| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Darinaparsin perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Darinaparsin_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SAMD4A | sterile alpha motif domain containing 4A | 0.143082 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.131138 |
| LAMC2 | laminin, gamma 2 | 0.121048 |
| MYO1E | myosin IE | 0.103505 |
| ASPH | aspartate beta-hydroxylase | 0.0833511 |
| LAMB3 | laminin, beta 3 | 0.0721821 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0706809 |
| MT2A | metallothionein 2A | 0.0700642 |
| TMSB10 | thymosin beta 10 | 0.0672163 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0661825 |
| KYNU | kynureninase | 0.0658146 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0653372 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0643945 |
| EFNA5 | ephrin-A5 | 0.0604476 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0593191 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0570961 |
| RBM47 | RNA binding motif protein 47 | 0.0568872 |
| NABP1 | nucleic acid binding protein 1 | 0.0549108 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0524943 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0513321 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0507969 |
| EGFR | epidermal growth factor receptor | 0.0504013 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 0.0485803 |
| PLEC | plectin | 0.0481409 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0457938 |
| STC1 | stanniocalcin 1 | 0.0456942 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.044861 |
| SMAD3 | SMAD family member 3 | 0.0445605 |
| VIM | vimentin | 0.0435066 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0434868 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0424552 |
| INTS6 | integrator complex subunit 6 | 0.0423225 |
| PKM | pyruvate kinase, muscle | 0.0417244 |
| STK17A | serine/threonine kinase 17a | 0.0415301 |
| RPS8 | ribosomal protein S8 | 0.0409759 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0404807 |
| LMO7 | LIM domain 7 | 0.0402017 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0392431 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0391427 |
| DSPP | dentin sialophosphoprotein | 0.037662 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0374105 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0360326 |
| SACK1A | scaffolding CK1 anchoring protein A | 0.0357088 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | 0.035369 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0348188 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0347631 |
| MCL1 | myeloid cell leukemia 1 | 0.0341224 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0340937 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0336243 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0332858 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0323688 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0322009 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | 0.03214 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | 0.0321294 |
| AK1 | adenylate kinase 1 | 0.03199 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | 0.0319715 |
| DTNA | dystrobrevin, alpha | 0.0319528 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0319229 |
| TPCN1 | two pore segment channel 1 | 0.0312272 |
| RAB10 | RAB10, member RAS oncogene family | 0.0310403 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0310048 |
| SSH2 | slingshot protein phosphatase 2 | 0.0308618 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0305442 |
| KCNH8 | potassium channel, voltage gated eag related subfamily H, member 8 | 0.0304404 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.029877 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0296729 |
| MSN | moesin | 0.0296707 |
| PRELID2 | PRELI domain containing 2 | 0.0295641 |
| GRAMD1B | GRAM domain containing 1B | 0.0295506 |
| ANGPTL4 | angiopoietin-like 4 | 0.0295498 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.029427 |
| KLC1 | kinesin light chain 1 | 0.0292646 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0291907 |
| SMYD3 | SET and MYND domain containing 3 | 0.0291439 |
| MTAP | methylthioadenosine phosphorylase | 0.0285635 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0283853 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | 0.0283237 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0282612 |
| TTC9 | tetratricopeptide repeat domain 9 | 0.028203 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | 0.0281699 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0281257 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0281176 |
| TJP1 | tight junction protein 1 | 0.0279161 |
| TUFT1 | tuftelin 1 | 0.0278372 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0276467 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0275331 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0275077 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0274978 |
| IGF2R | insulin-like growth factor 2 receptor | 0.0273255 |
| SGMS2 | sphingomyelin synthase 2 | 0.0272654 |
| RPLP1 | ribosomal protein, large, P1 | 0.0271223 |
| RUNX1 | runt-related transcription factor 1 | 0.0270237 |
| HDAC9 | histone deacetylase 9 | 0.0267148 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.0267113 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0266535 |
| KRT17 | keratin 17, type I | 0.0266312 |
| CALU | calumenin | 0.0266201 |
| RNF169 | ring finger protein 169 | 0.02657 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.0265232 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0261195 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.128674 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0965507 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0943775 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0933674 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0888505 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.088492 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0760656 |
| ATOSA | atos homolog A | -0.0682568 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0614006 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0595624 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0576517 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0569919 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0556294 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0539254 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0534701 |
| FAM107B | family with sequence similarity 107, member B | -0.0531022 |
| ZNF207 | zinc finger protein 207 | -0.0523479 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.05197 |
| ANXA1 | annexin A1 | -0.0510564 |
| USP34 | ubiquitin specific peptidase 34 | -0.0506578 |
| FDPS | farnesyl diphosphate synthase | -0.050056 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0499082 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0494036 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0485969 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0467337 |
| SLMAP | sarcolemma associated protein | -0.0466822 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0461357 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0450194 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0448816 |
| CPNE8 | copine VIII | -0.0446598 |
| H3-3B | H3.3 histone B | -0.0445214 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0440038 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0439973 |
| ATXN2 | ataxin 2 | -0.0439852 |
| IGF2 | insulin-like growth factor 2 | -0.0434219 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0433716 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0433323 |
| RPS6 | ribosomal protein S6 | -0.0431191 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0423526 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | -0.0423444 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0419688 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0418481 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0415343 |
| DST | dystonin | -0.0414859 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0414786 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0411261 |
| TXNRD1 | thioredoxin reductase 1 | -0.0409003 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0406945 |
| COPA | coatomer protein complex, subunit alpha | -0.0402459 |
| SNX9 | sorting nexin 9 | -0.0396799 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0394129 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0391004 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0388403 |
| S100A8 | S100 calcium binding protein A8 | -0.0385357 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0383204 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0380043 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0374391 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0373266 |
| TNPO1 | transportin 1 | -0.0369382 |
| CANX | calnexin | -0.0369354 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0368671 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0365244 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0364546 |
| RPL23 | ribosomal protein L23 | -0.0359554 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0357392 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0350282 |
| FMN1 | formin 1 | -0.0347393 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0345908 |
| SPAG9 | sperm associated antigen 9 | -0.0345791 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | -0.0343855 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0343337 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0340192 |
| DSG2 | desmoglein 2 | -0.0338269 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | -0.0336112 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0333731 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.03332 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0331618 |
| DENND1A | DENN/MADD domain containing 1A | -0.0331224 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0329828 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0328607 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0328086 |
| TAOK3 | TAO kinase 3 | -0.0328052 |
| FOXO3 | forkhead box O3 | -0.0318873 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0317969 |
| BBX | bobby sox homolog (Drosophila) | -0.0317396 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0316907 |
| ABLIM1 | actin binding LIM protein 1 | -0.0310523 |
| TCF12 | transcription factor 12 | -0.0309974 |
| PARD3 | par-3 family cell polarity regulator | -0.0307417 |
| EVI5 | ecotropic viral integration site 5 | -0.0305742 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0303758 |
| LMTK2 | lemur tyrosine kinase 2 | -0.0303305 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0300363 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0300337 |
| RPS25 | ribosomal protein S25 | -0.0299754 |
| RORA | RAR-related orphan receptor A | -0.029876 |
| NCKAP1 | NCK-associated protein 1 | -0.0298466 |
| TOP1 | topoisomerase (DNA) I | -0.0296579 |
| GPATCH8 | G patch domain containing 8 | -0.0294612 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0291995 |
