| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Darinaparsin perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
192 genes differentially expressed following the Darinaparsin_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.174733 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.151823 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.125038 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.113829 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.107088 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.102621 |
| ASPH | aspartate beta-hydroxylase | 0.0940525 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.092145 |
| RPL34 | ribosomal protein L34 | 0.0860513 |
| STC1 | stanniocalcin 1 | 0.0857129 |
| RPS5 | ribosomal protein S5 | 0.0815931 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0776256 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0775149 |
| B2M | beta-2-microglobulin | 0.068563 |
| LAMA4 | laminin, alpha 4 | 0.0680209 |
| CANX | calnexin | 0.0677595 |
| HMGA2 | high mobility group AT-hook 2 | 0.0652296 |
| VIM | vimentin | 0.0648911 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0626558 |
| RPL27A | ribosomal protein L27a | 0.058485 |
| CENPF | centromere protein F, 350/400kDa | 0.0577222 |
| RPL11 | ribosomal protein L11 | 0.0557086 |
| RPS19 | ribosomal protein S19 | 0.0540426 |
| HLA-A | major histocompatibility complex, class I, A | 0.0535417 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.050737 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0502696 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0492906 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0484405 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0457687 |
| TMSB10 | thymosin beta 10 | 0.0453979 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0452901 |
| SYT1 | synaptotagmin I | 0.0445262 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0442517 |
| RPL31 | ribosomal protein L31 | 0.0440863 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0427031 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | 0.0418787 |
| MORF4L2 | mortality factor 4 like 2 | 0.0413828 |
| DSPP | dentin sialophosphoprotein | 0.0390182 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0389199 |
| EHBP1 | EH domain binding protein 1 | 0.0386609 |
| RPS17 | ribosomal protein S17 | 0.0377482 |
| INHBA | inhibin, beta A | 0.0373904 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0371453 |
| NAV2 | neuron navigator 2 | 0.0345809 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0337836 |
| RPL35A | ribosomal protein L35a | 0.0335791 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0333925 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0321674 |
| RPS8 | ribosomal protein S8 | 0.0321571 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0316728 |
| LMNA | lamin A/C | 0.0312134 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.03063 |
| RPL13A | ribosomal protein L13a | 0.0303626 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0300677 |
| RORA | RAR-related orphan receptor A | 0.0293371 |
| DSCAM | Down syndrome cell adhesion molecule | 0.028848 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0287569 |
| PTMA | prothymosin, alpha | 0.0272735 |
| ADNP | activity-dependent neuroprotector homeobox | 0.0268907 |
| TPM4 | tropomyosin 4 | 0.0268404 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0262502 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0257053 |
| PRKCA | protein kinase C, alpha | 0.0255712 |
| FAT1 | FAT atypical cadherin 1 | 0.0249122 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.024434 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0239315 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0239198 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0235615 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.023079 |
| ENO1 | enolase 1, (alpha) | 0.0217749 |
| ATXN1 | ataxin 1 | 0.0207856 |
| YY1 | YY1 transcription factor | 0.0185165 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0183495 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0182291 |
| DST | dystonin | 0.018136 |
| SEPTIN7 | septin 7 | 0.0168687 |
| RRBP1 | ribosome binding protein 1 | 0.0168153 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0162513 |
| ZNF638 | zinc finger protein 638 | 0.0161919 |
| GALNT1 | polypeptide N-acetylgalactosaminyltransferase 1 | 0.0149495 |
| CDK6 | cyclin-dependent kinase 6 | 0.0148856 |
| SMAD3 | SMAD family member 3 | 0.0143643 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.012349 |
| GLG1 | golgi glycoprotein 1 | 0.0121746 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0116974 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0113189 |
| RPS3 | ribosomal protein S3 | 0.0110681 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0107419 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0106112 |
| FTL | ferritin, light polypeptide | 0.00901902 |
| PDE10A | phosphodiesterase 10A | 0.00819673 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.00762874 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0048151 |
| GRB10 | growth factor receptor-bound protein 10 | 0.00294335 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.00256389 |
