Darolutamide_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Darolutamide perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Darolutamide_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.192651
PTMA prothymosin, alpha 0.111167
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.105583
VIM vimentin 0.0969185
VCL vinculin 0.0843925
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0756367
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0750927
FAM13A family with sequence similarity 13, member A 0.075049
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0731814
AKAP12 A kinase (PRKA) anchor protein 12 0.0719608
HELZ helicase with zinc finger 0.0664885
TLE4 transducin-like enhancer of split 4 0.0664673
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0642424
KDM3A lysine (K)-specific demethylase 3A 0.0629658
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0551049
DDIT4 DNA-damage-inducible transcript 4 0.0525619
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0503034
LPIN1 lipin 1 0.0501085
EIF1 eukaryotic translation initiation factor 1 0.0500489
PRRC2C proline-rich coiled-coil 2C 0.0497744
DSCAM Down syndrome cell adhesion molecule 0.0484982
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0476343
CCDC47 coiled-coil domain containing 47 0.0461053
RPS6 ribosomal protein S6 0.045692
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0441278
WAC WW domain containing adaptor with coiled-coil 0.0439115
ZSWIM6 zinc finger, SWIM-type containing 6 0.0434973
POTEF POTE ankyrin domain family, member F 0.0433753
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0429654
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0423817
FMN1 formin 1 0.0422858
HILPDA hypoxia inducible lipid droplet-associated 0.0416399
HMGB2 high mobility group box 2 0.0398003
MED13 mediator complex subunit 13 0.039532
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0391134
ACTG1 actin gamma 1 0.0387867
WDR45B WD repeat domain 45B 0.0380837
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0380711
COL3A1 collagen, type III, alpha 1 0.0368326
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0363402
PCBP2 poly(rC) binding protein 2 0.0362707
TRA2A transformer 2 alpha homolog (Drosophila) 0.0362631
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0360916
KIF5B kinesin family member 5B 0.0355941
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.03559
TMSB10 thymosin beta 10 0.0341235
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0337772
PKM pyruvate kinase, muscle 0.0332772
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0331885
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0331345
SET SET nuclear proto-oncogene 0.0329057
CANX calnexin 0.0328123
MYH9 myosin, heavy chain 9, non-muscle 0.0325064
NAP1L1 nucleosome assembly protein 1-like 1 0.0318061
RPL23 ribosomal protein L23 0.0316248
CSDE1 cold shock domain containing E1, RNA-binding 0.0316083
ANXA2 annexin A2 0.0315031
RPL35A ribosomal protein L35a 0.0314049
ENO1 enolase 1, (alpha) 0.0313792
LDHA lactate dehydrogenase A 0.031246
B2M beta-2-microglobulin 0.0310515
PTK2 protein tyrosine kinase 2 0.0310472
SQSTM1 sequestosome 1 0.0308098
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0307335
KMT2C lysine (K)-specific methyltransferase 2C 0.0307191
KPNB1 karyopherin (importin) beta 1 0.030648
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0306156
RAB1A RAB1A, member RAS oncogene family 0.0306082
TPM4 tropomyosin 4 0.0299601
RPS12 ribosomal protein S12 0.0299402
RPL11 ribosomal protein L11 0.0298977
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0296091
FNBP1 formin binding protein 1 0.0293828
DSTN destrin (actin depolymerizing factor) 0.0293063
EEF2 eukaryotic translation elongation factor 2 0.0291328
MATR3 matrin 3 0.0291228
VMP1 vacuole membrane protein 1 0.0290646
RLF rearranged L-myc fusion 0.0289989
PGK1 phosphoglycerate kinase 1 0.0286895
APP amyloid beta (A4) precursor protein 0.0284802
GPBP1 GC-rich promoter binding protein 1 0.0281446
RPLP1 ribosomal protein, large, P1 0.0279421
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0277983
RSRC2 arginine/serine-rich coiled-coil 2 0.0277725
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0277685
RPLP0 ribosomal protein, large, P0 0.0276256
ZNF292 zinc finger protein 292 0.0275683
RPL19 ribosomal protein L19 0.0275537
TPT1 tumor protein, translationally-controlled 1 0.0274322
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0273456
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0271824
NDRG1 N-myc downstream regulated 1 0.0270818
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.026983
ENAH enabled homolog (Drosophila) 0.0266389
SOX9 SRY (sex determining region Y)-box 9 0.0260195
AKAP9 A kinase (PRKA) anchor protein 9 0.0254617
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0254258
AFF4 AF4/FMR2 family, member 4 0.0253099
RPL37 ribosomal protein L37 0.0251331
RPL37A ribosomal protein L37a 0.0250904

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.0983465
NRG1 neuregulin 1 -0.0937469
