Darolutamide_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Darolutamide perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Darolutamide_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.21714
TFPI2 tissue factor pathway inhibitor 2 0.0805807
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0801133
TM4SF1 transmembrane 4 L six family member 1 0.0773714
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0770621
TXNRD1 thioredoxin reductase 1 0.0637478
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0602359
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0579931
FGB fibrinogen beta chain 0.0545181
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0521538
RAD21 RAD21 homolog (S. pombe) 0.0515175
CAVIN1 caveolae associated protein 1 0.0515161
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0508945
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0485825
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0440099
ERRFI1 ERBB receptor feedback inhibitor 1 0.0413925
ASPH aspartate beta-hydroxylase 0.0408643
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0384101
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0380078
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0372243
NAMPT nicotinamide phosphoribosyltransferase 0.0357484
HSPA8 heat shock 70kDa protein 8 0.0356615
KIF5B kinesin family member 5B 0.0340352
SLC38A1 solute carrier family 38, member 1 0.0332196
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0328246
KDM3A lysine (K)-specific demethylase 3A 0.0315046
WDR43 WD repeat domain 43 0.0313703
YBX3 Y box binding protein 3 0.0312082
USP3 ubiquitin specific peptidase 3 0.0311354
CXCL8 chemokine (C-X-C motif) ligand 8 0.0308517
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0307337
BZW1 basic leucine zipper and W2 domains 1 0.03039
RPLP0 ribosomal protein, large, P0 0.0303119
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0301309
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0297779
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0296759
CYRIB CYFIP related Rac1 interactor B 0.0293056
NAP1L1 nucleosome assembly protein 1-like 1 0.0292477
AKAP12 A kinase (PRKA) anchor protein 12 0.0288797
PTMA prothymosin, alpha 0.0287035
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0282745
MYL12B myosin, light chain 12B, regulatory 0.0280627
KLF6 Kruppel-like factor 6 0.0280281
FAM168A family with sequence similarity 168, member A 0.0277711
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0277313
EIF4A1 eukaryotic translation initiation factor 4A1 0.0267669
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.026692
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0264599
JAK1 Janus kinase 1 0.0264411
TPX2 TPX2, microtubule-associated 0.0264137
RTN4 reticulon 4 0.0263723
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0263225
EIF3H eukaryotic translation initiation factor 3, subunit H 0.025794
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0254832
ANXA2 annexin A2 0.0253702
CENPF centromere protein F, 350/400kDa 0.0252936
YBX1 Y box binding protein 1 0.0250461
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0249019
TPM3 tropomyosin 3 0.0247549
SPAG9 sperm associated antigen 9 0.0247033
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0244792
OSBPL9 oxysterol binding protein-like 9 0.0244076
TPD52 tumor protein D52 0.02379
HMGB2 high mobility group box 2 0.0235412
NUSAP1 nucleolar and spindle associated protein 1 0.0232315
ANXA1 annexin A1 0.0231795
RRM2 ribonucleotide reductase M2 0.0227723
ANLN anillin, actin binding protein 0.0226404
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.022625
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0222812
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0221239
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0219554
TUBB tubulin, beta class I 0.0217562
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 0.0217398
SSB Sjogren syndrome antigen B (autoantigen La) 0.0217008
RSL1D1 ribosomal L1 domain containing 1 0.0215717
ECT2 epithelial cell transforming 2 0.0215348
FXR1 fragile X mental retardation, autosomal homolog 1 0.0213818
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0213782
MORF4L1 mortality factor 4 like 1 0.0212706
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0212568
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0212225
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.020975
CSDE1 cold shock domain containing E1, RNA-binding 0.0208525
RACK1 receptor for activated C kinase 1 0.0207816
ENO1 enolase 1, (alpha) 0.0207682
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0206392
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0204607
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0203422
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0202766
STC1 stanniocalcin 1 0.0197134
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0196706
SDC4 syndecan 4 0.0194562
IQGAP1 IQ motif containing GTPase activating protein 1 0.0193779
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0193323
