear antigen | 0.0255806 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | 0.0252482 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | 0.0250213 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0248366 |
| DAPP1 | dual adaptor of phosphotyrosine and 3-phosphoinositides | 0.0248205 |
| HOMER1 | homer scaffolding protein 1 | 0.0246739 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0246275 |
| TJP1 | tight junction protein 1 | 0.0244441 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0243903 |
| GPATCH2L | G patch domain containing 2-like | 0.0238776 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0238515 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0238282 |
| CES1 | carboxylesterase 1 | 0.0234853 |
| FAT1 | FAT atypical cadherin 1 | 0.0231148 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0229164 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.022734 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.022395 |
| RAP2B | RAP2B, member of RAS oncogene family | 0.0219118 |
| SIK3 | SIK family kinase 3 | 0.0216001 |
| EFNA5 | ephrin-A5 | 0.0215365 |
| TUFT1 | tuftelin 1 | 0.0212096 |
| JAK1 | Janus kinase 1 | 0.0211518 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.021045 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.020969 |
| TLE4 | transducin-like enhancer of split 4 | 0.0207333 |
| OXSR1 | oxidative stress responsive 1 | 0.0205802 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0205558 |
| SPAG9 | sperm associated antigen 9 | 0.0205202 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0200118 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.019905 |
| HIBCH | 3-hydroxyisobutyryl-CoA hydrolase | 0.0197149 |
| RUNX1 | runt-related transcription factor 1 | 0.0196182 |
| MYO1B | myosin IB | 0.0192057 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0191887 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0190492 |
| SEPTIN10 | septin 10 | 0.0190371 |
| GM2A | GM2 ganglioside activator | 0.0188136 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0186895 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0181913 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.018096 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 0.0177943 |
| SMYD3 | SET and MYND domain containing 3 | 0.0177339 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.297767 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.181097 |
| NDRG1 | N-myc downstream regulated 1 | -0.164167 |
| EGFR | epidermal growth factor receptor | -0.145431 |
| FAM13A | family with sequence similarity 13, member A | -0.111948 |
| PKM | pyruvate kinase, muscle | -0.0913631 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0913095 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0872551 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0863399 |
| TMSB10 | thymosin beta 10 | -0.0833487 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0811073 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0737832 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0723329 |
| S100A10 | S100 calcium binding protein A10 | -0.0698642 |
| PTMA | prothymosin, alpha | -0.0628709 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0603791 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0595405 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0588628 |
| PDE8A | phosphodiesterase 8A | -0.0524549 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0506257 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0491125 |
| KRT7 | keratin 7, type II | -0.0485079 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0469345 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0456042 |
| TMEM165 | transmembrane protein 165 | -0.0447033 |
| CST3 | cystatin C | -0.0429456 |
| LDHA | lactate dehydrogenase A | -0.0426087 |
| HDLBP | high density lipoprotein binding protein | -0.0415095 |
| CAV2 | caveolin 2 | -0.0399108 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0398602 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0392333 |
| ACTG1 | actin gamma 1 | -0.0390218 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0385611 |
| POTEF | POTE ankyrin domain family, member F | -0.0383245 |
| EGR1 | early growth response 1 | -0.0382363 |
| RPL35A | ribosomal protein L35a | -0.0379711 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0369938 |
| TPD52 | tumor protein D52 | -0.0362244 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0353439 |
| RPLP1 | ribosomal protein, large, P1 | -0.0347031 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0346636 |
| HMGA1 | high mobility group AT-hook 1 | -0.0345259 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.033861 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0335589 |
| GNAS | GNAS complex locus | -0.0332553 |
| SRP54 | signal recognition particle 54kDa | -0.0329076 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0328133 |
| ENO1 | enolase 1, (alpha) | -0.0325236 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0324378 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0323257 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.032267 |
| FNIP1 | folliculin interacting protein 1 | -0.031813 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0311798 |
| AGR2 | anterior gradient 2 | -0.0311322 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0306907 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0305739 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0304819 |
| WASF2 | WAS protein family, member 2 | -0.0304641 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.0304408 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0304047 |
| RPS6 | ribosomal protein S6 | -0.0293338 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.028638 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0286373 |
| VEGFA | vascular endothelial growth factor A | -0.0285932 |
| ATOSA | atos homolog A | -0.0285587 |
| LMNA | lamin A/C | -0.0284005 |
| GOLGB1 | golgin B1 | -0.0283947 |
| S100P | S100 calcium binding protein P | -0.02839 |
| PCBP2 | poly(rC) binding protein 2 | -0.0280981 |
| BMP7 | bone morphogenetic protein 7 | -0.0276479 |
| ZNF292 | zinc finger protein 292 | -0.0271015 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0269253 |
| PER2 | period circadian clock 2 | -0.026722 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0266749 |
| CDK2AP2 | cyclin-dependent kinase 2 associated protein 2 | -0.0266418 |
| CCNY | cyclin Y | -0.0265265 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0264475 |
| GOLGA4 | golgin A4 | -0.0261694 |
| MKI67 | marker of proliferation Ki-67 | -0.0261368 |
| MLF1 | myeloid leukemia factor 1 | -0.0259153 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0257616 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0257494 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | -0.0256146 |
| CCND1 | cyclin D1 | -0.025312 |
| MED13L | mediator complex subunit 13-like | -0.0251683 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0250108 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0248963 |
| KRT18 | keratin 18, type I | -0.0248627 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0247719 |
| RBM39 | RNA binding motif protein 39 | -0.0245517 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0244911 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0243975 |
| ANXA2 | annexin A2 | -0.024344 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0242535 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0240887 |
| S100A6 | S100 calcium binding protein A6 | -0.0239165 |
| PTEN | phosphatase and tensin homolog | -0.0239034 |
| CUX1 | cut-like homeobox 1 | -0.0237874 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0237461 |
| ARF4 | ADP-ribosylation factor 4 | -0.0236526 |
