Darolutamide_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Darolutamide perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Darolutamide_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.0745577
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0575546
RAI1 retinoic acid induced 1 0.0410727
EZR ezrin 0.0402383
TXNRD1 thioredoxin reductase 1 0.0402325
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0399109
CENPF centromere protein F, 350/400kDa 0.0345059
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0330966
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0297947
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0284814
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0279237
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.027841
SPAG9 sperm associated antigen 9 0.0267596
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.024659
KDM3A lysine (K)-specific demethylase 3A 0.0233189
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0226907
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.022165
GARS1 glycyl-tRNA synthetase 1 0.021892
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0216404
NUP58 nucleoporin 58 0.0207081
XPO1 exportin 1 0.0204062
ANXA1 annexin A1 0.0202797
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0200411
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0200201
BZW1 basic leucine zipper and W2 domains 1 0.0192772
EREG epiregulin 0.0191632
USP9X ubiquitin specific peptidase 9, X-linked 0.0186721
TM4SF1 transmembrane 4 L six family member 1 0.0181084
TPX2 TPX2, microtubule-associated 0.0177348
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0175783
ADAM17 ADAM metallopeptidase domain 17 0.0174223
ECT2 epithelial cell transforming 2 0.0173063
TMEM41B transmembrane protein 41B 0.0170945
ZEB1 zinc finger E-box binding homeobox 1 0.0169195
RTN4 reticulon 4 0.0164816
CKAP5 cytoskeleton associated protein 5 0.0163582
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0161808
KLF6 Kruppel-like factor 6 0.0159101
MKI67 marker of proliferation Ki-67 0.0157246
OGA O-GlcNAcase 0.0157101
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0148686
TFRC transferrin receptor 0.0148472
ARRDC3 arrestin domain containing 3 0.0145662
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0142555
FXR1 fragile X mental retardation, autosomal homolog 1 0.0141894
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0141462
DDIT4 DNA-damage-inducible transcript 4 0.0141236
MIS18BP1 MIS18 binding protein 1 0.0141077
ATP13A3 ATPase type 13A3 0.0140905
MATR3 matrin 3 0.0138263
CKAP2 cytoskeleton associated protein 2 0.0137578
RLF rearranged L-myc fusion 0.013722
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0134507
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0134082
RBM39 RNA binding motif protein 39 0.0132038
AFF4 AF4/FMR2 family, member 4 0.0131842
HMGB2 high mobility group box 2 0.0131609
USP34 ubiquitin specific peptidase 34 0.0129888
KMT2E lysine (K)-specific methyltransferase 2E 0.0128974
RRM2 ribonucleotide reductase M2 0.0126542
KIF5B kinesin family member 5B 0.0122471
JMJD1C jumonji domain containing 1C 0.0122014
ANLN anillin, actin binding protein 0.0121997
CANX calnexin 0.012116
SET SET nuclear proto-oncogene 0.0120396
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0120388
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0120221
SMC4 structural maintenance of chromosomes 4 0.0118657
STAG2 stromal antigen 2 0.0117403
CSNK1A1 casein kinase 1, alpha 1 0.011717
RNMT RNA (guanine-7-) methyltransferase 0.0116405
PUM2 pumilio RNA-binding family member 2 0.0116091
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0115902
MYH9 myosin, heavy chain 9, non-muscle 0.0115564
FNBP1L formin binding protein 1-like 0.0114619
HP1BP3 heterochromatin protein 1, binding protein 3 0.0113971
EEF2 eukaryotic translation elongation factor 2 0.0113081
ADAM9 ADAM metallopeptidase domain 9 0.0112519
KIF1B kinesin family member 1B 0.0112317
POM121 POM121 transmembrane nucleoporin 0.0111195
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0110185
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0110066
NAMPT nicotinamide phosphoribosyltransferase 0.0110018
SERINC1 serine incorporator 1 0.01098
TRA2A transformer 2 alpha homolog (Drosophila) 0.0108702
WDR26 WD repeat domain 26 0.0108576
HJURP Holliday junction recognition protein 0.0107109
CCDC47 coiled-coil domain containing 47 0.0106942
RAD23B RAD23 homolog B (S. cerevisiae) 0.0106635
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0106089
RSRC2 arginine/serine-rich coiled-coil 2 0.0105904
EIF3A eukaryotic translation initiation factor 3, subunit A 0.010537
FLNB filamin B, beta 0.0104256
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0103806
