| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Darinaparsin perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Darinaparsin_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.162564 |
| PM20D1 | peptidase M20 domain containing 1 | 0.151772 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.139175 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | 0.0922077 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0838841 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0753076 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0737037 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.069891 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0684441 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0673011 |
| MYOF | myoferlin | 0.0651962 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0629218 |
| PDE10A | phosphodiesterase 10A | 0.06265 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0573574 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0562829 |
| ENO1 | enolase 1, (alpha) | 0.0513373 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0508463 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0496159 |
| SMAD2 | SMAD family member 2 | 0.049537 |
| ASPH | aspartate beta-hydroxylase | 0.048863 |
| PRELID2 | PRELI domain containing 2 | 0.0481467 |
| SQSTM1 | sequestosome 1 | 0.0478803 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0478046 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0472547 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0467325 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0459395 |
| RGS2 | regulator of G-protein signaling 2 | 0.0442111 |
| RAD51B | RAD51 paralog B | 0.044158 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0432738 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0426299 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0418745 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0411755 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0405712 |
| VCL | vinculin | 0.0395584 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.038138 |
| INTS6 | integrator complex subunit 6 | 0.0375603 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0361851 |
| LDHA | lactate dehydrogenase A | 0.0361073 |
| CADM2 | cell adhesion molecule 2 | 0.0358435 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0350133 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0341869 |
| DST | dystonin | 0.0337391 |
| LSAMP | limbic system-associated membrane protein | 0.0336844 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0316281 |
| EZR | ezrin | 0.0315562 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0309683 |
| FMNL2 | formin-like 2 | 0.0306829 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0306147 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0305512 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0304685 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0302214 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0302177 |
| GRAMD1B | GRAM domain containing 1B | 0.0300851 |
| WWOX | WW domain containing oxidoreductase | 0.0299265 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0297838 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0297382 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 0.0294442 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0291688 |
| TPM3 | tropomyosin 3 | 0.029019 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0288497 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0288178 |
| IRS2 | insulin receptor substrate 2 | 0.0287384 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0282176 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0274516 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0272797 |
| NRXN3 | neurexin 3 | 0.0269511 |
| ACTG1 | actin gamma 1 | 0.0264983 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.026423 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0259619 |
| SET | SET nuclear proto-oncogene | 0.0258091 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0257964 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0255202 |
| PKM | pyruvate kinase, muscle | 0.0252478 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0252472 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0251653 |
| CENPF | centromere protein F, 350/400kDa | 0.0248134 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0247046 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0245465 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0245307 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.024264 |
| ANXA1 | annexin A1 | 0.0242308 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0239153 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | 0.0238918 |
| AHNAK | AHNAK nucleoprotein | 0.0238497 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0235349 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.023534 |
| FLNA | filamin A, alpha | 0.0235103 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0235101 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0232854 |
| RPS4X | ribosomal protein S4, X-linked | 0.0230757 |
| PGK1 | phosphoglycerate kinase 1 | 0.0228627 |
| RRM2 | ribonucleotide reductase M2 | 0.0227215 |
| STAG2 | stromal antigen 2 | 0.0223385 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0219359 |
| GALC | galactosylceramidase | 0.021888 |
| ARHGEF7 | Rho guanine nucleotide exchange factor (GEF) 7 | 0.0215639 |
| GLCE | glucuronic acid epimerase | 0.0214124 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0212493 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0210771 |
| TPI1 | triosephosphate isomerase 1 | 0.0210708 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.160348 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.150774 |
| FN1 | fibronectin 1 | -0.14386 |
| EFNA5 | ephrin-A5 | -0.12251 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.111266 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.106636 |
| GDA | guanine deaminase | -0.0966991 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0898552 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.086904 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0747042 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0691983 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0679564 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0666972 |
| MFF | mitochondrial fission factor | -0.0643387 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0602162 |
| RTN4 | reticulon 4 | -0.0601115 |
| OSMR | oncostatin M receptor | -0.0584417 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0581352 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0538543 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0524639 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0517335 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0515728 |
| NEK7 | NIMA-related kinase 7 | -0.0513678 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0503778 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0491799 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0475292 |
| COL4A6 | collagen, type IV, alpha 6 | -0.0473005 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0453143 |
| TBXT | T-box transcription factor T | -0.0446205 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.044583 |
| TMX4 | thioredoxin-related transmembrane protein 4 | -0.0431121 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0419157 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0419128 |
| VMP1 | vacuole membrane protein 1 | -0.0412897 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0405194 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | -0.0403374 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0398893 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0391791 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0387833 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.037919 |
| SRPK2 | SRSF protein kinase 2 | -0.0375165 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.0368943 |
| BMERB1 | bMERB domain containing 1 | -0.0367442 |
| MCL1 | myeloid cell leukemia 1 | -0.0361872 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0360382 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.03584 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0344936 |
| RPS6 | ribosomal protein S6 | -0.0342944 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0339963 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0326084 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0325408 |
| RTN1 | reticulon 1 | -0.0312085 |
| VIM | vimentin | -0.0310361 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0308134 |
| CD109 | CD109 molecule | -0.0302266 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.030196 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0299893 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0297909 |
| PTEN | phosphatase and tensin homolog | -0.0290326 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.02891 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0288522 |
| RPS27 | ribosomal protein S27 | -0.0288495 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0288405 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0282709 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.028061 |
| JMJD1C | jumonji domain containing 1C | -0.0274871 |
| HLA-A | major histocompatibility complex, class I, A | -0.0268748 |
| TENM3 | teneurin transmembrane protein 3 | -0.0267451 |
| STEAP1B | STEAP family member 1B | -0.026641 |
| CD44 | CD44 molecule (Indian blood group) | -0.0265597 |
| NRCAM | neuronal cell adhesion molecule | -0.0261656 |
| TXNRD1 | thioredoxin reductase 1 | -0.0260666 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0258214 |
| NCKAP5 | NCK-associated protein 5 | -0.0256 |
| ENAH | enabled homolog (Drosophila) | -0.0255429 |
| POTEF | POTE ankyrin domain family, member F | -0.0254703 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0252698 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0246853 |
| IL6 | interleukin 6 | -0.0246222 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0246119 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0245465 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0244781 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0240719 |
| PTGR1 | prostaglandin reductase 1 | -0.0237091 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0233928 |
| GOLGA4 | golgin A4 | -0.0233078 |
| ABLIM1 | actin binding LIM protein 1 | -0.0231767 |
| EGR1 | early growth response 1 | -0.0226214 |
| RPLP1 | ribosomal protein, large, P1 | -0.0225031 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0219472 |
| CDK17 | cyclin-dependent kinase 17 | -0.0218935 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.021827 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.021734 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0216177 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0215364 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.021431 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.0213656 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0213154 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0212354 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0211438 |
