| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Darinaparsin perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Darinaparsin_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0761475 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0555417 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0527388 |
| TPM3 | tropomyosin 3 | 0.046424 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0453614 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0439484 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0378678 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0363194 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0356536 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0348381 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0340793 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0331357 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0329218 |
| PDLIM5 | PDZ and LIM domain 5 | 0.032665 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0319364 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0292757 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0287042 |
| HOMER1 | homer scaffolding protein 1 | 0.0271276 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0270051 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0243356 |
| RAD51B | RAD51 paralog B | 0.02387 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0238519 |
| VCL | vinculin | 0.0238363 |
| SPAG9 | sperm associated antigen 9 | 0.0228947 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0226967 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0226945 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0225072 |
| TXNRD1 | thioredoxin reductase 1 | 0.0223973 |
| JMJD1C | jumonji domain containing 1C | 0.0215927 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0214223 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0213915 |
| KLF6 | Kruppel-like factor 6 | 0.0209043 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0208575 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0208341 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0202189 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | 0.0199067 |
| IER2 | immediate early response 2 | 0.0198255 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0193853 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0193254 |
| ASPH | aspartate beta-hydroxylase | 0.0192403 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0191538 |
| DUSP16 | dual specificity phosphatase 16 | 0.0191514 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0187712 |
| CAPRIN2 | caprin family member 2 | 0.0186554 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0181126 |
| MMP12 | matrix metallopeptidase 12 | 0.0179981 |
| SET | SET nuclear proto-oncogene | 0.0179534 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0179436 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0179365 |
| CALD1 | caldesmon 1 | 0.0179337 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.017882 |
| PLEC | plectin | 0.0176313 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.0175389 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0174583 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0172813 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0171628 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.0170161 |
| NASP | nuclear autoantigenic sperm protein (histone-binding) | 0.0169794 |
| DST | dystonin | 0.0167737 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | 0.0165689 |
| NRG1 | neuregulin 1 | 0.016554 |
| STC1 | stanniocalcin 1 | 0.0165298 |
| SON | SON DNA binding protein | 0.0164902 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0162898 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0162447 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0158222 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0157793 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0157072 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.0156634 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.015639 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0156387 |
| TCIM | transcriptional and immune response regulator | 0.015492 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.0153723 |
| R3HDM2 | R3H domain containing 2 | 0.0153424 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0153416 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0152531 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0152282 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0151712 |
| SAFB | scaffold attachment factor B | 0.0150349 |
| RBM28 | RNA binding motif protein 28 | 0.0149562 |
| TPM2 | tropomyosin 2 (beta) | 0.0147153 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.014527 |
| CTTN | cortactin | 0.0145012 |
| MYO10 | myosin X | 0.014378 |
| SYAP1 | synapse associated protein 1 | 0.0143445 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0143434 |
| FANCI | Fanconi anemia, complementation group I | 0.0143425 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.014318 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.014223 |
| KLF10 | Kruppel-like factor 10 | 0.01412 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0139223 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0137612 |
| DIAPH1 | diaphanous-related formin 1 | 0.0136883 |
| MYPN | myopalladin | 0.013681 |
| FLNA | filamin A, alpha | 0.0136372 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0135127 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0135082 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0134588 |
