Darolutamide_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Darolutamide perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Darolutamide_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.209703
TIMP3 TIMP metallopeptidase inhibitor 3 0.197237
MTSS1 metastasis suppressor 1 0.147731
LMO7 LIM domain 7 0.125263
B2M beta-2-microglobulin 0.102182
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.09344
PDE4D phosphodiesterase 4D, cAMP-specific 0.0903576
RPS6 ribosomal protein S6 0.0889397
STC1 stanniocalcin 1 0.0857371
TPT1 tumor protein, translationally-controlled 1 0.0852113
RPS8 ribosomal protein S8 0.0834218
CD44 CD44 molecule (Indian blood group) 0.0700679
SLC35F3 solute carrier family 35, member F3 0.0698106
POTEF POTE ankyrin domain family, member F 0.0695372
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0683038
PDLIM5 PDZ and LIM domain 5 0.0662007
FTH1 ferritin, heavy polypeptide 1 0.0642653
KLF5 Kruppel-like factor 5 (intestinal) 0.0631629
RPL37 ribosomal protein L37 0.0619029
ENO1 enolase 1, (alpha) 0.0572133
RPLP2 ribosomal protein, large, P2 0.0569268
RPS13 ribosomal protein S13 0.0568735
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.056478
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0551791
RPS12 ribosomal protein S12 0.0547841
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0541055
LAMC2 laminin, gamma 2 0.0538908
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0536457
MT2A metallothionein 2A 0.0524011
AKAP13 A kinase (PRKA) anchor protein 13 0.0516829
PLS3 plastin 3 0.0510712
HLA-B major histocompatibility complex, class I, B 0.0510088
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0509919
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0500341
EXT1 exostosin glycosyltransferase 1 0.0497715
HMGA2 high mobility group AT-hook 2 0.0492001
LDHA lactate dehydrogenase A 0.0479321
VCL vinculin 0.045
INTS6 integrator complex subunit 6 0.0446642
RPL11 ribosomal protein L11 0.0440469
PRSS23 protease, serine, 23 0.0436979
RPS25 ribosomal protein S25 0.043298
RPS19 ribosomal protein S19 0.0427841
RPLP1 ribosomal protein, large, P1 0.0426588
SQSTM1 sequestosome 1 0.042317
RPL23 ribosomal protein L23 0.040812
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0408077
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0407494
RPL37A ribosomal protein L37a 0.0402985
RASAL2 RAS protein activator like 2 0.0384811
RPL12 ribosomal protein L12 0.0384583
RACK1 receptor for activated C kinase 1 0.038334
CDK6 cyclin-dependent kinase 6 0.0383139
RPS3 ribosomal protein S3 0.0382691
IFITM1 interferon induced transmembrane protein 1 0.0364736
MBNL1 muscleblind-like splicing regulator 1 0.0362184
HLA-E major histocompatibility complex, class I, E 0.035187
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0351088
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0350424
PSD3 pleckstrin and Sec7 domain containing 3 0.0349523
RAI14 retinoic acid induced 14 0.0345065
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.034375
RPL31 ribosomal protein L31 0.0343093
MSN moesin 0.0338647
PALLD palladin, cytoskeletal associated protein 0.0338598
ZSWIM6 zinc finger, SWIM-type containing 6 0.0335817
ACTG1 actin gamma 1 0.0335167
MACF1 microtubule-actin crosslinking factor 1 0.0332601
RPL26 ribosomal protein L26 0.0331611
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0330553
SRRM2 serine/arginine repetitive matrix 2 0.0330444
HSPH1 heat shock 105kDa/110kDa protein 1 0.0328007
IFI6 interferon, alpha-inducible protein 6 0.0327826
RPL35A ribosomal protein L35a 0.0327778
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0326265
FN1 fibronectin 1 0.0326184
CALB1 calbindin 1, 28kDa 0.0325623
RPS27 ribosomal protein S27 0.0324776
EFNA5 ephrin-A5 0.032136
RPS24 ribosomal protein S24 0.0317886
ECE1 endothelin converting enzyme 1 0.0315092
S100A9 S100 calcium binding protein A9 0.0313815
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0310588
RPL34 ribosomal protein L34 0.0308528
RPS14 ribosomal protein S14 0.0305796
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0302101
RNF217 ring finger protein 217 0.0299711
DST dystonin 0.0298856
DOK5 docking protein 5 0.029662
OSMR oncostatin M receptor 0.0294953
TPM4 tropomyosin 4 0.0294756
RPS23 ribosomal protein S23 0.0294219
RIGI RNA sensor RIG-I 0.0293563
RPL39 ribosomal protein L39 0.0293276
TMSB4X thymosin beta 4, X-linked 0.0293161
ASTN2 astrotactin 2 0.0292724
KTN1 kinectin 1 (kinesin receptor) 0.0292579
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0289049
CD9 CD9 molecule 0.0286806
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.028673

decreased expression

Symbol Name Standardized Value
FLNB filamin B, beta -0.0827095
NAMPT nicotinamide phosphoribosyltransferase -0.0791709
EMP1 epithelial membrane protein 1 -0.056398
