Darinaparsin_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Darinaparsin perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Darinaparsin_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.144592
PM20D1 peptidase M20 domain containing 1 0.129345
AKAP12 A kinase (PRKA) anchor protein 12 0.117752
GRAMD1B GRAM domain containing 1B 0.115084
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.111408
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0732522
ASPH aspartate beta-hydroxylase 0.0623086
TXNRD1 thioredoxin reductase 1 0.0581183
MT2A metallothionein 2A 0.0575983
LDHA lactate dehydrogenase A 0.0536738
CXCL8 chemokine (C-X-C motif) ligand 8 0.0499989
TPI1 triosephosphate isomerase 1 0.0468696
WWOX WW domain containing oxidoreductase 0.0468507
MYH9 myosin, heavy chain 9, non-muscle 0.0458365
TPM3 tropomyosin 3 0.0427465
BASP1 brain abundant, membrane attached signal protein 1 0.0419763
ANGPTL4 angiopoietin-like 4 0.0419021
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0388049
TMSB10 thymosin beta 10 0.0387035
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0377998
FAM107B family with sequence similarity 107, member B 0.036822
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0364408
STC1 stanniocalcin 1 0.0363813
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0338999
DST dystonin 0.0336288
KYNU kynureninase 0.0335369
SMOC1 SPARC related modular calcium binding 1 0.0315585
PKM pyruvate kinase, muscle 0.0310263
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.029769
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0295997
FGB fibrinogen beta chain 0.0295714
NTN4 netrin 4 0.0293084
PFN1 profilin 1 0.0286261
ENO1 enolase 1, (alpha) 0.0283443
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0277217
S100A6 S100 calcium binding protein A6 0.0275821
MYOF myoferlin 0.0274628
LAMB1 laminin, beta 1 0.0270063
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0261016
VIM vimentin 0.0254195
PDE10A phosphodiesterase 10A 0.0252717
CMIP c-Maf inducing protein 0.0252598
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0252361
FTH1 ferritin, heavy polypeptide 1 0.0250201
DOCK4 dedicator of cytokinesis 4 0.0245217
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0239189
TPM4 tropomyosin 4 0.0234102
ATXN1 ataxin 1 0.0232198
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0231309
PDIA3 protein disulfide isomerase family A, member 3 0.0222342
POTEF POTE ankyrin domain family, member F 0.0221384
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0219648
TFPI2 tissue factor pathway inhibitor 2 0.0216515
PRDX1 peroxiredoxin 1 0.0215846
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0214815
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0210396
FTL ferritin, light polypeptide 0.0206737
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0206315
MSN moesin 0.0205354
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.020532
NRG1 neuregulin 1 0.0204818
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0200288
HDGF hepatoma-derived growth factor 0.0197677
SRRM2 serine/arginine repetitive matrix 2 0.0196402
FHIT fragile histidine triad 0.0194731
SVIL supervillin 0.0193152
UTRN utrophin 0.0191447
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0191111
LOC102724023 ES1 protein homolog, mitochondrial 0.0188229
BIRC3 baculoviral IAP repeat containing 3 0.0188137
IL6 interleukin 6 0.0187189
SON SON DNA binding protein 0.0186284
NNMT nicotinamide N-methyltransferase 0.0186239
NEGR1 neuronal growth regulator 1 0.018529
LDHB lactate dehydrogenase B 0.0184609
MAP1B microtubule-associated protein 1B 0.0184222
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0180168
RPS12 ribosomal protein S12 0.0176248
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0173392
TRAPPC9 trafficking protein particle complex 9 0.0172425
FGA fibrinogen alpha chain 0.0172052
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0171484
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0171292
MCFD2 multiple coagulation factor deficiency 2 0.0170569
RPL3 ribosomal protein L3 0.0168825
FLNA filamin A, alpha 0.0168275
LAMC2 laminin, gamma 2 0.0167447
MCL1 myeloid cell leukemia 1 0.0166392
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0165992
TRIP11 thyroid hormone receptor interactor 11 0.0164242
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0162093
RPL18 ribosomal protein L18 0.0160544
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0160019
KTN1 kinectin 1 (kinesin receptor) 0.0159383
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0157209
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0156766
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0154559
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0153986
TBC1D5 TBC1 domain family, member 5 0.0152178
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0152066

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.0601205
RBM39 RNA binding motif protein 39 -0.0586234
ZFAND3 zinc finger, AN1-type domain 3 -0.048984
