Darolutamide_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Darolutamide perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Darolutamide_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.227597
TMSB10 thymosin beta 10 0.129298
PTMA prothymosin, alpha 0.1142
STC1 stanniocalcin 1 0.113229
AKAP12 A kinase (PRKA) anchor protein 12 0.111763
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0982271
TPT1 tumor protein, translationally-controlled 1 0.0949654
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0835224
PRRC2C proline-rich coiled-coil 2C 0.080826
MT2A metallothionein 2A 0.078736
EZR ezrin 0.0763819
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0736865
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0694107
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0683694
TIMP3 TIMP metallopeptidase inhibitor 3 0.066025
LOC112694756 uncharaterized LOC112694756 0.0650007
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.064877
CANX calnexin 0.0642819
RPL12 ribosomal protein L12 0.0639326
TRIO trio Rho guanine nucleotide exchange factor 0.0626549
DSCAM Down syndrome cell adhesion molecule 0.061823
FTH1 ferritin, heavy polypeptide 1 0.061236
RPL35A ribosomal protein L35a 0.0607863
VCL vinculin 0.0604768
TPM4 tropomyosin 4 0.0561566
IGFBP3 insulin-like growth factor binding protein 3 0.0557303
NDRG1 N-myc downstream regulated 1 0.0554877
INHBA inhibin, beta A 0.0552936
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0547116
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0531386
RPS8 ribosomal protein S8 0.0522686
CDH13 cadherin 13 0.0513973
NOP58 NOP58 ribonucleoprotein 0.0502232
HLA-B major histocompatibility complex, class I, B 0.0493285
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0492381
FNDC3B fibronectin type III domain containing 3B 0.0489233
PCBP2 poly(rC) binding protein 2 0.0485993
PTK2 protein tyrosine kinase 2 0.0459024
RACK1 receptor for activated C kinase 1 0.0457859
PGK1 phosphoglycerate kinase 1 0.0452934
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0450702
ASPH aspartate beta-hydroxylase 0.0447491
HDLBP high density lipoprotein binding protein 0.0446272
NAMPT nicotinamide phosphoribosyltransferase 0.0444784
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0444502
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0441938
LOXL2 lysyl oxidase-like 2 0.0440561
TOP1 topoisomerase (DNA) I 0.0435589
TTC3 tetratricopeptide repeat domain 3 0.043401
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0421256
SEC31A SEC31 homolog A (S. cerevisiae) 0.0416437
BPTF bromodomain PHD finger transcription factor 0.041466
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0413099
EIF1 eukaryotic translation initiation factor 1 0.0411716
USP34 ubiquitin specific peptidase 34 0.0408052
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0407287
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0400177
TPR translocated promoter region, nuclear basket protein 0.0398726
PRKCA protein kinase C, alpha 0.0397913
GARS1 glycyl-tRNA synthetase 1 0.0396085
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0393908
ELL2 elongation factor, RNA polymerase II, 2 0.0391186
ERRFI1 ERBB receptor feedback inhibitor 1 0.0391151
B2M beta-2-microglobulin 0.039034
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0389453
ITCH itchy E3 ubiquitin protein ligase 0.0387468
CD44 CD44 molecule (Indian blood group) 0.037896
SQSTM1 sequestosome 1 0.0375342
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0373545
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0371233
EMP1 epithelial membrane protein 1 0.0368383
SRP54 signal recognition particle 54kDa 0.0361721
RAI1 retinoic acid induced 1 0.0360976
SBF2 SET binding factor 2 0.0360297
ESYT2 extended synaptotagmin-like protein 2 0.0358558
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0355663
WWTR1 WW domain containing transcription regulator 1 0.0349384
CLTC clathrin, heavy chain (Hc) 0.034127
CALU calumenin 0.0339983
PSD3 pleckstrin and Sec7 domain containing 3 0.0339452
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0334775
ETNK1 ethanolamine kinase 1 0.0333107
EFNA5 ephrin-A5 0.0332431
ACTG1 actin gamma 1 0.0331769
BIRC6 baculoviral IAP repeat containing 6 0.0328253
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0316187
RPS13 ribosomal protein S13 0.0314209
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0311268
EIF5B eukaryotic translation initiation factor 5B 0.0303078
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0302779
FN1 fibronectin 1 0.0299514
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0298866
LMNA lamin A/C 0.0296937
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0296328
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0295698
CHD1 chromodomain helicase DNA binding protein 1 0.0294837
NT5C2 5'-nucleotidase, cytosolic II 0.0294692
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0293657
RAB8B RAB8B, member RAS oncogene family 0.0291013
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0290419

decreased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0963056
IGF2 insulin-like growth factor 2 -0.0837323