DLG1 discs, large homolog 1 (Drosophila) -0.046846
H1-0 H1.0 linker histone -0.0399915
MEF2A myocyte enhancer factor 2A -0.0377089
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0370218
BCL2L1 BCL2-like 1 -0.0351192
ITCH itchy E3 ubiquitin protein ligase -0.0335266
OGA O-GlcNAcase -0.0307056
ANKRD33B ankyrin repeat domain 33B -0.0297959
ANLN anillin, actin binding protein -0.0296087
RTN4 reticulon 4 -0.0293663
NPEPPS aminopeptidase puromycin sensitive -0.0284895
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0281656
CEMIP cell migration inducing protein, hyaluronan binding -0.0275277
COG5 component of oligomeric golgi complex 5 -0.0269817
KDM3A lysine (K)-specific demethylase 3A -0.0269359
KDM5B lysine (K)-specific demethylase 5B -0.0258891
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.0258184
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0254195
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0248834
AHNAK AHNAK nucleoprotein -0.0246771
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0243157
GOLGA4 golgin A4 -0.0241744
GARS1 glycyl-tRNA synthetase 1 -0.0241526
RBM39 RNA binding motif protein 39 -0.0239629
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0236528
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0234068
YBX3 Y box binding protein 3 -0.0233595
NDRG1 N-myc downstream regulated 1 -0.0229333
DOCK9 dedicator of cytokinesis 9 -0.0228663
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0227793
SULF1 sulfatase 1 -0.0225226
TRIO trio Rho guanine nucleotide exchange factor -0.0224352
RLF rearranged L-myc fusion -0.0222969
ARHGAP29 Rho GTPase activating protein 29 -0.0220064
USP3 ubiquitin specific peptidase 3 -0.0218338
AFAP1 actin filament associated protein 1 -0.021612
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0215607
LMAN1 lectin, mannose-binding, 1 -0.0213746
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0213447
TMEM135 transmembrane protein 135 -0.0213298
SBF2 SET binding factor 2 -0.0212467
BRWD3 bromodomain and WD repeat domain containing 3 -0.020822
METTL15 methyltransferase like 15 -0.020708
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0206973
EZR ezrin -0.0206939
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0204987
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0204745
EXOC6B exocyst complex component 6B -0.0204025
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 -0.0203917
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0202455
QKI QKI, KH domain containing, RNA binding -0.0197225
KDM6A lysine (K)-specific demethylase 6A -0.019578
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0192622
SPAG9 sperm associated antigen 9 -0.0191718
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0190734
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0189668
MT1X metallothionein 1X -0.0187629
NF1 neurofibromin 1 -0.0186627
NRG1 neuregulin 1 -0.0186268
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0185052
FOSL1 FOS-like antigen 1 -0.0184848
OSBPL3 oxysterol binding protein-like 3 -0.0184772
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0181084
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0180871
HELZ helicase with zinc finger -0.0180668
TMEM263 transmembrane protein 263 -0.0180355
FCHSD2 FCH and double SH3 domains 2 -0.0179928
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0179648
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0179375
TFG TRK-fused gene -0.0177342
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0173734
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0173514
SEC24D SEC24 family member D -0.0170668
SKIC3 SKI3 subunit of superkiller complex -0.0169614
CD99 CD99 molecule -0.0169551
MON2 MON2 homolog (S. cerevisiae) -0.0168447
ITSN1 intersectin 1 (SH3 domain protein) -0.016767
GRB10 growth factor receptor-bound protein 10 -0.016724
MARCHF6 membrane associated ring-CH-type finger 6 -0.0167071
EFHD2 EF-hand domain family, member D2 -0.0166001
PPARG peroxisome proliferator-activated receptor gamma -0.016596
UFM1 ubiquitin-fold modifier 1 -0.0163906
DPYD dihydropyrimidine dehydrogenase -0.0163274
CUL4B cullin 4B -0.0162357
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0161059
ITPK1 inositol-tetrakisphosphate 1-kinase -0.0159374
FSTL1 follistatin-like 1 -0.0157382
RAB6A RAB6A, member RAS oncogene family -0.0156476
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.015604
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.015505
PLAC8 placenta-specific 8 -0.0154215
BLCAP bladder cancer associated protein -0.0152791
SUCO SUN domain containing ossification factor -0.0151821
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.0151817
LNPEP leucyl/cystinyl aminopeptidase -0.0150402
GATA6 GATA binding protein 6 -0.0150173
TMEM41B transmembrane protein 41B -0.014911