| SAP30BP | SAP30 binding protein | 0.0134423 |
| RRM2 | ribonucleotide reductase M2 | 0.0133947 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.518216 |
| EGR1 | early growth response 1 | -0.0829943 |
| TMSB10 | thymosin beta 10 | -0.0716054 |
| VIM | vimentin | -0.0684546 |
| RPL35A | ribosomal protein L35a | -0.0633785 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0560653 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0558054 |
| RPS8 | ribosomal protein S8 | -0.0553424 |
| RPLP1 | ribosomal protein, large, P1 | -0.0534276 |
| RPL37 | ribosomal protein L37 | -0.0531105 |
| RPS6 | ribosomal protein S6 | -0.0523417 |
| OSMR | oncostatin M receptor | -0.0515553 |
| POTEF | POTE ankyrin domain family, member F | -0.0505266 |
| RPS27 | ribosomal protein S27 | -0.0470738 |
| RPS15 | ribosomal protein S15 | -0.0467882 |
| RPL12 | ribosomal protein L12 | -0.0462627 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0449927 |
| YBX1 | Y box binding protein 1 | -0.0449568 |
| RPL23 | ribosomal protein L23 | -0.0416785 |
| PTMA | prothymosin, alpha | -0.0404126 |
| RPLP0 | ribosomal protein, large, P0 | -0.0399863 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0392695 |
| RPL5 | ribosomal protein L5 | -0.0384608 |
| RPL19 | ribosomal protein L19 | -0.0383091 |
| RPL38 | ribosomal protein L38 | -0.036549 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0364108 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0358986 |
| RPL34 | ribosomal protein L34 | -0.0355064 |
| PYGL | phosphorylase, glycogen, liver | -0.0354671 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0349653 |
| FTL | ferritin, light polypeptide | -0.0340096 |
| RPS21 | ribosomal protein S21 | -0.0339952 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0335706 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0330033 |
| PFN1 | profilin 1 | -0.0324634 |
| RPS29 | ribosomal protein S29 | -0.032463 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0321949 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0321635 |
| TAPBP | TAP binding protein (tapasin) | -0.0316292 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0315448 |
| S100A10 | S100 calcium binding protein A10 | -0.0314671 |
| RPL37A | ribosomal protein L37a | -0.0314299 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0313347 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0313292 |
| RPL32 | ribosomal protein L32 | -0.0310031 |
| RPLP2 | ribosomal protein, large, P2 | -0.0307579 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0305617 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0298122 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0297171 |
| RPL31 | ribosomal protein L31 | -0.0294766 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0293507 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0291967 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0288374 |
| LOC112694756 | uncharaterized LOC112694756 | -0.028797 |
| ENO1 | enolase 1, (alpha) | -0.0284499 |
| RPS13 | ribosomal protein S13 | -0.0283103 |
| RPL8 | ribosomal protein L8 | -0.0281395 |
| ATXN1 | ataxin 1 | -0.0280142 |
| RPL28 | ribosomal protein L28 | -0.0278226 |
| RPL9 | ribosomal protein L9 | -0.0278214 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0277512 |
| RACK1 | receptor for activated C kinase 1 | -0.0276797 |
| RPS10 | ribosomal protein S10 | -0.0270736 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0268138 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0267868 |
| PRKCE | protein kinase C, epsilon | -0.026502 |
| RPS19 | ribosomal protein S19 | -0.0264765 |
| RPL35 | ribosomal protein L35 | -0.0264742 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0263237 |
| MKI67 | marker of proliferation Ki-67 | -0.0260969 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0260276 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.025799 |
| SEPTIN7 | septin 7 | -0.0256257 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0254819 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0254124 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0253888 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0252796 |
| RPL11 | ribosomal protein L11 | -0.0249721 |
| RPS14 | ribosomal protein S14 | -0.024648 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0246359 |
| PKM | pyruvate kinase, muscle | -0.0244599 |
| RPS16 | ribosomal protein S16 | -0.0239331 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0235763 |
| PFKP | phosphofructokinase, platelet | -0.0235593 |
| MCL1 | myeloid cell leukemia 1 | -0.0233673 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0232702 |
| RPS23 | ribosomal protein S23 | -0.0231717 |
| TAOK1 | TAO kinase 1 | -0.0229755 |
| EGFR | epidermal growth factor receptor | -0.0228928 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0227299 |
| RPL27 | ribosomal protein L27 | -0.0227054 |
| RPL26 | ribosomal protein L26 | -0.0226237 |
| TLK1 | tousled-like kinase 1 | -0.0225931 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0225342 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.02253 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0222421 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0222397 |
| RPS25 | ribosomal protein S25 | -0.0222115 |
| RTN4 | reticulon 4 | -0.0221612 |
| HLA-B | major histocompatibility complex, class I, B | -0.0221329 |
