Darolutamide_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Darolutamide perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Darolutamide_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.256262
MT2A metallothionein 2A 0.186561
TMSB10 thymosin beta 10 0.157605
IGFBP3 insulin-like growth factor binding protein 3 0.139025
FTL ferritin, light polypeptide 0.11225
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0898344
LGALS1 lectin, galactoside-binding, soluble, 1 0.0889945
RPS8 ribosomal protein S8 0.0837766
ENO1 enolase 1, (alpha) 0.0826198
TGFBI transforming growth factor, beta-induced, 68kDa 0.0777416
RPL35A ribosomal protein L35a 0.0729977
RPS6 ribosomal protein S6 0.0693695
TIMP3 TIMP metallopeptidase inhibitor 3 0.067638
B2M beta-2-microglobulin 0.0674953
CDH13 cadherin 13 0.0627377
S100A9 S100 calcium binding protein A9 0.0624389
RPL11 ribosomal protein L11 0.0548363
RPS19 ribosomal protein S19 0.0544089
STC1 stanniocalcin 1 0.0535432
RPL12 ribosomal protein L12 0.0533456
RPL23 ribosomal protein L23 0.0523673
CALR calreticulin 0.0511585
RPS12 ribosomal protein S12 0.047997
EIF1 eukaryotic translation initiation factor 1 0.047385
RPL37A ribosomal protein L37a 0.0459231
IER3 immediate early response 3 0.0456581
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0454752
PTMA prothymosin, alpha 0.0447639
RPLP1 ribosomal protein, large, P1 0.0438045
RPL26 ribosomal protein L26 0.0436503
MTDH metadherin 0.0426339
PSD3 pleckstrin and Sec7 domain containing 3 0.0411799
RACK1 receptor for activated C kinase 1 0.0410545
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0410268
S100A6 S100 calcium binding protein A6 0.0407546
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0403685
RPS3 ribosomal protein S3 0.0398162
MYDGF myeloid-derived growth factor 0.0395711
RPL7 ribosomal protein L7 0.0394287
IFI6 interferon, alpha-inducible protein 6 0.0391396
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0387769
ATF4 activating transcription factor 4 0.0382967
RPLP2 ribosomal protein, large, P2 0.0378066
LDHA lactate dehydrogenase A 0.0375738
RPL37 ribosomal protein L37 0.0372401
ACTG1 actin gamma 1 0.03718
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0371402
RPL36 ribosomal protein L36 0.0370205
RPL19 ribosomal protein L19 0.0365583
INHBA inhibin, beta A 0.0359015
IFITM3 interferon induced transmembrane protein 3 0.0357227
RPS27A ribosomal protein S27a 0.0353217
HLA-B major histocompatibility complex, class I, B 0.0348011
TPT1 tumor protein, translationally-controlled 1 0.0344162
RPL18 ribosomal protein L18 0.0338294
RPL8 ribosomal protein L8 0.033599
SQSTM1 sequestosome 1 0.0331467
IGFBP7 insulin-like growth factor binding protein 7 0.0329479
RPS14 ribosomal protein S14 0.0326911
RPL31 ribosomal protein L31 0.0320208
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 0.031496
NDRG1 N-myc downstream regulated 1 0.031271
RPL28 ribosomal protein L28 0.031094
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0309972
RPL30 ribosomal protein L30 0.0309724
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0304675
ZBTB20 zinc finger and BTB domain containing 20 0.030369
RPS20 ribosomal protein S20 0.0302831
JARID2 jumonji, AT rich interactive domain 2 0.0299028
RPS13 ribosomal protein S13 0.0287412
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0283097
ADM adrenomedullin 0.0276807
RPS16 ribosomal protein S16 0.0271607
S100A10 S100 calcium binding protein A10 0.0270857
CTSB cathepsin B 0.0270469
RPS5 ribosomal protein S5 0.026948
HLA-A major histocompatibility complex, class I, A 0.0262865
RPL9 ribosomal protein L9 0.0261842
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0260536
LIMS1 LIM and senescent cell antigen-like domains 1 0.0257873
CD63 CD63 molecule 0.025287
RPL34 ribosomal protein L34 0.0252132
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0251787
SEC61G Sec61 gamma subunit 0.024113
RPS17 ribosomal protein S17 0.0237031
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0232689
FTH1 ferritin, heavy polypeptide 1 0.023238
HDAC9 histone deacetylase 9 0.0232326
RND3 Rho family GTPase 3 0.022783
RPL32 ribosomal protein L32 0.022696
RPS25 ribosomal protein S25 0.0225339
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0219675
WSB1 WD repeat and SOCS box containing 1 0.0216829
AKAP9 A kinase (PRKA) anchor protein 9 0.0216363
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0215647
RPS11 ribosomal protein S11 0.0210453
ARL4C ADP-ribosylation factor-like 4C 0.0209357
RPS27 ribosomal protein S27 0.0209043
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0208405
TTC3 tetratricopeptide repeat domain 3 0.0206915

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.427626
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.112443
ATP13A3 ATPase type 13A3 -0.061007
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0575782