| LMO7 | LIM domain 7 | 0.00223001 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.00200915 |
| MSN | moesin | 0.00167412 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.00158525 |
| RPL23 | ribosomal protein L23 | 0.00153501 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VMP1 | vacuole membrane protein 1 | -0.105925 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0920682 |
| NDRG1 | N-myc downstream regulated 1 | -0.0875332 |
| PTK2 | protein tyrosine kinase 2 | -0.0857814 |
| LDHA | lactate dehydrogenase A | -0.0855243 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0827337 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0824686 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0795585 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0784698 |
| GPC6 | glypican 6 | -0.0763868 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0713591 |
| SBF2 | SET binding factor 2 | -0.0712658 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0706918 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0682155 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0675149 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0659174 |
| RBM25 | RNA binding motif protein 25 | -0.0659025 |
| JMJD1C | jumonji domain containing 1C | -0.0592169 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.0585253 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0572101 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0551732 |
| HDLBP | high density lipoprotein binding protein | -0.0544242 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0536101 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0532281 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0516622 |
| ACTG1 | actin gamma 1 | -0.0515642 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.050589 |
| MYO1E | myosin IE | -0.0495101 |
| EGFR | epidermal growth factor receptor | -0.0479435 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0477784 |
| USP34 | ubiquitin specific peptidase 34 | -0.0473004 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0463023 |
| YBX3 | Y box binding protein 3 | -0.046023 |
| MYOF | myoferlin | -0.0452528 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0452431 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0446999 |
| MEF2A | myocyte enhancer factor 2A | -0.0438287 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0436106 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0433164 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0403329 |
| MYO6 | myosin VI | -0.0390458 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.038264 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0361578 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0356867 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0350521 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0350042 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0343024 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0322139 |
| ZNF292 | zinc finger protein 292 | -0.0322069 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0308421 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0295206 |
| FMNL2 | formin-like 2 | -0.0278732 |
| SLTM | SAFB-like, transcription modulator | -0.0275304 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0273317 |
| PARD3 | par-3 family cell polarity regulator | -0.0270635 |
| RPS12 | ribosomal protein S12 | -0.0265445 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.025978 |
| SRPK2 | SRSF protein kinase 2 | -0.0246171 |
| CD44 | CD44 molecule (Indian blood group) | -0.0240048 |
| FN1 | fibronectin 1 | -0.0233378 |
| VCL | vinculin | -0.0216112 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0209754 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0202973 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0195975 |
| CALR | calreticulin | -0.0193797 |
| MYO10 | myosin X | -0.0169757 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0147686 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0146764 |
| SPAG9 | sperm associated antigen 9 | -0.013468 |
| RPL19 | ribosomal protein L19 | -0.0122207 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0118404 |
| RASA3 | RAS p21 protein activator 3 | -0.0116218 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0107595 |
| OGA | O-GlcNAcase | -0.0106721 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0106201 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0104684 |
| RPL26 | ribosomal protein L26 | -0.0103793 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.00948906 |
| RUNX1 | runt-related transcription factor 1 | -0.00824106 |
| TNS3 | tensin 3 | -0.00711677 |
| PGK1 | phosphoglycerate kinase 1 | -0.00682292 |
| RPS6 | ribosomal protein S6 | -0.00678778 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.00656926 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.00511999 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.00424822 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.00402011 |
| GOLGA4 | golgin A4 | -0.00360539 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.00207137 |
| RPLP1 | ribosomal protein, large, P1 | -0.0014434 |
| MAP1B | microtubule-associated protein 1B | -0.00124001 |
| BPTF | bromodomain PHD finger transcription factor | -5.93323E-4 |
| RPL12 | ribosomal protein L12 | -1.27684E-4 |
