Darolutamide_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Darolutamide perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Darolutamide_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.212147
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0603693
ERRFI1 ERBB receptor feedback inhibitor 1 0.0600689
THSD4 thrombospondin, type I, domain containing 4 0.0566867
GRAMD1B GRAM domain containing 1B 0.0554433
OSMR oncostatin M receptor 0.0405983
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0405769
RAD51B RAD51 paralog B 0.0335696
VCL vinculin 0.0312585
USP34 ubiquitin specific peptidase 34 0.0307989
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0304557
EXOC4 exocyst complex component 4 0.0283509
HMGA2 high mobility group AT-hook 2 0.0281107
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0278134
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0270613
AFF3 AF4/FMR2 family, member 3 0.0263744
MCL1 myeloid cell leukemia 1 0.0261669
SMAD3 SMAD family member 3 0.0254476
EHBP1 EH domain binding protein 1 0.024932
MACF1 microtubule-actin crosslinking factor 1 0.0237523
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0236839
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0224502
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0221809
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0218803
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0214959
TRIO trio Rho guanine nucleotide exchange factor 0.0211482
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0207365
ATXN1 ataxin 1 0.0206949
ANO6 anoctamin 6 0.0206263
DOCK5 dedicator of cytokinesis 5 0.0205654
EGFR epidermal growth factor receptor 0.0203125
FMNL2 formin-like 2 0.0202304
ZBTB20 zinc finger and BTB domain containing 20 0.0200475
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0197732
STAT1 signal transducer and activator of transcription 1, 91kDa 0.019192
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0189984
ICAM1 intercellular adhesion molecule 1 0.0189917
MSN moesin 0.0189887
RIMS2 regulating synaptic membrane exocytosis 2 0.0187207
PTK2 protein tyrosine kinase 2 0.018713
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0186856
POTEF POTE ankyrin domain family, member F 0.0183676
PDE10A phosphodiesterase 10A 0.0182432
STC1 stanniocalcin 1 0.0179676
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0174569
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0174395
CDK17 cyclin-dependent kinase 17 0.0172708
TPM3 tropomyosin 3 0.0171035
FNDC3B fibronectin type III domain containing 3B 0.0170593
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0170232
IGF1R insulin-like growth factor 1 receptor 0.0169139
MMP12 matrix metallopeptidase 12 0.0168944
TAS2R14 taste receptor, type 2, member 14 0.0167969
PYGL phosphorylase, glycogen, liver 0.0163145
BABAM2 BRISC and BRCA1 A complex member 2 0.016137
WWTR1 WW domain containing transcription regulator 1 0.0161337
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0160381
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.015899
PDLIM5 PDZ and LIM domain 5 0.0157853
CSNK1A1 casein kinase 1, alpha 1 0.0156364
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0153668
SFPQ splicing factor proline/glutamine-rich 0.015357
DSPP dentin sialophosphoprotein 0.0151461
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0150186
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0148597
PRKCE protein kinase C, epsilon 0.0148531
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0146914
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0146261
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0146191
XPO1 exportin 1 0.0146164
EML4 echinoderm microtubule associated protein like 4 0.0146052
MYOF myoferlin 0.0145721
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0145634
PDE4D phosphodiesterase 4D, cAMP-specific 0.0145624
ITSN1 intersectin 1 (SH3 domain protein) 0.0142486
ACTN1 actinin, alpha 1 0.0141596
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.014129
SRSF4 serine/arginine-rich splicing factor 4 0.0140938
R3HDM2 R3H domain containing 2 0.0140508
YAP1 Yes-associated protein 1 0.0140367
ANKRD36 ankyrin repeat domain 36 0.0140031
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0137144
VMP1 vacuole membrane protein 1 0.0137024
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.013684
ATP13A3 ATPase type 13A3 0.0135722
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0134214
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.013253
DST dystonin 0.0132261
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0129618
NCOA7 nuclear receptor coactivator 7 0.0129296
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0127117
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0126534
USP9X ubiquitin specific peptidase 9, X-linked 0.0126412