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0474393
KDM3A lysine (K)-specific demethylase 3A -0.0441828
PUM2 pumilio RNA-binding family member 2 -0.0425505
PARD3 par-3 family cell polarity regulator -0.0402685
WDR43 WD repeat domain 43 -0.0384519
WAC WW domain containing adaptor with coiled-coil -0.0382717
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0364995
ANKRD11 ankyrin repeat domain 11 -0.0357224
USP3 ubiquitin specific peptidase 3 -0.0346884
FBXO11 F-box protein 11 -0.0339183
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0332431
MARCHF6 membrane associated ring-CH-type finger 6 -0.032458
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0322608
PTMA prothymosin, alpha -0.0312085
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0309185
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0307472
ERBIN erbb2 interacting protein -0.030126
RAB1A RAB1A, member RAS oncogene family -0.0300211
ZNF207 zinc finger protein 207 -0.0299674
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.029965
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0299578
TPT1 tumor protein, translationally-controlled 1 -0.0293894
FOXO3 forkhead box O3 -0.0290591
NOP58 NOP58 ribonucleoprotein -0.02873
CCNL1 cyclin L1 -0.0280383
PTK2 protein tyrosine kinase 2 -0.0278309
EIF1 eukaryotic translation initiation factor 1 -0.0275077
FMNL2 formin-like 2 -0.0270923
FUS FUS RNA binding protein -0.0267251
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.026651
MATR3 matrin 3 -0.0265064
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0252926
RPS29 ribosomal protein S29 -0.0250998
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0249243
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0248049
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0239748
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0236955
RNF145 ring finger protein 145 -0.0234209
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0233547
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0230971
RPL35A ribosomal protein L35a -0.0230589
PUM1 pumilio RNA-binding family member 1 -0.0229064
TLK1 tousled-like kinase 1 -0.0225848
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0222293
TM4SF1 transmembrane 4 L six family member 1 -0.0219006
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0216118
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0216019
COPA coatomer protein complex, subunit alpha -0.0215799
ZNF292 zinc finger protein 292 -0.0213079
CFAP73 cilia and flagella associated protein 73 -0.0212434
ADAM17 ADAM metallopeptidase domain 17 -0.0210897
ITCH itchy E3 ubiquitin protein ligase -0.0208649
RBM25 RNA binding motif protein 25 -0.0208352
CYRIB CYFIP related Rac1 interactor B -0.0207762
FNBP1L formin binding protein 1-like -0.0203468
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0202761
EWSR1 EWS RNA-binding protein 1 -0.0202653
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0198816
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0196752
GLG1 golgi glycoprotein 1 -0.0195641
MAPK8 mitogen-activated protein kinase 8 -0.0195007
KMT2E lysine (K)-specific methyltransferase 2E -0.0194774
TRA2A transformer 2 alpha homolog (Drosophila) -0.0193043
QKI QKI, KH domain containing, RNA binding -0.0192831
RPL38 ribosomal protein L38 -0.0192556
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0192224
CTBP2 C-terminal binding protein 2 -0.019018
WTAP Wilms tumor 1 associated protein -0.0189072
SAMD4A sterile alpha motif domain containing 4A -0.0187177
RLF rearranged L-myc fusion -0.0186541
ECT2 epithelial cell transforming 2 -0.0184222
RBM33 RNA binding motif protein 33 -0.0182838
TRIO trio Rho guanine nucleotide exchange factor -0.0182339
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.017921
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0178075
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0176386
NEK7 NIMA-related kinase 7 -0.0175967
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0175833
UGCG UDP-glucose ceramide glucosyltransferase -0.0174916
BHLHE40 basic helix-loop-helix family, member e40 -0.017397
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0173295
FAM168B family with sequence similarity 168, member B -0.017306
STRN3 striatin, calmodulin binding protein 3 -0.0171889
SREBF2 sterol regulatory element binding transcription factor 2 -0.0170899
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.017001
RPS21 ribosomal protein S21 -0.0169736
DENND4A DENN/MADD domain containing 4A -0.0168362
IER3 immediate early response 3 -0.0168155
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0166874
TFG TRK-fused gene -0.0165114
BIRC6 baculoviral IAP repeat containing 6 -0.0164123
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0163273
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0162452
AGFG1 ArfGAP with FG repeats 1 -0.0162271
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0161914
MTMR3 myotubularin related protein 3 -0.0160854
RHEB Ras homolog enriched in brain -0.0159851