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0340541
ANTXR1 anthrax toxin receptor 1 -0.0285587
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0269496
NALF1 NALCN channel auxiliary factor 1 -0.0265178
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0260515
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0248264
CADM2 cell adhesion molecule 2 -0.0245965
FRMD4A FERM domain containing 4A -0.0234333
PTPRE protein tyrosine phosphatase, receptor type, E -0.0218622
SYT1 synaptotagmin I -0.0216146
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.021454
COL4A5 collagen, type IV, alpha 5 -0.0206066
CEMIP cell migration inducing protein, hyaluronan binding -0.0204674
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0201678
MAML2 mastermind-like 2 (Drosophila) -0.0200095
ZBTB20 zinc finger and BTB domain containing 20 -0.0199841
NCAM2 neural cell adhesion molecule 2 -0.0197212
DLC1 DLC1 Rho GTPase activating protein -0.0195814
PLAT plasminogen activator, tissue -0.0189224
GDF15 growth differentiation factor 15 -0.0188375
ATRNL1 attractin-like 1 -0.0185049
THSD4 thrombospondin, type I, domain containing 4 -0.0184801
ANTXR2 anthrax toxin receptor 2 -0.0179615
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0177431
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0174006
NRP1 neuropilin 1 -0.0168822
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0164166
GPC5 glypican 5 -0.0162767
SOS1 son of sevenless homolog 1 (Drosophila) -0.0160925
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0158808
ANGPT1 angiopoietin 1 -0.015676
COL4A6 collagen, type IV, alpha 6 -0.0155959
LIMCH1 LIM and calponin homology domains 1 -0.0154436
ZNF804A zinc finger protein 804A -0.0148011
PTPRK protein tyrosine phosphatase, receptor type, K -0.0141505
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.0135653
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0134315
PTEN phosphatase and tensin homolog -0.0133821
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0133761
TBCK TBC1 domain containing kinase -0.0132104
BICD1 bicaudal D homolog 1 (Drosophila) -0.013209
ADGRG6 adhesion G protein-coupled receptor G6 -0.0131854
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -0.0129898
TBC1D19 TBC1 domain family, member 19 -0.0128257
IGF1R insulin-like growth factor 1 receptor -0.0127826
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0126532
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0125672
SSH1 slingshot protein phosphatase 1 -0.0125447
NBEA neurobeachin -0.012357
AHR aryl hydrocarbon receptor -0.0123469
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0123284
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.0121617
HDAC8 histone deacetylase 8 -0.012092
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.011996
CRADD CASP2 and RIPK1 domain containing adaptor with death domain -0.0119664
HMGA2 high mobility group AT-hook 2 -0.011902
GPATCH2L G patch domain containing 2-like -0.0118717
RPTOR regulatory associated protein of MTOR, complex 1 -0.0118441
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0118196
ANK2 ankyrin 2, neuronal -0.0115202
ZNF521 zinc finger protein 521 -0.0111634
ANKRD50 ankyrin repeat domain 50 -0.0110789
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0110311
EXOC4 exocyst complex component 4 -0.0108616
AOPEP aminopeptidase O (putative) -0.0107851
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 -0.0106973
FHIT fragile histidine triad -0.010614
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0105064
ZNF652 zinc finger protein 652 -0.0104984
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked -0.0104219
DISC1 disrupted in schizophrenia 1 -0.0103854
CSMD3 CUB and Sushi multiple domains 3 -0.0102414
WDR49 WD repeat domain 49 -0.0102169
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0101487
PRR14L proline rich 14-like -0.0101403
TRPS1 trichorhinophalangeal syndrome I -0.0100528
KRIT1 KRIT1, ankyrin repeat containing -0.00993622
NPAS3 neuronal PAS domain protein 3 -0.00980954
MTSS2 MTSS I-BAR domain containing 2 -0.0097881
TOX thymocyte selection-associated high mobility group box -0.00973963
SRBD1 S1 RNA binding domain 1 -0.00971717
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.00968521
RIC1 RAB6A GEF complex partner 1 -0.00967851
NSRP1 nuclear speckle splicing regulatory protein 1 -0.00965737
NREP neuronal regeneration related protein -0.00957857
BBS9 Bardet-Biedl syndrome 9 -0.0095436
DTWD1 DTW domain containing 1 -0.00953312
SLIT2 slit homolog 2 (Drosophila) -0.00942201
MRC2 mannose receptor, C type 2 -0.00936603
SCFD1 sec1 family domain containing 1 -0.00928427
SH3PXD2B SH3 and PX domains 2B -0.00925871
SLC39A11 solute carrier family 39, member 11 -0.00918419
DISP1 dispatched homolog 1 (Drosophila) -0.00913103
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5 -0.00911362
DGKH diacylglycerol kinase, eta -0.00911034
PRH1 proline-rich protein HaeIII subfamily 1 -0.00904722
ADARB1 adenosine deaminase, RNA-specific, B1 -0.00902355
RANBP17 RAN binding protein 17 -0.00902237