RYR3 ryanodine receptor 3 0.012547
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0124668
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0124542
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0122434
TIAM1 T-cell lymphoma invasion and metastasis 1 0.012171
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0121119
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0120109

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.362367
TFPI2 tissue factor pathway inhibitor 2 -0.106614
TMSB10 thymosin beta 10 -0.105298
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0835524
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0809773
PTMA prothymosin, alpha -0.0762718
EGR1 early growth response 1 -0.0663921
RPLP1 ribosomal protein, large, P1 -0.0656469
RPS8 ribosomal protein S8 -0.0648885
RPL35A ribosomal protein L35a -0.060316
RPL37A ribosomal protein L37a -0.0573853
YBX1 Y box binding protein 1 -0.0544737
RPS21 ribosomal protein S21 -0.0539809
RPL12 ribosomal protein L12 -0.0510841
EEF2 eukaryotic translation elongation factor 2 -0.050636
RPS29 ribosomal protein S29 -0.0494799
RPL26 ribosomal protein L26 -0.0469148
RPL5 ribosomal protein L5 -0.0453617
RPS15 ribosomal protein S15 -0.0443042
RPS3 ribosomal protein S3 -0.043148
RPL23 ribosomal protein L23 -0.0423272
RPS27 ribosomal protein S27 -0.0419841
VIM vimentin -0.0419311
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0418495
RPL37 ribosomal protein L37 -0.0410061
RPLP2 ribosomal protein, large, P2 -0.0407083
RPS10 ribosomal protein S10 -0.039485
RPS19 ribosomal protein S19 -0.0388248
RPL32 ribosomal protein L32 -0.0384559
RPL19 ribosomal protein L19 -0.0381682
RPL8 ribosomal protein L8 -0.0372741
RPLP0 ribosomal protein, large, P0 -0.0359793
MYL12B myosin, light chain 12B, regulatory -0.0359159
FTL ferritin, light polypeptide -0.0351022
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0349947
RPL36 ribosomal protein L36 -0.0345739
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0345484
ACTG1 actin gamma 1 -0.0338421
PFN1 profilin 1 -0.0337435
RPS6 ribosomal protein S6 -0.0333548
RPL34 ribosomal protein L34 -0.0330944
RPL38 ribosomal protein L38 -0.0326053
RPL28 ribosomal protein L28 -0.032067
RPL11 ribosomal protein L11 -0.0320403
EIF1 eukaryotic translation initiation factor 1 -0.0313185
RPL31 ribosomal protein L31 -0.0312294
TPI1 triosephosphate isomerase 1 -0.0308974
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0296621
GSTP1 glutathione S-transferase pi 1 -0.0296321
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0282945
RPS27A ribosomal protein S27a -0.028122
RPL13A ribosomal protein L13a -0.0280588
RPS25 ribosomal protein S25 -0.0280185
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.027944
SEPTIN7 septin 7 -0.0278514
RPS13 ribosomal protein S13 -0.0278338
RPS4X ribosomal protein S4, X-linked -0.0277162
RPL9 ribosomal protein L9 -0.0266048
RPS20 ribosomal protein S20 -0.0261331
RPL27 ribosomal protein L27 -0.0259315
NAP1L1 nucleosome assembly protein 1-like 1 -0.0257202
GOLGA4 golgin A4 -0.0249001
TPM2 tropomyosin 2 (beta) -0.0244759
RPL35 ribosomal protein L35 -0.0242317
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0242238
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0236006
HMGA1 high mobility group AT-hook 1 -0.0235137
RPS14 ribosomal protein S14 -0.0235084
TPT1 tumor protein, translationally-controlled 1 -0.0234437
ATP5F1E ATP synthase F1 subunit epsilon -0.0228422
MT2A metallothionein 2A -0.022659
RPS16 ribosomal protein S16 -0.0225305
GNAS GNAS complex locus -0.0223148
EIF5B eukaryotic translation initiation factor 5B -0.0222879
BRD2 bromodomain containing 2 -0.022052
S100A11 S100 calcium binding protein A11 -0.0218633
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0217852
DEK DEK proto-oncogene -0.0216218
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0213834
LOC112694756 uncharaterized LOC112694756 -0.020933
LMAN1 lectin, mannose-binding, 1 -0.0208914
RPS23 ribosomal protein S23 -0.0207575
FUS FUS RNA binding protein -0.0207556
RPS17 ribosomal protein S17 -0.0205118
OAZ1 ornithine decarboxylase antizyme 1 -0.020447
LDHB lactate dehydrogenase B -0.0202799
UBB ubiquitin B -0.0202747
RPS24 ribosomal protein S24 -0.0200946
RACK1 receptor for activated C kinase 1 -0.020042
PKM pyruvate kinase, muscle -0.0200119
EEF1G eukaryotic translation elongation factor 1 gamma -0.0199955
CAMKMT calmodulin-lysine N-methyltransferase -0.0196013
RPS2 ribosomal protein S2 -0.019476
BSG basigin (Ok blood group) -0.0193144
GARS1 glycyl-tRNA synthetase 1 -0.019093
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0188489
RPL30 ribosomal protein L30 -0.0188354
RPL7A ribosomal protein L7a -0.0181992
RPL18 ribosomal protein L18 -0.0181555
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0181391