| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Darolutamide perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Darolutamide_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.116678 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.108992 |
| AREG | amphiregulin | 0.0843774 |
| PCBP2 | poly(rC) binding protein 2 | 0.0729124 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0658758 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.063196 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0614976 |
| KIF5B | kinesin family member 5B | 0.0493892 |
| ECT2 | epithelial cell transforming 2 | 0.0433334 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0432398 |
| ANXA1 | annexin A1 | 0.0420036 |
| NEK7 | NIMA-related kinase 7 | 0.0409822 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0399084 |
| CCNL1 | cyclin L1 | 0.0391504 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0390589 |
| MED13L | mediator complex subunit 13-like | 0.0383378 |
| XPO1 | exportin 1 | 0.036042 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0359391 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0343686 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0324164 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.032219 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0319297 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0317165 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0307148 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0290766 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0290681 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0279874 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0276132 |
| EPHA6 | EPH receptor A6 | 0.0274152 |
| POTEF | POTE ankyrin domain family, member F | 0.0271697 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0259894 |
| TPI1 | triosephosphate isomerase 1 | 0.0253118 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0252518 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0250779 |
| DST | dystonin | 0.0249862 |
| CLDND1 | claudin domain containing 1 | 0.0248786 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0248165 |
| SPAG9 | sperm associated antigen 9 | 0.0243865 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0241729 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0241351 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0239345 |
| PCM1 | pericentriolar material 1 | 0.0239273 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0239115 |
| TFG | TRK-fused gene | 0.0238082 |
| OXR1 | oxidation resistance 1 | 0.0236772 |
| CKAP5 | cytoskeleton associated protein 5 | 0.02359 |
| MATR3 | matrin 3 | 0.0235595 |
| ZNF292 | zinc finger protein 292 | 0.0235566 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0234122 |
| MGAT4C | MGAT4 family, member C | 0.0233683 |
| EDN1 | endothelin 1 | 0.023301 |
| OGA | O-GlcNAcase | 0.0229609 |
| PLK2 | polo-like kinase 2 | 0.0228555 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0227771 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0226162 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0222735 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0220343 |
| KLHL24 | kelch-like family member 24 | 0.0219856 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0217734 |
| QKI | QKI, KH domain containing, RNA binding | 0.0217421 |
| TNPO1 | transportin 1 | 0.021328 |
| NCKAP1 | NCK-associated protein 1 | 0.0210809 |
| CPOX | coproporphyrinogen oxidase | 0.0208823 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0208669 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | 0.020819 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0207495 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0207229 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0204667 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0203465 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0203249 |
| CEP192 | centrosomal protein 192kDa | 0.0202951 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0202899 |
| IPMK | inositol polyphosphate multikinase | 0.0201927 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0201416 |
| ARRDC3 | arrestin domain containing 3 | 0.0200408 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0198341 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.019829 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0197761 |
| RNF145 | ring finger protein 145 | 0.0197556 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0197243 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0196374 |
| USP34 | ubiquitin specific peptidase 34 | 0.019483 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 0.0194488 |
| YTHDC1 | YTH domain containing 1 | 0.0193577 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0193149 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0192087 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0192082 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0191598 |
| GASK1B | golgi associated kinase 1B | 0.0190727 |
| RAD21 | RAD21 homolog (S. pombe) | 0.018937 |
| MEMO1 | mediator of cell motility 1 | 0.0189143 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0188112 |
| THOC1 | THO complex 1 | 0.0187803 |
| SERINC3 | serine incorporator 3 | 0.0186368 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0186026 |
| SET | SET nuclear proto-oncogene | 0.0185399 |