BCLAF1 BCL2-associated transcription factor 1 0.0192114
TMEM123 transmembrane protein 123 0.0191496
BASP1 brain abundant, membrane attached signal protein 1 0.019035
SERINC1 serine incorporator 1 0.0190097
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0188262

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.317387
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.183962
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.107544
PDE4D phosphodiesterase 4D, cAMP-specific -0.099676
IGFBP3 insulin-like growth factor binding protein 3 -0.0950376
THSD4 thrombospondin, type I, domain containing 4 -0.0794581
CMIP c-Maf inducing protein -0.0708906
SAMD4A sterile alpha motif domain containing 4A -0.0664005
GRAMD1B GRAM domain containing 1B -0.0618486
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0611976
DOCK4 dedicator of cytokinesis 4 -0.0608045
HLA-B major histocompatibility complex, class I, B -0.0585649
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0578926
RPS29 ribosomal protein S29 -0.0576114
FNDC3B fibronectin type III domain containing 3B -0.0540624
RPS8 ribosomal protein S8 -0.053077
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0514286
RPL31 ribosomal protein L31 -0.049395
PYGL phosphorylase, glycogen, liver -0.0473156
HLA-A major histocompatibility complex, class I, A -0.0439494
EGFR epidermal growth factor receptor -0.0435128
SVIL supervillin -0.0434225
SMOC1 SPARC related modular calcium binding 1 -0.0431364
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0428252
IGF2 insulin-like growth factor 2 -0.0425675
UBASH3B ubiquitin associated and SH3 domain containing B -0.0420608
RPS6 ribosomal protein S6 -0.0409357
NDRG1 N-myc downstream regulated 1 -0.0401563
VIM vimentin -0.0389522
DOCK5 dedicator of cytokinesis 5 -0.0379275
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0373815
RPL35A ribosomal protein L35a -0.0373287
CUX1 cut-like homeobox 1 -0.0357808
RPL28 ribosomal protein L28 -0.0357501
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0351399
TMSB10 thymosin beta 10 -0.0350214
EIF1 eukaryotic translation initiation factor 1 -0.0349663
RPS15 ribosomal protein S15 -0.0342013
RPL37A ribosomal protein L37a -0.0338435
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0334249
RPS23 ribosomal protein S23 -0.032673
ARHGAP26 Rho GTPase activating protein 26 -0.0326532
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0318241
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0317143
RPS27 ribosomal protein S27 -0.0315111
IL6 interleukin 6 -0.0306808
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0303881
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0298475
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0292272
RPS25 ribosomal protein S25 -0.0287794
PDIA3 protein disulfide isomerase family A, member 3 -0.0286354
RPS13 ribosomal protein S13 -0.0285566
RPS19 ribosomal protein S19 -0.0283364
RPS11 ribosomal protein S11 -0.028067
FMNL2 formin-like 2 -0.0275152
RPLP1 ribosomal protein, large, P1 -0.0267167
FLNB filamin B, beta -0.0264015
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0263042
CD99 CD99 molecule -0.0262972
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0262519
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.025828
MT1F metallothionein 1F -0.0256262
KTN1 kinectin 1 (kinesin receptor) -0.0255631
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0253219
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0252379
PCNX4 pecanex 4 -0.0252126
HM13 histocompatibility (minor) 13 -0.0248732
WAC WW domain containing adaptor with coiled-coil -0.0247233
ATXN1 ataxin 1 -0.0238179
COPA coatomer protein complex, subunit alpha -0.0235833
FTH1 ferritin, heavy polypeptide 1 -0.0234969
USP36 ubiquitin specific peptidase 36 -0.023462
RPL36 ribosomal protein L36 -0.0230648
ANKRD11 ankyrin repeat domain 11 -0.0228968
KYNU kynureninase -0.0228871
LAMA5 laminin, alpha 5 -0.022858
RAD51B RAD51 paralog B -0.0226586
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0225116
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0224384
NUMB numb homolog (Drosophila) -0.0224383
RPS17 ribosomal protein S17 -0.0223775
OSMR oncostatin M receptor -0.0220622
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0219829
MCL1 myeloid cell leukemia 1 -0.0219418
PARD3 par-3 family cell polarity regulator -0.0218295
TPM1 tropomyosin 1 (alpha) -0.0216059
RCC1 regulator of chromosome condensation 1 -0.021535
GOLGA4 golgin A4 -0.0215282
STC2 stanniocalcin 2 -0.0215171
S100A10 S100 calcium binding protein A10 -0.0214524
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0213864
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0213682
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0211294
ATG7 autophagy related 7 -0.0209794
ASTN2 astrotactin 2 -0.0208483
BICD1 bicaudal D homolog 1 (Drosophila) -0.0208342
KIF13A kinesin family member 13A -0.0207931
CTBP2 C-terminal binding protein 2 -0.0207909
NEBL nebulette -0.0207814
USP34 ubiquitin specific peptidase 34 -0.0207236