NCAPD2 non-SMC condensin I complex, subunit D2 0.0103149
MTF2 metal response element binding transcription factor 2 0.0102918
SEC24A SEC24 family member A 0.0102075
CSDE1 cold shock domain containing E1, RNA-binding 0.0101622
FMNL2 formin-like 2 0.0101328
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0100969

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.195808
TP63 tumor protein p63 -0.121841
TMSB10 thymosin beta 10 -0.11238
MT2A metallothionein 2A -0.104904
HLA-B major histocompatibility complex, class I, B -0.0889593
RPL35A ribosomal protein L35a -0.0858537
CD44 CD44 molecule (Indian blood group) -0.0836409
FTL ferritin, light polypeptide -0.0794832
RPS8 ribosomal protein S8 -0.0743261
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.068311
RPS19 ribosomal protein S19 -0.0662633
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0625861
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0606343
VIM vimentin -0.0605928
RPS6 ribosomal protein S6 -0.0597939
RPL31 ribosomal protein L31 -0.0593021
PSD3 pleckstrin and Sec7 domain containing 3 -0.0579736
RPL37A ribosomal protein L37a -0.0570998
CADM2 cell adhesion molecule 2 -0.0553274
PTMA prothymosin, alpha -0.0552598
RPL36 ribosomal protein L36 -0.0527395
RPLP2 ribosomal protein, large, P2 -0.0488202
RPL12 ribosomal protein L12 -0.047816
DST dystonin -0.0464203
TPT1 tumor protein, translationally-controlled 1 -0.0450298
RPS23 ribosomal protein S23 -0.0447237
RPS29 ribosomal protein S29 -0.0440527
RPS12 ribosomal protein S12 -0.0439799
RPL28 ribosomal protein L28 -0.0425977
RPLP1 ribosomal protein, large, P1 -0.0423187
WARS1 tryptophanyl-tRNA synthetase 1 -0.0417498
RPL26 ribosomal protein L26 -0.041722
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0409638
RPL23 ribosomal protein L23 -0.0400754
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0390366
IFI6 interferon, alpha-inducible protein 6 -0.0386404
RPL19 ribosomal protein L19 -0.0378252
DPYD dihydropyrimidine dehydrogenase -0.037666
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0368411
RPL37 ribosomal protein L37 -0.036789
RPS25 ribosomal protein S25 -0.0364561
RPS10 ribosomal protein S10 -0.0355432
TNS3 tensin 3 -0.0349247
HLA-A major histocompatibility complex, class I, A -0.0341776
IFITM1 interferon induced transmembrane protein 1 -0.0341402
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0334733
RPL36A ribosomal protein L36a -0.0327631
RPS27 ribosomal protein S27 -0.0327072
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0325643
RIGI RNA sensor RIG-I -0.0317506
RPS14 ribosomal protein S14 -0.0317484
B2M beta-2-microglobulin -0.0316248
RPS17 ribosomal protein S17 -0.0316077
RPS27A ribosomal protein S27a -0.0315422
RPL38 ribosomal protein L38 -0.0313173
RPS3 ribosomal protein S3 -0.0312911
HMGA1 high mobility group AT-hook 1 -0.0310838
RPS13 ribosomal protein S13 -0.030939
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0306915
MT1E metallothionein 1E -0.0299452
RPL11 ribosomal protein L11 -0.0293391
EGR1 early growth response 1 -0.0290769
TSC22D1 TSC22 domain family, member 1 -0.029031
RPL34 ribosomal protein L34 -0.0288325
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0283849
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0282942
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0280329
EFNA5 ephrin-A5 -0.0274236
RPL35 ribosomal protein L35 -0.0272591
RPS24 ribosomal protein S24 -0.0271199
RPL27 ribosomal protein L27 -0.0270099
ISG15 ISG15 ubiquitin-like modifier -0.0269324
SP100 SP100 nuclear antigen -0.0266798
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0263069
CFAP299 cilia and flagella associated protein 299 -0.0259633
IFIH1 interferon induced with helicase C domain 1 -0.025579
RPL9 ribosomal protein L9 -0.0249661
RPL8 ribosomal protein L8 -0.0249265
RNF213 ring finger protein 213 -0.0247816
RPS21 ribosomal protein S21 -0.0245341
RPS15 ribosomal protein S15 -0.0235657
RACK1 receptor for activated C kinase 1 -0.0231026
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0230758
PLSCR1 phospholipid scramblase 1 -0.0229218
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0222948
EHBP1 EH domain binding protein 1 -0.0220001
RPS5 ribosomal protein S5 -0.0215594
RAD51B RAD51 paralog B -0.0215189
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0215134
RPS20 ribosomal protein S20 -0.0214329
RPS16 ribosomal protein S16 -0.0211489
CSMD3 CUB and Sushi multiple domains 3 -0.0210975
RPL7A ribosomal protein L7a -0.0207176
RPL32 ribosomal protein L32 -0.0205803
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0204764
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0201005
ENO1 enolase 1, (alpha) -0.0200334
ACTG1 actin gamma 1 -0.0199829
RPS11 ribosomal protein S11 -0.0195094
DLG1 discs, large homolog 1 (Drosophila) -0.0191883