| TBK1 | TANK-binding kinase 1 | 0.0185108 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0184822 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0183872 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 0.0182955 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.243768 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.144685 |
| NLGN1 | neuroligin 1 | -0.136464 |
| TMSB10 | thymosin beta 10 | -0.0944095 |
| VIM | vimentin | -0.089623 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0892104 |
| HMGA2 | high mobility group AT-hook 2 | -0.0876038 |
| ACTG1 | actin gamma 1 | -0.0788795 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0705926 |
| RPL35A | ribosomal protein L35a | -0.0601324 |
| FTL | ferritin, light polypeptide | -0.0547215 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.051499 |
| RPS8 | ribosomal protein S8 | -0.0497378 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0477771 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0441569 |
| ZNF804A | zinc finger protein 804A | -0.0420722 |
| PCDH7 | protocadherin 7 | -0.0405524 |
| EGR1 | early growth response 1 | -0.0363767 |
| HMGA1 | high mobility group AT-hook 1 | -0.0358888 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0356006 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0353676 |
| RAB7A | RAB7A, member RAS oncogene family | -0.035047 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0349008 |
| EHBP1 | EH domain binding protein 1 | -0.0346566 |
| RPL34 | ribosomal protein L34 | -0.0334041 |
| RPS29 | ribosomal protein S29 | -0.0324219 |
| JMJD1C | jumonji domain containing 1C | -0.0318577 |
| NHSL1 | NHS-like 1 | -0.0313791 |
| RPS23 | ribosomal protein S23 | -0.0311727 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0311436 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0308936 |
| RPS6 | ribosomal protein S6 | -0.0303616 |
| PTMA | prothymosin, alpha | -0.030207 |
| ASPH | aspartate beta-hydroxylase | -0.0297672 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | -0.029399 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0293126 |
| RPS27A | ribosomal protein S27a | -0.0291515 |
| BCHE | butyrylcholinesterase | -0.0290447 |
| INTS6 | integrator complex subunit 6 | -0.0286752 |
| CCND1 | cyclin D1 | -0.0286147 |
| RASAL2 | RAS protein activator like 2 | -0.0283818 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0281784 |
| CUX1 | cut-like homeobox 1 | -0.0280811 |
| RPLP1 | ribosomal protein, large, P1 | -0.0279216 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.027168 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0271149 |
| RPL9 | ribosomal protein L9 | -0.0259924 |
| RPL37A | ribosomal protein L37a | -0.0258228 |
| RPL38 | ribosomal protein L38 | -0.0257356 |
| TUBA1B | tubulin, alpha 1b | -0.0256625 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0256383 |
| RPL23 | ribosomal protein L23 | -0.0253346 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0247323 |
| S100A10 | S100 calcium binding protein A10 | -0.0244191 |
| RPS15 | ribosomal protein S15 | -0.0243155 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0242913 |
| NAV3 | neuron navigator 3 | -0.0238091 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0236933 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0236321 |
| RPL19 | ribosomal protein L19 | -0.0231967 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0230191 |
| AHNAK | AHNAK nucleoprotein | -0.0229839 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0227908 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0226372 |
| YAP1 | Yes-associated protein 1 | -0.0226175 |
| RPS19 | ribosomal protein S19 | -0.0219608 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0217973 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.021689 |
| RPS24 | ribosomal protein S24 | -0.0214645 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0214209 |
| MAP1B | microtubule-associated protein 1B | -0.0212924 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0212515 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0212481 |
| COMMD10 | COMM domain containing 10 | -0.0211705 |
| RPS27 | ribosomal protein S27 | -0.0211068 |
| PRDX1 | peroxiredoxin 1 | -0.0210203 |
| RPL37 | ribosomal protein L37 | -0.020956 |
| LRRC23 | leucine rich repeat containing 23 | -0.0207717 |
| EGFR | epidermal growth factor receptor | -0.0194603 |
| MTAP | methylthioadenosine phosphorylase | -0.0193738 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0193217 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | -0.0192653 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.019247 |
| NABP1 | nucleic acid binding protein 1 | -0.0192306 |
| RPL31 | ribosomal protein L31 | -0.0191491 |
| HMGB1 | high mobility group box 1 | -0.019135 |
| ADIPOR2 | adiponectin receptor 2 | -0.0190857 |
| ANK2 | ankyrin 2, neuronal | -0.0190649 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0190624 |
| PRKCE | protein kinase C, epsilon | -0.018944 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0188642 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0186959 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0185881 |
| RPL26 | ribosomal protein L26 | -0.0185017 |
| DIAPH2 | diaphanous-related formin 2 | -0.0183204 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0181288 |
| GNAS | GNAS complex locus | -0.0180937 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0179271 |
| CMIP | c-Maf inducing protein | -0.0175722 |
| RPS21 | ribosomal protein S21 | -0.0174548 |