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0799137
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 -0.0727989
GRB10 growth factor receptor-bound protein 10 -0.068422
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0679039
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0661714
SAMD4A sterile alpha motif domain containing 4A -0.0655718
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0602192
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0565663
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0562368
BRWD1 bromodomain and WD repeat domain containing 1 -0.0554023
EPB41L5 erythrocyte membrane protein band 4.1 like 5 -0.0551549
ZNF292 zinc finger protein 292 -0.0533333
NUP98 nucleoporin 98kDa -0.0519433
LCORL ligand dependent nuclear receptor corepressor-like -0.0519057
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.051876
GLS2 glutaminase 2 (liver, mitochondrial) -0.0517004
TNIP1 TNFAIP3 interacting protein 1 -0.0493734
ZFR zinc finger RNA binding protein -0.0485105
JMJD1C jumonji domain containing 1C -0.0484102
PDE10A phosphodiesterase 10A -0.0473207
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0457833
DTNA dystrobrevin, alpha -0.0457264
NAV2 neuron navigator 2 -0.0450678
CDK19 cyclin-dependent kinase 19 -0.0447416
ANKRD10 ankyrin repeat domain 10 -0.0447127
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -0.04442
C3 complement component 3 -0.044131
CFDP1 craniofacial development protein 1 -0.0440487
OGA O-GlcNAcase -0.0432524
DENND1A DENN/MADD domain containing 1A -0.0422839
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.042014
UBE2H ubiquitin-conjugating enzyme E2H -0.0419824
USP9X ubiquitin specific peptidase 9, X-linked -0.0414349
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 -0.0402724
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0401283
CEMIP cell migration inducing protein, hyaluronan binding -0.0400714
RAB10 RAB10, member RAS oncogene family -0.0397881
ZNF638 zinc finger protein 638 -0.0396296
ATOSA atos homolog A -0.0395458
RBM25 RNA binding motif protein 25 -0.0394324
PERP PERP, TP53 apoptosis effector -0.0393627
ARL15 ADP-ribosylation factor-like 15 -0.0392316
TRIM56 tripartite motif containing 56 -0.0388862
CAMTA1 calmodulin binding transcription activator 1 -0.0388366
PTEN phosphatase and tensin homolog -0.0387059
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0386984
CNKSR3 CNKSR family member 3 -0.038174
CHD7 chromodomain helicase DNA binding protein 7 -0.0377647
AGO3 argonaute RISC catalytic component 3 -0.037349
HIPK3 homeodomain interacting protein kinase 3 -0.0369947
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0369287
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0368954
SLK STE20-like kinase -0.0365711
SPAG9 sperm associated antigen 9 -0.0362533
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0362278
CPE carboxypeptidase E -0.0359349
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 -0.0359266
AHNAK AHNAK nucleoprotein -0.0358445
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0353499
NPTN neuroplastin -0.0353009
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains -0.035188
CHD6 chromodomain helicase DNA binding protein 6 -0.0351756
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0348767
MED13 mediator complex subunit 13 -0.0346787
KLC1 kinesin light chain 1 -0.0344412
ZDHHC20 zinc finger, DHHC-type containing 20 -0.0344246
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.034349
LSAMP limbic system-associated membrane protein -0.0341016
SOD2 superoxide dismutase 2, mitochondrial -0.0337766
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0333886
HELZ helicase with zinc finger -0.0327819
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -0.0327806
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0327009
MAP4 microtubule-associated protein 4 -0.0323141
TENT2 terminal nucleotidyltransferase 2 -0.032207
NGLY1 N-glycanase 1 -0.032202
SNX9 sorting nexin 9 -0.032195
PAPOLA poly(A) polymerase alpha -0.0320196
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0319008
PEAK1 pseudopodium-enriched atypical kinase 1 -0.0318603
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0318557
MCTP1 multiple C2 domains, transmembrane 1 -0.0318129
TRA2A transformer 2 alpha homolog (Drosophila) -0.031414
TBC1D5 TBC1 domain family, member 5 -0.031346
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0312991
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme -0.0311855
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0311266
WAC WW domain containing adaptor with coiled-coil -0.0310652
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0307998
DCAF6 DDB1 and CUL4 associated factor 6 -0.0306472
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0303806
NAP1L4 nucleosome assembly protein 1-like 4 -0.0300347
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0299805
LAMB3 laminin, beta 3 -0.0297467
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0297075
SMC5 structural maintenance of chromosomes 5 -0.0296854
RUNX1 runt-related transcription factor 1 -0.029556
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -0.0293867