| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Darolutamide perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Darolutamide_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.216399 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.116926 |
| CPE | carboxypeptidase E | 0.112638 |
| DSPP | dentin sialophosphoprotein | 0.102543 |
| IGF2 | insulin-like growth factor 2 | 0.0822804 |
| TF | transferrin | 0.0764818 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0714051 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0688592 |
| AHSG | alpha-2-HS-glycoprotein | 0.0678212 |
| RPS6 | ribosomal protein S6 | 0.0567267 |
| PLIN2 | perilipin 2 | 0.0547204 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0545638 |
| RPLP0 | ribosomal protein, large, P0 | 0.0529223 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0526595 |
| RPS12 | ribosomal protein S12 | 0.0517869 |
| AFDN | afadin, adherens junction formation factor | 0.0503598 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0488283 |
| INSIG2 | insulin induced gene 2 | 0.0483276 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0481407 |
| A2M | alpha-2-macroglobulin | 0.0463108 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0446028 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0439686 |
| KIF5B | kinesin family member 5B | 0.0418613 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0415692 |
| TRIM26 | tripartite motif containing 26 | 0.040887 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0402216 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0387942 |
| RBM25 | RNA binding motif protein 25 | 0.0371351 |
| PEG3 | paternally expressed 3 | 0.0367124 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.036504 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.0349059 |
| PCBP2 | poly(rC) binding protein 2 | 0.0348881 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0334404 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0333857 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0333351 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 0.0321854 |
| VEGFA | vascular endothelial growth factor A | 0.031612 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0315111 |
| APOA1 | apolipoprotein A-I | 0.0309192 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0305226 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0299299 |
| ADM | adrenomedullin | 0.0297754 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0294375 |
| VDAC1 | voltage-dependent anion channel 1 | 0.0284895 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0283819 |
| RPL11 | ribosomal protein L11 | 0.0282807 |
| CFB | complement factor B | 0.0281802 |
| LYZ | lysozyme | 0.0266631 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0265567 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0264412 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0255536 |
| AGXT | alanine-glyoxylate aminotransferase | 0.0251983 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0251843 |
| GDF15 | growth differentiation factor 15 | 0.0249344 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0249312 |
| SERINC3 | serine incorporator 3 | 0.0248373 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.024547 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0242278 |
| PHYHIPL | phytanoyl-CoA 2-hydroxylase interacting protein-like | 0.0238975 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.0237675 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.023714 |
| SELENOP | selenoprotein P | 0.0235379 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0228955 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | 0.0225821 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0224978 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0224644 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0224217 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0224208 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0221642 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0220582 |
| RDX | radixin | 0.0219667 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.021895 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0216327 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0216157 |
| RPS3 | ribosomal protein S3 | 0.021586 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0215316 |
| GRB2 | growth factor receptor-bound protein 2 | 0.0213892 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0211338 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.020899 |
| GPT2 | glutamic pyruvate transaminase (alanine aminotransferase) 2 | 0.0205047 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | 0.0203676 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0202169 |
| SLC11A2 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 | 0.0201196 |
| SFTPA2 | surfactant protein A2 | 0.0201134 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0200784 |
| GDI2 | GDP dissociation inhibitor 2 | 0.019999 |
| RPL35A | ribosomal protein L35a | 0.0199688 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0197855 |
| CTSB | cathepsin B | 0.0197832 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0195446 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0193751 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0193339 |
| SPOPL | speckle-type POZ protein-like | 0.019253 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0192126 |
| DDOST | dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) | 0.0191915 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.0191656 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0190837 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.019029 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0188809 |
| ATF4 | activating transcription factor 4 | 0.0188425 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.22957 |
| GPC6 | glypican 6 | -0.125765 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.108019 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0927623 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0925266 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0916387 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0863011 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0763247 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0721619 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0714763 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0691986 |
| UBC | ubiquitin C | -0.0679274 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.062262 |
| PARD3 | par-3 family cell polarity regulator | -0.0607628 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0583518 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0570905 |
| SVIL | supervillin | -0.0567432 |
| MT2A | metallothionein 2A | -0.0565464 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0562707 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0533438 |
| RPS27A | ribosomal protein S27a | -0.0526926 |
| TMSB10 | thymosin beta 10 | -0.0522465 |
| DST | dystonin | -0.050732 |
| ASPH | aspartate beta-hydroxylase | -0.0498405 |
| NPAS2 | neuronal PAS domain protein 2 | -0.049076 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0483273 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0481446 |
| EHBP1 | EH domain binding protein 1 | -0.0476616 |
| KRT8 | keratin 8, type II | -0.0469949 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0465515 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0456391 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0454591 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.044092 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0438657 |
| FRMD5 | FERM domain containing 5 | -0.0435178 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0416518 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0411306 |
| RUNX1 | runt-related transcription factor 1 | -0.0399491 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0398625 |
| AHNAK | AHNAK nucleoprotein | -0.0397828 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0390153 |
| ATXN1 | ataxin 1 | -0.0389709 |
| NHSL1 | NHS-like 1 | -0.038941 |
| JUN | jun proto-oncogene | -0.0380557 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0380514 |
| CNKSR3 | CNKSR family member 3 | -0.0369735 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0362167 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0356122 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0354897 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0352906 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0352601 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0337851 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0336628 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.033367 |
| APOB | apolipoprotein B | -0.0330824 |
| ACTN1 | actinin, alpha 1 | -0.0328532 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.032773 |
| KRT18 | keratin 18, type I | -0.0323837 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0319008 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0317725 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0315109 |
| HDAC4 | histone deacetylase 4 | -0.0312741 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0310741 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0308866 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0305942 |
| FAM135A | family with sequence similarity 135, member A | -0.0300089 |
| RPL23 | ribosomal protein L23 | -0.0297939 |
| FUS | FUS RNA binding protein | -0.0297841 |
| FAM107B | family with sequence similarity 107, member B | -0.0293437 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0291315 |
| FOXP1 | forkhead box P1 | -0.0289058 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0285715 |
| PTCHD4 | patched domain containing 4 | -0.028558 |
| SMAD3 | SMAD family member 3 | -0.0282513 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0280402 |
| ACTN4 | actinin, alpha 4 | -0.0280021 |
| RNF213 | ring finger protein 213 | -0.0278899 |
| ITGAV | integrin, alpha V | -0.0278098 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.027466 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0268199 |
| TXNRD1 | thioredoxin reductase 1 | -0.0267218 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0266785 |
| BCL2L1 | BCL2-like 1 | -0.0266129 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0263259 |
| GLG1 | golgi glycoprotein 1 | -0.0259295 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0258145 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0256018 |
| PLXDC2 | plexin domain containing 2 | -0.0254108 |
| GPC3 | glypican 3 | -0.0251031 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0249754 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0247223 |
| H1-0 | H1.0 linker histone | -0.0246804 |
| ITGA1 | integrin, alpha 1 | -0.0245959 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0245307 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0244933 |
| RRBP1 | ribosome binding protein 1 | -0.0244333 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.024316 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0242177 |
| MCL1 | myeloid cell leukemia 1 | -0.0241473 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0241095 |