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0515781
COL6A3 collagen, type VI, alpha 3 -0.0511049
POSTN periostin, osteoblast specific factor -0.0454716
SPAG9 sperm associated antigen 9 -0.0384243
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0380917
CLIC4 chloride intracellular channel 4 -0.0379123
ELL2 elongation factor, RNA polymerase II, 2 -0.0373641
PTK2 protein tyrosine kinase 2 -0.0346752
SMAD3 SMAD family member 3 -0.0341148
TAPBP TAP binding protein (tapasin) -0.0330918
FNDC3B fibronectin type III domain containing 3B -0.0324423
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0302485
NAMPT nicotinamide phosphoribosyltransferase -0.0297657
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0291443
SOD2 superoxide dismutase 2, mitochondrial -0.0289608
RASA2 RAS p21 protein activator 2 -0.0284726
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0278697
ZNF292 zinc finger protein 292 -0.0275002
FLNA filamin A, alpha -0.0273343
KMT2E lysine (K)-specific methyltransferase 2E -0.0270339
ANXA5 annexin A5 -0.0266263
USP3 ubiquitin specific peptidase 3 -0.0262126
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0261658
TFG TRK-fused gene -0.025403
MYH9 myosin, heavy chain 9, non-muscle -0.0246326
LOXL2 lysyl oxidase-like 2 -0.0241884
AZIN1 antizyme inhibitor 1 -0.0239817
COL7A1 collagen, type VII, alpha 1 -0.0238808
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0237526
MAP1B microtubule-associated protein 1B -0.0237476
CADM1 cell adhesion molecule 1 -0.0236685
TRIO trio Rho guanine nucleotide exchange factor -0.023557
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0233903
ADAM9 ADAM metallopeptidase domain 9 -0.023301
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.022877
LTBP1 latent transforming growth factor beta binding protein 1 -0.0221892
CD44 CD44 molecule (Indian blood group) -0.0220611
ICAM1 intercellular adhesion molecule 1 -0.0213018
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0210865
COL1A2 collagen, type I, alpha 2 -0.0210315
CCNL1 cyclin L1 -0.0210215
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0209734
ADAM17 ADAM metallopeptidase domain 17 -0.0206848
KDM7A lysine (K)-specific demethylase 7A -0.0206813
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.020228
GSK3B glycogen synthase kinase 3 beta -0.0199321
RLF rearranged L-myc fusion -0.0199007
ANTXR2 anthrax toxin receptor 2 -0.0198138
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0197403
CSF1 colony stimulating factor 1 (macrophage) -0.0193738
ECE1 endothelin converting enzyme 1 -0.0193131
DPYSL3 dihydropyrimidinase-like 3 -0.0190383
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0188431
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0188242
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0186737
ZFAND3 zinc finger, AN1-type domain 3 -0.018077
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0180269
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0180021
NRP1 neuropilin 1 -0.0176472
AGFG1 ArfGAP with FG repeats 1 -0.0175139
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0174239
BHLHE40 basic helix-loop-helix family, member e40 -0.0172082
HMGA2 high mobility group AT-hook 2 -0.0171993
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0171448
AFAP1 actin filament associated protein 1 -0.0170986
QKI QKI, KH domain containing, RNA binding -0.0168261
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0167174
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0165917
VEGFC vascular endothelial growth factor C -0.0162511
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0162217
SRPK2 SRSF protein kinase 2 -0.0160712
FAT1 FAT atypical cadherin 1 -0.0160256
RNF145 ring finger protein 145 -0.0159429
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0159172
TBC1D5 TBC1 domain family, member 5 -0.0158945
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.015615
ANKRD28 ankyrin repeat domain 28 -0.0150256
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0150175
TENT4A terminal nucleotidyltransferase 4A -0.0149873
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0148724
FCHSD2 FCH and double SH3 domains 2 -0.0148389
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0148283
HIPK1 homeodomain interacting protein kinase 1 -0.0147418
JAK2 Janus kinase 2 -0.0146997
KIAA1217 KIAA1217 -0.0146673
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0145395
NRIP1 nuclear receptor interacting protein 1 -0.0144014
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0143837
NALF1 NALCN channel auxiliary factor 1 -0.0143726
TOP2B topoisomerase (DNA) II beta 180kDa -0.0143587
LENG8 leukocyte receptor cluster (LRC) member 8 -0.0142125
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0141315
RTN4 reticulon 4 -0.0141273
ARRDC3 arrestin domain containing 3 -0.014077
PRRC1 proline-rich coiled-coil 1 -0.0140519
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.013883